Presentation
Insoluble functionalized copolymers were found to develop specific interactions with viruses through chemical groups present on their surfaces. [ncbi.nlm.nih.gov]
Data Sources and Contributions The description has been compiled from data in the ICTV Report presented by Wengler G, Bradley DW, Collett MS, Heinz FX, Schlesinger RW, Strauss JH. [web.archive.org]
The 3'- terminus has no poly (A) tract but the poly (A) tract is present in some strains of tick-born encephalitis complex of flaviviruses. [microbewiki.kenyon.edu]
The principal mosquito vector of dengue virus is Aedes (Ae.) aegypti, present in most tropical and subtropical countries. Ae. polynesiensis [3] and Ae. scutellaris are vectors in the South and Central Pacific. [researchers.dellmed.utexas.edu]
Entire Body System
- Fever
Louis encephalitis Tick-borne encephalitis West Nile encephalitis Yellow fever Zika fever References[edit] ^ "Flaviviridae". Microbe Wiki. [en.wikipedia.org]
Flaviviridae viruses produce a wide range of diseases including fever, arthralgia, rash, haemorrhagic fever and encephalitis. [microbewiki.kenyon.edu]
Genera Genus Flavi Dengue Fever Virus 1-4 – fever, rash, arthralgia, myalgia West Nile Fever Virus - fever, rash, arthralgia, myalgia Yellow Fever Virus - fever, hemorrhage, jaundice St. [web.stanford.edu]
[…] virus (isolate Angola/14FA/1971) (YFV) 1 entry Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV) 1 entry Yellow fever virus (isolate Ivory Coast/1999) (YFV) 1 entry Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV) 1 entry Yellow fever [expasy.org]
- Pain
Since there is no vaccine or specific treatment against CHIKV, infected patients receive only palliative care to alleviate pain and arthralgia. Thus, drug repurposing is necessary to identify antivirals against CHIKV. [biorxiv.org]
(Roby J.A, et al, 2014) Yellow Fever Virus Vaccine Yellow fever is a viral disease caused by the yellow fever virus, their symptoms often include chills, muscle pains, fever, and headache. [creative-biolabs.com]
Symptoms typically begin three to 14 days after the infection, and may include a high fever, headache, vomiting, muscle and joint pains, and rashes. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito. [daily-sun.com]
These include the body temperature falling below 100°F along with severe abdominal pain, persistent vomiting, rapid breathing, bleeding gums, fatigue, restlessness and blood in vomit, he added. [theindependentbd.com]
- Asymptomatic
The first is an asymptomatic infection; the second is a mild febrile syndrome termed West Nile Fever; the third is a neuroinvasive disease termed West... [amazon.es]
Mammals and birds are the usual primary hosts, in which infections range from asymptomatic to severe or fatal haemorrhagic fever or neurological disease. [ictv.global]
Although most of the infections are asymptomatic or present as mild illness, a portion of the infected patients develops severe symptoms and may result in death. [hindawi.com]
HPgV establishes an asymptomatic infection and circulates as at least five closely related, yet phylogenetically distinct, genotypes that cluster geographically [16]. [dx.doi.org]
In contrast to the predominantly persistent infection by HCV, human infections with flaviviruses are acute and self-limiting and are either asymptomatic or present as an undifferentiated febrile illness that can, in specific cases, lead to more severe [nature.com]
- High Fever
Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. [ncbi.nlm.nih.gov]
Symptoms typically begin three to 14 days after the infection, and may include a high fever, headache, vomiting, muscle and joint pains, and rashes. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito. [daily-sun.com]
"Now, dengue is diagnosed in patients who don’t develop early signs like high fever, headaches or rashes," he added. [theindependentbd.com]
- Falling
These include the body temperature falling below 100°F along with severe abdominal pain, persistent vomiting, rapid breathing, bleeding gums, fatigue, restlessness and blood in vomit, he added. [theindependentbd.com]
[…] determine whether the spatial distribution of synonymous and nonsynonymous substitutions along the polyprotein was homogeneous for SPgV krc, we aggregated SNPs from these 13 samples, mapped them along the ORF and quantified the percent of total SNPs falling [dx.doi.org]
The initial and subsequent phylogenetic analysis of these universal genes has suggested that the giant viruses did not fall into any of three domains of cellular life (bacteria, archaea and eukaryote) and prompted the hypothesis that these viruses evolved [ncbi.nlm.nih.gov]
Gastrointestinal
- Diarrhea
Bovine Viral Diarrhea Virus Vaccine Bovine viral diarrhea virus (BVDV), a member of genus Pestivirus of the Flaviviridae family, is one of the most important ruminant pathogens in clinic and economy. [creative-biolabs.com]
The Flaviviridae family consists of 3 genera which include the Flavivirus genus (type species, yellow fever virus) as the largest genus, the Hepacivirus (type species, hepatitis C virus) and the Pestivirus (type species, bovine virus diarrhea). [eurekaselect.com]
Those studies prompted us to design a new class of protected nucleoside analogs, reported herein, which displays interesting anti-bovine viral diarrhea virus (BVDV) activity and low cytotoxicity in cell-based assays (4, 23, 29 EC(50): 14, 11, 26 microM [ncbi.nlm.nih.gov]
The pestivirus genus has three serotypes of bovine viral diarrhea, but no human pathogens are yet known. Genus Hepacivirus consists of hepatitis C virus and its relatives. [microbewiki.kenyon.edu]
- Nausea
Yellow fever appears with a sudden onset of fever, chills, headache, backache, nausea, and vomiting. [britannica.com]
Spondweni virus can cause a self-limiting febrile illness characterized by headache, myalgia, nausea, and arthralgia similar to Zika virus infections [10]. [hindawi.com]
- Abdominal Pain
These include the body temperature falling below 100°F along with severe abdominal pain, persistent vomiting, rapid breathing, bleeding gums, fatigue, restlessness and blood in vomit, he added. [theindependentbd.com]
Liver, Gall & Pancreas
- Jaundice
Yellow fever, in turn, derives its name from its propensity to cause jaundice in sufferers. [bmj.com]
The family gets its name from the yellow fever virus, the type virus of Flaviviridae; flavus is Latin for "yellow", and yellow fever in turn was named because of its propensity to cause jaundice in victims.[1] Currently, over 100 species are in this family [en.wikipedia.org]
Genera Genus Flavi Dengue Fever Virus 1-4 – fever, rash, arthralgia, myalgia West Nile Fever Virus - fever, rash, arthralgia, myalgia Yellow Fever Virus - fever, hemorrhage, jaundice St. [web.stanford.edu]
Musculoskeletal
- Myalgia
Genera Genus Flavi Dengue Fever Virus 1-4 – fever, rash, arthralgia, myalgia West Nile Fever Virus - fever, rash, arthralgia, myalgia Yellow Fever Virus - fever, hemorrhage, jaundice St. [web.stanford.edu]
Spondweni virus can cause a self-limiting febrile illness characterized by headache, myalgia, nausea, and arthralgia similar to Zika virus infections [10]. [hindawi.com]
Skin
- Eruptions
(b) Koplik spots on the soft palate and oropharynx due to pre-eruptive measles on day 3 of the illness. Figure 2: Measles cases in the United States, 1962–2016. [annualreviews.org]
Neurologic
- Headache
West Nile meningitis is characterized by fever, headache, a stiff neck and photophobia. [de.slideshare.net]
Yellow fever appears with a sudden onset of fever, chills, headache, backache, nausea, and vomiting. [britannica.com]
(Roby J.A, et al, 2014) Yellow Fever Virus Vaccine Yellow fever is a viral disease caused by the yellow fever virus, their symptoms often include chills, muscle pains, fever, and headache. [creative-biolabs.com]
Symptoms typically begin three to 14 days after the infection, and may include a high fever, headache, vomiting, muscle and joint pains, and rashes. When a mosquito bites a person infected with a dengue virus, the virus enters the mosquito. [daily-sun.com]
Workup
Biopsy
- Hepatocellular Carcinoma
Hepatitis C virus (HCV) is an RNA virus of the Flaviviridae family and is a major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma [18]. [wikigenes.org]
The progression of the disease upon infection is rapid, as in more than 80% of patients a persistent infection will be established, which will eventually progress to liver cirrhosis and in most cases, hepatocellular carcinoma. [peerj.com]
HCV is a major cause of liver disease, and majority of infected patients develop chronic infection, which increases the risk of developing liver cirrhosis, liver failure, and eventually hepatocellular carcinoma (HCC). [hindawi.com]
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med. 1998; 4 :1065–1067. [ PubMed : 9734402 ] Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Ishibashi K, Matsuura Y, Miyamura T, Koike K. [ncbi.nlm.nih.gov]
Treatment
No effective antiviral therapy is currently available for the treatment of flaviviruses or pestiviruses. [ncbi.nlm.nih.gov]
Epidemiology
Type of: arborvirus, arbovirus a large heterogeneous group of RNA viruses divisible into groups on the basis of the virions; they have been recovered from arthropods, bats, and rodents; most are borne by arthropods; they are linked by the epidemiologic [vocabulary.com]
Abstract Assays with the ability to detect multiple antibodies in parallel have a wide range of potential applications in epidemiologic research. [ncbi.nlm.nih.gov]
& Holmes, E.C. 2001: Evolution, epidemiology and dispersal of flaviviruses revealed by molecular phylogenies. Adv. Virus Res., 57: 71–103. Kuno, G., Chang, G. [species.wikimedia.org]
The data reported here suggest that VT of ZIKV to progeny from naturally infected females may have a critical epidemiological role in the dissemination and maintenance of the virus circulating in the vector. [jhu.pure.elsevier.com]
Pathophysiology
It is noted that oxidative stress as a mere imbalance between ROS production and neutralization is being substituted by a concept of redox pathophysiology, which focuses on searching for exact reactions between ROS or oxidation products with exact groups [hindawi.com]
Prevention
BVDV vaccines play an important role in livestock disease prevention. [creative-biolabs.com]
Author information 1 Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. [email protected]. 2 Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu [ncbi.nlm.nih.gov]
Otherwise the best ways to prevent infection with arboviruses are behavioral, such as using mosquito nets, bug repellent and protective clothing. [web.stanford.edu]
In many countries, patients with severe cases of flavivirus infections are treated only by supportive care, which includes intravenous fluids, hospitalization, respiratory support, and prevention of secondary infections. [eurekaselect.com]