Presentation
Objectives To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present [jamanetwork.com]
Entire Body System
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Asymptomatic
These lesions are usually asymptomatic, but can on occasion be quite painful and of cosmetic concern7 (Figure 1). [jamanetwork.com]
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Pain
These lesions are usually asymptomatic, but can on occasion be quite painful and of cosmetic concern7 (Figure 1). [jamanetwork.com]
Psychiatrical
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Suggestibility
Conclusions The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13. [jamanetwork.com]
Workup
Microbiology
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Human Papillomavirus
Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. [jamanetwork.com]
HLA Type
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HLA-DR4
Nineteen (86%) of 22 patients were HLA-DR4 positive; 7 of them (37%) were homozygous. [jamanetwork.com]
Treatment
There is no specific treatment for this disease, although there have been successful results with carbon dioxide laser, surgical excision, cryosurgery, and topical agents such as podophyllum resin.17-19 The factors that determine susceptibility to FEH [jamanetwork.com]
Epidemiology
The epidemiologic data were analyzed with descriptive statistics. Nonparametric tests were used for statistical analysis of the HLA-DR alleles and the HPV type. Gene frequencies were compared between patients and controls. [jamanetwork.com]
Pathophysiology
In summary, we propose a hypothesis that the HLA-DR locus has a role in the pathophysiology of FEH by selecting genetically susceptible individuals, particularly those homozygous for HLA-DR4 (DRB1*0404 subtypes), who have certain amino acid sequences [jamanetwork.com]