On the opposite side of the spectrum, the group of benign epilepsy syndromes presented in this book is clearly more prevalent in childhood than the intractable epilepsies. [books.google.com]

Five patients had epigastric auras often associated to oro-alimentary automatic activity, 3 patients presented loss of contact, and 2 experienced secondary generalizations. [ncbi.nlm.nih.gov]

ORPHA:163717 Synonym(s): Benign FMTLE Prevalence: - Inheritance: Autosomal dominant Age of onset: - ICD-10: - OMIM: 611630 614417 615697 UMLS: - MeSH: - GARD: - MedDRA: - The documents contained in this web site are presented for information purposes [orpha.net]

• Epilepsy

  RESULTS: The family had 6 members with temporal lobe epilepsy. Age at seizure onset ranged from 8 to 13 years. [ncbi.nlm.nih.gov]

  Pathways for Benign Familial Mesial Temporal Lobe Epilepsy GO Terms for Benign Familial Mesial Temporal Lobe Epilepsy Sources for Benign Familial Mesial Temporal Lobe Epilepsy [malacards.org]

  Homepage Rare diseases Search Search for a rare disease Benign familial mesial temporal lobe epilepsy Disease definition Benign familial mesial temporal lobe epilepsy is a rare epilepsy characterized by seizures with viscerosensory or experential auras [orpha.net]

• Fever

  Factors that may contribute to these seizures include screen brightness, sleep deprivation, fatigue, fever and short distance from the screen. [aafp.org]

  It is best to let a child rest during these times, remain well nourished, and have judicious control of fever. [childneurologyfoundation.org]

  CSF examination is recommended in children (except for infants younger than 6 months of age) and adults only when cerebral infection is suspected or fever is present which cannot be explained by an extracranial origin (Hirtz et al. 2000; Beghi 2008). [slideshare.net]

  At discharge patient’s examination was normal except for persistence of fever and oral prednisone was started but he developed a cerebral venous sinus thrombosis. [docksci.com]

• Weakness

  Seizures from the motor area of the brain are often followed by weakness of the involved parts of the body. This is called postictal (after a seizure) hemiparesis or hemiplegia. It can also be called a Todd paralysis. [childneurologyfoundation.org]

  Unilateral nuclear third nerve palsy ischaracterized by bilateral ptosis and bilateral superior rectus weakness; ipsilateral mydriasis, weakness of the medial rectus, inferior rectus, and inferior oblique muscles. [docksci.com]

  Focal motor seizures may be followed by a weakness of the involved muscle groups that lasts for up to several hours (Todd’s paralysis). • Versive seizures, which are tonic or clonic postural seizures with turning of the head and the eyes, and sometimes [slideshare.net]

• Nausea

  Temporal lobe seizures are often accompanied by strange sensations, sweating, flushing, vertigo, epigastric sensations, taste, and hearing of sounds or melodies, nausea, hallucinations or feelings of déjà vu. [epilepsyqueensland.com.au]

  […] and perceptual phenomena, as well as autonomic symptoms is possible in this epilepsy syndrome: déjà vu, jamais vu, “stranger behind the back”, feeling of detachment from oneself, sensation of enlightenment, extreme pleasure, fear and dread, anxiety, nausea [doctorstrizhak.com]

  Symptoms are myriad but tend to localize around the eyes (glassy-eyed, “drugged”, dazed, far-away look), the mouth (lip-smacking, drooling, gurgling) and the abdomen (nausea, vomiting, epigastric sensation). 8 Most seizures last for several minutes and [aafp.org]

  Children with these types of seizures can present with pallor, visual changes, vomiting, nausea, dilated pupils, or fainting spells. The eyes and head can be deviated towards one direction and consciousness can be impaired. [childneurologyfoundation.org]

  however, be minimal or absent Transient global amnesia Sudden onset of isolated anterograde and retrograde amnesia for usually 2–8 h Panic attack Abrupt onset with intense feeling of fear, no loss of consciousness, autonomic features (tachycardia, nausea [slideshare.net]

• Suggestibility

  CONCLUSIONS: Our data suggest the existence of a novel locus for benign familial mesial temporal lobe epilepsy on chromosome 3q26. [ncbi.nlm.nih.gov]

  Scott Baraban, Edward Cooper, Donald Schomer, and Robert Sloviter for their useful suggestions and critical review. [nejm.org]

  Thus, the finding of at least two MTLE patients in one family is suggestive of familial MTLE. [neupsykey.com]

• Aggressive Behavior

  Seizures from the cingulate gyrus can involve screaming, aggressive behavior, and feelings of intense fear. The heart and breathing rate may rise, and sweating and pallor can also occur. [childneurologyfoundation.org]

• Euphoria

  They can also be characterised by irritating senses of smell or taste, autonomic symptoms (flushing, sweating, changes of heart rate), emotional changes (rising fear or anxiety, anger, depression, euphoria) or memory symptoms (déjà vu or jamais vu – a [epilepsyqueensland.com.au]

• Psychiatric Symptoms

  Patients suffer from psychiatric symptoms, including memory loss and confusion, and from epilepsy. A subset of patients with LE have autoantibodies directed against the LGI1 protein. [epilepsygenetics.net]

• Seizure

  Age at seizure onset ranged from 8 to 13 years. Five patients had epigastric auras often associated to oro-alimentary automatic activity, 3 patients presented loss of contact, and 2 experienced secondary generalizations. [ncbi.nlm.nih.gov]

  It is defined as at least 24 months of seizure freedom with or without antiepileptic medication. [orpha.net]

  The frequent occurrence of seizures refractory to antiepileptic drug treatments is of great concern. [books.google.com]

• Febrile Seizures

  […] refractory epilepsies, often with a history of febrile seizures and with frequent hippocampal atrophy and high T₂ signal on magnetic resonance imaging. [ncbi.nlm.nih.gov]

  Febrile seizures occurred in 2 family members, 1 of whom also had temporal lobe epilepsy. EEG showed focal slow waves and epileptic abnormalities on temporal regions in 1 patient and was normal in the other affected individuals. [diagenode.com]

  Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. [genecards.org]

  Complex febrile seizures. Epilepsia. 1996;37:126–33. 5. Practice parameter: long-term treatment of the child with simple febrile seizures. American Academy of Pediatrics. Committee on Quality Improvement, Subcommittee on Febrile Seizures. [aafp.org]

• Aura

  Five patients had epigastric auras often associated to oro-alimentary automatic activity, 3 patients presented loss of contact, and 2 experienced secondary generalizations. [ncbi.nlm.nih.gov]

  Homepage Rare diseases Search Search for a rare disease Benign familial mesial temporal lobe epilepsy Disease definition Benign familial mesial temporal lobe epilepsy is a rare epilepsy characterized by seizures with viscerosensory or experential auras [orpha.net]

  Some of the reported families, grouped on the basis of a specific aura, may represent an interesting subgroup on whom to focus future linkage studies. [scipers.com]

  There are several reports of patients with LGI1 mutations with other partial seizures including receptive aphasia (loss of speech comprehension) and visual auras. [epilepsygenetics.net]

• Generalized Tonic-Clonic Seizure

  Hippocampal atrophy was found also in patients that did not fulfill the criteria for MTLE: 3 of 10 (30%) patients with febrile seizure alone, 6 of 10 (60%) patients with recurrent generalized tonic-clonic seizures, and 1 of 4 (25%) patients with a single [repositorio.unicamp.br]

  tonic-clonic seizures alone Progressive myoclonic epilepsies Autosomal dominant partial epilepsy with auditory features 1/29 Saima Saima Piotr Other familial temporal lobe epilepsies Familial focal epilepsy with variable foci Reflex epilepsies 2/26 Adriana [loyolamedicine.org]

  Generalized tonic-clonic seizures (GTCS; 2/3 of patients) are infrequent ( Rising epigastric sensation does not occur. [epilepsy.com]

  These episodes sometimes occurred seconds before she had a generalized tonic-clonic seizure.” LGI1. [epilepsygenetics.net]

  Seizure semiologies included predominantly SPS with déjà vu feeling, infrequent CPS, and rare secondarily generalized tonic-clonic seizures. [neurology.org]

• Generalized Seizure

  seizures Generalized seizures affect both the cerebral hemispheres right from the onset of the seizure. [ispub.com]

  Grand mal seizures can be primarily generalized seizures or can evolve from focal seizures (bilateral convulsive seizures, old term: secondarily generalized seizures). [slideshare.net]

  Symptoms vary from small absence seizures, where the person is unresponsive for a few seconds or minutes, to generalized seizures, with possible falling, convulsions and repetitive behavior. [neurosurgery.ucla.edu]

  Often, these children present for medical attention because of the high association (50 percent) with generalized seizures, which tend to be nocturnal or early-morning episodes. [aafp.org]

• Onset in Adolescence

  […] in adolescence or early adulthood and good prognosis. [orpha.net]

  […] in adolescence or adulthood Often prominent ictal déjà vu, dreamlike state, fear, and nausea, with simple partial and complex partial seizures and infrequent secondary generalization. [slideshare.net]

No other workup or CSF markers were obtained. MRI of 10/05: Lesion is recorded as 8 10 mm. [med.virginia.edu]

[…] lesion for neoplastic signal Electroencephalography (EEG); indicated in all patients with suspected temporal lobe epilepsy Magnetoencephalography (MEG); mainly used for coregistration with MRI to give magnetic source imaging in 3-dimensional space See Workup [emedicine.medscape.com]

The same is valid if in the later course of the diagnostic workup, localization information is acquired by PET, SPECT or MEG. [slideshare.net]

This requires extensive workup with detailed brain imaging and EEGs. A neurosurgeon will then surgically remove the area of the brain that is causing the seizures. This is called epilepsy surgery. [childneurologyfoundation.org]

Additional workup in selected patients may include serologies and CSF analysis. Ocular miastenia must be included in the differential diagnosis in all cases of motility disorders, expecially when pupil is not involved. [docksci.com]

• Focal Slow-Waves

  EEG showed focal slow waves and epileptic abnormalities on temporal regions in 1 patient and was normal in the other affected individuals. MRI was normal in all temporal lobe epilepsy patients. [ncbi.nlm.nih.gov]

  Inter-ictal EEG Usually normal (half the cases) or with mild focal slow waves (28%) or sparse sharp- and slow-wave complexes localized in the temporal region and usually unilateral (22%). Sleep may activate epileptiform abnormalities. [epilepsy.com]

  Inter-ictal EEG is often abnormal with focal slow waves and spikes over the affected temporal lobe. Ictal EEG demonstrates 4 to 7 Hz rhythmic activity or fast spiking in the leads over the affected temporal lobe. [doctorstrizhak.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

The frequent occurrence of seizures refractory to antiepileptic drug treatments is of great concern. [books.google.com]

Some of the services we provide include: • Brachial Plexus Palsy treatment • Cerebral Palsy treatment • Epilepsy treatment • General Neurology treatment • Movement Disorders treatment • Neurofibromatosis Center treatment • Stroke treatment • Tuberous [neuro.wustl.edu]

The text has truly become a pragmatic and helpful guide in the treatment of epilepsy." (George L. [axon.es]

[…] disease Benign familial mesial temporal lobe epilepsy Disease definition Benign familial mesial temporal lobe epilepsy is a rare epilepsy characterized by seizures with viscerosensory or experential auras, onset in adolescence or early adulthood and good prognosis [orpha.net]

Neurologists and paediatricians should be familiar with these conditions because accurate diagnosis, and its consequent good prognosis, may save much suffering to the family. [books.google.com]

Prognosis and Treatment of Lateral Temporal Epilepsy The prognosis largely depends on the cause of the brain lesion and is not very predictable. [doctorstrizhak.com]

Studies on the prognosis of TLE-NL are still limited, so this assumption has not been confirmed to date. [dovepress.com]

These seizures range from benign neonatal convulsions to infantile spasms (West syndrome) to absence seizures and partial seizures associated with well-defined focal pathology with many types and etiologies. [clinicalgate.com]

Epilepsy due to perinatal insults Epilepsy due to malformations of cortical development 4/16 Chandler Preston Chandler Epilepsy due to mitochondrial and metabolic disorders Benign neonatal seizures Breath holding spells 5/7 Chandler Amy Amy Cardiac etiologies [loyolamedicine.org]

Etiology Hippocampal sclerosis Approximately two thirds of patients with temporal lobe epilepsy treated surgically have hippocampal sclerosis as the pathologic substrate. [emedicine.medscape.com]

The most common etiology is hippocampal sclerosis (HS), which is responsible for 60%–70% of all TLE cases. [dovepress.com]

Etiology and Basic Mechanisms The etiology of familial epilepsies is first determined by the genetic pattern that indicates an inherited disease and second by the structural/functional abnormalities that are associated with this genetic background. [neupsykey.com]

Página 67 - Socioeconomic characteristics of childhood seizure disorders in the New Haven area: an epidemiologic study ‎ Página 67 - Epilepsy after penetrating head injury. I. Clinical correlates: a report of the Vietnam Head Injury Study. [books.google.es]

A population based epidemiological study. Epilepsia Volume 35 Issue 5 Page 950-8, September 1994. 4. Loh Ngai Kun, Lee Wei Ling, Yew Woon Wah, Tjia Tjoei Lian (1999). [ispub.com]

Relevant External Links for CPA6 Genetic Association Database (GAD) CPA6 Human Genome Epidemiology (HuGE) Navigator CPA6 Atlas of Genetics and Cytogenetics in Oncology and Haematology: CPA6 No data available for Genatlas for CPA6 Gene Characterization [genecards.org]

Definitions Making the correct diagnosis in epilepsies The ILAE classification of epileptic seizures and epileptic syndromes Epidemiology of epilepsies 2 - Epileptic seizures and their classification The formal definition of epileptic seizures Classification [bokkilden.no]

Before we enter the discussion regarding the effect of seizures on the brain, it is essential that we differentiate among the different types of epilepsy and seizures because it is clear that the pathophysiology of the many syndromes and situations are [clinicalgate.com]

This overview shall cover the classification, pathophysiology, clinical semiology and treatment options available for different types of seizure disorders. [ispub.com]

[…] with atopic dermatitis Yamazaki et al. 2007 Association analysis of genetic variants in IL23R, ATG16L1 and 5p13. 1 loci with Crohn's disease in Japanese patients Pigeyre et al. 2016 Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology [google.ch]

The frequency of neurological involvement in BD is very variable, ranging from 3 to 59%, with two main different pathophysiologic mechanisms: first, and most commonly, through the development of an immune-mediated meningoencephalitis, which predominantly [docksci.com]

Hospital for Sick Children Health A-Z Search a complete list of child health articles expand_more View All Drug A-Z Search a list of articles about medications expand_more View All Learning Hubs Browse a complete list of content groups Healthy Living & Prevention [aboutkidshealth.ca]

This review highlights research findings that suggest possibilities for the prevention and treatment of epilepsy. Funding and Disclosures Supported in part by a grant (NS39950) from the National Institutes of Health. We are indebted to Drs. [nejm.org]

In addition, parents should also be aware that these drugs may prevent recurrences but do not alter the long-term prognosis for attaining seizure remission. [aafp.org]

A possible or certain diagnosis of a CVE requires investigation, as outlined in the separate Stroke Prevention article. Referral to a neuropsychologist may still be useful to elucidate the precise nature of the problem and for help with management. [patient.info]

Second, we could not obtain video-EEG monitoring results from all of our patients, thus preventing the detection of exact seizure semiology, including automatisms and ictal EEG patterns. [dovepress.com]