We present the clinical features observed in 77 patients (89 eyes) seen in the Uveitis Clinic at Leicester Royal Infirmary over a 2-year period. The most common presenting symptom was visual deterioration (96.1%) rather than pain (18.2%). [ncbi.nlm.nih.gov]

Diagnosis [ edit ] Diagnosis is made by an ophthalmologist or optometrist based on the clinical presentation. [en.wikipedia.org]

• Asymptomatic

  Unlike other uveitis, this disease can be asymptomatic for many years with no redness or eye pain and can be diagnosed accidentally during routine eye examination. [webeyeclinic.com]

  Patients are often asymptomatic and the disease is often discovered through investigation of the cause of the heterochromia or cataract. [en.wikipedia.org]

  Patients are usually asymptomatic but may present with floaters and blurry vision. There is a mild but persistent anterior chamber reaction with diffuse and characteristic white stellate keratic precipitates. [ncbi.nlm.nih.gov]

• Nausea

  Common side effects of methotrexate include nausea, anorexia, stomatitis and transient elevation of serum aminotransferase. Alopecia, hematological toxicity, headache, dizziness, fatigue, and mood changes may also occur. [intechopen.com]

• Vomiting

  Diagnosis Patients with acute closed-angle glaucoma may present with ocular and brow ace, blurred vision, halos, photophobia and even nausea and vomiting. Patients with open or chronic angle closure glaucoma are asymptomatic. [intechopen.com]

• Heterochromia Iridis

  Heterochromia iridis facts Heterochromia iridis is an uncommon condition in which the two eyes are different in color from each other. Heterochromia iridis may be congenital (present at birth) or acquired. [medicinenet.com]

  A heterochromia iridis-associated acquired Horner syndrome is usually due to a lesion of the postganglionic neuron (third order). 2. Heterochromia iridis-associated acquired Horner syndrome only occurs in children? 3. [neuro-ophthalmology.stanford.edu]

  Affected people at times experience heterochromia iridis. [disabled-world.com]

  Harper & Row, New York 1979. 23 Sugar HS : Heterochromia iridis with special consideration of its relation to cyclitic disease. [nature.com]

• Visual Impairment

  Inverse RP, also called RP centralis is a rare form of RP initially affecting the photoreceptors located in the macula, causing important visual impairment in very early stages of presentation. [journalretinavitreous.biomedcentral.com]

The possible causes are quite numerous and a medical workup will likely be undertaken. A definitive cause can only be found about half of the time or less. [medhelp.org]

Workup should be performed to rule out other causes of uveitis. [eyewiki.aao.org]

Most patients (73.0%) did not require active treatment; pre- and postoperative anti-inflammatory treatment for cataract extraction was performed successfully to minimize the risk of inflammation. [ncbi.nlm.nih.gov]

Surgical treatment, other than what is necessary for removal of glaucoma or cataracts, is not usually possible. [wisegeek.com]

This is one clinical diagnostic sign of FHI slit lamp examination shows stringy keratic precipitates Treatment [ edit ] Patients usually do not require treatment due to benign nature of the disease. [en.wikipedia.org]

Abstract After reviewing the records of 111 patients with Fuchs' heterochromic iridocyclitis, we studied the therapy and prognosis of secondary glaucoma in 30 of these 111 patients (27%) who had glaucoma or could be considered glaucoma suspects. [ncbi.nlm.nih.gov]

Fuchs' heterochromic iridocyclitis (FHI) is a chronic, low grade, usually unilateral, ocular inflammatory disease with a good visual prognosis. [eyewiki.org]

Those who developed FHI tend to be aged between 29 and 44 years old and are often given a positive prognosis. Treatment Options In cases of inflammation, therapy may not be required. [news-medical.net]

Treatment and prognosis of secondary glaucoma in Fuchs’ heterochromic iridocyclitis. Am J Ophthalmol. 1993;116:327–40. CrossRef PubMed Google Scholar 26. Da Mata A, Burk SE, Netland PA, et al. [link.springer.com]

Cataracts and glaucoma were more frequent and associated with a poorer prognosis than previously reported. Topical applications of corticosteroids are occasionally useful, but the patients later become refractory. [jamanetwork.com]

A role of embryologic factors in neural crest cells in the etiology of both diseases cannot be excluded. [ncbi.nlm.nih.gov]

Etiology Historical etiological theories for FHI included sympathetic denervation, which could account for iris hypochromia, and infectious etiologies such as herpes simplex virus, toxoplasma, and cytomegalovirus (CMV). [glaucomatoday.com]

Etiology of Fuchs Heterochromic Iridocyclitis Unfortunately, research has not identified the exact etiology of FHI; there are, however, several factors which have been linked to the onset of the condition. [news-medical.net]

Etiology While the exact etiology of FHI remains unknown, several associations have been proposed, suggesting a multi-factorial disease process. [eyewiki.aao.org]

Epidemiologic relationship between Fuchs’ heterochromic iridocyclitis and the United States rubella vaccination program. Am J Ophthalmol. 2007;144(3):424–8. CrossRef PubMed Google Scholar 13. Norrsell K, Sjodell L. [link.springer.com]

Epidemiology of uveitis. Int Ophthalmol Clin. 2005; 45(2):1-13. Quentin CD, Reiber H. Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor. Am J Ophthalmol. 2004;138(1):46-54. Gordon L. [glaucomatoday.com]

[…] vitreous floaters caused by inflammatory debris may be able to improve their vision by using para plana vitrectomy. 25 SECONDARY GLAUCOMAS Fuchs Heterochromic Iridocyclitis Sources Fuchs’ Heterochromic Iridocyclitis in an Italian Tertiary Referral Centre: Epidemiology [news-medical.net]

The epidemiologic association of Fuchs’ heterochromic Iridocyclitis and ocular toxoplasmosis. Am J Ophthalmol 1991; 111:356-62. ↑ Arffa RC, Schlaegel TF. Chorioretinal scars in Fuchs’ heterochromic Iridocyclitis. [eyewiki.aao.org]

Epidemiological characteristics of uveitis in Switzerland. Int Ophthalmol 1994-95;18(5):293-8. Quentin CD, Reiber H. Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor. Am J Ophthalmol 2004 Jul;138(1):46-54. Vol. [reviewofoptometry.com]

The appearance of a hyphema after peribulbar anesthesia in Fuchs' heterochromic iridocyclitis is an unusual sign that may have the same pathophysiology as the Amsler-Verrey sign. [ncbi.nlm.nih.gov]

Pathophysiology Add text here Primary prevention Add text here Clinical diagnosis of exclusion based on history and physical findings. Laboratory testing is of no value. History Floaters and visual deterioration. [eyewiki.org]

We are unaware of any other cases presenting with both Horner and Waardenburg syndromes and believe that this case serves as an excellent opportunity to briefly review the pathophysiology involved with these disorders.” [neuro-ophthalmology.stanford.edu]

Early detection and treatment could prevent vision loss. See an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes of light. [icdlist.com]

We believe that finding the way these entities connect can shed some light into their complex pathogenesis and help find ways to foresee and prevent the appearance of complications such as cataract and macular edema. [journalretinavitreous.biomedcentral.com]

The position of the Argon iridotomy in this case is preferably supero-nasal to prevent injury to the macula. [intechopen.com]

Pathophysiology Add text here Primary prevention Add text here Clinical diagnosis of exclusion based on history and physical findings. Laboratory testing is of no value. History Floaters and visual deterioration. [eyewiki.org]

Filtering surgery is successful in preventing IOP spikes and for long-term IOP control. 17 We start with medical therapy, which includes prednisolone 1% and topical drops to lower IOP and reserve incisional surgery for refractory cases. [glaucomatoday.com]