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Ganglioglioma
Presentation
- These usually occur in young patients, who present with therapy-resistant seizures. Clinical presentation of ganglioglioma with diabetes insipidus is extremely rare with only one case reported earlier in the available literature.[ncbi.nlm.nih.gov]
Entire Body System
Fatigue
- He presented with headache, fatigue and occasional nausea and vomiting. MRI revealed three large, distinct tumours with striking cyst formation. Stereotactic craniotomy and excision of the temporal and occipital tumours confirmed ganglioglioma.[ncbi.nlm.nih.gov]
- We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: March 31, 2019[patientslikeme.com]
- Common symptoms may include: Headache(generally upon awakening in the morning) Vomiting Fatigue Seizures Weakness on one side of the body Diagnosis Physical and Neurological examination – the child may demonstrate evidence of increased pressure inside[drarunlnaik.com]
Developmental Delay
- Abstract We report on a 5-year-old male with expressive language delay, developmental delay, short stature, and facial anomalies consistent with Floating-Harbor syndrome (FHS). In addition, he developed an intramedullary ganglioglioma.[ncbi.nlm.nih.gov]
Malaise
- A 61-year-old male presented with a 12-day history of headaches and general malaise.[ncbi.nlm.nih.gov]
Rigor
- Due to the limited number of cases, it is not possible to conduct a rigorous statistical evaluation. Thus, larger numbers of patients are required.[ncbi.nlm.nih.gov]
Soft Tissue Mass
- DIAGNOSES: Computer tomography scan of the chest revealed a soft tissue mass at the right upper lobe which was consistent with IMT. Histopathologic examination confirmed the diagnosis of IMT.[ncbi.nlm.nih.gov]
Respiratoric
Cough
- PATIENT CONCERNS: We present a 12-year-old girl with 2 months history of none productive cough and right-sided chest pain.[ncbi.nlm.nih.gov]
Productive Cough
- PATIENT CONCERNS: We present a 12-year-old girl with 2 months history of none productive cough and right-sided chest pain.[ncbi.nlm.nih.gov]
Gastrointestinal
Nausea
- He presented with headache, fatigue and occasional nausea and vomiting. MRI revealed three large, distinct tumours with striking cyst formation. Stereotactic craniotomy and excision of the temporal and occipital tumours confirmed ganglioglioma.[ncbi.nlm.nih.gov]
- […] provide support and protection of neurons) Epidemiology of Ganglioglioma especially in children and young adults represent less than 2% of all primary brain tumours Symptoms of Ganglioglioma epileptic seizures signs of intracranial pressure (headache, nausea[hirntumorhilfe.org]
- Deling (2013) 15/M 1 year Headache, nausea, unsteady gait GTR No recurrence (19 months) 5. Deling (2013) 27/M 2 years Headache TR No recurrence (8 months) 6.[jstage.jst.go.jp]
- She reported a three-month history of progressive headache and nausea which were falsely attributed to pregnancy both by the patient and her treating physician leading to a delay in diagnosis and management.[ijrcog.org]
Skin
Facial Angiofibroma
- Their mother has facial angiofibroma, cortical tuber, and seizures during infancy. Ganglioglioma may be a phenotypic expression of TSC1. Genetic testing is recommended for infants with brain tumors, especially those with an abnormal familial history.[ncbi.nlm.nih.gov]
Psychiatrical
Psychomotor Retardation
- He also had mild psychomotor retardation. Magnetic resonance imaging (MRI) revealed a large tumor in the left middle cerebellar peduncle.[ncbi.nlm.nih.gov]
Face, Head & Neck
Frontal Bossing
- Here we report on a 9-year-old girl who was diagnosed as having a clavicular arteriovenous malformation with limb enlargement, an axillary port wine stain and macrocephaly with frontal bossing.[ncbi.nlm.nih.gov]
Urogenital
Polyuria
- CASE: A 7-year boy presented with polyuria, polydipsia, and progressive visual loss for 18 months. Investigations revealed diabetes insipidus.[ncbi.nlm.nih.gov]
Neurologic
Headache
- A 61-year-old male presented with a 12-day history of headaches and general malaise.[ncbi.nlm.nih.gov]
Hyperactivity
- The latter patient presented with an 8-year history of epilepsy, attention deficient hyperactivity disease, and a pervasive developmental disorder. Imaging identified a lesion in the left posterior temporal and occipital region.[ncbi.nlm.nih.gov]
Neglect
- He had a left visual field hemianopia and left visual field neglect. Brain computer tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in his right atrium.[ncbi.nlm.nih.gov]
Focal Seizure
- Infratentorial GGs typically present with signs and symptoms of increased intracranial pressure (ICP), cranial nerve deficits, or focal cerebellar findings; rarely, these tumors have been associated with focal seizures.[ncbi.nlm.nih.gov]
Dysphasia
- In this article, we presented a 53-year-old patient who presented with headache and dysphasia. The patient was operated for the cystic mass in the left parietal lobe reported as an abscess.[ncbi.nlm.nih.gov]
Workup
- Extensive workup for an inflammatory or infectious etiology was unfruitful and two brain biopsies were inconclusive.[ncbi.nlm.nih.gov]
EEG
Spike-and-Slow-Waves
- Interictal electroencephalography (EEG) showed diffuse bursts of slightly irregular high-voltage spikes and slow waves without hypsarrhythmia.[ncbi.nlm.nih.gov]
Treatment
- Treatment with Vemurafenib as single agent was started. For the first time, a radiological and clinical response was obtained after 3 months of treatment and sustained after 6 months.[ncbi.nlm.nih.gov]
- Patients usually present with seizures refractory to medical treatment. Association with neurofibromatosis type I and tuberous sclerosis has been reported.[orpha.net]
Prognosis
- Its prognosis and relationship with complicating hydrocephalus are unclear.[ncbi.nlm.nih.gov]
- Prognosis A prognosis is an estimate of the likely progress of a disease after a diagnosis, based on an average patient group.[braintumour.ca]
Etiology
- Extensive workup for an inflammatory or infectious etiology was unfruitful and two brain biopsies were inconclusive.[ncbi.nlm.nih.gov]
- They may co-occur with adjacent focal cortical dysplasia (FCD IIIb), suggesting a common developmental etiology for both structural abnormalities.[epilepsydiagnosis.org]
- The etiology of gangliogliomas is controversial as is their biological potential. Some lesions display neoplastic features including the potential to enlarge and behave in a malignant fashion.[path.upmc.edu]
- He had macroscopic hematuria, for which etiologies other than nephrotoxicity secondary to the antineoplastic treatment were ruled out.[elsevier.es]
Epidemiology
- Through this case and literature review, the authors discuss some epidemiological, histological, clinical, radiological and management features of this very rare tumor.[ncbi.nlm.nih.gov]
- Histology of Ganglioglioma mainly slowly growing tumour WHO grade I also WHO grad II and III can occur emerge from neoplastic ganglion cells (neural cells) and glia cells (provide support and protection of neurons) Epidemiology of Ganglioglioma especially[hirntumorhilfe.org]
- Pediatric low-grade ganglioglioma: epidemiology, treatments, and outcome analysis on 348 children from the surveillance, epidemiology, and end results database. Neurosurgery. 2015 ;76: 313 – 319. Google Scholar Crossref Medline 6.[journals.sagepub.com]
Sex distribution
Age distribution
Prevention
- The patient is scheduled for adjuvant radiotherapy with the hope of prevention of progression.[ncbi.nlm.nih.gov]
- Therefore, currently, no guidelines or methods are available towards preventing tumor formation Active research is currently being performed to explore the possibilities for treatment and prevention of tumors such as Anaplastic Ganglioglioma Regular medical[dovemed.com]
- Radiation therapy Radiation therapy uses X-rays to kill the cells and prevent them from growing. External radiation therapy, a type of radiation therapy uses machines outside the body to deliver the dose.[isitcurable.com]
- Patients With Newly Diagnosed Pontine Glioma 3 NCT01188096 A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas 2 NCT03152318 A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 2 NCT03194906 Memantine for Prevention[virtualtrials.com]
- The patient is scheduled for adjuvant radiotherapy with the hope of prevention of progression. 2015 S. Karger AG, Basel References Courville CB: Ganglioglioma, tumor of the central nervous system: review of the literature and report of two cases.[karger.com]