Presentation
Other hematological parameters are presented in Table III. [spandidos-publications.com]
Nivestim is a new filgrastim available in three presentations - 48 MU (480 mcg), 30 MU (300 mcg) and the unique 12 MU (120 mcg) low weight presentation. [fiercebiotech.com]
Abstract Bronchiolitis obliterans organizing pneumonia (BOOP) presents with fever, dyspnoea, pleuritic chest pain and hypoxia. [ncbi.nlm.nih.gov]
Eyes
- Retinal Hemorrhage
This was complicated by marked hyperleukocytosis and retinal hemorrhages. The patient's symptoms improved gradually following leukopheresis. [ncbi.nlm.nih.gov]
- Corneal Infiltrate
One week after starting therapy with intravenous filgrastim, a 66-year-old woman developed bilateral keratitis, evidenced by epithelial defects and peripheral corneal infiltrates. [ncbi.nlm.nih.gov]
Workup
Serologic workup was negative for anti-nuclear antibody, antistreptococcal antibodies, hepatitis B and C, ANCA, and antiglomerular basement membrane antibodies. [jasn.asnjournals.org]
Serum
- Alanine Aminotransferase Increased
Observed adverse drug reactions with an incidence of > 5% were back pain (60.6%), bone pain (9.6%), alanine aminotransferase increase (8.7%), aspartate aminotransferase increase (5.8%) and arthralgia (5.8%). [ncbi.nlm.nih.gov]
Treatment
PURPOSE: Chemotherapy-induced febrile neutropenia (FEN), which causes treatment delays or chemotherapy dose reductions, is a serious side effect of cancer treatment. [ncbi.nlm.nih.gov]
Prognosis
To determine the effect of r-metHu granulocyte colony-stimulating factor (G-CSF) on the proportion of patients with metastatic poor-prognosis malignant germ cell tumors who receive full dose-intensity combination chemotherapy. [jco.ascopubs.org]
[…] with a chemotherapy regimen that carries a >20 per cent risk of febrile neutropenia, elderly and frail patients at increased risk, and patients undergoing high-intensity chemotherapy schedules or where delays in treatment are known adversely to affect prognosis [pharmaceutical-journal.com]
This may have a negative impact on its effectiveness and worsen patient prognosis. [spandidos-publications.com]
Champlin Article Figures/Media 25 References 51 Citing Articles Letters Abstract Background Patients whose leukemia relapses after allogeneic bone marrow transplantation have a poor prognosis; few respond to further chemotherapy, and almost none survive [nejm.org]
Patients diagnosed with AML have a relatively poor prognosis, with a 5-year survival rate of about 20%, 8 although various prognostic factors affect the probability of response to chemotherapy and survival. 2 Since the life expectancy for patients with [nature.com]
Etiology
[…] generalized signs and symptoms such as fever, abdominal pain, malaise, back pain, and increased inflammatory markers (e.g., c-reactive protein and white blood cell count) Consider aortitis in patients who develop these signs and symptoms without known etiology [neupogenhcp.com]
Consider aortitis in patients who develop these signs and symptoms without known etiology. Discontinue NIVESTYM TM if aortitis is suspected. [pfizerpro.com]
Our patient, previously asymptomatic with respect to sickling (other than back pain of uncertain etiology), developed this syndrome concomitant with the introduction of G-CSF. [bloodjournal.org]
Epidemiology
We thank Robert Ball, MD, MPH, ScM, and Michael Blum, MD, MPH, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, for critical review of this manuscript. [jamanetwork.com]
Author information 1 Department of Medical Oncology, University Hospital Zurich, Zurich, Switzerland. 2 Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. 3 Department of Hematology [ncbi.nlm.nih.gov]
Approved in the EU Oct 13 [4] Category Pharmacology Immunostimulating medicinal product (L03AA02) which regulates the production and release of functional neutrophils from the bone marrow Epidemiology The incidence of drug-induced neutropenia is one case [sps.nhs.uk]
Materials and methods Study design This was a multicenter, non-interventional, real-life, epidemiological study sponsored by Accord Healthcare Polska (Warsaw, Poland), which involved an electronic questionnaire. [spandidos-publications.com]
Sanz Department of Internal Medicine, University of Vienna, Vienna, Austria K Lechner Department of Haematology, University of Ghent, Ghent, Belgium L Noens Clinical Haematology, Royal Melbourne Hospital, Melbourne, Australia J Szer Biostatistics and Epidemiology [nature.com]
Pathophysiology
This report explores the spectrum of GN with monoclonal IgG deposits and the pathophysiologic role of granulocyte colony-stimulating factor in exacerbation of preexisting GN. [ncbi.nlm.nih.gov]
This thoroughly updated Third Edition covers newly approved drugs, has separate chapters on drugs affecting fungal and viral infections, and includes more pathophysiology information. [books.google.ro]
Pending a better understanding of the pathophysiology of vaso-occlusion, patients with sickle cell disease should receive G-CSF with great caution. Copyright © 2001 The American Society of Hematology References ↵ ↵ Abboud M, Laver J, Blau C-A. [bloodjournal.org]
The pathophysiology of this injury may be attributed to the cytokine nature of G-CSF. [2] As the trough tacrolimus levels are within acceptable limits, with no histopathological features of CNI toxicity, it is unlikely that the ATI is related to the CNI [sjkdt.org]
Prevention
Recently, Nivestim™, a biosimilar of reference of filgrastim, was approved for prevention of chemotherapy-related febrile neutropenia (FN). [ncbi.nlm.nih.gov]
[…] it as secondary prevention. [spandidos-publications.com]
Nivestim(TM), a New Biosimilar Filgrastim, is Approved in Europe for the Prevention of Febrile Neutropenia Associated With Chemotherapy - Nivestim(TM), Hospira's filgrastim, has received approval from the European Commission (EC) for the prevention of [fiercebiotech.com]
Randomized phase II study of loratadine for the prevention of bone pain caused by pegfilgrastim. Support Care Cancer. 2016 ;24: 3085 - 3093. Google Scholar | Medline | ISI 17. Gavioli, E, Abrams, M. [doi.org]