Symptoma

Fibrous Dysplasia

Patient presented with bilateral leg pain on examination and imaging showed bilateral tibia lytic lesion. [ncbi.nlm.nih.gov]

  • Recurrent Sinusitis

    Patients typically complain of nasal congestion ( 34% of those with symptoms and sinus involvement), headaches or facial pain, recurrent sinusitis, and hyposmia. [doi.org]

  • Anterior Uveitis

    Clinical symptoms comprised headache (n 3) and sensorineural disorder: recurrent anterior uveitis (n 1), visual acuity loss, epiphora and vestibular syndrome (n 1), and hearing loss (n 1). All cases were monostotic. [ncbi.nlm.nih.gov]

  • Normal Stature

    Its presentation may be as subtle as normal stature in a young adult who experienced precocious puberty and should have short stature as a consequence of early growth plate closure. [doi.org]

  • Fear

    In some patients, the fear of malignant disease may be so profound that the surgeon is unable to adequately reassure the patient of the benign nature of the process. [doi.org]

  • Episodic Vertigo

    Two patients had experienced severe episodic vertigo with nausea and vomiting. Two were referred to us with external canal obstruction and secondary cholesteatoma formation with broad middle ear destruction. [ncbi.nlm.nih.gov]

A 43-year-old woman with breast cancer underwent Tc-hydroxymethylene diphosphonate bone scintigraphy for preoperative workup. [ncbi.nlm.nih.gov]

  • Pleural Mass

    Chest radiograph shows expansion of multiple ribs involved by fibrous dysplasia that mimics pleural masses. Spine Spinal involvement is common in polyostotic disease and rare in monostotic disease. [emedicine.com]

In patients with severe symptoms medical treatment can be implemented, but safety of this treatment in children remain controversial. [ncbi.nlm.nih.gov]

A, Proximal femur of patient 13 at the start of pamidronate treatment. B, After 2.0 yr of treatment. [doi.org]

The prognosis may be difficult to establish because of the wide spectrum of disease severity. We have analyzed the data from the French National Reference center for FD. We have established a database from standardized medical records. [ncbi.nlm.nih.gov]

PROGNOSIS Biological Behavior • Benign tumor • Monostotic lesions have good prognosis • Polyostotic lesions tend to be more active or aggresive • Recurrence following curettage is common particularly when bone grafting the defect with autologous bone [tumorsurgery.org]

The prognosis generally is good, although poor outcomes are more frequent in younger patients and in those with polyostotic forms of the disease. The risk of malignant transformation is low. Dr. [journals.lww.com]

Microscopic Fibrous Dysplasia : Microscopic Fibrous Dysplasia : Microscopic Fibrous Dysplasia : Microscopic Fibrous Dysplasia : Microscopic Fibrous Dysplasia : Molecular Genetics Fibrous Dysplasia Fibrous Dysplasia Fibrous Dysplasia : Treatment & Prognosis [webpathology.com]

Fibrous dysplasia is a nonneoplastic, developmental disease of the bone that begins in childhood with obscure etiology. Clinically, it is presented as a continuously growing, painless mass at late childhood. [ncbi.nlm.nih.gov]

Updated Molecular and Epidemiologic diagrams added to all new chapters. [books.google.de]

The authors review the biological, epidemiologic, clinical, genetic, and radiographic characteristics of adult FD, with an emphasis on surgical management of FD. [ncbi.nlm.nih.gov]

Home About Us Acknowledgements Feedback Contact Us Site Map High Quality Pathology Images of Benign and Malignant Neoplasms and Related Entities Fibrous Dysplasia Home Orthopedic Tumor-like Lesions of Bone Fibrous Dysplasia Fibrous Dysplasia : Intro & Epidemiology [webpathology.com]

Johanna Benhamou, Deborah Gensburger, Claude Messiaen and Roland Chapurlat, Prognostic Factors From an Epidemiologic Evaluation of Fibrous Dysplasia of Bone in a Modern Cohort: The FRANCEDYS Study, Journal of Bone and Mineral Research, 31, 12, (2167-2172 [doi.org]

This review summarizes the pathophysiology, clinical findings, and treatment of FD, with an emphasis on the craniofacial and oral manifestations of the disease. Published 2016. This article is a U.S. [ncbi.nlm.nih.gov]

Pathophysiology, evaluation, and treatment. J Bone Joint Surg Am. 2005;87:1848-1864. Lietman SA, Ding C, Levine MA. [rarediseases.org]

The goal was to better define the natural history of FD encasing the optic nerve and to identify the pathophysiological mechanisms contributing to the development of optic neuropathy. [doi.org]

There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe. [nlm.nih.gov]

En bloc resection and bone graft cannot prevent recurrence in skeletally immature patients with monostotic expansile fibrous dysplasia, and cannot alter for the natural history of the disease. [ncbi.nlm.nih.gov]

Awareness of the syndrome, particularly when the myxoma is solitary, can prevent misdiagnosis of intramuscular myxomas (especially when large) as malignant mesenchymal tumors containing myxoid tissue. [doi.org]

Images