Presentation
CASE PRESENTATION: A 66-year-old Hispanic man with liver cirrhosis, type 2 diabetes mellitus, and obesity presented to a critical access hospital with complaints of hematemesis. He was evaluated by gastroenterology and found to have gastritis. [journal.chestnet.org]
Bootstrap values >50% based on 1000 replicates are presented close to the branches. [mdpi.com]
We present, to our knowledge, the second case of isolation of this organism in a patient with AIDS along with a review of the literature on human infection with A. pullulans. Case presentation. [microbiologyresearch.org]
This is mostly seen in people who are on broad spectrum antibiotics which kill all the bacteria present within the intestines where some amount of fungi is always present. [epainassist.com]
Candida krusei infection may present in a variety of manners. Mild local infection may produce skin lesions nearly identical to those of C. albicans. [escholarship.org]
Entire Body System
- Candidiasis
The most common type, also known as candidemia, candedemia, or systemic candidiasis, is caused by Candida species, but infections by other fungi, including Saccharomyces, Aspergillus and Cryptococcus, are also called fungemia. [en.wikipedia.org]
See also Bacteremia Candidiasis [bionity.com]
Clin Res. 1979; 27: 41A Google Scholar Hughes JM Remington JS Systemic candidiasis, a diagnostic challenge. Calif Med. 1972; 116: 8 PubMed Google Scholar Gaines JD Remington JS Disseminated Candidiasis in the surgical patient. [amjmed.com]
- Fever
On day 24, the patient’s condition worsened, he had fever up to 40.1°C, developed acute renal failure and, again, septic shock requiring catecholamine infusion. [aspergillus.org.uk]
In conclusion, disseminated C. krusei must be considered in any immunocompromised patient with fever, skin lesions, or organ failure. [escholarship.org]
After 5 days of treatment with meropenem and vancomycin, the fever subsides and reappears again after another 5 days. By the time the fever reappears he had an 8-day central venous catheter. [medigraphic.com]
Blood samples were obtained from all the patients and were loaded into Bactec 9050 blood culture instruments (Bectone Dickinson, Baltimore, Md., USA), and organisms responsible for causing fever were detected. [advbiores.net]
Case report We present the case of a 73 year-old man with diarrhea, anorexia and fever. In the blood analyses, both aerobic blood culture bottles yielded the growth of Rhodotorula dairenensis. [elsevier.es]
- Sepsis
Unfortunately, after a week on the carbapenem, the bacterial sepsis was followed by candidemia. Parenteral fluconazole therapy was started pending identification of the yeast(s). [ukm.pure.elsevier.com]
Rarely, it is the cause of catheter-related sepsis. [medscape.com]
Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy. [profiles.umassmed.edu]
Alternate ICD10s to consider coding instead or in addition Shock, septic Severe sepsis Any infection that is the source of this fungemia. [ccmdb.kuality.ca]
- Fatigue
[…] chevron_left chevron_right ES "fungemia" en inglés expand_more Traducciones Traducciones Ejemplos monolingües English Cómo usar "fungemia" en una frase Many symptoms may be associated with fungemia, including pain, mental disorders, chronic fatigue, and [es.bab.la]
Pain, mental disorders, chronic fatigue, infections, are a few of the long list of associated symptoms with Fungemia. See also Bacteremia Candidiasis [bionity.com]
Many symptoms may be associated with fungemia, including pain, acute confusion, chronic fatigue, and infections. [en.wikipedia.org]
- Camping
Ruiz Camps I, Jarque I. Enfermedades invasoras por hongos levaduriformes en pacientes neutropénicos. Rev Iberoam Micol. 2016;33(3). Acceso: 18/05/2018. [medigraphic.com]
Gastrointestinal
- Vomiting
A 49-year-old man with advanced AIDS and a history of recurrent oesophageal candidiasis was admitted with nausea with vomiting, and odynophagia. He was treated as having a recurrence of oesophageal candidiasis. [microbiologyresearch.org]
On March 8th, 2019, multiple vomiting episodes led to employ peripheral parenteral nutrition; being the clinical presentation compatible with a small bowel obstruction secondary to peritoneal carcinomatosis, a CT scan was also ordered. [elsevier.es]
Case presentation A 81-year-old woman was admitted to the emergency room on January 19th, 2018 for fever and vomiting. Her medical history consisted only in mild cognitive disorders and she received no treatment. [bmcinfectdis.biomedcentral.com]
In adult studies, the primary adverse effects are fever, headache, vomiting, diarrhea, signs of histamine release and irritation at the injection site. 16, 17, 18 Caspofungin has been approved in adults for the treatment of esophageal and invasive candidiasis [nature.com]
- Nausea
A 49-year-old man with advanced AIDS and a history of recurrent oesophageal candidiasis was admitted with nausea with vomiting, and odynophagia. He was treated as having a recurrence of oesophageal candidiasis. [microbiologyresearch.org]
Skin
- Skin Lesion
(NCI Thesaurus) YOU MAY ALSO LIKE A type of skin lesion that is marked by ulcerations (breaks on the skin or surface of an organ) and necrosis (death… A type of skin lesion that is marked by ulcerations (breaks on the skin or surface of an organ) and [tititudorancea.com]
In conclusion, disseminated C. krusei must be considered in any immunocompromised patient with fever, skin lesions, or organ failure. [escholarship.org]
It is worth noting that our patient's skin lesions were only discovered thanks to a rigorous and exhaustive examination by the treating physician. [elsevier.es]
Physical findings can vary from a normal exam to findings specific to localized deep-seated tissue infections, for example, endophthalmitis skin lesions, candiduria, and central nervous system findings.[10] Evaluation The gold standard for diagnosis of [statpearls.com]
American Society for Microbiology, Washington D.C1974 Google Scholar Bodey GP Luna M Skin lesions associated with disseminated Candidiasis. JAMA. 1974; 229: 1466 Scopus (114) PubMed Crossref Google Scholar Balandran L Rothschild H Pugh N et al. [amjmed.com]
- Ulcer
(NCI Thesaurus) YOU MAY ALSO LIKE A type of skin lesion that is marked by ulcerations (breaks on the skin or surface of an organ) and necrosis (death… A type of skin lesion that is marked by ulcerations (breaks on the skin or surface of an organ) and [tititudorancea.com]
Gastroenteritis Gastrointestinal neoplasm Hepatitis Hernia Inflammatory Bowel Disease Intra-abdominal infection Ischemic gut Liver disease Liver failure Pancreas disease Pancreatitis Peptic ulcer Musculoskeletal/soft tissue Hernia Joint/ligament trauma [ccmdb.kuality.ca]
Davis Company ET - 24 DB - Taber's Online DP - Unbound Medicine ER - fungal infection fungal infection of nail nail infection fungal septicemia fungal ulcer fungate fungating fungemia Fungi fungi fungicide fungiform fungiform papilla -fungin [tabers.com]
Pathology examination showed (Fig. 1) squamous mucosa extensively ulcerated and presence of numerous pseudohyphae within the vessels and in the adjacent tissue, positive with the PAS (periodic acid-Schiff) and Grocott stain histochemical techniques. [elsevier.es]
Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis. Oncotarget 2017, 8, 107577–107588. [mdpi.com]
Neurologic
- Meningism
It has been implicated clinically as causing skin and soft tissue infections, meningitis, splenic abscesses and peritonitis. [microbiologyresearch.org]
Infectious disease Antibiotic resistance Bacteria COVID Double duty pathogen Encephalitis Fungus Iatrogenic infection Infection requiring pathogen Infection with implied pathogen Influenza Intra-abdominal infection Lower respiratory tract infection Meningitis [ccmdb.kuality.ca]
A growing number of case reports suggest COVID-19 may be associated with increased risk of fungal infections, including fungemia and meningitis. [journal.chestnet.org]
Initial treatment with an azole should be considered in a patient with concomitant meningitis, endophthalmitis, urinary tract infections (due to low penetrance of echinocandins to this areas), as well as in patients with prior exposure to echinocandins [statpearls.com]
Rhodotorula glutinis meningitis: a case report and review of literature. Mycoses. 2014;57(7):447-51. doi: 10.1111/myc.12180. PubMed PMID: 24589085. Epub 2014 Mar 3 Quindós Andrés Guillermo. Criptococosis y otras micosis causadas por levaduras. [medigraphic.com]
Workup
Blood cultures from a central catheter source have a better yield than those from peripheral sites. [3] A positive peripheral blood smear, as seen in this case, is rare. [4] Malassezia fungemia should be considered in the workup of sepsis in patients [medscape.com]
Blood cultures from a central catheter source have a better yield than those from peripheral sites.3 A positive peripheral blood smear, as seen in this case, is rare.4Malassezia fungemia should be considered in the workup of sepsis in patients with a [patientcareonline.com]
] Voriconazole can also be given as an intravitreal injection and may be safer than amphotericin B given the lack of demonstrated dose-dependent toxicity in animal studies. [35] Ultimately, diagnosis of endogenous endophthalmitis warrants a systemic workup [eyewiki.aao.org]
Microbiology
- Candida
Two distinct Candida species were isolated from her blood which were identified biochemically using ID 32 C as Candida tropicalis and Candida lipolytica. [ukm.pure.elsevier.com]
[…] krusei and Candida glabrata ). [elsevier.es]
Treatment regimens and outcomes for three patients with Candida auris fungemia. [pubmed.ncbi.nlm.nih.gov]
Species 2001-2003 2011-2013 Total N % N % N % Candida albicans 91 39.7 88 30.3 179 34.5 Candida glabrata 1 0.4 7 2.4 8 1.5 Candida guilliermondii 3 1.3 4 1.4 7 1.3 Candida kefyr 0 0 2 0.7 2 0.4 Candida krusei 0 0 9 3.1 9 1.7 Candida parapsilosis 60 26.2 [scielo.br]
- Blood Culture Positive
Median delay from candidemia to first antifungal therapy was 3 days, in line with the observed delay of blood culture positivity. [paperity.org]
Blood culture positivity varied by system, species, and procedure. [jcm.asm.org]
8 (1.37) 2013 571 17 (2.97) 10 (1.75) 2014 568 13 (2.28) 1 (0.17) Total 3227 61 (10.98) 33 (6.11) Year Total number of specimens received in Mycology (blood cultures and bone marrow cultures) Positive blood cultures (%) Positive bone marrow cultures [academic.oup.com]
[…] of vascular catheter; arrows, dates of positive blood culture. [pubmed.ncbi.nlm.nih.gov]
Treatment
After 13 days of treatment, the patient developed fungemia with S boulardii. Treatment with Sacchaflor was immediately discontinued and the patient was successfully treated with amphotericin B. [casereports.bmj.com]
Mortality by species and initial antifungal treatment for the 278 patients receiving antifungal treatment DISCUSSION This study has revealed several important issues concerning the epidemiology, diagnostics, and treatment of fungemia, with implications [jcm.asm.org]
Mycoses 64(12): 1521-1526, 2021 Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. [eurekamag.com]
Treatment with an echinocandin was started, but the patient died. [elsevier.es]
Candidemia persisted in all patients despite treatment with amphotericin B. [nature.com]
Prognosis
[…] to: navigation, search Fungemia Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Differentiating Fungemia from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis [wikidoc.org]
Due to intrinsic resistance to echinocandins, poor susceptibility to polyenes, and preferred occurrence in immunocompromised patients, such infections are often of poor prognosis. Yet no consensual therapeutic guidelines are presently available. [dovepress.com]
A worst prognosis was significantly associated with: age over 65 years, surgical procedures during present admission, leucocytosis, shock, and delay in antifungal treatment Conclusions Fungal bloodstream infection incidence is high in our environment. [elsevier.es]
Nosocomial candidemia; risk factors and prognosis revisited; 11 years experience from a Norwegian secondary hospital. PLoS One. 2014;9(7):5–10. [link.springer.com]
They can include retinal detachments, chorioretinal scarring, epiretinal membrane, cataract formation, and persistent vitreous opacification. [40] Prognosis The prognosis for fungal endophthalmitis, as with other forms of infectious endophthalmitis, is [eyewiki.aao.org]
Etiology
Although the detection of the etiologic agents of fungal infection is difficult, it has been shown that blood culture media for mycobacteria are more effective for the detection of fungemia than media for aerobes and anaerobes. [jstage.jst.go.jp]
26 patients with fungemia and cancer treated with chemotherapy (group A) were compared to 25 patients with fungemia and cancer treated with surgery (group B), to assess differences in etiology, risk factors and outcome. [tandfonline.com]
Retinal lesions as clues to disseminated bacterial and candida infections: frequency, natural history, and etiology. Med (Baltim). 2003;82:187e202. Google Scholar Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. [nature.com]
Etiologic organisms as independent predictor of death and morbility associated with bloodstream infections. J Infect Dis, 156 (1987), pp. 471-477 [37.] Filler SG, Edwards JE Jr. [elsevier.es]
Etiology and Risk Factors The etiology depends on the mode of transmission of the fungus: Endogenous fungal endophthalmitis Endogenous endophthalmitis is due to hematogenous ('blood-borne') seeding. [eyewiki.aao.org]
Epidemiology
Epidemiology of opportunistic fungal infections in Latin America. Clin Infect Dis. 2010;51:561-70.. [scielo.br]
Candidemia in a tertiary care hospital: Epidemiology, risk factors, and predictors of mortality. Clin Infect Dis, 15 (1992), pp. 414-421 [7.] M. Pfaller, R.P. Wenzel. Impact of the changing epidemiology of fungal infections in the 1990s. [elsevier.es]
MIC value of C.pelliculosa was above the epidemiological cut-off proposed for fluconazole. [link.springer.com]
2015 Oct 8 [PubMed PMID: 26444731] [2] Nosocomial Bloodstream Infection Due to Candida spp. in China: Species Distribution, Clinical Features, and Outcomes., Li Y,Du M,Chen LA,Liu Y,Liang Z,, Mycopathologia, 2016 Mar 19 [PubMed PMID: 26994763] [3] Epidemiology [statpearls.com]
Epidemiology of endemic systemic fungal infections in Latin America Med Mycol 2011 49 785 798 25. Epidemiology surveillance of fungal infection Med Mycol 2000 38 S1 173 182 26. [academic.oup.com]
Pathophysiology
Jump to: navigation, search Fungemia Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Differentiating Fungemia from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and [wikidoc.org]
[…] surgery (especially if repeated laparotomies or anastomotic leakage is present), malignancy (solid organ and hematologic), acute necrotizing pancreatitis, organ transplant recipients, and total parenteral nutrition are other major risk factors.[3][4][7] Pathophysiology [statpearls.com]
Prevention
Conclusion: Half of HOB events are potentially preventable in this pilot study. HOB may be an indicator for a large number of preventable HAIs not currently measured by NHSN. [open.library.emory.edu]
A genetically very similar subtype, S boulardii, is used in a probioticum (Sacchaflor) to prevent antibiotic-associated diarrhoea and in the treatment of recurrent Clostridium difficile associated diarrhoea. [casereports.bmj.com]
Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. [wwwnc.cdc.gov]
[PDF - 554.63 KB] [PDF - 554.63 KB] [PDF - 435.09 KB] Centers for Disease Control and Prevention (U.S.) [stacks.cdc.gov]
Differentiating Fungemia from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis Diagnosis History and Symptoms Physical Examination Laboratory Findings Other Diagnostic Studies Treatment Medical Therapy Prevention [wikidoc.org]