A case of gamma heavy chain disease is reported in a 52-year-old white male who presented with fever and generalized lymphadenopathy. A lymph node biopsy showed malignant lymphoma. [ncbi.nlm.nih.gov]

Generalized lymphadenopathy, splenomegaly and hepatomegaly are present in about half of the patients. Patients with localized medullary disease typically present with cytopenia, most commonly a normocytic, normochromic anemia. [atlasgeneticsoncology.org]

splenomegaly. ( 22694793 ) Zhang L....Sokol L. 2013 13 Gamma heavy chain disease in a patient with underlying lymphoplasmacytic lymphoma of the thyroid. [malacards.org]

Following splenectomy, the patient has remained in complete remission for both conditions with no further treatment. [ncbi.nlm.nih.gov]

Patients with Franklin disease usually have a history of progressive weakness, fatigue, intermittent fever, night sweats and weight loss and may present with lymphadenopathy (62%), splenomegaly (52%) or hepatomegaly (37%). [en.wikipedia.org]

A young Turkish girl presented with all the clinicopathological features of a digestive form of alpha chain disease. [ncbi.nlm.nih.gov]

: Five-year results of the treatment of 23 patients with immunoproliferative small intestinal disease: a Turkish experience. Cancer 1997, 80:8–14. PubMed CrossRef Google Scholar 32. [link.springer.com]

manifestations associated with gamma heavy chain disease. [malacards.org]

: Cutaneous manifestations associated with gamma heavy chain disease: report of an unusual case and review of literature. J Am Acad Dermatol 1990, 23:988–991. PubMed CrossRef Google Scholar 12. [link.springer.com]

The covalent linkage suggests that the hinge region of this gamma heavy chain is intact. [ncbi.nlm.nih.gov]

[…] and recipient selection in renal transplantation 587 Immunosuppression and treatment of rejection in renal transplantation 595 XIII 606 Renal tubular and metabolic dysfunction following kidney homotransplantation 617 Infectious malignant surgical 630 Nephrolithiasis [books.google.com]

In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient. [ncbi.nlm.nih.gov]

"Penicillium pneumonia in a patient with newly diagnosed Franklin disease". Am J Med Sci. 344 (1): 69–71. doi : 10.1097/MAJ.0b013e31824a8927. PMID 22543591. Wahner-Roedler DL, Witzig TE, Loehrer LL, Kyle RA (2003). [en.wikipedia.org]

[…] associated lymphoproliferative disorders through analysis of 13 cases. ( 22301495 ) Bieliauskas S....Cook J.R. 2012 15 Gamma heavy chain disease in a patient with rheumatoid arthritis--a laboratory evaluation. ( 23092068 ) Johannis W....Wielckens K. 2012 16 Penicillium [malacards.org]