Presentation
Abstract The present study documents a characteristic tomographic sellar abnormality in five patients with Forbes-Albright syndrome (ammenorrhea-galactorrhea) and surgically proved pituitary microadenomas. [ncbi.nlm.nih.gov]
The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]
VL - 130 IS - 7 N2 - The present study documents a characteristic tomographic sellar abnormality in five patients with Forbes-Albright syndrome (ammenorrhea-galactorrhea) and surgically proved pituitary microadenomas. [unboundmedicine.com]
A pituitary adenoma may or may not be present. Symptoms are subjective pain in trunk, back, and head; often mental depression. [med.cmu.ac.th]
It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person. Disclaimer: Whonamedit? does not give medical advice. [whonamedit.com]
Entire Body System
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Galactorrhea
TY - JOUR T1 - Tomographic diagnosis of pituitary microadenomas in Forbes-Albright syndrome (amenorrhea-galactorrhea). [unboundmedicine.com]
Abstract The present study documents a characteristic tomographic sellar abnormality in five patients with Forbes-Albright syndrome (ammenorrhea-galactorrhea) and surgically proved pituitary microadenomas. [ncbi.nlm.nih.gov]
Albright syndrome … Medical dictionary galactorrhea-amenorrhea syndrome — amenorrhea accompanied by galactorrhea, sometimes associated with increased levels of prolactin; several different types are known. [med_en_es.esacademic.com]
Forbes-Albright syndrome --- an endocrine disease characterized by amenorrhea, prolactinemia, and galactorrhea, caused by an adenoma of the anterior pituitary. [med.cmu.ac.th]
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Arm Pain
pain Neck mass28 Neck pain28 Necrotizing pneumonias1 Nephritic syndrome acute1 Nephrocalcinosis Neurogenic bladder29 Neurologic deficit focal26 Neurologic deficit multifocal26 Neuronopathies sensory ganglionopathies2 Neuropathic bladder Neuropathies [books.google.com]
Gastrointestinal
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Rectal Pain
[…] causes16a Pulmonary mass solitary mimics16a Pulseless electrical activity Pupillary dilatation poor response to darkness Purpura Purpura nonpalpable20 Purpura nonpurpuric disorders simulating purpura1 Qt interval prolongation22 Rectal mass palpable38 Rectal [books.google.com]
Cardiovascular
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Diastolic Murmur
Murmur systolic Muscle cramps and aches Muscle weakness ICD9CM Myelodysplastic syndromes Myocardial ischemia suspected Myopathy statininduced Myositis Nail dystrophy Neck mass Neck pain ICD9CM Nephrolithiasis Neuropathic pain Neutropenia Nonhodgkins [books.google.com]
Jaw & Teeth
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Oral Pigmentation
Expanding the cutaneous phenotype to include oral pigmentation further characterizes the clinical findings in this mosaic condition, broadens the differential diagnosis of syndromes with oral pigmentation, and in some cases may aid in earlier diagnosis [ncbi.nlm.nih.gov]
Eyes
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Dry Eyes
eye Dyspareunia12 Dysphagia Dysphagia oropharyngeal38 Dyspnea Dysuria Earache33 Edema children19 Edema generalized Edema leg unilateral26 Ejection sound or click Elbow pain Elevated hemidiaphragm Emboli arterial26 Emesis pediatric age19 Encephalomyelitis [books.google.com]
Musculoskeletal
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Ankle Pain
Eyelid neoplasm Eyelid retraction Eye pain Facial pain Failure to thrive Fatigue Fatty liver Fever and jaundice Fever and rash Fever in returning travelers and immigrants28 Fever noninfectious causes2 Finger lesions inflammatory Flushing27 Foot and ankle [books.google.com]
Skin
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Skin Lesion
lesions Erythroderma Esophageal perforation26 Esotropia Exanthems28 Eyelid neoplasm Eyelid retraction Eye pain Facial pain Failure to thrive Fatigue Fatty liver Fever and jaundice Fever and rash Fever in returning travelers and immigrants28 Fever noninfectious [books.google.com]
Psychiatrical
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Decreased Libido
In men, the most common symptoms of hyperprolactinaemia are decreased libido, sexual dysfunction (in both men and women), erectile dysfunction, infertility, and gynecomastia. [dict.eudic.net]
Women classically present in the second or third decade of life with symptoms related to increased prolactin levels such as amenorrhea and galactorrhea (Forbes-Albright syndrome), infertility, and decreased libido. [med.virginia.edu]
Elevated 17-α-hydroxyprogesterone A 24-yr-old man complains of decreased libido, ED & galactorrhoea. The prolactin level is increased and MRI shows a 4mm pituitary tumour. The best therapeutic option is: Select one: a. [quizlet.com]
Intercourse may become difficult or painful because of vaginal dryness. [ medical citation needed ] In men, the most common symptoms of hyperprolactinaemia are decreased libido, sexual dysfunction (in both men and women), erectile dysfunction, infertility [en.wikipedia.org]
Breast
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Nipple Discharge
TOC ENDO *GALACTORRHEA / HYPERPROLACTINEMIA Milky nipple discharge. Galactorrhea technically does not include serous, purulent, or bloody nipple discharge. SX: Milky nipple discharge. [enotes.tripod.com]
discharge evaluation Breast radiologic evaluation Breast routine screen or palpable mass evaluation Breastfeeding difficulties Bullae on lower extremities Carcinoid tumors ICD9CM ICD9CM Cardiomyopathy hypertrophic Cardiomyopathy ischemic ICD9CM Cerebral [books.google.com]
Neurologic
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Mydriasis
[…] nonocclusive26 Metastatic neoplasms Microcephaly4 Micropenis27 Miosis Monocytosis20 Mononeuropathy Mononeuropathy isolated2 Mononucleosis monospot negative1 Muscle disease34a Muscle weakness Muscle weakness lower motor neuron versus upper motor neuron40 Mydriasis [books.google.com]
Urogenital
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Amenorrhea
TY - JOUR T1 - Tomographic diagnosis of pituitary microadenomas in Forbes-Albright syndrome (amenorrhea-galactorrhea). [unboundmedicine.com]
Albright syndrome … Medical dictionary galactorrhea-amenorrhea syndrome — amenorrhea accompanied by galactorrhea, sometimes associated with increased levels of prolactin; several different types are known. [med_en_es.esacademic.com]
Forbes-Albright syndrome --- an endocrine disease characterized by amenorrhea, prolactinemia, and galactorrhea, caused by an adenoma of the anterior pituitary. [med.cmu.ac.th]
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Sexual Dysfunction
In men, the most common symptoms of hyperprolactinaemia are decreased libido, sexual dysfunction (in both men and women), erectile dysfunction, infertility, and gynecomastia. [dict.eudic.net]
In contrast, men usually present in the fourth or fifth decades of life and have sexual dysfunction and symptoms related to mass effect attributable to an enlarging sellar mass. [med.virginia.edu]
Intercourse may become difficult or painful because of vaginal dryness. [ medical citation needed ] In men, the most common symptoms of hyperprolactinaemia are decreased libido, sexual dysfunction (in both men and women), erectile dysfunction, infertility [en.wikipedia.org]
dysfunction female1 Sexually transmitted diseases anorectal region26 Sexual precocity41 Shoulder pain Shoulder pain by location Shoulder pain in different age groups8 Small bowel masses38 Small intestine ulceration Smell disturbance Spastic paraplegias [books.google.com]
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Oligomenorrhea
In one, who presented with hirsutism, oligomenorrhea, obesity, infertility, and enlarged cystic ovaries, the initial diagnosis was polycystic ovarian syndrome. [annals.org]
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Secondary Amenorrhea
Biopsy, the number of primordial follicles is normal. give secondary amenorrhea iperestrogenica, sometimes alternating with menorrhagia. [brainscape.com]
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Pruritus Vulvae
vulva Pseudogout Pseudohermaphroditism Psychotic patient Puberty delayed Pulmonary embolism Pulmonary nodule Purpura palpable Reactive erythema pediatric patient ICD9CM Renal artery stenosis Renal disease ischemic management ICD9CM ICD9CM Respiratory [books.google.com]
Workup
Patients deserve a thorough workup. Postgrad Med. 2000;107:165-68, 171. Olive D. Indications for hyperprolactinemia therapy. J Reproduct Med. 1999;44(12 Suppl):1091-94. Luciano AA. Clinical presentation of hyperprolactinemia. [rarediseases.org]
GENERAL PRINCIPLES OF DIAGNOSIS AND TREATMENT Patients presenting with signs and symptoms suggestive of a pituitary adenoma require a comprehensive workup and treatment plan reflecting a strong interdisciplinary effort with endocrinologists, neurosurgeons [med.virginia.edu]
While a majority of patients with endogenous Cushing syndrome have thyrotrophic adenomas (called Cushing Disease - see below), other tumors should also be considered as part of the endocrinologic workup, including adrenal tumors and especially ACTH-secreting [eyewiki.aao.org]
The following laboratory tests are mandatory to confirm this diagnosis: CaP workup and plasma level of PTH. Urine cAMP measurement after PTH challenge. Evaluation of protein Gs activity. [em-consulte.com]
Diagnostic imaging modalities that may be considered include plain radiography, ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), and radionuclide bone scanning (as clinically indicated) (see Workup). [emedicine.medscape.com]
X-Ray
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Mediastinal Mass
masses or widening on chest xray Mediastinitis acute25 Melanonychia Memory loss symptoms elderly patients Meningitis chronic26 Meningitis recurrent25 Mental status changes and coma2 Mesenteric arterial embolism associated factors2 Mesenteric ischemia [books.google.com]
Serum
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Hyperprolactinemia
Forbes Albright syndrome Get Update Overview Hyperprolactinemia is characterized by too much prolactin in the blood. [diseaseinfosearch.org]
Nonpuerperal mastitis may induce transient hyperprolactinemia (neurogenic hyperprolactinemia) of about three weeks' duration; conversely, hyperprolactinemia may contribute to nonpuerperal mastitis. [dict.eudic.net]
Hyperprolactinaemia or hyperprolactinemia is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mIU/L for men. [882m.com]
[…] hormone hypersecretion Non-pregnancy related A-G syndrome Physiological hyperprolactinemia Pituitary stalk compression hyperprolactinemia Pregnancy hyperprolactinemia Pregnancy-related A-G syndrome Prepuberal hyperpituitarism Secondary hyperprolactinemia [icd9data.com]
Hyperprolactinemia and female infertility. J Reprod Med. 1989;34:117-26 [rarediseases.org]
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Androgens Decreased
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein, Diabetes, 2002, vol. 51 (pg. 2734 - 2741 ) Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study, Diabetes [molehr.oxfordjournals.org]
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Estrogen Decreased
In the luteal-follicle phase transition period the serum levels of progesterone and estrogen decrease and no longer suppress the release of FSH, the cohort of small antral follicles is normally sufficiently in number to produce enough Inhibin B to lower [wikivisually.com]
Treatment
Treatment Basic information Diagnosis Treatment Basic information Diagnosis Treatment Pearls considerations Basic information Diagnosis Treatment Pearls considerations Basic information Diagnosis Treatment Pearls considerations Basic information Diagnosis [books.google.com]
Surgery may be necessary if tumor does not respond to treatment with medications. [diseaseinfosearch.org]
The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]
Prognosis
Prognosis - Forbes Albright syndrome Not supplied. Treatment - Forbes Albright syndrome Two drugs that have been used are the dopamine agonists cabergoline and bromocriptine. Resources - Forbes Albright syndrome Not supplied. [checkorphan.org]
This therapy is given in two forms: Gamma knife or stereotactic radiosurgery Conventional radiation Prolactinoma Prognosis The outcome of patients is based on the accomplishment of medical treatment or surgery. [hxbenefit.com]
Thus, the prognosis varies according to the manifestations of MAS. With precocious puberty, the prognosis depends on the duration of premature estrogen exposure. [emedicine.medscape.com]
Parents should talk to their child’s physician and medical team about their specific case, associated symptoms and overall prognosis. The parts of the body most commonly affected by MAS are the bone, skin and endocrine system. [rarediseases.org]
Etiology
Article in It MEDLINE ID: mdl-5535854 Subject(s) Adenoma, Chromophobe/complications Amenorrhea/diagnosis Follicle Stimulating Hormone/urine Lactation Disorders/diagnosis Pituitary Neoplasms/complications Adult Amenorrhea/etiology Cerebral Angiography [carphaevidenceportal.bvsalud.org]
At the beginning of this century cases were described with symptoms of hypofunction identical with those of postoperative hypoparathyroidism but with absence of the etiologic factor, the operation. [jamanetwork.com]
Pulseless electrical activity Pupillary dilatation poor response to darkness Purpura Purpura nonpalpable20 Purpura nonpurpuric disorders simulating purpura1 Qt interval prolongation22 Rectal mass palpable38 Rectal pain Red blood cell aplasia acquired etiology [books.google.com]
Etiology of fibrous dysplasia and McCune-Albright syndrome. Int J Oral Maxillofac Surg. 1999 Oct. 28(5):366-71. [Medline]. Diaz A, Danon M, Crawford J. McCune-Albright syndrome and disorders due to activating mutations of GNAS1. [emedicine.medscape.com]
Epidemiology
The risk of diabetes or metabolic syndrome in KS Epidemiological studies Epidemiological study concerning mortality in KS has been performed in Great Britain ( Swerdlow et al ., 2005 ) and in Denmark ( Bojesen et al ., 2004 ) including more than 3500 [molehr.oxfordjournals.org]
Metyrapone may also be used for treatment. [12] Epidemiology [ edit ] McCune–Albright syndrome is estimated to occur at a frequency between 1 person in 100,000 to 1 person in 1,000,000 individuals worldwide. [15] Notable cases [ edit ] Mauricio Saravia [en.wikipedia.org]
Epidemiology United States and international statistics The exact incidence of MAS in the United States and internationally is unknown, but its prevalence is probably between 1 case in 100,000 population and 1 case in 1 million population, rendering it [emedicine.medscape.com]
[…] less commonly patients may also have Ocular motility deficits and/or Diplopia, certain forms of Nystagmus, signs and symptoms of Increased intracranial pressure due to mass effect, Optic atrophy, or sequelae of Pituitary apoplexy. [3] [4] [5] General Epidemiology [eyewiki.aao.org]
Pathophysiology
Physiology, pathophysiology and clinical management. Philadelphia, Saunders, 1978, pp. 297-372. What is an eponym? An eponym is a word derived from the name of a person, whether real or fictional. [whonamedit.com]
Hyperprolactinemia: pathophysiology and management. Treat Endocrinol. 2003;2:23-32. Lamberts SW, Quik RF. A comparison of the efficacy and safety of pergolide and bromocriptine in the treatment of hyperprolactinemia. [rarediseases.org]
The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndrome. J Clin Endocrinol Metab. 2008 Jun. 93(6):2383-9. [Medline]. [Full Text]. Lietman SA, Ding C, Levine MA. [emedicine.medscape.com]
"The Role of Type 1 and Type 2 5′-Deiodinase in the Pathophysiology of the 3,5,3′-Triiodothyronine Toxicosis of McCune-Albright Syndrome". The Journal of Clinical Endocrinology and Metabolism. 93 (6): 2383–2389. doi : 10.1210/jc.2007-2237. [en.wikipedia.org]
Prevention
Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]
And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. [wellnessadvocate.com]
Prevention - Forbes Albright syndrome Not supplied. [checkorphan.org]
Drugs such as letrozole and anastrozole can sindrome forbes albright used to prevent short stature in both males and females. [todaypdf.pw]
[…] a woman from releasing an egg, setting the stage for the first birth control pills, • show that progesterone can prevent uterine cancer in women who lack that hormone, • demonstrate the cause of overactive adrenal glands (Cushing's syndrome), • warn [drmirkin.com]