Fetal alcohol syndrome is a group of defects that occur in a fetus due to high levels of alcohol consumption during pregnancy.
The main organ affected in fetal alcohol syndrome is the developing brain which can result in permanent sequalae in the form of mental, psychological and behavioral disturbances . There are an array of defects including poor memory, attention deficit, impulsiveness and poor reasoning. The babies who suffer from fetal alcohol syndrome are more prone to mental health problems even later in life including drug addictions, aggressiveness etc. Alcohol exposure can cause damage to the brain during any period of pregnancy as fetal brain growth occurs throughout pregnancy upto the first 2 years of life.
The presence of facial features in fetal alcohol syndrome indicates significant brain damage; however, brain damage can occur even in the absence of facial features. The facial deformities are caused mainly due to alcohol consumption between 10-20 weeks gestation.
Facial features include small head circumference (microcephaly), small eyes (small palpebral fissures), low nasal bridge, midface hypoplasia, thin upper lip and indistinct philtrum (the groove between nose and upper lip) .
The baby is small for date i.e. has below average weight and height due to growth retardation. The growth can be severely affected when the weight for height is less than 3rd percentile for the age.
The three features that are characteristic of fetal alcohol syndrome are the smooth philtrum, thin vermillon and small palpebral fissures .
The risk of neuron damage worsens as the eyes get smaller, lip gets thinner and the philtrum gets flatter. The development of eyeballs and midface occurs in close relation to the development of the brain, therefore in fetal alcohol syndrome, midface and eyeballs are characteristically affected along with brain.
Alcohol acts as a teratogen affecting the developing Central Nervous System (CNS) leading to damage based on the quantity, frequency and the timing of alcohol consumption during pregnancy . Alcohol can cause CNS damage in structural as well as functional areas of brain.
Structural abnormalities include microcephaly (small head circumference of three standard deviation below average) or other abnormalities like agenesis of corpus callosum, cerebellar hypoplasia and hydrocephalus.
Neurological problems might be expressed as hard signs like epilepsy or seizure disorder, or soft signs like impaired fine motor skills, sensory hearing loss, impaired gait, clumsiness and poor hand eye coordination .
Functional problems are seen in the form of delays, disabilities and deficits caused as a result of prenatal exposure and not by hereditary causes or post natal insults. Functional problems include learning disabilities, scholastic backwardness, impulsiveness, inattention, poor memory and attention span, poor reasoning and abstract thinking.
Other conditions may commonly co-occur with fetal alcohol syndrome as a result of antenatal exposure of alcohol, however these conditions are considered as alcohol-related congenital defects and are not a part of the diagnostic criteria of Fetal alcohol syndrome. Common associations are:
- Cardiac: Ventricular septal defect, atrial septal defect;
- Skeletal: Joint abnormalities including abnormal position and function, altered dermatoglyphics, small distal phalanges and small fifth finger nails;
- Renal: Horseshoe kidney, dysplastic/hypoplastic kidney
- Ocular: Strabismus seen along with optic nerve hypoplasia;
- Others: Cleft lip and palate, webbed short neck, tetralogy of fallot, coarctation of aorta and spina bifida.
Entire Body System
BACKGROUND: Primary disabilities in children with fetal alcohol syndrome (FAS) are the results of alcohol's teratogen effect on the fetal brain. Reduced cognitive and executive functions and social cognition are examples of such disabilities. [ncbi.nlm.nih.gov]
Fetal alcohol syndrome may be the most common cause of noninherited intellectual disability. [merckmanuals.com]
- Developmental Delay
We show that developmental ethanol exposure causes reduced viability, developmental delay and reduced adult body size. [ncbi.nlm.nih.gov]
Introduction Syndrome of physical and mental developmental delays secondary to alcohol consumption during pregnancy Epidemiology incidence 1.9 per 1,000 births Associated conditions medical manifestations growth disturbances (before and after birth) central [orthobullets.com]
The vast majority of the most responsible diagnoses, which account for the majority of a patient's length of stay in hospital, fall within the ICD-10 category Mental and Behavioural Disorders (F00-F99). [ncbi.nlm.nih.gov]
Four diagnoses fall under the umbrella of FASD: FAS, Partial FAS, Static Encephalopathy/Alcohol Exposed (SE/AE) and Neurobehavioral Disorder/Alcohol Exposed (ND/AE). [depts.washington.edu]
These fall under the term “ Fetal Alcohol Spectrum Disorders (FASD),” the most known of which are Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE). [americanpregnancy.org]
Diagnostic criteria based on physical, particularly facial features like a small upper lip or small palpebral fissures fall far short to identify the FAS. Symptoms in FAS are predominantly not somatic but behavioural and emotional. [fasq.eu]
Signs of a drinking problem include insomnia, loss of employment, blackouts, depression, auto accidents, bruises, frequent falls, and anxiety. Treatment involves stabilization, detoxification, and rehabilitation of the alcohol-dependent person. [emedicinehealth.com]
- Developmental Disorder
Fetal alcohol spectrum disorder (FASD) is a developmental disorder that affects up to 0.2% of births. [ncbi.nlm.nih.gov]
- Short Stature
FASD comprises severe cognitive and structural birth defects including cleft lip/palate, small jaw, wide-set eyes, dental abnormalities, digit abnormalities, small head, and short stature. [ncbi.nlm.nih.gov]
A small-sized head and short stature do continue into adulthood. What is the prognosis of fetal alcohol syndrome? As noted in the above discussion, an individual with FAS may experience a lifelong litany of both physical and intellectual challenges. [medicinenet.com]
Developmental abnormalities in infants born to alcoholic mothers, including characteristic facial appearance (microcephaly, maxillary hypoplasia, short palpebral fissures, and short upturned nose), growth deficiency, delayed intellectual development, [icd10data.com]
Children with this condition are born with characteristic physical and mental defects, including short stature, and small head and brain. There is no cure. [who.int]
The latter include microcephaly (small head), short palpebral fissures (small eye openings), ptosis (eyelid droop), epicanthic folds (skin folds over the inside eye corner), a short upturned nose, a long smooth philtrum (area between nose and mouth), [britannica.com]
During pregnancy, only 35% (49/139) of cases had stopped drinking, varying between sites (from 21% to 54% in chronological order of surveys; p CONCLUSIONS: Increasing rates of drinking cessation during pregnancy over time suggest rising awareness of FAS [ncbi.nlm.nih.gov]
Take an 8 in. piece of 3/16” white cord and make a circle about the size of your thumb, then tie right over left and under; left over right and under. It looks like two loops intertwined. [fasworld.com]
- Visual Impairment
A wide variety of ocular and neuro-ophthalmic conditions occur in FAS and result in lifelong visual impairment. [ncbi.nlm.nih.gov]
Visual impairment and hearing problems may also exist. Children with FAS are often naïve. With poor judgment and decision-making skills, they sometimes find themselves facing substance abuse and difficulties with the law later in life. [medbroadcast.com]
Hearing and visual impairments There may be partial deafness and significant visual disability. [patient.info]
- Anxiety Disorder
Our team sees children with a wide range of psychiatric conditions, including mood and anxiety disorders, problems with impulse control and developmental disorders and psychosis, which are sometimes brought on by FAS. [childrenshospital.org]
Face, Head & Neck
- Thin Lips
Guide), and (3) thin upper lip (Rank 4 or 5 on the Lip-Philtrum Guide). [pediatrics.aappublications.org]
Often these patients develop attention deficit hyperactivity disorder. [ncbi.nlm.nih.gov]
To diagnose FAS, doctors look for unusual facial features, lower-than-average height and/or weight, small head size, problems with attention and hyperactivity, and poor coordination. [webmd.com]
Children born with fetal alcohol spectrum disorder (FASD) may have: A small head (microcephaly); Delayed growth; Problems with their heart or other vital organs; Problems with agitation or trouble sleep. [vitalitenb.ca]
C HICAGO — The agitated mom had three kids in foster care and she wanted them back. But she didn’t understand how to parent. She’d never worked. She had a short fuse. She was slow and didn’t seem to learn from experience. Dr. [statnews.com]
As Armstrong (1998 a ) has noted in an earlier analysis, the diagnosis of FAS arose at a period of intense gender agitation in the USA, and thus reflects widespread social unease about the conflict between the traditional maternal role of women and their [academic.oup.com]
- Memory Impairment
impairment Pronounced impulsiveness (continued lying, stealing, unusual defiance) Prevention Children with FASD which was identified early have an improved prognosis. [quitalcohol.com]
- Cognitive Disorder
From the functional point view, there are complex cognitive disorders and behavioral disorders, attention disorders and impulse control disorders, learning difficulties, and social communication and perception difficulties. [ncbi.nlm.nih.gov]
The following criteria must be fulfilled to diagnose a child with fetal alcohol syndrome:
- Growth deficiency
- Facial features characteristic of fetal alcohol syndrome: Measurement of fetal alcohol syndrome facial features is done by a criteria made by University of Washington. The lip and philtrum are measured with the lip philtrum guide. On a 5 point likert scale with representative photographs of lip and philtrum combinations, scores are given ranging from normal (1) to severe (5). Palpebral fissures are measured with calipers in millimeters and then compared to the palpebral fissure growth chart, developed by the University of Washington.
- CNS damage
- Prenatal alcohol exposure 
Amount, frequency and timing of prenatal alcohol consumption can have varied impact on the developing fetus. Consensus exists over alcohol being a teratogen, there is not much data as to what level of exposure is toxic.
There is no cure for fetal alcohol syndrome, because the CNS damage is permanent. Epileptic seizures can be treated with anticonvulsants like Phenobarbital, etc. Nutrition should be taken care of as these babies are at high risk of repeated respiratory infections and cerebral palsy.
A multidisciplinary approach is required with active involvement from a pediatrician, physiotherapist, orthopedic surgeon, ENT surgeon and an ophthalmologist. The treatment plan needs to be individualized.
Behavioral therapy is required in many cases as the diagnoses of oppositional defiance disorder, conduct disorder, attention deficit hyperactivity disorder often coexist with fetal alcohol syndrome. Special education services with outcome based approach are required commonly.
The child may have special areas of interest like music, art, singing, composing, reading, computers, mechanics, woodworking, skilled vocations, poetry etc. This special talent needs to be identified in the individual and nurtured with due attention and a professional attitude.
The prognosis is poor. Although not life-threatening, the primary disabilities of fetal alcohol syndrome are the CNS damages due to teratogenicity of alcohol . These patients are more prone to mental health problems like attention deficit hyperactivity disorder (ADHD), depression etc. They can have disrupted school experience. They are found to be delinquent and often need foster home treatment.
Patients have inappropriate sexual behavior and tend to have alcohol and drug addiction. They are usually dependant on family and friends and often need assistance. They have problems with employment and require ongoing job training and coaching.
Research has suggested that a range of effects could arise from maternal prenatal alcohol exposure, so the term fetal alcohol spectrum disorder was discarded for fetal alcohol syndrome along with other conditions resulting from prenatal alcohol exposure .
Fetal alcohol syndrome develops as a result of the teratogenic effect of alcohol on the developing fetus. It involves a wide spectrum of physical and mental defects and is thus referred to as a syndrome.
Fetal alcohol syndrome is one of the leading causes of intellectual disability in the developed countries where there is high incidence of alcohol consumption by young women. Fetal alcohol syndrome prevalence rate is 0.2-2:1000 live births in the developed countries.
Alcohol can cross the placental barrier and can cause adverse effects on the developing fetus. It can cause intrauterine growth retardation leading to a small for age baby. It can cause characteristic facial stigmata, damage neurons and can result in intellectual impairment and other psychological and behavioral problems in the child .
The maternal placenta allows entry of ethanol and other toxic metabolites like acetaldehyde freely into the fetal compartment. The developing fetal nervous system is particularly sensitive to ethanol toxicity. Alcohol affects neuronal proliferation, differentiation, migration of neurons and also the axonal outgrowth.
The main detoxifying organ in adults is liver, fetal liver is incapable of detoxifying alcohol as it is deficient of enzymes alcohol dehydrogenase and aldehyde dehydrogenase required for detoxification of alcohol.
All these result in fetal alcohol syndrome. During the first trimester of pregnancy, alcohol can interfere with migration and organization of neurons, which can lead to structural abnormalities. During the third trimester, alcohol can cause damage to the hippocampus which can create neurological and functional impairments. Alcohol can also affect brainstem and cerebellum both of which are extremely important.
Prenatal maternal alcohol consumption is the cause of fetal alcohol syndrome and therefore avoiding alcohol during pregnancy can prevent fetal alcohol syndrome.
Consumption of less than 15 drinks per week has been proven to not lead to fetal alcohol syndrome related effects. However, only one drink per day is allowed as the alcohol pharmacokinetics varies in different individuals and different people can have different teratogenic levels depending on genetic variation. A human fetus is at triple risk from maternal alcohol consumption .
Fetal alcohol syndrome is a constellation of symptoms that develops as a result of consumption of large amount of alcohol by the mother during pregnancy. The exact amount of alcohol required has not been determined but maternal alcohol exposure leads to facial deformities, mental dysfunction and overall growth retardation.
Fetal alcohol syndrome is a disorder caused by ingestion of alcohol during pregnancy. It leads to numerous adverse effects in the development of the fetus. A set of characteristic facial defects are observed along with maximum insult to the developing neurons. Thus, the fetus tends to be small for age and with deformities with slow brain development.
Pregnant women are advised not to have alcohol as alcohol can pass the blood brain barrier and lead to destruction of the brain tissues of the growing fetus.
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