Edit concept Question Editor Create issue ticket

Fungal Osteomyelitis


Presentation

  • In addition, a review of the literature regarding case reports of fungal osteomyelitis after ACL reconstruction is presented. Copyright 2011 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
  • In the present report, we describe a rare case of fungal osteomyelitis localized to the calcaneus in an elderly female patient who was successfully treated with surgical debridement and a 6-week course of oral fluconazole.[ncbi.nlm.nih.gov]
  • We present a case of fungal osteomyelitis caused by Lasiodiplodia species in a patient with multiple myeloma after autologous stem cell transplant. The patient was successfully treated with a combination of surgery and oral voriconzole.[ncbi.nlm.nih.gov]
  • Hayda or an immediate family member is a member of a speakers’ bureau or has made paid presentations on behalf of AO North America; serves as an unpaid consultant to BioIntraface; and serves as a board member, owner, officer, or committee member of the[journals.lww.com]
  • Miscellaneous manifestations have included endocarditis, keratomycosis, endophthalmitis, peritonitis, various pulmonary presentations, osteomyelitis, rarely disseminated systemic infection (1).[webmedcentral.com]
Fever
  • A 23-year-old man developed fever, swelling and pain of the affected knee from 18 days after arthroscopic ACL reconstruction.[ncbi.nlm.nih.gov]
  • Osteomyelitis Symptom Fever The definition of fever is an elevation in body temperature or a high body temperature.[medicinenet.com]
  • Symptoms of bone infections include Pain in the infected area Chills and fever Swelling, warmth, and redness A blood test or imaging test such as an x-ray can tell if you have a bone infection. Treatment includes antibiotics and often surgery.[medlineplus.gov]
  • The disease is commonest in children, and causes fever and severe pain at the affected site.[medical-dictionary.thefreedictionary.com]
  • Unlike children, adults with osteomyelitis generally have no fever.[medbroadcast.com]
Collapse
  • . - weakening of the bone may cause vertebral collapse. - hematogenous osteomyelitis is seen more often in the child than the adult; - since the adult does not have an epiphyseal plate , site of origin is different from that of childhood; - risk factors[wheelessonline.com]
  • The L2–L3 disk is collapsed. F, Axial T1-weighted (500/18/1.5) spin-echo image at the L3 level depicts epidural and paraspinal inflammation ( arrows ).[ajnr.org]
Rigor
  • Expanded coverage and rigorous updates—including 40 online-only chapters—keep you current with the latest advances in cartilage repair and regeneration, allograft and autografts, computer robotics in total knee arthroplasty, and other timely topics.[books.google.com]
Bone Pain
  • A nuclear imaging method to evaluate any degenerative and/or arthritic changes in the joints; to detect bone diseases and tumors; to determine the cause of bone pain or inflammation.[chop.edu]
  • […] had any surgery on a bone a weakened immune system – for example, because of chemotherapy or you have another serious illness had osteomyelitis before diabetes, especially if you also have a foot ulcer Sometimes an infection in the blood affects the bone[nhs.uk]
  • When to see a doctor See your doctor if you experience worsening bone pain along with fever.[mayoclinic.org]
  • Persistent, severe, and increasing bone pain; tenderness; guarding on movement; regional muscle spasm; and fever suggest this diagnosis. Draining sinus tracts may accompany posttraumatic osteomyelitis or osteomyelitis from a contiguous infection.[medical-dictionary.thefreedictionary.com]
Bone Disorder
  • The book details the pathologic and radiologic characteristics of all bone and joint diseases, including arthritis, metastatic bone disease, osteoporosis, trauma, osteomyelitis, developmental bone disorders, and tumor-like lesions.[books.google.com]
Spine Pain
  • . - h/o of unremmiting spine pain at any level is characteristic, & tenderness, spasm, and loss of motion are seen; - initially onset of pain may be insidious; - w/ time, pain may be so severe that jarring the bed may be agonizing; - pain restricts ROM[wheelessonline.com]
Distractibility
  • We report lower extremity salvage by radical bony debridement, free tissue transfer, distraction osteogenesis with bone-docking, and a novel antifungal regimen in a clinical setting of infection with Scedosporium inflatum, historically requiring amputation[ncbi.nlm.nih.gov]
Excitement
  • Douglas Jones Lippincott Williams & Wilkins , 2006 - 2808 من الصفحات Click here to view a narrated demo to see all the features of this exciting new Solution![books.google.com]
  • A, Sagittal T1-weighted (416/19/2 [TR/TE/excitations]) spin-echo image in the midline of the lumbar spine shows minimal hypointensity within the L2, L3, and L4 vertebral bodies ( arrows ).[ajnr.org]

Workup

Scedosporium
  • We report lower extremity salvage by radical bony debridement, free tissue transfer, distraction osteogenesis with bone-docking, and a novel antifungal regimen in a clinical setting of infection with Scedosporium inflatum, historically requiring amputation[ncbi.nlm.nih.gov]
  • Host immune response against Scedosporium species. Med Mycol. 2009;47:443–50. CrossRef Google Scholar 38. Ochiai N, Shimazaki C, Uchida R, et al. Disseminated infection due to Scedosporium apiospermum in a patient with acute myelogenous leukemia.[link.springer.com]

Treatment

  • Treatment must be aggressive and should include radical local debridement. The quest for effective systemic chemotherapy should continue. Persistent drainage, ascending infection, and a functionless extremity are reasons for considering amputation.[ncbi.nlm.nih.gov]
  • Because fungal osteomyelitis and fungal septic arthritis are rare conditions, study of their pathophysiology and treatment has been limited. In the literature, evidence-based treatment is lacking and, historically, outcomes have been poor.[ncbi.nlm.nih.gov]
  • Treatment Treatment is involved and is not always successful. Expensive anti-fungal drugs have to be given by a vet and repeat tests performed to ensure it is clearing up. See also... Osteosarcoma of the elbow Osteosarcoma of the radius[berryhavenvet.com.au]
  • Mycetoma: Current concepts in treatment. Int J Dermatol 30: 387-98.[webmedcentral.com]

Prognosis

  • Sections on the prognosis and prevention of this illness are also included. The book will help the reader in choosing the most appropriate way to manage this challenging bone infection.[books.google.com]
  • What is the prognosis for osteomyelitis? With early diagnosis and appropriate treatment, the prognosis for osteomyelitis is good.[medicinenet.com]
  • Post-sternotomy sternal osteomyelitis and mediastinitis by Trichosporon asahii : a rare occurrence with a grave prognosis. Mycoses. 2010;53:272–4. PubMed CrossRef Google Scholar 61. Davies F, Logan S, Johnson E, Klein JL.[link.springer.com]
  • Prognosis Prognosis varies depending on how quickly an infection is identified, and what other underlying conditions exist to complicate the infection.[medical-dictionary.thefreedictionary.com]
  • What is the outlook (prognosis)? If the infection is treated promptly, there is a good chance of a complete cure. The best outcome occurs if you have treatment within 3-5 days of the start of infection.[patient.info]

Etiology

  • In cases of chronic osteomyelitis with draining sinuses occurring in uncommon anatomic locations, fungal etiology should be suspected (3). 1. Silveira F, Nucci M (2001) Emergence of black moulds in fungal disease:Epidemiology and Therapy.[webmedcentral.com]
  • A swab culture was obtained from the fistula and was found to be positive with Periodic Acid Schiff, which indicated a fungal etiology. Oral antifungals were given for 1 month (Tablet.[ijdr.in]
  • "Etiologic diagnosis of chronic osteomyelitis: A prospective study". Archives of Internal Medicine . 166 (1): 95–100. doi : 10.1001/archinte.166.1.95 . ISSN 0003-9926 . PMID 16401816 .[en.wikipedia.org]

Epidemiology

  • Aspergillus osteomyelitis: epidemiology, clinical manifestations, management, and outcome. J Infect. 2014;68:478–93.[link.springer.com]
  • The epidemiology of these fungal infections, their musculoskeletal presentations, and their treatment are considered in this chapter.[musculoskeletalkey.com]
  • Epidemiology and pathogenesis of paranasal sinus mycoses.[ijdr.in]
  • Epidemiological and laboratory studies traced the potential source of Candida contamination to lemon juice used to dissolve the injected heroin [ 61-64 ].[academic.oup.com]
Sex distribution
Age distribution

Pathophysiology

  • Because fungal osteomyelitis and fungal septic arthritis are rare conditions, study of their pathophysiology and treatment has been limited. In the literature, evidence-based treatment is lacking and, historically, outcomes have been poor.[ncbi.nlm.nih.gov]
  • Cranial Osteomyelitis provides an in-depth review of knowledge of the management of skull osteomyelitis, with an emphasis on risk factors, causative pathogens, pathophysiology of dissemination, clinical presentations, neuroradiological findings and treatment[books.google.com]
  • Pathophysiology Department, Medical School National and Kapodistrian University of Athens Athens Greece 2.[link.springer.com]
  • "Infectious diseases: pathophysiology and mechanisms of hyperbaric oxygen" . J. Hyperbaric Med . 2 (3): 133–140. Archived from the original on 2009-02-13 . Retrieved 2008-05-16 .[en.wikipedia.org]

Prevention

  • Sections on the prognosis and prevention of this illness are also included. The book will help the reader in choosing the most appropriate way to manage this challenging bone infection.[books.google.com]
  • Osteomyelitis surgery prevents the infection from spreading further or getting so bad that amputation is the only remaining option. Preventing Osteomyelitis The best way to prevent osteomyelitis is to keep things clean.[webmd.com]
  • Prevention If you've been told that you have an increased risk of infection, talk to your doctor about ways to prevent infections from occurring. Reducing your risk of infection will also help your risk of developing osteomyelitis.[mayoclinic.org]
  • Prevention About the only way to have any impact on the development of osteomyelitis involves excellent care of any wounds or injuries. Resources Periodicals Calhoun, Jason H., et al. "Osteomyelitis: Diagnosis, Staging, Management."[medical-dictionary.thefreedictionary.com]
  • Treatment and Prevention Treatment of osteomyelitis depends on how the infection has spread to the bone and how deeply it has penetrated.[medbroadcast.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!