Presentation
A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories. [books.google.com]
No abnormal serum creatinine, serum creatinine clearance or urinalysis levels were present. [karger.com]
When SE is present, the type and location of emboli guides the treatment strategy. [intechopen.com]
[…] with positive lupus serologies. 1 On the other hand, patients with lupus nephritis present with ANCA seroconversion in 20% of cases. [revistanefrologia.com]
Circulating immune complexes are present in 90% of glomerulonephritis due to endocarditis. [antimicrobe.org]
Entire Body System
- Renal Artery Stenosis
Renal Artery Stenosis Renal Cell Cancer Renal Cyst Renal Hypouricemia with Exercise-induced Acute Renal Failure Renal Infarction Renal Osteodystrophy Renal Tubular Acidosis Renin Mutations and Autosomal Dominant Tubulointerstitial Kidney Disease Renin [kidney.nyc]
[…] bilateral renal artery stenosis Use of prostaglandin synthesis inhibitors with decreased renal profusion Intrinsic or parenchymal renal Acute tubular necrosis: temporary loss of kidney function Diseases involving large renal vessels as listed above Diseases [glowm.com]
Cardiovascular
- Thrombosis
References: [8] [1] [15] [17] [18] [19] [20] Complications Thrombotic complications Deep vein thrombosis Renal vein thrombosis Atherosclerotic complications Cause: Abnormal lipid metabolism in combination with a hypercoagulable state lead to an increased [amboss.com]
Hypercoagulability may manifest as venous or arterial thrombosis - eg, deep vein thrombosis, myocardial infarction. [patient.info]
Encyclopedia) Obstructive uropathy (Medical Encyclopedia) Perirenal abscess (Medical Encyclopedia) Proximal renal tubular acidosis (Medical Encyclopedia) Reflux nephropathy (Medical Encyclopedia) Renal papillary necrosis (Medical Encyclopedia) Renal vein thrombosis [icdlist.com]
The first child of the second family died at 11 months after having been ill for two months (no necropsy), the second at 2 years 11 months of pulmonary embolism after thrombosis of the inferior vena cava and right renal vein. [thieme-connect.com]
Renal ultrasonography may identify renal venous thrombosis if suggestive features, such as flank pain, hematuria, or acute renal failure, are present. [aafp.org]
Musculoskeletal
- Arthritis
Local - severe bleeding, toxic megacolon, perforation, carcinoma in longstanding total colitis Systemic - Anaemia, weight loss, electrolyte disturbance, pericholangitis, arthritis, uveitis, ankylosing spondylitis, erythema nodosum, pyoderma gangrenosum [alancam.com]
[…] basement membrane, nodules within glomeruli ( Kimmelstiel-Wilson nodules ) Treatment of underlying disease Amyloidosis May also involve other tissues (e.g., heart ) Can be associated with multiple myeloma or chronic inflammatory disease (e.g., rheumatoid arthritis [amboss.com]
Arthritis Research & Therapy. 13 (5): 240. doi : 10.1186/ar3378. ISSN 1478-6354. PMC 3308062. PMID 22078716. ^ a b c "Lupus Nephritis". www.niddk.nih.gov. Retrieved 2015-10-31. ^ a b c d e Lewis, Edmund J.; Schwartz, Melvin M. (2010-11-04). [en.wikipedia.org]
Renin Mutations and Autosomal Dominant Tubulointerstitial Kidney Disease Renin Secreting Tumors (Juxtaglomerular Cell Tumor) Reset Osmostat Retrocaval Ureter Retroperitoneal Fibrosis Rhabdomyolysis, Rhabdomyolysis related to Bariatric Sugery Rheumatoid Arthritis-Associated [kidney.nyc]
Collagen vascular diseases - eg, systemic lupus erythematosus, rheumatoid arthritis, polyarteritis nodosa, Henoch-Schönlein purpura, vasculitides. Metabolic diseases - eg, diabetes mellitus, amyloidosis. [patient.info]
Neurologic
- Confusion
Endocardial fibroelastosis - of infants (Not to be confused with endomyocardial fibroelastosis (EMF) of tropical origin). Rare disease of unknown cause. Presents with congestive cardiac failure in infancy. [alancam.com]
The presenting complaints may arise from organs or sites other than the heart, which may confuse the diagnosis. [what-when-how.com]
Should not be confused with Buerger disease ( thromboangiitis obliterans ). General More common in Asians. [librepathology.org]
- Vertigo
Focal neurological symptoms (hemiparesis, facial droop, diplopia, aphasia, vertigo) are present in approximately 40% of affected patients, and nonfocal presentations (headaches, seizures, altered mental status) occur in approximately one-third of cases [intechopen.com]
Urogenital
- Renal Insufficiency
[…] involvement in dysproteinemias 314 The hyperuricemic nephropathies 327 Therapy of renal disorders in liver disease 334 The management of renal insufficiency 495 Management of renal osteodystrophy 505 Peritoneal dialysis 516 Jonas Bergstrom M D 521 Dialysis [books.google.com]
[…] are usually not affected with mild renal insufficiency. [glowm.com]
Renal ultrasonography may identify renal venous thrombosis if suggestive features, such as flank pain, hematuria, or acute renal failure, are present. [aafp.org]
However, the renal function continued to deteriorate, and serum CR increased to 640 μmol/l. The patient was then transferred to the Division of Nephrology for treatment of renal insufficiency. [spandidos-publications.com]
- Kidney Failure
It constitutes about 40% of cases. [13] Kidney failure is common in this form. [13] Class V is membranous nephritis and is characterized by extreme edema and protein loss. [en.wikipedia.org]
Long-term glomerulonephritis is a common cause of chronic kidney failure. [enetmd.com]
Three examples of these types are: Acute postinfectious it: This form of this follows an infection and often causes high blood pressure, dark urine, water retention and swelling because of kidney failure. [medigoo.com]
Joshua Schwimmer A List of Kidney Diseases Abderhalden–Kaufmann–Lignac syndrome (Nephropathic Cystinosis) Abdominal Compartment Syndrome Acetaminophen-induced Nephrotoxicity Acute Kidney Failure/Acute Kidney Injury Acute Lobar Nephronia Acute Phosphate [kidney.nyc]
These include: high blood pressure high cholesterol blood clots – including deep vein thrombosis (DVT) or a pulmonary embolism damage to other organs chronic kidney disease kidney failure If you're diagnosed with glomerulonephritis, your doctor may prescribe [nhs.uk]
- Dark Urine
Urine tests : This test can measure: Urine is dark. Specific gravity is greater than 1020 osm. Proteinuria is observed. RBCs and red cell casts are present. [medigoo.com]
- Renal Function Impairment
While the majority of the patients had some degree of renal functional impairment, hemodialysis or other renal replacement methods were applied in only 15.0% of the patients. [cureus.com]
Workup
Rapidly progressive GN workup: hepatitis viral panel was negative. [dovepress.com]
There are no established guidelines on the diagnostic workup or management of nephrotic syndrome. [aafp.org]
[…] consistent with IE Echocardiogram results consistent with IE but not meeting major echocardiographic criteria A definitive clinical diagnosis can be made based on the following: 2 major criteria 1 major criterion and 3 minor criteria 5 minor criteria See Workup [emedicine.medscape.com]
Urine
- Glycosuria
Glomerulosclerosis Focal Segmental Glomerulosclerosis (Familial) with Complete Heart Block Galloway Mowat syndrome Giant Cell (Temporal) Arteritis with Kidney Involvement Gestational Hypertension Gitelman Syndrome Glomerular Diseases Glomerular Tubular Reflux Glycosuria [kidney.nyc]
Particular attention should be directed toward any history of renal disorders, proteinuria, hypertension, collagen vascular diseases, or glycosuria affecting either the patient or close relatives. [glowm.com]
Serum
- Abnormal Renal Function
Infective endocarditis can present as apparently primary renal disease and a fifth of our patients were referred initially to nephrologists with abnormal renal function or abnormal urinalysis. [academic.oup.com]
Therefore, it is possible for renal function to be normal in the presence of an abnormal BUN or abnormal in the presence of a normal BUN. [glowm.com]
Microbiology
- Human Parvovirus B19
Renal involvement induced by human parvovirus B19 infection. Nephron 89, 280–285 (2001). 96. Eiam-Ong, S. Malarial nephropathy. Semin. Nephrol. 23, 21–33 (2003). 97. Ginsburg, B. E., Wasserman, J., Huldt, G. & Bergstrand, A. [nature.com]
Treatment
545 Dialysis ultrafiltration and hemofiltration 555 Use of drugs in uremia and dialysis 567 Donor and recipient selection in renal transplantation 587 Immunosuppression and treatment of rejection in renal transplantation 595 XIII 606 Renal tubular and [books.google.com]
C 16 Corticosteroid treatment has no proven benefit, but is recommended by some physicians for persons with nephrotic syndrome who are not responsive to conservative treatment. [aafp.org]
Adult prognosis is variable and largely related to the underlying cause, its severity, progression and response to any treatment used to modify it. [patient.info]
However, because of the toxicity of these regimens, most nephrologists reserve such treatment for those with severe nephrotic syndrome or deteriorating renal function. [enetmd.com]
There is a universal consensus among clinical physicians concerning the treatment of these types of symptoms using antimicrobial therapy ( 3, 5 ), yet there has been no definitive agreement on the use of other treatments such as surgery and steroid therapy [spandidos-publications.com]
Prognosis
Prognosis of post-streptococcal glomerulonephritis: Chandigarh study. Ann. Acad. Med. Singapore 11, 36–41 (1982). 75. Clark, G. et al. Poststreptococcal glomerulonephritis in children: clinicopathological correlations and long-term prognosis. [nature.com]
Most importantly, we performed repeat biopsy to elucidate the prognosis and turnover of this condition. [spandidos-publications.com]
Prognosis This is very variable depending on the underlying cause. Congenital nephrotic syndrome usually carries a very poor prognosis. Corticosteroids have reduced the mortality rate in children to around 3% [ 17 ]. [patient.info]
The prognosis is significantly influenced by proper diagnosis and adequate therapy. In cases with unconfirmed IE, besides careful clinical examination, transesophageal echocardiography is the imaging technique of choice. [link.springer.com]
Etiology
The etiology may be embolic or immune. The association with Streptococcus viridans during the pre antibiotic era has been superceded by a more frequent association with Staphylococcus aureus. [rwjms1.umdnj.edu]
In the setting of an infectious etiology, pleocytosis may be evident. [medigoo.com]
Definition Etiology Differential diagnoses of nephrotic syndrome Associations Findings Treatment Minimal change disease Most common cause of nephrotic syndrome in children Can be associated with tumors (e.g., Hodgkin lymphoma ) LM: no changes EM: effacement [amboss.com]
A Gram stain and culture of material from a skin lesion sometimes can reveal the etiologic agent and thus direct antibiotic therapy. Emboli are common in ABE. [what-when-how.com]
Associations: [61] Smoking - common; thought to be important in the etiology. [62] Hypertension. Microscopic Features: [61] Looks like diabetic nodular glomerulosclerosis. IF Nonspecific. EM Nonspecific. [librepathology.org]
Epidemiology
This Review focuses on acute postinfectious glomerulonephritis, and covers its epidemiology, presentation, pathology, pathogenesis, treatment and outcomes. [nature.com]
During the past 3 decades although, a major shift has occurred in the epidemiology, characteristics, and outcomes of this disease. [dovepress.com]
Epidemiological data: Over the 26 years (1991-2016), there were 777 notifications of APSGN, of which Indigenous people comprised 94 %. Males represented 411 (53%) episodes and median age was 7 years (range 0-64). [anzsnasm.com]
[…] subgroups has changed, as have many other aspects of its epidemiology. [what-when-how.com]
Infective endocarditis epidemiology over five decades: a systematic review. PLoS One. 2013. 8 (12):e82665. [Medline]. Mendiratta P, Tilford JM, Prodhan P, Cleves MA, Wei JY. [emedicine.medscape.com]
Pathophysiology
To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. [books.google.com]
Lupus nephritis affects approximately 3 out of 10,000 people. [1] Pathophysiology [ edit ] The pathophysiology of lupus nephritis has autoimmunity contributing significantly. Autoantibodies direct themselves against nuclear elements. [en.wikipedia.org]
Definition / general Most common cause of nephrotic syndrome in adults (40%); 5% of cases in children Diffuse glomerular wall thickening due to in situ immune complexes (electron dense) in glomerular basement membrane but NOT in mesangium Pathophysiology [pathologyoutlines.com]
The underlying pathophysiology of nephrotic syndrome is not completely clear. 4 Although the more intuitive “underfill” mechanism of edema from reduced oncotic pressure caused by marked proteinuria may be the primary mechanism in children with acute [aafp.org]
References: [3] [4] [5] [6] [7] [8] [1] [9] [10] [11] Pathophysiology Structural damage of glomerular filtration barrier → massive renal loss of protein → reactively increased hepatic protein synthesis Loss of negative charge of GBM → loss of selectivity [amboss.com]
Prevention
Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.de]
The management of less acute disease is largely directed towards the control of blood pressure in an attempt to prevent or retard progressive renal disease. [enetmd.com]
ANTIBIOTICS There are no data from prospective clinical trials about treatment and prevention of infection in adults with nephrotic syndrome. [aafp.org]
Good control of blood sugar levels and blood pressure may prevent or slow kidney damage. [medigoo.com]
A quality study on the topic of optimal VTE prevention/treatment in patients with NS is scarce with a lack of randomized controlled trials in the subject area. [anzsnasm.com]