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Fusobacterium Nucleatum

Corynebacterium Fusiforme


Presentation

  • To our knowledge, F. nucleatum infection presenting with multiple liver masses and Trousseau-like syndrome has not been reported earlier.[ncbi.nlm.nih.gov]
  • The patient presented with a headache and nonspecific musculoskeletal symptoms and was misdiagnosed as having polymyalgia rheumatica.[ncbi.nlm.nih.gov]
  • Abstract A wide clinical spectrum of bacteremic disease caused by Fusobacterium has been presented in this journal. We wish to extend this spectrum by presenting a case of myopericarditis resulting from a liver abscess caused by F. nucleatum.[ncbi.nlm.nih.gov]
  • Nucleoside monophosphate kinases for all types of nucleotides are present.[dx.doi.org]
Intravenous Drugs
  • A case of endocarditis due to Fusobacterium nucleatum in an intravenous drug abuser is reported, accompanied by a review of the literature.[ncbi.nlm.nih.gov]
  • We report a case of F. nucleatum right-sided endocarditis in a patient with no known intravenous drug abuse.[ncbi.nlm.nih.gov]
Leg Swelling
  • We describe a patient presenting with constitutional symptoms, poor oral hygiene and leg swelling who was diagnosed with Fusobacterium nucleatum osteomyelitis of femur and empyema. Long bone osteomyelitis is rarely caused by this microorganism.[ncbi.nlm.nih.gov]
Candidiasis
  • Multiple coexisting incidental infections were discovered, including oesophageal candidiasis, Helicobacter pylori, stool cultures positive for Strongyloides stercoralis, and sputum cultures positive for Enterobacter cloacae, Escherichia coli and Mycobacterium[ncbi.nlm.nih.gov]
Weight Loss
  • A 48-year-old man presented with fevers, chills, weight loss, multiple liver masses, and several superficial and deep venous thromboses in lower extremities. Cancer work up was negative. A liver biopsy grew Fusobacterium nucleatum.[ncbi.nlm.nih.gov]
Disability
  • Multiple brain abscesses are serious neurological problems with high mortality and disabling morbidity. The frequency is rising as a result of AIDS and the increasing number of immunocompromised patients.[ncbi.nlm.nih.gov]
Aspiration
  • The usefulness of real-time ultrasound in fine needle aspiration diagnosis of a peripheral lung lesion is demonstrated, and the role of Liu's stain in FNAC is emphasized.[ncbi.nlm.nih.gov]
  • This case emphasizes the value of diagnostic aspirates. Therapy with a combination of intravenous and oral clindamycin led to successful resolution of the infection.[ncbi.nlm.nih.gov]
  • The clinical manifestations of pulmonary Fusobacterium nucleatum infections range from simple aspiration pneumonia to severe diseases as necrotizing pneumonia, lung abscess, and empyema.[ncbi.nlm.nih.gov]
Sputum
  • Multiple coexisting incidental infections were discovered, including oesophageal candidiasis, Helicobacter pylori, stool cultures positive for Strongyloides stercoralis, and sputum cultures positive for Enterobacter cloacae, Escherichia coli and Mycobacterium[ncbi.nlm.nih.gov]
Orthopnea
  • A pericardial effusion was diagnosed by echocardiography in a 49 year old man who suffered acute cough, orthopnea, and chest pain. Because of a positive tuberculin skin test, mycobacteria were initially suspected as the cause of the pericarditis.[ncbi.nlm.nih.gov]
Chest Pain
  • A pericardial effusion was diagnosed by echocardiography in a 49 year old man who suffered acute cough, orthopnea, and chest pain. Because of a positive tuberculin skin test, mycobacteria were initially suspected as the cause of the pericarditis.[ncbi.nlm.nih.gov]
Stroke
  • However, despite immediate antibiotic therapy, her condition remained unstable over the next few days, and she eventually developed an ischemic stroke.[ncbi.nlm.nih.gov]
Cognitive Deficit
  • The patient recovered with only mild cognitive deficits. The experience of our patient and the review of the literature indicate that multiple brain abscesses due to Fusobacterium nucleatum are rare. The most probable source is oral infection.[ncbi.nlm.nih.gov]
Lethargy
  • An elderly woman was admitted with an altered level of consciousness (lethargy). The ensuing workup revealed a posterior oral cavity tumour (squamous cell carcinoma), Fusobacterium nucleatum bacteraemia and liver abscesses.[ncbi.nlm.nih.gov]
Neck Stiffness
  • A 59-year-old woman developed signs and symptoms of diffuse brain dysfunction including fever and neck stiffness. A brain CT scan demonstrated nine contrast-enhancing ring-shaped lesions.[ncbi.nlm.nih.gov]

Workup

  • The ensuing workup revealed a posterior oral cavity tumour (squamous cell carcinoma), Fusobacterium nucleatum bacteraemia and liver abscesses.[ncbi.nlm.nih.gov]
Pericardial Effusion
  • The pericardial effusion failed to resolve, however, and pericardiectomy was performed. Culture of the pericardial fluid yielded pure Fusobacterium nucleatum growth.[ncbi.nlm.nih.gov]
Liver Biopsy
  • A liver biopsy grew Fusobacterium nucleatum. To our knowledge, F. nucleatum infection presenting with multiple liver masses and Trousseau-like syndrome has not been reported earlier.[ncbi.nlm.nih.gov]

Treatment

  • He was unresponsive to routine antibiotic treatment with flucloxacillin/gentamicin as the pain and fluid collection increased. Synovial fluid cultures are negative and gram stain remained negative.[ncbi.nlm.nih.gov]
  • It is important to perform enhanced MRI and blood culture for patients with chronic headache related to dental treatment.[ncbi.nlm.nih.gov]
  • EO have potential for the treatment of periodontal inflammation. KEYWORDS: matrix metalloproteinase (MMP); medicinal plant; periodontal inflammation; pharmacognosy[ncbi.nlm.nih.gov]
  • Effective treatment includes thoracolumbar orthosis bracing and intravenous antibiotic therapy.[ncbi.nlm.nih.gov]
  • F. nucleatum treatment significantly altered lumen microbial structures, with increased Tenericutes and Verrucomicrobia (opportunistic pathogens) (P 0.05 in wild-type C57BL/6 and mice with DMH treatment).[ncbi.nlm.nih.gov]

Prognosis

  • ., CD3 , CD8 , CD45RO , and FOXP3 cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity.[ncbi.nlm.nih.gov]
  • Characteristics of Fn -associated CRC were identified through studies using human CRC cohorts and include right-sided colon location, CpG island methylation phenotype (CIMP)-high, high level of microsatellite instability (MSI-H), and poor patient prognosis[jstage.jst.go.jp]
  • Annexin A1 is specifically expressed in colorectal cancer cells and is a predictor of poor prognosis. The Fusobacterium nucleatum FadA adhesin up‐regulates Annexin A1 expression through E‐cadherin.[embor.embopress.org]
  • Infiltration of TAMs CD68 /iNOS in colorectal tumor stroma is confirmed to be related to the poor prognosis of CRC[ 78 ]. Some researchers have reported that tumor-infiltrating T-cell subpopulations distinctly regulate the prognosis of CRC[ 82 ].[wjgnet.com]
  • Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review.[ncbi.nlm.nih.gov]

Etiology

  • Clinicians should be aware that F. nucleatum could be the etiologic agent of hematogenous osteomyelitis of a long bone in an immunocompetent patient.[ncbi.nlm.nih.gov]
  • Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum are strongly associated with periodontitis, and their evaluations are relevant to understand their role in the etiology and progression of periodontal diseases.[ncbi.nlm.nih.gov]
  • The present study investigated the effect of a polyphenol-rich lowbush blueberry (Vaccinium angustifolium Ait.) extract on the two main etiologic components of periodontitis, a multifactorial disorder affecting the supporting structures of the teeth.[ncbi.nlm.nih.gov]
  • Abstract Plaque biofilm is the primary etiological agent of periodontal disease.[ncbi.nlm.nih.gov]
  • Etiology and Pathology The exact cause of cancrum oris is unknown but there appear to be three factors instrumental in its development: (1) a predisposing state of debilitation and malnutrition; (2) a specific infection of the mouth usually due to a spirochete[isradiology.org]

Epidemiology

  • KEYWORDS: CANCER EPIDEMIOLOGY; COLONIC BACTERIA; COLONIC MICROFLORA; COLORECTAL CANCER; INTESTINAL BACTERIA Conflict of interest statement Dr.[ncbi.nlm.nih.gov]
  • This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes. Copyright 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.[ncbi.nlm.nih.gov]
  • Chan School of Public Health, Boston, Massachusetts, USA 3 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA 4 Department of Biostatistics, Harvard T.H.[gut.bmj.com]
  • Article Navigation From the Departments of Obstetrics and Gynecology, Epidemiology, and Medicine, University of Washington, Seattle, Washington Reprints or correspondence: Dr. Sharon L.[doi.org]
  • These two seemingly unrelated health problems have recently been linked, with periodontal disease being recognized as a potential risk factor for preterm birth, based on epidemiologic studies ( 18 ).[dx.doi.org]
Sex distribution
Age distribution

Prevention

  • Further studies are warranted to determine if F. nucleatum ssp. animalis could be a novel target for colorectal cancer prevention and treatment. Cancer Prev Res; 10(7); 398-409. 2017 AACR . 2017 American Association for Cancer Research.[ncbi.nlm.nih.gov]
  • This response was inhibited by preventing F. nucleatum invasion into HEK293T cells. p38 MAPK but not the NFĸB signalling pathway was required for F. nucleatum-mediated IL-8 production. HEK293T cells expressed NOD-1 but not NOD-2.[ncbi.nlm.nih.gov]
  • Additionally, desulfuration of cysteine and methionine yields ammonia, H(2)S, methyl mercaptan, and butyrate, which are capable of arresting fibroblast growth, thus preventing wound healing and aiding penetration of the gingival epithelium.[ncbi.nlm.nih.gov]
  • Author information 1 1 Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, P. R. China.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Preventive Dentistry, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.[ncbi.nlm.nih.gov]

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