Presentation
We report for the first time an unusual presentation of blueberry muffin lesions in a neonate born from a mother affected by severe anemia during pregnancy. [ncbi.nlm.nih.gov]
Entire Body System
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Cerebral Palsy
More recently, materno-fetal infection has been implicated as a causative factor in cases of cerebral palsy associated with preterm and term birth. [ncbi.nlm.nih.gov]
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Hunting
Follow-up assessment included growth measures, neurological examination, Bayley Scales of Infant Development, and a modified Uzgiris and Hunt Scale. Eight children (13%) had a major deficit and 10 children (16%) had a minor deficit at 1 year. [ncbi.nlm.nih.gov]
Skin
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Papule
Neonatal blueberry muffin lesions are rare cutaneous eruptions, presenting as transient, non-blanching, red-violaceous papules, mostly localized in the trunk, head and neck, attributable to a marked dermal hematopoietic activity. [ncbi.nlm.nih.gov]
Fetus
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Fetal Disorder
Fetal outcomes were studied with actocardiograms of central nervous system lesion and common fetal disorders. The relation of hypoxic rabbit heart rate and PaO 2 were studied. [omicsonline.org]
Neurologic
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Neonatal Seizures
However, this current strategy fails to recognize as many as 85% of growth restricted fetuses and although intrapartum monitoring has reduced the incidence of neonatal seizures, the rates of cerebral palsy and neonatal death have not decreased since its [journals.plos.org]
When compared with intermittent auscultation of FHR, continuous electronic FHR monitoring is associated with a reduction in the risk of neonatal seizures at the expense of an increased risk of cesarean delivery9, Irrespective of the method used to analyze [ispub.com]
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Motor Disturbances
Despite the enormous impact of CP, there is no animal model that reproduces the hypertonia and motor disturbances of this disorder. [ncbi.nlm.nih.gov]
Workup
Usually the diagnostic workup is initiated based on the risk factors of the pregnant mother and the presenting signs and symptoms. [xpertdox.com]
Other Test Results
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Cardiac Output Decreased
Moreover, in experimental animals during steady state hypoxia, several cardiovascular parameters are affected (heart rate/cardiac output decreases and blood pressure increases) while placental flow don't show a significant variation thus suggesting a [ncbi.nlm.nih.gov]
REFLEX REDISTRIBUTION OF FETAL CARDIAC OUTPUT DECREASED FLOW INCREASED FLOW KIDNEYS (OLIGURIA) BRAIN (OLIGOAMNIOS) LUNGS (RDS) HEART GUT (NEC) LIVER/MUSCLE (IUGR) BODY FAT/ ADRENALS GLYCOGEN STORES 18. [slideshare.net]
Ultrasound
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Small For Gestational Age Fetus
Ultrasonic recognition of the small-for-gestational-age fetus. Obstet Gynecol. 1987;69:631–5. 13. Rutherford SE, Phelan JP, Smith CV, Jacobs N. The four-quadrant assessment of amniotic fluid volume: an adjunct to antepartum fetal heart rate testing. [aafp.org]
Treatment
CONCLUSIONS: Maternal treatment with allopurinol during fetal hypoxia did not significantly lower neuronal damage markers in cord blood. Post hoc analysis revealed a potential beneficial treatment effect in girls. [ncbi.nlm.nih.gov]
Mild to severe instances of hypoxic-ischemia encephalopathy can know a 60 percent survival rate with lifelong treatments and monitoring necessary. [wisegeek.com]
Animal studies have suggested the possibility of prophylactic treatment to prevent neuronal loss after the hypoxic event. Intrapartum diagnostic tools should aim for detecting fetal hypoxemia/hypoxia when the fetus is still compensated. [journals.lww.com]
Prognosis
The presence of seizures indicates a poor prognosis, particularly as further brain damage will likely occur. Related wiseGEEK Articles [wisegeek.com]
In this population, the prematurity and impairment of the placental area proved to have a key role in the prognosis of survival of the newborn. [scielo.br]
One-minute Apgar score usually predicts immediate neonatal outcome of the baby, while 5-minute or later Apgar score is fairly predictive of future mental prognosis of such infant. [easymbbs.org]
Treatment options and prognosis As mentioned, the majority of brachial plexus injuries will resolve spontaneously over the course of several months to a year. [shoulderdystociainfo.com]
The exciting discovery that microRNAs circulate in the blood and may reflect gene expression in a distant tumour, has led to enthusiasm for the role of circulating miRs as biomarkers for cancer detection and prognosis [8]. [journals.plos.org]
Etiology
Abstract To investigate the hypothesis that chronic fetal hypoxia contributes to the etiology of sudden infant death syndrome (SIDS), a possible interaction between the effect of maternal cigarette smoking and low hematocrit during pregnancy on the risk [ncbi.nlm.nih.gov]
However, a recent meta-analysis concluded it is premature to implicate specific pregnancy complications in etiology of ASD[ 12 ]. [bmcmedresmethodol.biomedcentral.com]
If myocardial depression is severe enough, late decelerations may be absent all together Etiologies of Late Decelerations Excessive uterine contractions Maternal hypotension Maternal hypoxemia (asthma, pneumonia) Reduced placental exchange as in: Hypertensive [perinatology.com]
Epidemiology
OBJECTIVE: The authors examined in an epidemiologic sample the contributions of genetic predisposition and history of fetal hypoxia to hippocampal volume in patients with psychosis. [ncbi.nlm.nih.gov]
Epidemiology. 2001, 12: 291-294. 10.1097/00001648-200105000-00005. [bmcmedresmethodol.biomedcentral.com]
The epidemiology of molar pregnancy and choriocarcinoma. Clin Obstet Gynecol 1984; 27: 153. Pagina 773 - Pediatr 1989:115:105. 56. Boepple PA. Mansfield MJ. Link K. et al. [books.google.ro]
References: Fetal Distress: Diagnosis, Conditions & Treatment at Fetal Distress – Pathogenesis, Epidemiology, Presentation, Investigations, Management at Hofmeyr GJ, Lawrie TA (2012 Jan 18) Amnioinfusion for potential or suspected umbilical cord compression [medicalfoxx.com]
Epidemiology The overall risk of prompt caesarean delivery needed for fetal concern was shown to be 3.1% in an unselected population [ 1 ]. [patient.info]
Pathophysiology
“If there are more focus on pattern recognition and pathophysiology it all becomes more evident.” [neoventa.com]
Clerici G, Luzietti R, Di Renzo G. " Monitoring of Antepartum and intrapartum fetal hypoxemia: pathophysiological basis and available techniques. "Biol Neonate, 2001; 246-253. 3. Bobrow C, Soothill P. "Causes and consequences of fetal acidosis." [ispub.com]
While a sense of the degree and type of injury can be estimated by physical exam and clinical observation of the baby’s movement limitations, the true extent of brachial plexus injuries and the specific pathophysiology involved can only be definitively [shoulderdystociainfo.com]
It will discuss the clinical consequences of intrauterine hypoxia and how to identify patients that present with placental pathophysiology. [dovepress.com]
Prevention
Animal studies have suggested the possibility of prophylactic treatment to prevent neuronal loss after the hypoxic event. Intrapartum diagnostic tools should aim for detecting fetal hypoxemia/hypoxia when the fetus is still compensated. [ncbi.nlm.nih.gov]