Conclusion The present case highlighted a rare presentation of HPV 16 infection as multifocal epithelial hyperplasia of the oral cavity with associated skin lesions. [ncbi.nlm.nih.gov]

Objectives To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present [jamanetwork.com]

Abstract A case of oral focal epithelial hyperplasia (FEH) treated with CO2 laser surgery is presented. Histological diagnosis is discussed. [ijoms.com]

• Polyps

  Oral Surg 20:201–212 Google Scholar Bergenholtz A (1965) Multiple polypous hyperplasias of the oral mucosa with regression after removal of amalgam fillings. [link.springer.com]

Laser surgery is suggested as a treatment of choice. [ijoms.com]

Human papillomavirus: manifestations, prevention and treatment: an overview. The Gulf Journal of Dermatology and Venereology. 2012;19(1):1–28. [ncbi.nlm.nih.gov]

There is no specific treatment for this disease, although there have been successful results with carbon dioxide laser, surgical excision, cryosurgery, and topical agents such as podophyllum resin.17-19 The factors that determine susceptibility to FEH [jamanetwork.com]

FEH sometimes resolves spontaneously however, treatment is often indicated as a consequence of aesthetic effects or any interference with occlusion. [pubmed.ncbi.nlm.nih.gov]

The prognosis of the disease is good, as most of the lesions remit spontaneously, although periodical clinical followups are crucial [4]. Considering the multifocal presentation of the case, we advised laser ablation of the entire lesion. [ncbi.nlm.nih.gov]

We also discuss the probable multifactorial etiology and variable clinical presentations of the lesions, including evidence of HPV 16 expression, as detected by polymerase chain reaction. [ncbi.nlm.nih.gov]

The epidemiologic data were analyzed with descriptive statistics. Nonparametric tests were used for statistical analysis of the HLA-DR alleles and the HPV type. Gene frequencies were compared between patients and controls. [jamanetwork.com]

In summary, we propose a hypothesis that the HLA-DR locus has a role in the pathophysiology of FEH by selecting genetically susceptible individuals, particularly those homozygous for HLA-DR4 (DRB1*0404 subtypes), who have certain amino acid sequences [jamanetwork.com]

Human papillomavirus: manifestations, prevention and treatment: an overview. The Gulf Journal of Dermatology and Venereology. 2012;19(1):1–28. [ncbi.nlm.nih.gov]