Although only anecdotal at present, the cases presented seem to indicate that children who had previously suffered from recurrent herpes entered into a period of partial or complete remission when receiving daily fluoride tablet supplementation. [ncbi.nlm.nih.gov]

• Skin Lesion

  High concentration of fluoride for extended time period causes adverse effects of health such as skin lesions, discoloration, cardiovascular disorders, dental fluorosis and crippling skeletal fluorosis. [ncbi.nlm.nih.gov]

Abstract The present study investigated the effect of periodic 1-min fluoride treatments on Streptococcus mutans biofilms and then determined the relationship between anti-biofilm activity, treatment frequency, and fluoride concentration using a linear-fitting [ncbi.nlm.nih.gov]

Prolonged post-injury dry extra-oral conditions worsen the prognosis and increase the risk of root resorption. Fluoride has the potential to delay replacement resorption. [ncbi.nlm.nih.gov]

Prognosis Death may result from ingesting as little as 2 g of fluoride in an adult and 16 mg/kg in children. Symptoms may appear with 3-5 mg/kg of fluoride. Estimated toxic dose for fluoride ingestion is 5-10 mg/kg. [emedicine.medscape.com]

Author information 1 Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang [ncbi.nlm.nih.gov]

[…] bone mineral density and increase skeletal fragility, leading to increased fracture risk. [5] In addition to effects on bone, a decrease in insulin sensitivity and insulin signaling has been reported in an animal model of chronic fluoride toxicity. [6] Etiology [emedicine.medscape.com]

Author information 1 Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang [ncbi.nlm.nih.gov]

Pathophysiology Fluoride has several mechanisms of toxicity. Upon ingestion, the GI tract is the earliest and most commonly affected organ system. [emedicine.medscape.com]

AgF SnF2 used to arrest and prevent caries in children can be modified to provide effective but minimally invasive care for an ageing and frail population. [ncbi.nlm.nih.gov]