Presentation
To our knowledge, F. nucleatum infection presenting with multiple liver masses and Trousseau-like syndrome has not been reported earlier. [ncbi.nlm.nih.gov]
Nucleoside monophosphate kinases for all types of nucleotides are present. [doi.org]
Entire Body System
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Intravenous Drugs
A case of endocarditis due to Fusobacterium nucleatum in an intravenous drug abuser is reported, accompanied by a review of the literature. [ncbi.nlm.nih.gov]
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Weight Loss
A 48-year-old man presented with fevers, chills, weight loss, multiple liver masses, and several superficial and deep venous thromboses in lower extremities. Cancer work up was negative. A liver biopsy grew Fusobacterium nucleatum. [ncbi.nlm.nih.gov]
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Chills
A 48-year-old man presented with fevers, chills, weight loss, multiple liver masses, and several superficial and deep venous thromboses in lower extremities. Cancer work up was negative. A liver biopsy grew Fusobacterium nucleatum. [ncbi.nlm.nih.gov]
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Disability
Multiple brain abscesses are serious neurological problems with high mortality and disabling morbidity. The frequency is rising as a result of AIDS and the increasing number of immunocompromised patients. [ncbi.nlm.nih.gov]
Respiratoric
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Orthopnea
A pericardial effusion was diagnosed by echocardiography in a 49 year old man who suffered acute cough, orthopnea, and chest pain. Because of a positive tuberculin skin test, mycobacteria were initially suspected as the cause of the pericarditis. [ncbi.nlm.nih.gov]
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Acute Cough
A pericardial effusion was diagnosed by echocardiography in a 49 year old man who suffered acute cough, orthopnea, and chest pain. Because of a positive tuberculin skin test, mycobacteria were initially suspected as the cause of the pericarditis. [ncbi.nlm.nih.gov]
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Sputum
Multiple coexisting incidental infections were discovered, including oesophageal candidiasis, Helicobacter pylori, stool cultures positive for Strongyloides stercoralis, and sputum cultures positive for Enterobacter cloacae, Escherichia coli and Mycobacterium [ncbi.nlm.nih.gov]
Cardiovascular
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Thrombosis
We report the first description of portal and mesenteric vein thrombosis associated with suppurative mesenteric adenitis in a 71-year-old woman. [ncbi.nlm.nih.gov]
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Chest Pain
A pericardial effusion was diagnosed by echocardiography in a 49 year old man who suffered acute cough, orthopnea, and chest pain. Because of a positive tuberculin skin test, mycobacteria were initially suspected as the cause of the pericarditis. [ncbi.nlm.nih.gov]
Neurologic
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Meningism
We describe our experience in the management of this case of anaerobic meningitis and the unusual complication of ischemic stroke; this case suggests that more aggressive therapy in addition to empirical antibiotics may be warranted. [ncbi.nlm.nih.gov]
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Neck Stiffness
A 59-year-old woman developed signs and symptoms of diffuse brain dysfunction including fever and neck stiffness. A brain CT scan demonstrated nine contrast-enhancing ring-shaped lesions. [ncbi.nlm.nih.gov]
Workup
The ensuing workup revealed a posterior oral cavity tumour (squamous cell carcinoma), Fusobacterium nucleatum bacteraemia and liver abscesses. [ncbi.nlm.nih.gov]
X-Ray
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Pericardial Effusion
The pericardial effusion failed to resolve, however, and pericardiectomy was performed. Culture of the pericardial fluid yielded pure Fusobacterium nucleatum growth. [ncbi.nlm.nih.gov]
Biopsy
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Liver Biopsy
A liver biopsy grew Fusobacterium nucleatum. To our knowledge, F. nucleatum infection presenting with multiple liver masses and Trousseau-like syndrome has not been reported earlier. [ncbi.nlm.nih.gov]
Treatment
He was unresponsive to routine antibiotic treatment with flucloxacillin/gentamicin as the pain and fluid collection increased. Synovial fluid cultures are negative and gram stain remained negative. [ncbi.nlm.nih.gov]
Prognosis
CD3 , CD8 , CD45RO , and FOXP3 cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. [ncbi.nlm.nih.gov]
Annexin A1 is specifically expressed in colorectal cancer cells and is a predictor of poor prognosis. The Fusobacterium nucleatum FadA adhesin up‐regulates Annexin A1 expression through E‐cadherin. [embor.embopress.org]
Characteristics of Fn -associated CRC were identified through studies using human CRC cohorts and include right-sided colon location, CpG island methylation phenotype (CIMP)-high, high level of microsatellite instability (MSI-H), and poor patient prognosis [jstage.jst.go.jp]
Infiltration of TAMs CD68 /iNOS in colorectal tumor stroma is confirmed to be related to the poor prognosis of CRC[ 78 ]. Some researchers have reported that tumor-infiltrating T-cell subpopulations distinctly regulate the prognosis of CRC[ 82 ]. [wjgnet.com]
Etiology
Clinicians should be aware that F. nucleatum could be the etiologic agent of hematogenous osteomyelitis of a long bone in an immunocompetent patient. [ncbi.nlm.nih.gov]
Etiology and Pathology The exact cause of cancrum oris is unknown but there appear to be three factors instrumental in its development: (1) a predisposing state of debilitation and malnutrition; (2) a specific infection of the mouth usually due to a spirochete [isradiology.org]
Epidemiology
KEYWORDS: CANCER EPIDEMIOLOGY; COLONIC BACTERIA; COLONIC MICROFLORA; COLORECTAL CANCER; INTESTINAL BACTERIA Conflict of interest statement Dr. [ncbi.nlm.nih.gov]
Chan School of Public Health, Boston, Massachusetts, USA 3 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA 4 Department of Biostatistics, Harvard T.H. [gut.bmj.com]
Article Navigation From the Departments of Obstetrics and Gynecology, Epidemiology, and Medicine, University of Washington, Seattle, Washington Reprints or correspondence: Dr. Sharon L. [doi.org]
Prevention
Further studies are warranted to determine if F. nucleatum ssp. animalis could be a novel target for colorectal cancer prevention and treatment. Cancer Prev Res; 10(7); 398-409. 2017 AACR. 2017 American Association for Cancer Research. [ncbi.nlm.nih.gov]