Familial tremor is described as a form of essential tremor. It is present in more than one individual in a family. It has a genetic component and is inherited in an autosomal dominant pattern. Variants in the LINGO1 (leucine-rich repeat and immunoglobulin domain-containing protein 1) gene have been found to be a predisposing factor for the disease, although the gene responsible for FT has yet to be identified [1].

The clinical features of FT and non-familial ET are almost identical, with the distinction of a negative family history of tremors in sporadic ET. It is further suggested that FT has an earlier age of onset than sporadic ET [2]. Most cases of ET have an onset in middle age, and a minority occur in children and the elderly.

There is no single definition of ET, however, The Movement Disorder Society's Tremor Investigation Group states that in cases of ET, there should not be an underlying etiology [3]. The presentation varies greatly between individuals [4].

The effects of the tremor are most prominent in the upper extremities and rarely affect the lower limbs. Patients may have difficulty carrying out motor tasks such as writing, holding objects and using tools or utensils. In addition, there may be involvement of muscle groups in the head, neck, and eyes. This gives rise to features such as head nodding and vocal tremor.

The amplitude and frequency of tremors vary but may be less prominent at rest. Some patients experience paroxysmal tremors. Although symmetry is a typical feature, a degree of asymmetry is not uncommon. Moreover, tremors are exacerbated by caffeine, heightened emotional states, hunger, certain drugs, and sleep deprivation. In contrast, tremors are alleviated by the ingestion of alcohol (this has been used in the diagnosis of ET) and sleep [5]. The signs are progressive, usually over many years [6]. ET that is diagnosed after the fifth decade of life, tends to progress more rapidly [2].

In a small proportion of reported cases, individuals exhibit neurological symptoms that may include ataxia, dysmetria, intention tremor, and other cerebellar signs [7].

• Anisocoria

  Anisocoria, ataxia, dysarthria, and confusional state were predominant manifestations. Beta activity in the EEG has been described previously with attacks of basilar migraine. [pediatricneurologybriefs.com]

• Tremor

  Familial tremor (FT) is a subtype of essential tremor (ET) that is autosomal dominant. ET and FT are common causes of tremors and can affect individuals both in childhood and adulthood. Familial tremor is described as a form of essential tremor. [symptoma.com]

  Postural tremor resembled essential tremor and responded to the anticonvulsants such as clonazepam, primidone and sodium valproate. Seizures were infrequent. [ncbi.nlm.nih.gov]

  Linkage of familial essential tremor to chromosome 5q35. [miami.pure.elsevier.com]

  […] familial tremor essential t. Medical dictionary. 2011. Look at other dictionaries: Tremor — For other uses, see Tremor (disambiguation). [medicine.academic.ru]

• Hand Tremor

  Essential tremor is different from Parkinson's disease is three distinct ways: Essential tremor of the hands usually occurs when you use your hands; with Parkinson’s disease, hand tremors occur when your hands are at rest. [houstonmethodist.org]

  Hand tremors also may be reduced with botulinum toxin, but the injections are most effective when only a few muscles are involved in a simple rhythmic motion, and this is not the case with all hand tremors. [hopkinsmedicine.org]

  See also: Drug-induced tremor Essential tremor Hand tremor Tremor Causes Return to top Tremors occur when there is a problem with the nerves supplying certain muscles. They may affect the whole body or just certain areas, such as your hand. [pacificschoolserver.org]

  Familial neck tremor or hands tremor are benign conditions that even with Western medicine are very hard to treat. [zeel.com]

• Action Tremor

  Onset of age is usually in the 60s Intentional Tremor: pastoral, bilateral action tremor of hands, forearms, head, neck, voice. Worsened with emotional stress and intentional movement. Tremor shortly relieved with alcohol. [quizlet.com]

  Essential tremor is also referred to as benign tremor, familial tremor, or idiopathic tremor. Tremors can happen at rest or when attempting an action. [essential-tremor.com]

  Some studies show that 90% of Parkinson's patients have action tremor and 20% of people with essential tremor have tremor at rest. Both conditions cause a loss of the sense of smell, but in essential tremor it's usually milder. [health.harvard.edu]

  Action tremor asymmetry profile does not aggregate in families with essential tremor. Front Neurol. 2017 Apr;19(8): 148. [sperlingmedicalgroup.com]

• Tremulousness

  The patients showed either tremulous finger movements or seizures as the initial symptoms between 19 and 30 years of the age without progression. [ncbi.nlm.nih.gov]

  […] voire d autres parties du corps et qui n… … Wikipédia en Français essential tremor — n a common usu. hereditary or familial disorder of movement that is characterized by uncontrolled trembling of the hands and often involuntary nodding of the head and tremulousness [medicine.academic.ru]

  The head can bob, and the voice can take on a tremulous quality because the vocal cords quiver. "Familial" in the "familial tremor" name has real meaning. This kind of tremor has a genetic basis. [articles.sun-sentinel.com]

  Obtaining a handwriting sample may be helpful in making an accurate diagnosis; in ET handwriting is generally large and tremulous, whereas in PD, micrographia (very small handwriting) is common. [practicalneurology.com]

  Case 1 A young boy aged 12 years attended the outpatient department of tertiary care medical college hospital with the complaint of tremulousness in the legs on standing but the problem resolved on walking or on lying down. [annalsofian.org]

• Vocal Tremor

  This gives rise to features such as head nodding and vocal tremor. The amplitude and frequency of tremors vary but may be less prominent at rest. Some patients experience paroxysmal tremors. [symptoma.com]

  […] familial tremor Darkness tremor Dystonic tremor Early onset cerebellar ataxia with essential tremor Essential tremor Intention tremor Intentional tremor Isolated facial tremor Isolated head tremor Isolated vocal tremor Medication-induced postural tremor [icd9data.com]

  Head tremor may appear as a "yes-yes" or "no-no" movement while the affected individual is seated or standing. In some people with essential tremor, the tremor may affect the voice (vocal tremor). Essential tremor does not shorten the lifespan. [ghr.nlm.nih.gov]

There is no specific diagnostic test for essential tremor and familial tremor, thus the diagnosis is often clinical. If there are atypical features, clinicians may carry out laboratory and imaging studies to exclude other causes of observed symptoms. These include measuring thyroid, renal and liver function, as well as electrolyte balance. Electromyography is not a routine procedure, although it may be useful.

Imaging techniques employed are computerized tomography (CT) scanning, which should be normal in cases of ET and FT, as well as magnetic resonance imaging (MRI), to rule out central nervous system lesions. Single photon emission CT (SPECT) can be used to accurately diagnose Parkinson's disease, as some cases of ET can be mistaken for the former [8]. Ultrasound has also been used to help delineate causes of tremor[9]. Further conditions to rule out are tremors due to alcohol withdrawal, caffeine, drugs, or anxiety.

Treatment Options for Tremors There are several options available for the treatment of tremors. These include both medical as well as surgical treatments. [emedicinehealth.com]

Non-medical approaches, such as relaxation therapies and “weighting” may also be recommended with other treatment options Presently, there are no known methods of preventing this disorder. [dovemed.com]

Treatment Return to top Treatment may not be necessary unless the tremors interfere with your daily activities or cause embarrassment. Medicines may help relieve symptoms. How well medicines work depend on the individual patient. [pacificschoolserver.org]

The severity of impairment and the availability of treatment vary widely. Knowledge of brain and nerve health has advanced rapidly in recent decades. Many new treatments and medicines are available to treat various disorders. [sharecare.com]

I don't know if any alternative treatments are effective. If you wanted to try anything in this direction I'd begin by trying acupuncture – but don't go chasing after a lot of alternative treatments – it'll just cost you a lot of money! [netdoctor.co.uk]

[…] quality of one’s life; it can also cause severe psychological stress Please find comprehensive information on Essential Tremor regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis [dovemed.com]

Prognosis ET can gradually worsen over many years, but is usually slowly progressive. It rarely becomes moderately or severely disabling. [brainfoundation.org.au]

Outlook (Prognosis) Return to top A familial tremor is not a dangerous condition, but some patients find the shaking annoying and embarrassing. [pacificschoolserver.org]

Per wikipedia on cause: "The underlying etiology is not clear but many cases seem to be familial.[14] It has been estimated that approximately one-half of the cases is due to a genetic mutation and the pattern of inheritance is most consistent with autosomal [paleohacks.com]

Autosomal dominant inherited disorder of unknown etiology. Onset of age is usually in the 60s Intentional Tremor: pastoral, bilateral action tremor of hands, forearms, head, neck, voice. Worsened with emotional stress and intentional movement. [quizlet.com]

There is no single definition of ET, however, The Movement Disorder Society's Tremor Investigation Group states that in cases of ET, there should not be an underlying etiology. The presentation varies greatly between individuals. [symptoma.com]

2000 PubMed search builder options Subheadings: analysis anatomy and histology blood cerebrospinal fluid chemically induced classification complications diagnosis diagnostic imaging diet therapy drug therapy economics enzymology epidemiology ethnology etiology [ncbi.nlm.nih.gov]

Therefore, it is unknown to what extent ET aggregates within families beyond that expected by chance, and the importance of genetic susceptibility in the etiology of ET at the population level has not been established. [n.neurology.org]

10) Year introduced: 2000 PubMed search builder options Subheadings: analysis anatomy and histology blood cerebrospinal fluid chemically induced classification complications diagnosis diagnostic imaging diet therapy drug therapy economics enzymology epidemiology [ncbi.nlm.nih.gov]

May 01, 1996 ; 46 (5) Views & Reviews The genetic epidemiology of essential tremor Elan D. Louis, Ruth Ottman First published May 1, 1996, DOI: https://doi.org/10.1212/WNL.46.5.1200 This article requires a subscription to view the full text. [n.neurology.org]

Essential tremor is so common that if it were clinically significant (i.e. if it caused signigicant morbidity or mortality) the pathophysiology would have been worked out and there would likely be some treatments. [justanswer.com]

[…] been identified but genetic linkage has been established with several chromosomal regions.[15][16] A number of environmental factors, including toxins, are also under active investigation and these may play a role in disease etiology.[17] In terms of pathophysiology [paleohacks.com]

Its pathophysiology remains poorly understood but candidate genes have been identified in some families. From a therapeutic point of view, a first-line treatment based on propanolol or primidone may be prescribed in case of discomfort. [ncbi.nlm.nih.gov]

Review Date: 5/28/2008 Reviewed By: Linda Vorvick, MD, Seattle Site Coordinator, Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; and Daniel B. [lutheranhealthcare.org]

Update Date: 5/28/2008 Updated by: Linda Vorvick, MD, Seattle Site Coordinator, Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; and Daniel B. [pacificschoolserver.org]

Non-medical approaches, such as relaxation therapies and “weighting” may also be recommended with other treatment options Presently, there are no known methods of preventing this disorder. [dovemed.com]

First, your tremor must have prevented you—or be expected to prevent you—from doing a significant amount of work (making over $1,200 per month) for at least 12 consecutive months. [disabilitysecrets.com]

[…] classification complications diagnosis diagnostic imaging diet therapy drug therapy economics enzymology epidemiology ethnology etiology genetics history metabolism mortality nursing organization and administration pathology physiology physiopathology prevention [ncbi.nlm.nih.gov]

1. Tan EK, Teo YY, Prakash KM, et al. LINGO1 variant increases risk of familial essential tremor. Neurology. 2009;73(14):1161–1162.
2. Louis ED, Dogu O. Does age of onset in essential tremor have a bimodal distribution? Data from a tertiary referral setting and a population-based study. Neuroepidemiology. 2007;29(3-4):208-212.
3. Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord. 1998;13(Suppl 3 M):2–23.
4. Whaley NR, Putzke JD, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord. 2007;13(6):333–339.
5. Voller B, Lines E, McCrossin G, et al. Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale. Mov Disord. 2014;29(4):555–558.
6. Putzke JD, Whaley NR, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: predictors of disease progression in a clinical cohort. J Neurol Neurosurg Psychiatry. 2006;77(11):1235–1237.
7. Rao AK, Gillman A, Louis ED. Quantitative gait analysis in essential tremor reveals impairments that are maintained into advanced age. Gait Posture. 2011;34(1):65–70.
8. Cuberas-Borrós G, Lorenzo-Bosquet C, Aguadé-Bruix S, et al. Quantitative evaluation of striatal I-123-FP-CIT uptake in essential tremor and parkinsonism. Clin Nucl Med. 2011;36(11):991-996.
9. Kim JS, Oh YS, Kim YI, Koo JS, Yang DW, Lee KS. Transcranial sonography (TCS) in Parkinson's disease (PD) and essential tremor (ET) in relation with putative premotor symptoms of PD. Arch Gerontol Geriatr. 2012;54(3):e436-439.