She came to the physicians of the Clinical Pharmacokinetic Service (Laboratory of Toxicology of IAHULA, Mérida-Venezuela) requesting a drug monitoring. [ncbi.nlm.nih.gov]

Can Fam Physician 1987; 33: 1801-1809. Fernández-Durán D, Rodríguez-Vidigal FF. Protocolo diagnóstico y tratamiento empírico de las lesiones ulceradas en el área genital. Medicine 2006; 9: 3601-3605. [new.medigraphic.com]

MOST RECENT ISSUE May 1, 2019 Access the latest issue of American Family Physician Read the Issue Email Alerts Don't miss a single issue. Sign up for the free AFP email table of contents. Sign Up Now [aafp.org]

Patients should notify their physicians of all drug allergies they have experienced. Mahboob A, Haroon TS. Drugs causing fixed eruptions: a study of 450 cases. Int J Dermatol. 1998 Nov. 37(11):833-8. [Medline]. Ozkaya-Bayazit E. [emedicine.medscape.com]

Mahboob A, Haroon TS, Iqbal Z, Iqbal F, Saleemi MA, Munir A J Coll Physicians Surg Pak. 2006 Dec;16(12):747-50. Objective: To determine the usefulness of topical provocation in detecting the incriminated drug causing fixed eruption. [aaaai.org]

It is characterized by distinctive skin eruptions and minimal constitutional symptoms [ 6 ]. [skin-diseases-and-skin-care.imedpub.com]

May be due to type 1hypersensitivity (e.g. penicillin), sometimes in association with anaphylaxis and constitutional symptoms (respiratory distress, vascular collapse and shock). [health.auckland.ac.nz]

Other cell surface molecules, such as CLA/alpha4beta1/CD4a, that bind E-selectin/vascular cellular adhesion molecule-2/ICAM1 help to further attract CD8 cells to the area. [24] The skin findings are usually associated with nonspecific constitutional symptoms [ispub.com]

Genetic predisposition to FDE appears to occur in individuals with a family history of diabetes mellitus, atopy, and drug allergies. [25] Histological findings of FDEs demonstrate mixed inflammatory infiltrate of lymphocytes, neutrophils and eosinophils [ispub.com]

692.84 deodorant 692.81 detergents 692.0 dichromate 692.4 drugs and medicinals (correct substance properly administered) (internal use) 693.0 dyes 692.89 epidermophytosis - see Dermatophytosis esters 692.2 external irritant NEC 692.9 eye shadow 692.81 fish [icd9data.com]

However, there was no history of insect bite. The lesions were not target shaped, which are typical of erythema multiforme; moreover, typical temporal association with drug and the fixed location also goes against it. [casereports.bmj.com]

Arch Dermatol 1984;120:520-524 Mizukawa Y, Shiohara T: Trauma-localized fixed drug eruption: involvement of burn scars, insect bites and venipuncture sites. [karger.com]

Occasionally FDE mimicked lichen planus, erythema multiforme, Stevens-Johnson syndrome, paronychia, cheilitis, psoriasis, housewife's dermatitis, melasma, lichen planus actinicus, discoid lupus erythematosus, erythema annulare centrifugum, pemphigus vulgaris [ncbi.nlm.nih.gov]

Levocetirizine is generally considered as a safe and effective drug for different allergic diseases such as allergic rhinitis and chronic urticaria. [jpharmacol.com]

Chronic skin complaints such as psoriasis or eczema (formally the two most common forms being atopic or chronic dermatitis (eczema) and. Cetaphil Restoraderm Eczema Calming Body Moisturizer 10-Fluid Ounces. [delekkerbek.eu]

A biopsy from the lesion showed a few necrotic keratinocytes with hydropic degeneration and superficial dermal infiltrate of admixture of lymphocytes with few eosinophils and neutrophils along with melanin incontinence in the upper dermis [Figure 2]. [ijdd.in]

Histopathologic findings include a vacuolar interface dermatitis with pigment incontinence and melanophages in the dermis. Individual necrotic keratinocytes are also seen in the epidermis. [dermatologyadvisor.com]

[…] reexposure to offending agents. [7] A genetic predisposition has been described; and human leukocyte antigen (HLA)-B22 and Cw1 were linked significantly with FDE. [8] Histology shows interface dermatitis, vacuolar change, necrotic keratinocytes, and incontinent [jcsjournal.org]

Pigmentary Figures 16-19 Chronology - very variable, can be a long time after the medication was commenced Most commonly associated drugs - minocycline, amiodarone, anti-malarials, co-danthramer (can stain peri-anal and surrounding skin in patients with incontinence [pcds.org.uk]

In this review, we focus on how the presence of intraepidermal CD8 T cells resident in the fixed drug eruption lesions can provide exciting new clues to our understanding of pathomechanisms of inflammatory skin diseases. [dx.doi.org]