To our knowledge, F. nucleatum infection presenting with multiple liver masses and Trousseau-like syndrome has not been reported earlier. [ncbi.nlm.nih.gov]

Nucleoside monophosphate kinases for all types of nucleotides are present. [dx.doi.org]

• Weakness

  On the contrary, the F. nucleatum without fadA may represent the avirulent or weak virulence genotype of F. nucleatum. [journals.plos.org]

  There is a large family of related Omps (over 2,000 aa long) in F. nucleatum, with weak similarity to adhesins of various pathogens. The functions of these are not known. [dx.doi.org]

• Intestinal Disease

  J Immunol 186(2):1199–1208 Article CAS Google Scholar Waldner MJ, Neurath MF (2014) Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development. [link.springer.com]

  Once the intestinal balance is damaged, it may cause numerous intestinal diseases including inflammatory bowel diseases (IBD) and colorectal neoplasms[ 8 - 10 ]. [wjgnet.com]

• Abdominal Pain

  Two days before, he had presented fever and abdominal pain, which limited itself. The patient had no other musculoskeletal symptoms or oropharyngeal manifestations. [reumatologiaclinica.org]

• Dental Abscess

  There have been reports of septic arthritis by this bacterium after dental procedures, tonsillectomy, dental abscess drainage and other pharyngeal infections.2,3 In the case of our patient, there was a history of frequent otitis, and signs of right maxillary [reumatologiaclinica.org]

• Confusion

  Since the first reports of Fusobacteriota in the late nineteenth century, the variety of species names has led to some confusion within the genera Fusobacterium and Leptotrichia. [en.wikipedia.org]

  In the oral niche, studies of F. nucleatum interactions with host cells have led to a confusing picture. [tandfonline.com]

The ensuing workup revealed a posterior oral cavity tumour (squamous cell carcinoma), Fusobacterium nucleatum bacteraemia and liver abscesses. [ncbi.nlm.nih.gov]

• Chlamydia

  Chlamydia trachomatis Chlamydophila Chlamydophila pneumoniae (previously called Chlamydia pneumoniae) Chlamydophila psittaci (previously called Chlamydia psittaci) Clostridium Clostridium botulinum Clostridium difficile Clostridium perfringens (previously [bionity.com]

  CHLAMYDIA A. Chlamydia psittaci (psittacosis, ornithosis) Azithromycin –or– Clarithromycin Parenteral 3 rd Gen Cephalosporin + Azithromycin B. Chlamydia trachomatis Doxycycline –or– Azithromycin Erythromycin, Ofloxacin 1. [medicalcorps.org]

  Infectious serology was negative (Brucella, Yersinia, Borrelia, Chlamydia, Campylobacter, parvovirus B19), as were blood cultures, Mantoux testing and autoimmunity tests (negative ANA, anti-DNA, ANCA, HLA B27, immunoglobulins and RF). [reumatologiaclinica.org]

  Global mapping of the inc-human interactome reveals that retromer restricts chlamydia infection. Cell Host Microbe. 2015;18:109–21. Article CAS PubMed PubMed Central Google Scholar Weßling R, Epple P, Altmann S, He Y, Yang L, Henz SR, et al. [microbiomejournal.biomedcentral.com]

• Polyps

  KEYWORDS: BRAF; Fusobacterium; KRAS; MLH1; colon polyp; colorectum; dysplasia; miR-31; microbiome; serrated neoplasia pathway [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

  Statistics from Altmetric.com colorectal cancer intestinal bacteria We read with great interest the article by Flemer et al, which suggests that analysis of the oral microbiota could potentially be used as a screening method for colorectal cancer (CRC) and polyp [gut.bmj.com]

  Int J Cancer 139(6):1318–1326 Article Google Scholar Li L, Fu X, Zhang W, Xiao L, Qiu Y, Peng Y, Shi L, Chen X, Zhou X, Deng M (2013) Wnt signaling pathway is activated in right colon serrated polyps correlating to specific molecular form of β-catenin [link.springer.com]

He was unresponsive to routine antibiotic treatment with flucloxacillin/gentamicin as the pain and fluid collection increased. Synovial fluid cultures are negative and gram stain remained negative. [ncbi.nlm.nih.gov]

Orthodontic treatment may create a living environment more conducive to periodontal anaerobe such as F. nucleatum, which might imply a potential risk for periodontal health in certain patients after longtime orthodontic treatment. [journals.plos.org]

Annexin A1 is specifically expressed in colorectal cancer cells and is a predictor of poor prognosis. The Fusobacterium nucleatum FadA adhesin up‐regulates Annexin A1 expression through E‐cadherin. [embor.embopress.org]

Characteristics of Fn -associated CRC were identified through studies using human CRC cohorts and include right-sided colon location, CpG island methylation phenotype (CIMP)-high, high level of microsatellite instability (MSI-H), and poor patient prognosis [jstage.jst.go.jp]

The CD45RO + -cell and FOXP3 ± (lo) T cell biomarkers are associated with a favorable prognosis in F. nucleatum -positive CRC, while the miR-21, LncRNA PANDAR, and TAMs CD68 + /iNOS − biomarkers are associated with a poor clinical prognosis of F. nucleatum [wjgnet.com]

Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets (i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. [ncbi.nlm.nih.gov]

In one previous study, the DNA status of Fusobacterium spp. in pancreatic cancer tissue was independently associated with the poor prognosis of patients (20). [spandidos-publications.com]

Abstract Plaque biofilm is the primary etiological agent of periodontal disease. [ncbi.nlm.nih.gov]

Etiology and Pathology The exact cause of cancrum oris is unknown but there appear to be three factors instrumental in its development: (1) a predisposing state of debilitation and malnutrition; (2) a specific infection of the mouth usually due to a spirochete [isradiology.org]

Article Navigation From the Departments of Obstetrics and Gynecology, Epidemiology, and Medicine, University of Washington, Seattle, Washington Reprints or correspondence: Dr. Sharon L. [doi.org]

KEYWORDS: CANCER EPIDEMIOLOGY; COLONIC BACTERIA; COLONIC MICROFLORA; COLORECTAL CANCER; INTESTINAL BACTERIA Conflict of interest statement Dr. [ncbi.nlm.nih.gov]

Chan School of Public Health, Boston, Massachusetts, USA 3 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA 4 Department of Biostatistics, Harvard T.H. [gut.bmj.com]

Strengths of this study include the use of our molecular pathological epidemiology database (of nearly 600 colorectal carcinoma cases in the 2 US nationwide, prospective cohort studies), which integrates key tumor molecular features, the amount of F nucleatum [jamanetwork.com]

Further studies are warranted to determine if F. nucleatum ssp. animalis could be a novel target for colorectal cancer prevention and treatment. Cancer Prev Res; 10(7); 398-409. ©2017 AACR. ©2017 American Association for Cancer Research. [ncbi.nlm.nih.gov]