A premature infant with disseminated Candida tropicalis infection with arthritis and osteomyelitis is presented. [ncbi.nlm.nih.gov]

• Fatigue

  • Miscellaneous : Fatigue, decrease in blood potassium and sugar level, weakness, allergic reactions, Lyell's syndrome. Store it at room temperature (25°C). Advertisement Most Popular On Medindia: [medindia.net]

  Adverse Reactions: Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others. [empr.com]

• Fulminant Sepsis

  After an extensive abdominal operation, a 70-year-old man developed a syndrome of fulminant sepsis due to Candida albicans with the beginnings of renal failure. [ncbi.nlm.nih.gov]

• Nausea

  Flucytosine may cause nausea and vomiting. If you take more than one capsule per dose, swallow one capsule at a time over a 15-minute period to help prevent nausea and vomiting. Use this medicine for the full prescribed length of time. [cigna.com]

  GIT manifestations: Nausea Vomiting Diarrhea Abdominal cramps and pain 4. Liver enzymes elevation 5. Nephrotoxicity 6. With prolonged use alopecia may occur as resembles anti-neoplastic drugs. [howmed.net]

  Administration • Give capsules a few at a time over 15 minutes to minimize nausea and vomiting. • Know that drug is rarely used alone. Expect to give another antifungal or amphotericin B concurrently. [medical-dictionary.thefreedictionary.com]

  It is also being tested in combination with the newer anti-fungal agents fluconazole ( Diflucan ) and itraconazole ( Sporanox ): adding flucytosine to these drugs can improve treatment outcomes in HIV-positive patients. 1 2 Side-effects can include nausea [aidsmap.com]

• Abdominal Pain

  pain, rash, elevated liver enzymes, blood disorders, confusion and headache. [aidsmap.com]

  • Respiratory : Respiratory arrest, chest pain and difficulty in breathing. • Skin : Rash, itching, hives and sensitivity to light. • Gastrointestinal : Nausea, vomiting, abdominal pain, diarrhea, loss of appetite, dry mouth, duodenal ulcer, gastrointestinal [medindia.net]

  GIT manifestations: Nausea Vomiting Diarrhea Abdominal cramps and pain 4. Liver enzymes elevation 5. Nephrotoxicity 6. With prolonged use alopecia may occur as resembles anti-neoplastic drugs. [howmed.net]

  Adverse Reactions: Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others. [empr.com]

  Adverse Effects Frequency Not Defined Confusion Headache Hallucinations Dizziness Drowsiness Psychosis Parkinsonism Ataxia Sedation Rash Photosensitivity Pruritus Urticaria Temporary growth failure Hypoglycemia Hypokalemia Nausea Vomiting Diarrhea Abdominal [reference.medscape.com]

• Macula

  […] for treatment of Candida ophthalmic infections † (keratitis, endophthalmitis). 140 IDSA states that IV amphotericin B with oral flucytosine is the regimen of choice for treatment of Candida endophthalmitis when lesions are advancing or threaten the macula [web.archive.org]

• Psychomotor Retardation

  Hydrocephalus and profound psychomotor retardation were present one year later. [ncbi.nlm.nih.gov]

• Kidney Failure

  failure. • Blood : Anemia, eosinophilia, decrease in white blood cells and platelets. • Central Nervous System : Incoordination, hearing loss, headache, tingling, Parkinsonism, peripheral neuropathy, fever, fainting, sleepiness, epilepsy, confusion, [medindia.net]

• Headache

  A 52-year-old man with a history of HIV (CD4 count 155, and viral load 154 K), who is on antiretroviral treatment presented in the emergency room with acute onset of headache. [ncbi.nlm.nih.gov]

  […] itraconazole ( Sporanox ): adding flucytosine to these drugs can improve treatment outcomes in HIV-positive patients. 1 2 Side-effects can include nausea and vomiting, diarrhoea, abdominal pain, rash, elevated liver enzymes, blood disorders, confusion and headache [aidsmap.com]

  • Central Nervous System : Incoordination, hearing loss, headache, tingling, Parkinsonism, peripheral neuropathy, fever, fainting, sleepiness, epilepsy, confusion, hallucinations and psychosis. • Miscellaneous : Fatigue, decrease in blood potassium [medindia.net]

  Adverse Effects: Hematologic: leucopenia, thrombocytopenia, bone marrow aplasia Gastric: intestinal perforation, ulcerating enterocolitis Hepatic: elevated liver enzymes, hepatitis, jaundice, azotemia Dermatologic: photosensitivity reaction CNS (rare): headache [antimicrobe.org]

An extensive infectious workup was carried out, which did not reveal any infectious aetiology. [ncbi.nlm.nih.gov]

• Paracoccidioides Brasiliensis

  Microsporum spp., Trichophyton spp. and Epidermophyton spp., Blastomyces dermatitidis, Paracoccidioides brasiliensis, Histoplasma capsulatum and Coccidioides immitis are resistant to flucytosine. [life-worldwide.org]

  brasiliensis, Histoplasma capsulatum, Blastomyces dermatitidis, Madurella species, phycomycetes, or dermatophytes. a Resistance has been reported in some strains of Candida or Cryptococcus ; 150 151 resistant strains of Candida, C. neoformans, or Cladosporium [web.archive.org]

• Coccidioides Immitis

  Microsporum spp., Trichophyton spp. and Epidermophyton spp., Blastomyces dermatitidis, Paracoccidioides brasiliensis, Histoplasma capsulatum and Coccidioides immitis are resistant to flucytosine. [life-worldwide.org]

  immitis, Paracoccidioides brasiliensis, Histoplasma capsulatum, Blastomyces dermatitidis, Madurella species, phycomycetes, or dermatophytes. a Resistance has been reported in some strains of Candida or Cryptococcus ; 150 151 resistant strains of Candida [web.archive.org]

• Toxoplasma Gondii

  Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [ PubMed:17016423 ] Fox BA, Belperron AA, Bzik DJ: Stable transformation of Toxoplasma gondii based on a pyrimethamine resistant trifunctional dihydrofolate reductase-cytosine deaminase-thymidylate synthase [drugbank.ca]

• Phialophora Verrucosa

  A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine. Br J Dermatol. 2005; 152:560-4. [PubMed 15787829] 162. [web.archive.org]

  A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5-flucytosine. [drugs.com]

Whereas the role of Flucytosine in the treatment of candidal urinary tract infections has been reviewed recently. [web.archive.org]

A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. The California Collaborative Treatment Group. [drugs.com]

Abstract The incidence of aspergillosis is increasing while the prognosis remains dismal. Standard single-drug therapy with amphotericin B offers unacceptably low cure rates. [ncbi.nlm.nih.gov]

PANA (3) Objective: to investigate the importance of various ultrasound prognosis features in the assessment of the cervical ectropion treatment monitoring. [chsjournal.org]

The etiology of candidiasis (Candida albicans in sputum) should be considered primarily in dermatology and gynecological conditions (especially the vagina with Candida albicans vulvovaginal). [ncbi.nlm.nih.gov]

Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. [ncbi.nlm.nih.gov]

Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed. [books.google.com]

Useful For Suggests clinical disorders or settings where the test may be helpful Monitoring serum concentration during therapy Evaluating potential toxicity May be useful to evaluate patient compliance Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

The aim of our study is to reveal possible significant statistical correlations between the two entities, which might warrant further study of the pathophysiological mechanisms behind this association. [chsjournal.org]

Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome. Journal of Infectious Diseases 173, 1216 –21. 42 Larsen, R. A., Bozzette, S. A., Jones, B. [doi.org]

(via organic amino compound ) antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. [ebi.ac.uk]

Author information 1 Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA. [email protected] Abstract Flucytosine and itraconazole are the only antifungal agents for which the Clinical [ncbi.nlm.nih.gov]

Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed. [books.google.com]