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Furosemide

Frusemid


Presentation

  • To present a case of ototoxicity induced by furosemide and once-daily gentamicin therapy. A 60-year-old white woman presented to the hospital with community-acquired pneumonia and urinary tract infection.[ncbi.nlm.nih.gov]
  • We then used health administrative data to identify all patients who presented to those hospitals with congestive heart failure.[ncbi.nlm.nih.gov]
  • We present the case of a patient with hypoxic hepatitis in the setting of heart failure and dehydration from furosemide as a reminder of an important clinical lesson.[ncbi.nlm.nih.gov]
  • OBJECTIVE: The aim of the present study was to study the oral performance of furosemide in neonates and young infants using a newly developed in vitro model simulating digestion and drug solubilization in the gastrointestinal (GI) tract of the human neonate[ncbi.nlm.nih.gov]
  • CONCLUSIONS: In this prospective multicenter, observational cohort study of patients presenting at the ED for AHF, early treatment with intravenous loop diuretics was associated with lower in-hospital mortality.[ncbi.nlm.nih.gov]
Intravenous Administration
  • A patient with long-standing hypertension developed urticaria, angioedema, and hypotension within 5 minutes after the intravenous administration of furosemide.[ncbi.nlm.nih.gov]
  • In early AKI, urine output after a furosemide stress test (FST), which involves intravenous administration of furosemide (1.0 or 1.5 mg/kg), can predict the development of stage 3 AKI.[ncbi.nlm.nih.gov]
  • In comparison, intravenous administration showed the expected more rapid and intense response. Sublingually administered furosemide tablets differ in certain kinetic and dynamic properties from identical tablets given orally.[ncbi.nlm.nih.gov]
  • Diuresis starts within 30 minutes of intravenous administration and peaks in 1 to 2 hours.[epmonthly.com]
  • administration 0.3 Oral solution 0.83 Oral tablet 1.45The pharmacokinetics of furosemide are apparently not significantly altered by food.No direct relationship has been found between furosemide concentration in the plasma and furosemide efficacy.[en.wikipedia.org]
Turkish
  • A 27-year-old Turkish male presented with fatigue, long lasting hypertension, hyperkalemia, hyperchloremic metabolic acidosis and normal glomerular filtration rate. His brother also showed hyperkalemia with no other features of the disease.[ncbi.nlm.nih.gov]
Nasal Irritation
  • The incidence of adverse effects (nasal irritation, headache, and constipation) were not significantly different between the 2 groups.[ncbi.nlm.nih.gov]
Diarrhea
  • CASE REPORT A 63 year old male who started furosemide for lower extremity edema 10 weeks prior presented with diarrhea, fever of 39.4 C, dry cough and maculopapular rash involving 50% of his body.[ncbi.nlm.nih.gov]
  • A 22-years-old female nurse with a body mass index 18 suffered from myalgias, vomiting and diarrhea.[ncbi.nlm.nih.gov]
  • Severe sweating , diarrhea , or vomiting can increase the risk of dehydration . Report prolonged diarrhea or vomiting to your doctor. Follow your doctor's instructions about the amount of fluids you can drink.[webmd.com]
  • Diarrhea and vomiting are common side effects of digoxin, according to Drugs.com. If these effects persist, you may develop dehydration due to excess loss of fluids in vomit and diarrhea.[livestrong.com]
Bulimia
  • We have discovered some members of this group utilizing the potentially dangerous rapid weight loss methods that are commonly seen in patients with bulimia and anorexia nervosa.[ncbi.nlm.nih.gov]
Retinal Hemorrhage
  • There were no specific findings in the anterior segment, but flame-shaped retinal hemorrhages were scattered over both posterior poles, neovascularization was observed in the left eye, and, of particular note, sub-retinal fluid was detected in the macula[ncbi.nlm.nih.gov]
Exanthema
  • Photosensitivity Rare: Skin and mucous membrane reactions may occasionally occur, e.g. itching, urticaria, other rashes or bullous lesions, fever, hypersensitivity to light, exsudative erythema multiforme (Lyell's syndrome and Stevens-Johnson syndrome), bullous exanthema[medicines.org.uk]
Dizziness
  • These side effects may include dizziness and fainting.[practo.com]
  • Side Effects Dizziness , lightheadedness , headache , blurred vision , loss of appetite, stomach upset, diarrhea , or constipation may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.[webmd.com]
  • This drug may make you dizzy or blur your vision . Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages.[webmd.com]
  • This drug may make you dizzy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages.[healthy.kaiserpermanente.org]
  • This drug may make you dizzy or cause blurred vision . Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.[webmd.com]
Vertigo
  • To describe possible cases of cochleosaccular endolymphatic hydrops without vertigo. Retrospective case report. University hospital. Three patients with possible cochleosaccular hydrops without vertigo were studied.[ncbi.nlm.nih.gov]
  • . • Central Nervous System : Ringing in the ear, hearing loss, tingling, vertigo, dizziness, headache and blurred vision/visual defect. • Blood : Anemia, decrease in platelets and white blood cells. • Skin : Skin inflammation, redness, bruising, photosensitivity[medindia.net]
  • Adverse reactions CNS: dizziness, headache, vertigo, weakness, lethargy, paresthesia, drowsiness, restlessness, light-headedness CV: hypotension, orthostatic hypotension, tachycardia, volume depletion, necrotizing angiitis, thrombophlebitis, arrhythmias[medical-dictionary.thefreedictionary.com]
  • Dizziness or vertigo could make this activity dangerous. Please discuss your concerns with the prescribing physician. There are many other options for treating high blood pressure.[peoplespharmacy.com]
  • Adverse reactions CNS: vertigo, headache, dizziness, paresthesia, restlessness, fever. CV: volume depletion and dehydration, orthostatic hypotension, thrombophlebitis with I.V. administration.[glowm.com]
Urinary Incontinence
  • In practical terms that means furosemide could lead to frequent urination, hard-to-control urinary urges and even an occasional bout of urinary incontinence ( BMC Geriatrics , June 10, 2013 ).[peoplespharmacy.com]
  • Increased urine production, urinary incontinence, can be caused or symptoms can be exacerbated in patients with urinary tract obstruction.[medicines.org.uk]
Microscopic Hematuria
  • Residual renal morbidity included reduced creatinine clearance, microscopic hematuria, and hypercalciuria. The phenomenon of renal calcifications associated with furosemide treatment is more frequent than previously recognized.[ncbi.nlm.nih.gov]

Workup

Phosphate Decreased
  • The urinary excretion of alpha-amino nitrogen, glucose, and phosphates decreased and tubular reabsorption of the two latter increased under furosemide.[ncbi.nlm.nih.gov]

Treatment

  • In-hospital mortality was significantly lower in the early treatment group (2.3% vs. 6.0% in the nonearly treatment group; p 0.002).[ncbi.nlm.nih.gov]
  • At the PET CO 2 producing 60% BDVAS pre-treatment, furosemide produced a clinically meaningful reduction of BDVAS (i.e., 20% FS) in 5/11 subjects; saline reduced dyspnea in 3/11 subjects; neither treatment worsened dyspnea in any subject.[ncbi.nlm.nih.gov]
  • Breathing Discomfort was induced by hypercapnia during constrained ventilation before and after treatment. Both treatments reduced breathing discomfort by 20% full scale.[ncbi.nlm.nih.gov]
  • Furosemide is widely used for the treatment of edema, a common manifestation of NS. However, whether furosemide treatment affects massive proteinuria-induced TEC injury in patients with NS is unknown.[ncbi.nlm.nih.gov]
  • We previously reported the efficacy of continuous infusion of 1.7 % hypertonic saline plus low-dose furosemide in treatment for ADHF.[ncbi.nlm.nih.gov]

Prognosis

  • An increasing daily dose of furosemide was associated with worse prognosis.[ncbi.nlm.nih.gov]
  • We investigated the effects of furosemide on the prognosis.[ncbi.nlm.nih.gov]
  • […] the refractoriness of the oral furosemide (80 mg/8 h), with stable renal function and extremely difficult venipuncture, it was decided to administer a continuous subcutaneous perfusion of furosemide at a rate of 250 mg/24 h and given the poor overall prognosis[revistanefrologia.com]
  • KEYWORDS: B-type natriuretic peptide; Get With the Guidelines; diuretics; emergency department; prognosis [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov]
  • Sensitivity analyses excluding trials with a follow-up Keywords Heart failure Loop diuretics Mortality Prognosis Network meta-analysis This is a preview of subscription content, log in to check access.[doi.org]

Etiology

  • The etiology for BP is mostly idiopathic with the highest occurrence in elderly patients; however, it is now well-accepted that BP has been triggered by or associated with drug therapy.[ncbi.nlm.nih.gov]
  • A 28-year-old Hispanic male was admitted for SJS, with a prolonged hospital course and unclear etiology throughout the majority of the stay.[ncbi.nlm.nih.gov]
  • We hypothesize a shift of free water following discontinuation of furosemide as a novel etiology for the development of serous chordoidal detachments. Ultrawide-field fundus photography was useful to document this lesion.[ncbi.nlm.nih.gov]
  • […] morbid obesity of years of evolution (BMI 48.7), arterial hypertension, diabetes mellitus type 2, severe obstructive sleep apnea syndrome, generalized osteoarthritis, multinodular goiter, kidney transplant in 1998 due to chronic renal failure of unknown etiology[revistanefrologia.com]
  • Pillinger , Etiology and Pathogenesis of Hyperuricemia and Gout , Kelley's Textbook of Rheumatology , 10.1016/B978-1-4377-1738-9.00094-3 , (1533-1553.e5) , (2013) .[doi.org]

Epidemiology

  • Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan. 20 Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan. 21 Department of Cardiology, Kobe Century Memorial Hospital, Kobe, Japan. 22 Departments of Epidemiology[ncbi.nlm.nih.gov]
  • Hinchcliff , Clinical Epidemiology and Evidence-Based Medicine , Equine Internal Medicine , 10.1016/B978-0-323-44329-6.00006-1 , (218-231) , (2018) . Jenifer R. Gold, Donald P. Knowles, Todd Coffey and Warwick M.[doi.org]
  • Hinchcliff, Clinical Epidemiology and Evidence-Based Medicine, Equine Internal Medicine, 10.1016/B978-0-323-44329-6.00006-1, (218-231), (2018). H. K. Knych, W. D. Wilson, A. Vale, P. H. Kass, R. M. Arthur and J. H.[doi.org]
  • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomized trials in the context of expectations from prospective epidemiologic studies. BMJ. 2009 ;338: b1665. Google Scholar Crossref Medline 7.[doi.org]
  • Umaporn Udomsubpayakul, Clinical Epidemiology Unit are greatly appreciated. This project was supported by The Thailand Research Fund and The Ramathibodi Research Fund, Mahidol University, Bangkok, Thailand.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Resolving these questions would increase the understanding of NKCCs and their actions and improve rational use of furosemide in pathophysiology of fluid volume expansion. Copyright 2016 the American Physiological Society.[ncbi.nlm.nih.gov]
  • The continued central role these drugs play highlights a lack of understanding of the underlying pathophysiology of the disease. Pathophysiology of APE In the 1940s the cardiorenal model was first put forward as the predominant explanation for APE.[emdocs.net]
  • Pharmacotherapy: a pathophysiologic approach. Norwalk, CT : Appleton and Lange, 1993 : 32 – 55. Google Scholar 11.. Franklin, MR, Franz, DN. Drug absorption, action, and disposition.[dx.doi.org]
  • Transition from chronic compensated to acute decompensated heart failure: Pathophysiological insights obtained from continuous monitoring of intracardiac pressures. Circulation [Internet]. 2008 Sep 30;118(14):1433-41.[epmonthly.com]

Prevention

  • We conducted a meta-analysis of randomized trials (RCTs) to investigate whether bolus furosemide to prevent or treat AKI is detrimental on patients' survival.[ncbi.nlm.nih.gov]
  • Future prospective studies of intraoperative aminophylline to prevent cardiac surgery-associated acute kidney injury may be warranted.[ncbi.nlm.nih.gov]
  • Consequently, since 2005, at CHU Sainte-Justine, furosemide has been administered to correct the volemic status and prevent PRBC transfusion.[ncbi.nlm.nih.gov]
  • Abstract Intraoperative bleeding reduction during functional endoscopic sinus surgery is a key factor in preventing surgery complications. That is implemented through prescribing systemic corticostroid before surgery.[ncbi.nlm.nih.gov]
  • A drug that could be a safe and effective treatment in humans could cause toxicity in animals, preventing it from being used in humans.[ncbi.nlm.nih.gov]

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