Presentation
Orthostatic hypotension without compensatory tachycardia is always present, as well as episodic hypertension in response to emotional stress or visceral pain. Chronic renal failure is common. [orpha.net]
Presentations such as left ventricular hypertrophy or even dilated cardiomyopathy have been described in patients with lipodystrophy. [scielo.br]
At present, treatment alleviates pain and can control some associated symptoms, but the process is generally progressive. As a complication, there is an increased risk of injury to the feet because of loss of sensation (see diabetic foot). [en.wikipedia.org]
Gastrointestinal
- Nausea
Gastrointestinal manifestations include gastroparesis, nausea, bloating, and diarrhea. Because many diabetics take oral medication for their diabetes, absorption of these medicines is greatly affected by the delayed gastric emptying. [en.wikipedia.org]
Treatment
This is the primary treatment of diabetic neuropathy that may change the course of the condition as the other treatments focus on reducing pain and other symptoms. [en.wikipedia.org]
Management and treatment Management should be tailored for each patient, as the clinical expression varies considerably. [orpha.net]
Prognosis
Prognosis Average age of death is in the third decade of life but patients may live into the seventh decade. The documents contained in this web site are presented for information purposes only. [orpha.net]
Other[edit] Low-quality evidence supports a moderate-large beneficial effect of botulinum toxin injections.[11] There is insufficient evidence to draw firm conclusions for the utility of the cannabinoids nabilone and nabiximols.[11] Prognosis[edit] The [en.wikipedia.org]
Etiology
Etiology The disease is due to a founder mutation in the ELP1 gene (9q31), encoding elongator-1 protein, resulting in a truncated unstable protein. [orpha.net]
Lipodystrophy is a rare disease characterized by the loss of adipose tissue, which may be generalized or partial.1 Its etiology may be congenital or acquired and there is a deficiency in the leptin hormone production, making the carriers of this pathology [scielo.br]
Epidemiology
Summary Epidemiology The disease affects individuals of Ashkenazi Jewish ancestry. The prevalence at birth in the Ashkenazi Jewish population is estimated at 1/10,000 in North America and 1/3,700 in Israel. [orpha.net]
Small infections can progress to ulceration and this may require amputation.[25] Epidemiology[edit] Globally diabetic neuropathy affects approximately 132 million people as of 2010 (1.9% of the population).[26] Diabetes is the leading known cause of neuropathy [en.wikipedia.org]
Pathophysiology
Five genes may be involved in the pathophysiology of this type of lipodystrophy, all leading to subcutaneous fat loss in the extremities. [scielo.br]
Prevention
"Enhanced glucose control for preventing and treating diabetic neuropathy". Cochrane Database of Systematic Reviews (6). doi:10.1002/14651858.cd007543.pub2. PMC 4048127. [en.wikipedia.org]