Presentation
Abstract Lyso-TPFP presents lysosomal targetability and an acidic pH-activatable response toward formaldehyde. Thus, it exclusively visualizes lysosomal formaldehyde and is immune against it in neutral cytosol and other organelles. [ncbi.nlm.nih.gov]
(A REL is an airborne level of a chemical that is not anticipated to present a significant risk of an adverse non-cancer health effect.) [web.archive.org]
Entire Body System
- Fatigue
Totally 20.6% had weekly headache and 22.1% fatigue. Indoor CO 2 were low (range 380-690 ppm). Indoor median NO 2 and formaldehyde concentrations over one week were 23μg/m 3 and 2.0μg/m 3, respectively. [ncbi.nlm.nih.gov]
Exposure to formaldehyde gas may cause burning sensations in the eye, nose and throat, skin rashes, tightness of the chest and wheezing, fatigue and headaches. [dermnetnz.org]
- Pathologist
Studies of workers handling formaldehyde or formaldehyde-containing products (e.g. pathologists, embalmers, painters) were excluded from the review as immunologic sensitization from dermal contact may modify or confound the effect of formaldehyde inhalation [web.archive.org]
Combined analysis of chromosomal aberrations and glutathione S-transferase M1 and T1 polymorphisms in pathologists occupationally exposed to formaldehyde. Arch Toxicol. 2011;85:1295-1302. [ Links ] 56. [scielo.isciii.es]
HARRINGTON, J.M. & OAKES, D. (1984) Mortality study of British pathologists (1974-80). Br. J. ind. Med., 41: 188-191. [inchem.org]
- Gastric Lavage
Gastric lavage with a small bore NG tube should be considered if it can be performed within 1 hour after ingestion. [atsdr.cdc.gov]
- Surgical Procedure
At our institution, GRF glue was applied in 40 patients who underwent surgical procedures for AAD from 1995, two of whom needed a reoperation because of the development of a redissection and/or a pseudoaneurysm at the anastomotic sites. [ncbi.nlm.nih.gov]
Respiratoric
- Cough
A 54-year-old male ingested 10% formaldehyde and inhaled while vomiting and he developed cough, dyspnea and wheezing with prevalent ronci and bilateral infiltrates on chest x-ray (cxr). [ncbi.nlm.nih.gov]
[…] for original (SCP) IDLH: Patty [1963] reported that “exposure to 10 to 20 ppm produces almost immediate eye irritation and a sharp burning sensation of the nose and throat which may be associated with sneezing, difficulty in taking a deep breath, and coughing [cdc.gov]
- Sneezing
LEL, 7,000 ppm) Original (SCP) IDLH: 30 ppm Basis for original (SCP) IDLH: Patty [1963] reported that “exposure to 10 to 20 ppm produces almost immediate eye irritation and a sharp burning sensation of the nose and throat which may be associated with sneezing [cdc.gov]
Breathing formaldehyde vapour can result in irritation of nerves in the eyes and nose, which may cause burning, stinging or itching sensations, a sore throat, teary eyes, blocked sinuses, runny nose, and sneezing. [nicnas.gov.au]
Tearing Neurological: Headaches Insomnia Attention Deficit Nausea Skin: Allergic Contact Dermatitus Rashes, Sores and Hives Respiratory: Chest Tightness Wheezing Asthma Nose or Throat: Stinging, Burning or Itching Sore Throat Runny Nose Blocked Sinuses Sneezing [chemsee.com]
Gastrointestinal
- Nausea
Health effects of formaldehyde are eye, nose and throat burning and irritation; nausea; skin rashes; and breathing difficulties in some people. High concentrations of formaldehyde can trigger asthma attacks. [homeaircheck.com]
Vol. 4, Pg. 261, 1991. man TDLo oral 646mg/kg (646mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: GASTRITIS Japanese Journal of Toxicology. [chem.sis.nlm.nih.gov]
Those signs include a “new car smell,” and visitors complaining of dizziness, nausea, headaches, disorientation, or breathing problems. The Sierra Club recommends these test kits, made by ACS Badge. [grist.org]
- Vomiting
Studies have shown the ingestion of formaldehyde caused vomiting, abdominal pain, dizziness, and in extreme cases can cause death. According to the prevailing quarantine... [thejakartapost.com]
A 54-year-old male ingested 10% formaldehyde and inhaled while vomiting and he developed cough, dyspnea and wheezing with prevalent ronci and bilateral infiltrates on chest x-ray (cxr). [ncbi.nlm.nih.gov]
Vol. 4, Pg. 261, 1991. man TDLo oral 646mg/kg (646mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: GASTRITIS Japanese Journal of Toxicology. [chem.sis.nlm.nih.gov]
- Abdominal Pain
Studies have shown the ingestion of formaldehyde caused vomiting, abdominal pain, dizziness, and in extreme cases can cause death. According to the prevailing quarantine... [thejakartapost.com]
(DuPont, 2018) First Aid Signs and Symptoms of Acute Formaldehyde Exposure: Acute exposure to formaldehyde may result in irritation or burns to the skin, eyes, and mucous membranes; lacrimation (tearing); nausea; vomiting (may be bloody); abdominal pain [cameochemicals.noaa.gov]
In humans, the ingestion of formaldehyde has been shown to cause vomiting, abdominal pain, dizziness, and in extreme cases can cause death. Testing for formaldehyde is by blood and/or urine by gas chromatography-mass spectrometry. [en.wikipedia.org]
Nausea, vomiting, diarrhea, abdominal pain, inflammation of the stomach, and ulceration and perforation of the oropharynx, epiglottis, esophagus, and stomach may occur. [atsdr.cdc.gov]
- Diarrhea
Diarrhea Caused by Bacteria 19. Diphtheria Toxoid 20. Ebola Vaccines 21. Enterovirus 71 22. Epstein-Barr Virus Vaccines 23. Haemophilus influenzae Type b Vaccines 24. Hepatitis A Vaccines 25. Hepatitis B Vaccines 26. Hepatitis C Vaccines 27. [elsevier.com]
If accidentally swallowed, you may experience symptoms such as: severe pain/swelling/ulcers of the mouth or throat, bloody vomit or diarrhea, dizziness, loss of consciousness, seizures. Notes Do not share this medication with others. [webmd.com]
Nausea, vomiting, diarrhea, abdominal pain, inflammation of the stomach, and ulceration and perforation of the oropharynx, epiglottis, esophagus, and stomach may occur. [atsdr.cdc.gov]
2018) First Aid Signs and Symptoms of Acute Formaldehyde Exposure: Acute exposure to formaldehyde may result in irritation or burns to the skin, eyes, and mucous membranes; lacrimation (tearing); nausea; vomiting (may be bloody); abdominal pain; and diarrhea [cameochemicals.noaa.gov]
Eyes
- Lacrimation
Incompatibilities & Reactivities Strong oxidizers, alkalis & acids; phenols; urea; oxides; isocyanates; caustics; anhydrides Exposure Routes inhalation, ingestion, skin and/or eye contact Symptoms irritation eyes, nose, throat, respiratory system; lacrimation [cdc.gov]
Vol. 23, Pg. 259, 1941. human TCLo inhalation 17mg/m3/30M (17mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES JAMA, Journal of the American Medical Association. [chem.sis.nlm.nih.gov]
- Excessive Tearing
Excess exposure to formaldehyde is known to cause many issues including: Eyes: Stinging, Burning or Itching Excess Tearing Neurological: Headaches Insomnia Attention Deficit Nausea Skin: Allergic Contact Dermatitus Rashes, Sores and Hives Respiratory: [chemsee.com]
Skin
- Eczema
We report a case of a 28-year-old female plywood worker who developed eczema on the dorsal side of her hands and wrists after 2 years of working on the melamine paper impregnation line. [ncbi.nlm.nih.gov]
Once the dermatitis appears on the skin, treatment is as for any acute dermatitis / eczema, i.e. topical corticosteroids, emollients, treatment of any secondary bacterial infection ( Staphylococcus aureus ), etc. [dermnetnz.org]
Eczema : Workers exposed to formaldehyde solutions or resins can develop eczema (flaking and itching skin), which may involve the eyelids, neck, hands, arms, armpits and scrotum. [afscme.org]
- Ulcer
Carvedilol did not show any ulcerative effect on the gastric mucosa of normal rats, and its use was associated with an improvement of both the gross and histopathological pictures of gastric ulcers in animals of the cold stress ulcer model compared with [ncbi.nlm.nih.gov]
Vol. 4, Pg. 261, 1991. man TDLo oral 646mg/kg (646mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: GASTRITIS Japanese Journal of Toxicology. [chem.sis.nlm.nih.gov]
If accidentally swallowed, you may experience symptoms such as: severe pain/swelling/ulcers of the mouth or throat, bloody vomit or diarrhea, dizziness, loss of consciousness, seizures. Notes Do not share this medication with others. [webmd.com]
Treatment
SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment. Intracellular TG levels decreased for 48h treatment of formaldehyde. [ncbi.nlm.nih.gov]
Marcia Teixeira Advanced Brazilian Keratin Treatment Marcia Teixeira Brazilian Keratin Treatment Marcia Teixeira Chocolate, extreme de-frizzing treatment Pro-Collagen RX Keratin Treatment QOD GOLD Solution Who tested these hair straightening products [health.ny.gov]
Prognosis
[…] and formaldehyde allergy are reviewed: applications, exposure scenarios, legislation, patch testing problems, frequency of sensitization, relevance of positive patch test reactions, clinical pattern of allergic contact dermatitis from formaldehyde, prognosis [ncbi.nlm.nih.gov]
Peter Elsner and Kaija Lammintausta, Prognosis of Irritant Contact Dermatitis, Kanerva’s Occupational Dermatology, 10.1007/978-3-319-40221-5_100-2, (1-9), (2018). [doi.org]
In MYC-amplified neuroblastoma patient samples, there was a significant correlation between SHMT2 and hypoxia-inducible factor-1 α (HIF1α), and SHMT2 expression correlated with unfavorable patient prognosis. [pubs.acs.org]
Etiology
Electronic address: [email protected] 5 State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping [ncbi.nlm.nih.gov]
The inability to quantify etiologically relevant formaldehyde levels is attributable to several factors. Formaldehyde levels were not measured at the same time of the year from one study to the next. [doi.org]
Three of these studies involved either embalmers or anatomists, which might suggest the operation of some other alternative or contributing etiological factors. [inchem.org]
Epidemiology
Epidemiologic associations between FA and myeloid leukemia, and between benzene, TCE and NHL are, however, still debated. [ncbi.nlm.nih.gov]
The purpose of this document is to revisit the guidelines developed for formaldehyde in view of epidemiological and toxicological studies published since 1987. [web.archive.org]
Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment † First published: 29 September 2009 Cited by: 12 † This article is a US Government work and, as such, is in the public domain in the United States of [doi.org]
Pathophysiology
Endogenous and exogenous formaldehyde (FA) has been linked to cancer, neurotoxicity, and other pathophysiologic effects. Molecular and cellular mechanisms that underlie FA-induced damage are poorly understood. [ncbi.nlm.nih.gov]
Prevention
Based on these data, we propose the methods be developed to prevent exposure to FA vapors released from cadavers. KEYWORDS: Adipose tissue; Dissection stage; Embalmed cadaver; Formaldehyde; Gross anatomy; Skin incision [ncbi.nlm.nih.gov]
[…] skin contact Eyes: Prevent eye contact Wash skin: When contaminated Remove: When wet or contaminated Change: No recommendation Provide: Eyewash, Quick drench First Aid ( See procedures ) Eye: Irrigate immediately Skin: Water flush promptly Breathing: [cdc.gov]