Presentation
They present the case of a forty-one-year-old man who presented with spontaneous bleeding despite normal results from coagulation screening tests, platelet count, platelet aggregation studies, platelet force development, and bleeding time. [ncbi.nlm.nih.gov]
Entire Body System
Eyes
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Anisocoria
In Patient 2, intraventricular subsequent bleeding was noted 4 hours after the second 4-mg dose of rt-PA, clinically apparent as anisocoria. In Patient 2, rt-PA administration was continued without further complications. [ncbi.nlm.nih.gov]
Urogenital
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Cesarean Section
A transient IVC filter was implanted just before cesarean section. An enhanced computed tomography scan 2 days after cesarean section revealed a wide thrombus just distal to the filter. [ncbi.nlm.nih.gov]
Neurologic
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Excitement
We report the exciting results of a novel mechanical-pharmacological hybrid approach in 3 patients with life-threatening massive pulmonary embolism, in whom systemic fibrinolysis was contraindicated. [ncbi.nlm.nih.gov]
Endogenous fibrinolysis, until recently a poorly-understood area, represents an expanding and exciting area for identifying patients at increased cardiovascular risk and as a potential target for pharmacological modulation to improve outcomes. [content.onlinejacc.org]
Workup
[…] may be necessary to definitively diagnose severe PAI-1 deficiency Plasminogen – activity testing Alpha-2-antiplasmin – activity testing tPA – antigen testing Genotyping ( SERPINE1 ) Consider in patient with recurrent deep vein thrombosis and negative workup [arupconsult.com]
Serum
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Base Deficit
Compared to SD and PHYS, HF patients had higher Injury Severity Score (25 vs. 25 vs. 34), greater base deficit (-8 vs. -6 vs. -12) and were more uniformly hypocoagulable on admission by PT, PTT, and TEG values; all p CONCLUSIONS: Previous data have shown [ncbi.nlm.nih.gov]
Blocks
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Right Bundle Branch Block
We report the case of a 75-year-old woman with new onset dyspnoea, hypotension, and right bundle branch block. Transthoracic echocardiography (TTE) showed a thrombus in the right pulmonary artery and acute pulmonary embolism was diagnosed. [ncbi.nlm.nih.gov]
Biopsy
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Liver Biopsy
He was admitted to the hospital and diagnosed with liver cirrhosis via transjugular liver biopsy. [ncbi.nlm.nih.gov]
Treatment
MATERIAL AND METHODS: Thrombin generation, fibrinolysis activators and inhibitors were determined before and after 12 months of treatment. [ncbi.nlm.nih.gov]
Prognosis
A good prognosis can be achieved if the treatment starts within the first 4 to 5 hours after occlusion. [ncbi.nlm.nih.gov]
Identifying symptoms of a stroke quickly and seeking prompt treatment can improve prognosis and maximize patient recovery. Fibrinolytic therapy can be a lifesaving treatment for stroke. [acls.com]
It is possible that the prognosis for some of these patients would have been worse if they had not been closely monitored and promptly treated when decompensation occurred; this notion is supported by the higher rates of death reported in noninterventional [nejm.org]
Etiology
CONCLUSION: In conclusion, acute fibrinolysis SD is not caused by a single etiology, and is clearly associated with PAI-1 activity. [ncbi.nlm.nih.gov]
[…] hemangiomas was first noted in 1940 by Kasabach and Merritt. 1 Since then approximately 50 additional cases have been reported, of which the majority have had sizeable benign hemangiomas, thrombocytopenia, and a severe bleeding diathesis. 2,3 Although many etiologies [jamanetwork.com]
Epidemiology
Most of these were large epidemiological studies assessing thousands of patients. [content.onlinejacc.org]
[…] injury to the myocardium as a result of acute pressure overload. 6,15-20 Fibrinolytic treatment promptly reduces pulmonary-artery resistance and pressure, 21 and trials that included patients with hemodynamic compromise, 11 as well as recently published epidemiologic [nejm.org]
Sepsis: definition, epidemiology, and diagnosis. BMJ. 2007;335:879–83. View Article PubMed Central PubMed Google Scholar Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258–64. [jintensivecare.biomedcentral.com]
Pathophysiology
The pathophysiology appears to relate to endothelial injury and hypoperfusion, with several molecular markers identified in playing a role. [ncbi.nlm.nih.gov]
However, the pathophysiology of sepsis-induced DIC is extremely complex and under extensive investigation [ 2 ]. [jintensivecare.biomedcentral.com]
SERPINE1 ) Consider in patient with recurrent deep vein thrombosis and negative workup for common defects Differential Diagnosis Factor deficiency Factor VIII or IX deficiency most common von Willebrand disease Functional platelet disorder Background Pathophysiology [arupconsult.com]
Molecular and Systemic Pathophysiology [link.springer.com]
Prevention
We have conducted a systematic review of the scientific literature to evaluate the efficacy and safety of intrapericardial fibrinolysis in preventing complications of pericardial effusion. [ncbi.nlm.nih.gov]
Fibrinolysis is a process that prevents blood clots from growing and becoming problematic. This process has two types: primary fibrinolysis and secondary fibrinolysis. [en.wikipedia.org]
The fibrinolytic system has to be constrained by regulatory mechanisms to prevent it from interfering with the vital process of haemostatic plug formation. [platelets.se]