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Funisitis


Presentation

  • When acute funisitis was present, HA was 700 /- 250 kD, and when necrotizing funisitis was present, HA was 520 /- 100 kD. The molecular weight of HA was significantly below normal in newborns with necrotizing funisitis.[ncbi.nlm.nih.gov]
  • RESULTS: Funisitis was present in 4% (30/832) of cases. A positive AF culture was more common in cases with funisitis than in those without funisitis (17% vs. 5%; p 0.05).[ncbi.nlm.nih.gov]
  • Acute chorioamnionitis was present in each case (100%) and varied from mild to severe.[ncbi.nlm.nih.gov]
  • Four cases chronic funisitis, a rare variant of umbilical cord inflammation, are presented and compared with the acute and subacute forms.[ncbi.nlm.nih.gov]
  • Chorioamnionitis was present in all cases. Twenty-four (75%) of the 32 infants were premature. There were 7 perinatal deaths, all in immature fetuses. Five (16%) of the 32 fetuses had congenital candidiasis.[ncbi.nlm.nih.gov]
Collapse
  • Her subsequent respiratory course was complicated by episodic lobar collapse with excessive thick mucoid secretions. A history of repeated vaginal thrush during pregnancy was obtained. Figure 1 Focal pearly lesions noted in cord (some arrowed).[adc.bmj.com]
Dental Abscess
  • The mother gave a history of a dental abscess that flared up and drained with each of her three pregnancies; the pain was particularly severe during the last 2 months of this pregnancy, so she had the tooth removed after delivery.[ncbi.nlm.nih.gov]
Cervical Mucus Plug
  • Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol. 2002;187:137–44. Google Scholar [51] Hein M, Helmig RB, Schonheyder HC, Ganz T, Uldbjerg N. An in vitro study of antibacterial properties of the cervical mucus plug in pregnancy.[degruyter.com]
  • Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol. 2002 Jul. 187(1):137-44. [Medline]. Akinbi HT, Narendran V, Pass AK. Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol. 2004 Dec. 191(6):2090-6.[emedicine.medscape.com]

Workup

  • […] diagnosis of acute chorioamnionitis Gross/microscopic examination of placenta, fetal membranes, umbilical cord [14] Complete blood cell (CBC) count and inflammatory biomarkers, blood culture, and chest x-ray Controversial: Lumbar puncture of neonates See Workup[emedicine.medscape.com]
Mycoplasma Hominis
  • Abstract Ureaplasma urealyticum (U. urealyticum) and Mycoplasma hominis (M. hominis) are known to cause an intrauterine infection for preterm deliveries, but it is not known whether they are actually pathogenically involved in the development of funisitis[ncbi.nlm.nih.gov]
  • hominis presence in umbilical cord is associated with pathogenesis of funisitis. ( 18204300 ) Egawa T....Matsuo M. 2007 44 Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate[malacards.org]
  • hominis presence in umbilical cord is associated with pathogenesis of funisitis. ( 18204300 ) Egawa T....Matsuo M. 2007 45 Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate[malacards.org]
  • Corioamnionitis y funisitis: Consecuencias para el Neonato CORIOAMNINITIS Y FUNISITIS CORIOAMNINITIS AGUDA Actinomyces sp Escherichia coli Prevotella bivia Mycoplasma hominis Corynebacterium sp Ureaplasma urealyticum Escherichia coli group B Streptococcus[slideshare.net]

Treatment

  • In the near future, elevated umbilical venous cord blood IL-6 concentrations at delivery could be clinically useful to identify children who might benefit from early treatment for systemic fetal inflammatory syndrome.[ncbi.nlm.nih.gov]
  • […] of HIV in Industrialized and Middle Income CountriesŠAdults Adolescents and Pediatric 1310 Chapter 115 Guidelines for the Treatment of HIV and AIDS in ResourceLimited Countries 1328 Chapter 116 Guidelines for Prevention of Perinatal HIV Infection 1345[books.google.de]
  • Treatment of invasive candida infection in neonates with congenital cutaneous candidiasis. Pediatrics 2001 ; 108 : 216 .[adc.bmj.com]
  • I have purchased several over-the-counter treatments, including Monistat cream to subside the symptoms. While it worked initially, eventually things wore off and left me with an even worse infection than before.[es.slideshare.net]

Prognosis

  • AIM: To compare pathological findings in the placenta and cord with the prognosis of full-term infants in cases of neonatal infection and microbial analyses.[ncbi.nlm.nih.gov]
  • Prematurity and birth defects are confounding factors that must be considered when a prognosis is offered to parents or caregivers of an infected newborn.[emedicine.medscape.com]

Etiology

  • We conclude that (1) NF has a polymicrobial etiology, (2) in the absence of other placental findings associated with syphilis NF should not be considered presumptive of this disease, and (3) factors leading to NF may also contribute to acute chorioamnionitis[ncbi.nlm.nih.gov]
  • Images necrotizing funisitis Types acute funisitis chronic funisitis sclerosing funisitis long standing infection inflammatory cells lysis calcification in: syphilis, chronic bacterial infections, viral infections necrotizing funisitis Etiology syphilis[humpath.com]
  • The etiology of preterm labor is usually can not be determined, which few concepts of the etiology usually correlated with infection of amniotic fluid, uteroplacental ischemia, overdistended uterus, endocrine disorder and abnormal immune response from[biomedpharmajournal.org]
  • […] endothelium and transmigrate through the vascular wall into the connective tissue of Wharton jelly Eventually, immune complexes from microbiologic antigens precipitate and elicit a maternal antibody response through the transplacental passage of antibodies Etiology[pathologyoutlines.com]
  • […] creating a chemoattractant chemical gradient for neutrophils Chemical gradient may be augmented by certain peptides released by microorganisms Activated neutrophils marginate against the vascular endothelium and transmigrate through the vascular wall Etiology[pathologyoutlines.com]

Epidemiology

  • 1865-1682 Subject: mares , horse diseases , fetus , placenta , inflammation , pneumonia , abortion (animals) , complications , bacterial infections , Dermatophilus congolensis , case studies , Thoroughbred , histopathology , lungs , stomach , molecular epidemiology[pubag.nal.usda.gov]
  • […] discouraged Inflammation may be localized to umbilical vein (phlebitis) or umbilical arteries (arteritis) Inflammation at the periphery or surface of the umbilical cord may also be a primary pattern (peripheral funisitis), distinct from necrotizing funisitis Epidemiology[pathologyoutlines.com]
  • Established or long standing infections can cause tissue necrosis and accumulation of cellular debris (necrotizing funisitis) Inflammation located at the periphery or surface of the umbilical cord may be the primary pattern seen (peripheral funisitis) Epidemiology[pathologyoutlines.com]
  • Pediatric and Perinatal Epidemiology. 2001;15:78-89. CrossRef (Visited 348 times, 1 visits today)[biomedpharmajournal.org]
  • Our study demonstrates the value of histologic and IHC analysis of umbilical cords for epidemiologic research.[wwwnc.cdc.gov]
Sex distribution
Age distribution

Pathophysiology

  • The conversion from high to low molecular weight HA in Wharton's jelly may be important in the pathophysiology of necrotizing funisitis.[ncbi.nlm.nih.gov]
  • […] surface of the umbilical cord may also be a primary pattern (peripheral funisitis), distinct from necrotizing funisitis Epidemiology Not well documented but seen as a sequela in a minority of severe cases of chorioamnionitis or umbilical vasculitis Pathophysiology[pathologyoutlines.com]
  • Occurs in patients with documented microorganisms (e.g. group B Streptococcus , Candida albicans ) and patients with preterm labor Sites Progressive infiltration involves umbilical vein, umbilical arteries and umbilical cord substance (Wharton jelly) Pathophysiology[pathologyoutlines.com]
  • The pathophysiology of premature rupture of membrane in the infection pathway is mentioned by Goldenberg (2000).[biomedpharmajournal.org]
  • Clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol 22: 281–342. View Article Google Scholar 10.[journals.plos.org]

Prevention

  • Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic[books.google.de]
  • Congenital syphilis can be controlled and prevented by widespread RPR testing and penicillin treatment during prenatal care. Dr.[wwwnc.cdc.gov]
  • As the result, the prevention and management of preterm labor will be improved and the incidence of neonatal sepsis can be avoided.[biomedpharmajournal.org]
  • Defense experts routinely testify that when a pregnancy is complicated by maternal infection, the infant's adverse neurological outcome could not have been prevented.[birthinjuryinfo.com]

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