Small doses produce relaxation, tranquility and drowsiness which make it extremely easy to fall asleep naturally. Higher doses increase the drowsiness effect and decrease the time it takes to fall asleep. [diagnose-me.com]

CAUTION GHB's dose/response curve is similar to that of alcohol : At higher doses, users fall unconscious and are temporarily unable to be awakened (coma). It may also dangerously depress breathing. Avoid Mixing With Alcohol. [erowid.org]

Mody, γ-Hydroxybutyrate induces cyclic AMP-responsive element-binding protein phosphorylation in mouse hippocampus: An involvement of GABAB receptors and cAMP-dependent protein kinase activation, Neuroscience, 141, 1, (269), (2006). Perry N. [doi.org]

The meta-analysis showed that GHB reduced cataplexy attacks both on a daily (weighted mean difference (WMD) -1.10; 95% confidence interval (CI) -1.29/-0.90, p 0.00001) and a weekly basis (WMD -7.04; 95% CI -12.45/-1.63, p 0.01), subjective nocturnal awakenings [ncbi.nlm.nih.gov]

A 27-year-old man was admitted with tremulousness, diaphoresis, tachypnea (28 breaths/min), full-body rigidity, irritability, paranoia, and auditory and visual hallucinations 2 days after stopping long-term gamma-hydroxybutyrate (GHB) and 8 hours after [ncbi.nlm.nih.gov]

The patient was administered a repeat dose of naloxone, 2 mg intravenously, with the minimal response of a brief episode of tachypnea. [aafp.org]

Respiratory depression Cocaine (70) Death from respiratory arrest, irregular (Cheyne-Stokes) respiration Ecstasy (MDMA a,b ) *,(71) Respiratory depression Ethanol a,(72) Respiratory depression Heroin/Opiate (73) Respiratory depression Methamphetamine *, (74) Dyspnea [ualberta.ca]

The girl had had persistent vomiting and a seizure. Urine metabolic screening tests were positive for gamma-hydroxybutyrate (GHB). Samples from toy beads ingested by both children contained 1,4-butanediol, which is metabolised to GHB in humans. [ncbi.nlm.nih.gov]

Adverse events included 2 instances of hypotension and 6 episodes of vomiting with GHB-plus-ethanol ingestion. [doi.org]

Other effects were headache, nausea, vomiting, myoclonic jerking, and short-term coma. There have been no reported deaths. If product use is discontinued, full recovery with no long-term side effects is universal. [ncbi.nlm.nih.gov]

Effects clumsiness, diarrhoea, dizziness, drowsiness, euphoria, headache, increased sex drive, lowered heart rate, lowered inhibitions, lowered temperature, memory lapses, nausea, urinary incontinence. [adf.org.au]

Negative effects may include sweating, loss of consciousness, nausea, hallucinations, amnesia, and coma, among other side effects. [drugs.com]

The girl had had persistent vomiting and a seizure. Urine metabolic screening tests were positive for gamma-hydroxybutyrate (GHB). Samples from toy beads ingested by both children contained 1,4-butanediol, which is metabolised to GHB in humans. [ncbi.nlm.nih.gov]

Coma and seizures have been reported following abuse of GHB, but dependence liability has received little attention. [ncbi.nlm.nih.gov]

Furthermore, these GHB-induced electroencephalogram-behavioral changes can be blocked by anticonvulsant drugs, which are specific in their action against petit-mal seizures. [jpet.aspetjournals.org]

Among the possible described side-effects after the continued consumption of GHB are amnesia and deterioration of memory. Likewise, recent studies indicate the existence of neurotoxicity in certain brain regions after its prolonged treatment. [ncbi.nlm.nih.gov]

Negative effects may include sweating, loss of consciousness, nausea, hallucinations, amnesia, and coma, among other side effects. [drugs.com]

In higher dosages it may induce amnesia, drowsiness, nausea, agitation, visual problems, unconsciousness, and even death. [about-addiction.com]

Amnesia is mainly present when GHB and benzodiazepines have been used; in particular, 1,4-benzodiazepines like flunitrazepam are more likely to cause amnesia than 1,5-benzodiazepines like clobazam ( 12 ). [doi.org]

The most common patient symptoms were tremor (67%), hallucinations (63%), tachycardia (63%) and insomnia (58%). Seizures and rhabdomyolysis each occurred in 7% of cases, but only 1 death occurred. [ncbi.nlm.nih.gov]

Features include auditory and visual hallucinations, tremors, tachycardia, hypertension, sweating, anxiety, agitation, paranoia, insomnia, disorientation, confusion, and aggression/combativeness. [doi.org]

This manifested as delirium, tremor, and seizures despite only small decreases in GHB dose and treatment with benzodiazepines. [ncbi.nlm.nih.gov]

The observed clinical symptoms ranged from confusion, disorientation, vomiting, and nystagmus to ataxia, sinus bradycardia, unconsciousness, and apnea. [ncbi.nlm.nih.gov]

Vomiting Irregular or shallow breathing Confusion, irritation and agitation Hallucinations Blackouts and memory loss Unconsciousness that can last for 3 to 4 hours Death 2 Long-term effects Little is known about the long-term effects of GHB use. [adf.org.au]

Features include auditory and visual hallucinations, tremors, tachycardia, hypertension, sweating, anxiety, agitation, paranoia, insomnia, disorientation, confusion, and aggression/combativeness. [doi.org]

None demonstrated response and, further, there were associated adverse events, including atrial fibrillation (2), pulmonary infiltrates (1) and significant bradycardia (1), and hypotension (1). [ncbi.nlm.nih.gov]