A premature infant with disseminated Candida tropicalis infection with arthritis and osteomyelitis is presented. [ncbi.nlm.nih.gov]

• Candidiasis

  Rapidly acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis. [ncbi.nlm.nih.gov]

  Used in dermatophytes, cutaneous candidiasis & vulvovaginal candidiasis, oropharyngeal candidiasis and dermatophytic infections like: Tinea corporis Tinea pedis Tinea cruris Side effects : Erythema, edema,, urticaria & mild vaginal burning sensation. [howmed.net]

  The combination is probably the treatment of choice in cryptococcal meningitis and offers promise in the therapy of systemic candidiasis and nonmeningeal cryptococcosis. FULL TEXT [annals.org]

• Swelling

  Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are breast-feeding or plan to breast-feed. [drugs.com]

  Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. [cigna.com]

  If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment: rash skin blisters wheezing difficulty breathing itching swelling of the face, throat, tongue, lips, eyes bloody vomit black and tarry stools blood [nlm.nih.gov]

• Fatigue

  • Miscellaneous : Fatigue, decrease in blood potassium and sugar level, weakness, allergic reactions, Lyell's syndrome. Store it at room temperature (25°C). Advertisement Most Popular On Medindia: [medindia.net]

  Adverse Reactions: Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others. [empr.com]

• Nausea

  Flucytosine may cause nausea and vomiting. If you take more than one capsule per dose, swallow one capsule at a time over a 15-minute period to help prevent nausea and vomiting. Use this medicine for the full prescribed length of time. [cigna.com]

  It is also being tested in combination with the newer anti-fungal agents fluconazole ( Diflucan ) and itraconazole ( Sporanox ): adding flucytosine to these drugs can improve treatment outcomes in HIV-positive patients. 1 2 Side-effects can include nausea [aidsmap.com]

  GIT manifestations: Nausea Vomiting Diarrhea Abdominal cramps and pain 4. Liver enzymes elevation 5. Nephrotoxicity 6. With prolonged use alopecia may occur as resembles anti-neoplastic drugs. [howmed.net]

• Abdominal Pain

  pain, rash, elevated liver enzymes, blood disorders, confusion and headache. [aidsmap.com]

  • Respiratory : Respiratory arrest, chest pain and difficulty in breathing. • Skin : Rash, itching, hives and sensitivity to light. • Gastrointestinal : Nausea, vomiting, abdominal pain, diarrhea, loss of appetite, dry mouth, duodenal ulcer, gastrointestinal [medindia.net]

  GIT manifestations: Nausea Vomiting Diarrhea Abdominal cramps and pain 4. Liver enzymes elevation 5. Nephrotoxicity 6. With prolonged use alopecia may occur as resembles anti-neoplastic drugs. [howmed.net]

  GI toxicity may be severe or rarely fatal and consists of anorexia, abdominal bloating, abdominal pain, diarrhea, dry mouth, duodenal ulcer, GI hemorrhage, nausea, vomiting, and ulcerative colitis. [en.wikipedia.org]

  Adverse Reactions: Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others. [empr.com]

• Kidney Failure

  failure. • Blood : Anemia, eosinophilia, decrease in white blood cells and platelets. • Central Nervous System : Incoordination, hearing loss, headache, tingling, Parkinsonism, peripheral neuropathy, fever, fainting, sleepiness, epilepsy, confusion, [medindia.net]

• Meningism

  Despite this profiteering, flucytosine remains a vital component of cryptococcal meningitis therapy. Cryptococcal meningitis is one of the most prolific opportunistic infections worldwide. [doi.org]

  Cryptococcal meningitis, a major cause of meningitis in adults living with HIV infection, accounts for 15% of global HIV-associated mortality. 1 Rajasingham R Smith RM Park BJ et al. [thelancet.com]

  Cryptococcal meningitis is a critical illness affecting 0.2% to 5% solid-organ transplant recipients with a 40% to 50% mortality. [ncbi.nlm.nih.gov]

  Treatment of cryptococcal meningitis in AIDS. Ann Intern Med. 1990; 113:992. 115. Larsen RA, Leal MAE. Treatment of cryptococcal meningitis in AIDS. Ann Intern Med. 1990; 113:992. 116. Dismukes WE. Cryptococcal meningitis in patients with AIDS. [web.archive.org]

• Headache

  A 52-year-old man with a history of HIV (CD4 count 155, and viral load 154 K), who is on antiretroviral treatment presented in the emergency room with acute onset of headache. [ncbi.nlm.nih.gov]

  […] itraconazole ( Sporanox ): adding flucytosine to these drugs can improve treatment outcomes in HIV-positive patients. 1 2 Side-effects can include nausea and vomiting, diarrhoea, abdominal pain, rash, elevated liver enzymes, blood disorders, confusion and headache [aidsmap.com]

  • Central Nervous System : Incoordination, hearing loss, headache, tingling, Parkinsonism, peripheral neuropathy, fever, fainting, sleepiness, epilepsy, confusion, hallucinations and psychosis. • Miscellaneous : Fatigue, decrease in blood potassium [medindia.net]

  Adverse Effects: Hematologic: leucopenia, thrombocytopenia, bone marrow aplasia Gastric: intestinal perforation, ulcerating enterocolitis Hepatic: elevated liver enzymes, hepatitis, jaundice, azotemia Dermatologic: photosensitivity reaction CNS (rare): headache [antimicrobe.org]

• Burning Sensation

  Used in dermatophytes, cutaneous candidiasis & vulvovaginal candidiasis, oropharyngeal candidiasis and dermatophytic infections like: Tinea corporis Tinea pedis Tinea cruris Side effects : Erythema, edema,, urticaria & mild vaginal burning sensation. [howmed.net]

An extensive infectious workup was carried out, which did not reveal any infectious aetiology. [ncbi.nlm.nih.gov]

Whereas the role of Flucytosine in the treatment of candidal urinary tract infections has been reviewed recently. [web.archive.org]

A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. The California Collaborative Treatment Group. [drugs.com]

Abstract The incidence of aspergillosis is increasing while the prognosis remains dismal. Standard single-drug therapy with amphotericin B offers unacceptably low cure rates. [ncbi.nlm.nih.gov]

PANA (3) Objective: to investigate the importance of various ultrasound prognosis features in the assessment of the cervical ectropion treatment monitoring. [chsjournal.org]

The etiology of candidiasis (Candida albicans in sputum) should be considered primarily in dermatology and gynecological conditions (especially the vagina with Candida albicans vulvovaginal). [ncbi.nlm.nih.gov]

Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. [ncbi.nlm.nih.gov]

Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed. [books.google.com]

Useful For Suggests clinical disorders or settings where the test may be helpful Monitoring serum concentration during therapy Evaluating potential toxicity May be useful to evaluate patient compliance Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

The aim of our study is to reveal possible significant statistical correlations between the two entities, which might warrant further study of the pathophysiological mechanisms behind this association. [chsjournal.org]

Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome. Journal of Infectious Diseases 173, 1216 –21. 42 Larsen, R. A., Bozzette, S. A., Jones, B. [doi.org]

(via organic amino compound ) antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. [ebi.ac.uk]

In particular, killing curves conducted in replicating cells showed that the addition of itraconazole prevented the development of flucytosine-resistant mutants of C. neoformans. [ncbi.nlm.nih.gov]

WHO Guidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children. [thelancet.com]