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Fluoroquinolone

Fluoroquinolones [chemical/ingredient]


Presentation

  • We present a case of lateral canthal tendon rupture that presented with an acute right lower eyelid ectropion in a young, renal compromised patient in the setting of recent fluoroquinolone use for pneumonia.[ncbi.nlm.nih.gov]
  • This report presents a case history of a 22-year-old man with compromised immune status and severe pneumonia caused by M. catarrhalis.[ncbi.nlm.nih.gov]
  • Observational case report of 5 patients with a history of contact lens wear who presented with infectious keratitis.[ncbi.nlm.nih.gov]
  • Her medical history was notable for a diagnosis of pneumonia managed with oral moxifloxacin several weeks prior to her initial presentation.[ncbi.nlm.nih.gov]
  • We present a case of acute T8-T11 osteomyelitis with cord compression caused by a fluoroquinolone resistant strain of Salmonella typhi.[ncbi.nlm.nih.gov]
Rigor
  • CONCLUSION: A program combining FQ restriction in combination with nonmodal messaging may have decreased the rate of prescribing for acute bronchitis and uncomplicated UTI, although the contributions of each individual element could not be rigorously[ncbi.nlm.nih.gov]
  • Rigorous patient evaluation and a detailed patient history, including short and long term medication use, is the likely key to reducing any risk of cardiac arrhythmias associated with macrolides and fluoroquinolones.[ncbi.nlm.nih.gov]

Workup

  • Yet extensive medical workups do not find any other cause. Worse, there are no known effective treatments. Thus, these people suffer pain and disability for weeks, months, and years."[articles.mercola.com]
Salmonella Typhi
  • We present a case of acute T8-T11 osteomyelitis with cord compression caused by a fluoroquinolone resistant strain of Salmonella typhi.[ncbi.nlm.nih.gov]
  • She was treated with cotrimoxazole and the subsequent blood culture was positive for Salmonella typhi (S. typhi), which was resistant to fluoroquinolones but susceptible to cotrimoxazole.[ncbi.nlm.nih.gov]
  • BACKGROUND: Suboptimal clinical response to fluoroquinolone (FQ) therapy has been clearly documented in patients with Salmonella typhi infection with reduced FQ susceptibility.[ncbi.nlm.nih.gov]
Capnocytophaga
  • Methods: Two reference strains ( Capnocytophaga gingivalis ATCC 33624 and Capnocytophaga sputigena ATCC 33612) and four Capnocytophaga spp. isolated from clinical samples were studied.[ncbi.nlm.nih.gov]
Mycobacterium Chelonae
  • While receiving moxifloxacin post LASIK, the patient was diagnosed with moxifloxacin-resistant Mycobacterium chelonae keratitis.[ncbi.nlm.nih.gov]

Treatment

  • The efficacy of 5 days of fluoroquinolone treatment does not seem different from 10 days of treatment for AUP.[ncbi.nlm.nih.gov]
  • We report two cases of epicondylitis of the elbow occurring after treatment with fluoroquinolone antibiotics. Both patients had intense pain which appeared very shortly after the first dose of the drug and was not relieved by conservative treatment.[ncbi.nlm.nih.gov]
  • Treatment failure with multiple doses of ofloxacin was observed in this case of gonorrhea.[ncbi.nlm.nih.gov]
  • Our results suggest caution in their use for empirical management of MDR-TB cases and recommended treatment regimens for MDR-TB may require re-evaluation.[ncbi.nlm.nih.gov]
  • The primary treatment outcome was treatment failure within 10 weeks after initiation of FQ therapy. RESULTS: From May 2008 to April 2011, we enrolled 29 exposed patients and 246 unexposed patients.[ncbi.nlm.nih.gov]

Prognosis

  • Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. Am J Gastroenterol 2010; 105: 2396-404.[livertox.nih.gov]

Etiology

  • Fluoroquinolone antibiotics (such as olprofloxacin, pefloxacin, ofloxacin, norfloxacin, temafloxacin, etc.) have recently been implicated in the etiology of Achilles tendinitis and subsequent tendon rupture.[ncbi.nlm.nih.gov]
  • The etiology of the disease remains unknown, though recent reports suggest an antecedent upper respiratory tract infection or systemic antibiotic administration may trigger the clinical syndrome.[ncbi.nlm.nih.gov]
  • We are more and more being confronted with the advance of multidrug-resistant bacterial etiologies in our patients.[healio.com]

Epidemiology

  • From these, 31 epidemiologically unrelated strains were randomly selected for antimicrobial susceptibility testing to determine the minimum inhibitory concentration (MIC) of four fluoroquinolones and the corresponding quinolone resistance-determining[ncbi.nlm.nih.gov]
  • Abstract Fluoroquinolone-induced peripheral neuropathies and tendinopathies are well documented, but there are no epidemiologic studies on the risk of carpal tunnel syndrome (CTS). We conducted a case-control study of 6 million patients.[ncbi.nlm.nih.gov]
  • Abstract The aim of the study was to provide an update on the epidemiology of C. difficile infection (CDI) in a representative number of hospitals within the Czech Republic in 2015.[ncbi.nlm.nih.gov]
  • The first of these cases was epidemiologically linked and had closely related molecular features to a 2006 case of fluoroquinolone-susceptible meningococcal disease that occurred in the same geographic region.[ncbi.nlm.nih.gov]
  • LEVEL OF EVIDENCE: Prognostic/Epidemiological, Level II; Therapy, level IV.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology: Bacterial Resistance Mechanisms Mutations of A Subunits of DNA gyrase Alterations of outer membrane porins Affects organism permeability VIII.[fpnotebook.com]

Prevention

  • Methods: MICs and mutation prevention concentrations were compared among E. coli strain TOP10 and two corresponding transformants harbouring the OqxAB-encoding plasmids.[ncbi.nlm.nih.gov]
  • Author information 1 College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Delta Region, Zhejiang University of Technology, Hangzhou, 310014, PR China; Key Laboratory of Drug Prevention and Control Technology[ncbi.nlm.nih.gov]
  • Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations.[ncbi.nlm.nih.gov]
  • A likely explanation for our findings was the use of bird feces by residents as a traditional remedy to prevent ear secretions caused by primary ear infection.[ncbi.nlm.nih.gov]
  • The substrate-binding pocket structure of CYP3A5 might prevent the nitroso intermediate from coordinate binding with the heme, thereby preventing quasi-irreversible inhibition.[ncbi.nlm.nih.gov]

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