HLA antibodies are commonly present in multiparous women who deliver healthy infants. [ncbi.nlm.nih.gov]

• Intravenous Administration

  In pregnancies with FNAIT and a previous affected child without ICH, weekly intravenous administration of immunoglobulins to the mother appears close to 100% effective to prevent fetal or neonatal ICH. [ncbi.nlm.nih.gov]

• Skin Lesion

  Physical examination revealed jaundice, without other skin lesions such as petechiae or hematomas. [file.scirp.org]

  Most cases are mild with widespread petechiae and other skin lesions. [jmedsoc.org]

  Most cases are mild, with evidence of widespread petechiae and other skin lesions. [ncbi.nlm.nih.gov]

• Suggestibility

  This systematic review suggests that first line antenatal management in FNAIT is weekly IVIG administration, with or without the addition of corticosteroids. Submitted October 26, 2016. Accepted January 11, 2017. [bloodjournal.org]

  We recommend laboratory monitoring for hemolytic anemia and suggest options for management including drug modification or cessation of therapy. [ncbi.nlm.nih.gov]

• Fear

  The most feared complication of a low platelet count in the fetus or the neonate is intracranial haemorrhage and subsequent neurological handicaps. [ncbi.nlm.nih.gov]

  The most feared complication of this disorder is the occurrence of intracranial hemorrhage (ICH) as a result of severe thrombocytopenia leading to death or neurological sequels. [ingentaconnect.com]

  The most feared complication is intracranial haemorrhage (ICH) in the case of severe thrombocytopenia. The morbidity has been estimated to be 20% of the reported cases and mortality up to 15%. [imedpub.com]

• Mood Swings

  Chronic steroid use can lead to osteoporosis, impaired glucose tolerance and gestational diabetes, hypertension, immunosuppression, mood swings, and fetal structural anomalies such as midline facial defects. [dovepress.com]

• Intracranial Hemorrhage

  RESULTS: Results of our noninvasive treatment strategy were comparable to results of the invasive method in the prevention of intracranial hemorrhage (intracranial hemorrhage was not observed). [ncbi.nlm.nih.gov]

Subsequently, a small study performed at our center found marked erythroid hypoplasia in the bone marrow of infants who underwent bone marrow biopsy as part of the diagnostic workup of their hypoproductive anemia. 14 This is in marked contrast to the [hematologyandoncology.net]

• Complement Fixing Antibody

  We report a premature twin infant who presented with severe thrombocytopenia and neutropenia clinically compatible with FNAIT and NAN, from a mother with no identifiable HPA or HNA antibodies, but with very high levels of complement-fixing antibodies [ncbi.nlm.nih.gov]

In group IIa, at least 2 diagnostic fetal blood samples were taken, and when necessary, intrauterine platelet transfusion and immunoglobulin were administered (invasive treatment). [ncbi.nlm.nih.gov]

As with prior variations, this variation might be a finished ebook on sufferer administration, replete with algorithms and circulate diagrams on prognosis and administration. [secretformulameals.com]

Conclusion Pregnancies affected by FNAIT, even with a severe history, now have an excellent prognosis. Our data confirm that there appears to be no benefit from invasive diagnostic or therapeutic procedures. [karger.com]

Long-term neurodevelopmental outcome is thought to be related to the extent and location of hemorrhage with intraparenchymal bleeds associated with the poorest prognosis ( 1 ). [ajnr.org]

Approximately 20% of these infants show evidence of intracranial haemorrhage (ICH) leading to death or neurological sequelae (see Prognosis). The platelet count is low at birth and may be associated with anaemia, secondary to bleeding. [ojrd.biomedcentral.com]

Nevertheless, in the absence of cerebral bleeding FNAIT is a transient disease with a good prognosis. Whereas FNAIT appears in the first pregnancy in approximately 50% ofcases, the recurren cerate in a subsequent pregnancy is 90% [4]. [file.scirp.org]

Finally, we will examine the interplay between lymphopoiesis and the placenta in an effort to further explore the phenomenon of neutropenia in preeclampsia, whose etiology remains unknown. [hematologyandoncology.net]

All other possible etiologies must be ruled out including sepsis, maternal idiopathic thrombocytopenic purpura, viral exposure, and disseminated intravascular coagulation ( Table 3 ). [dovepress.com]

Summary Epidemiology The incidence has been estimated at 1/800 to 1/1 000 live births. Clinical description NAIT has been considered to be the platelet counterpart of Rh Haemolytic Disease of the Newborn (RHD). [orpha.net]

Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. Transfusion 2005 ; 45 : 1945 –1956. 5. Spencer JA, Burrows RF. [cambridge.org]

Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000 Dec. 62(6):385-92. [Medline]. Howman RA, Barr AL, Shand AW, Dickinson JE. [emedicine.medscape.com]

A difference in the epidemiology of NAITP is unlikely: in a recent HPA-1a prospective screening study of 4090 pregnant women, the prevalence of the HPA-1a negative platelet phenotype was 2%, comparable to the published prevalence of this phenotype in [jcp.bmj.com]

Results from our recent large screening study suggest that the pathophysiology of FNAIT is more similar to hemolytic disease of the fetus and newborn (HDFN) than previously thought. [ncbi.nlm.nih.gov]

[…] to management. ( 20700860 ) Symington A...Paes B 2011 42 A new platelet alloantigen, Swi(a), located on glycoprotein Ia identified in a family with fetal and neonatal alloimmune thrombocytopenia. ( 21332723 ) Kroll H...Santoso S 2011 43 A review of pathophysiology [malacards.org]

At the core of the pathophysiology of FNAIT is the destruction of the fetal platelets by maternal IgG antibodies during pregnancy. [path.upmc.edu]

"A review of pathophysiology and current treatment for neonatal alloimmune thrombocytopenia (NAIT) and introducing the Australian NAIT registry". [en.wikipedia.org]

This preclinical proof-of-concept study investigated whether passive administration of anti-β3 integrin could induce AMIS and thereby prevent clinical complications of FNAIT. [ncbi.nlm.nih.gov]

Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia. PLoS ONE. 2016;11(9) [munin.uit.no]