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Ganglioneuroma


Presentation

  • On imaging, usually, they present as well-defined solid masses and can be quite large at presentation. Generally, they are hypoattenuating to muscle on CT and have a heterogeneous intermediate signal on both T1 and T2-weighted MRI sequences.[radiopaedia.org]
  • Rarely, it may also present in cervical region as slow growing painless neck mass. Here we present a 7 years old female child with 4 years duration of slow growing left lateral neck mass.[ncbi.nlm.nih.gov]
Soft Tissue Mass
  • Magnetic resonance imaging revealed a left paravertebral soft-tissue mass at the T11-L3 levels. Grossly, the encapsulated neoplasm had a white to yellowish cut surface and rubbery consistency.[ncbi.nlm.nih.gov]
  • The soft tissue mass may be illdefined and the tumor "ghost-like" in the case of primary neuroblastoma, but it is usually obvious in ganglioneuroma and metastatic disease.[ajronline.org]
  • Abdominal computed tomography (CT) imaging identified a 5.5 1.9 3.3 cm soft tissue mass within the aortocaval space, below the renal arteries and posterior to the duodenum. EUS-FNA was performed.[academic.oup.com]
  • Figure1: MRI showing showing a large soft tissue mass. Macroscopically, the specimen was a 13x13x5cm rounded well-encapsulated mass (Fig. 2). Upon sectioning in vitro, mass was seen to be solid, whorled and grey white.[bjmp.org]
  • (a) Lateral plain radiograph of the neck in a 12-month-old girl with stridor reveals a prevertebral soft-tissue mass ( ), resulting in anterior displacement of the hypopharynx, larynx, and upper trachea.[pubs.rsna.org]
Turkish
  • An 18-year-old Turkish male patient with no previous comorbidities was admitted to our hospital with lower-quadrant pain. He had no significant past medical or surgical history.[ncbi.nlm.nih.gov]
  • Indexing/Abstracting DOAJ, Tübitak/Ulakbim Turkish Medical Database, Academic OneFile, Healt h Reference Center Academic, US National Library of Medicine (NLM) Catalog, INDEX COPERNICUS, Genamics-JournalSeek, DRJI, J-Gate, Google Scholar, Research Bible[pediatricurologycasereports.com]
Pelvic Mass
  • Abstract Here we report the case of a 30-year-old woman with a history of neurofibromatosis type 2 (NF2) who presented with an incidentally discovered pelvic mass on an ultrasound.[ncbi.nlm.nih.gov]
  • USG and CECT abdomen and pelvis was performed which show pelvic mass in presacral region.[omicsonline.org]
  • If any progression of the tumour is seen then repeat laparotomy may be indicated. 2 Conclusion: Although pelvic ganglioneuroma is a very rare lesion, it should be considered in the differential diagnosis of any abdomeno-pelvic mass.[bjmp.org]
  • (a) On an abdominal radiograph obtained after oral and IV contrast enhancement, the bladder is elevated because of a pelvic mass. (b) Axial unenhanced CT scan shows the heterogeneous pelvic mass ( ) and the anteriorly displaced bladder (arrow).[pubs.rsna.org]
Left Flank Pain
  • We describe a 15-year-old normotensive adolescent girl with a 2-month history of left flank pain. Imaging revealed a left suprarenal mass with elevated urinary dopamine level.[ncbi.nlm.nih.gov]
Keratosis
  • Patients were 2 men and 2 women aged 53 to 76 years, who had flesh-colored nodules on the back, associated with adjacent keratotic changes, that is, epidermal nevus (1 case) or seborrheic keratosis (3 cases).[ncbi.nlm.nih.gov]
Diplopia
  • He also reported a two-week history of diplopia with right lateral gaze, which resolved spontaneously.[ncbi.nlm.nih.gov]
Anisocoria
  • Six children were symptomatic (three with abdominal pain and mass, one with stridor or dysphonia, and one each with anisocoria and opsomyoclonus). However, 18 (75%) were asymptomatic and the diagnosis was incidental.[ncbi.nlm.nih.gov]
Hyporeflexia
  • A 28-year-old woman developed progressive ataxia with hyporeflexia at the age of 19. Brain MRI showed progressive cerebellar atrophy.[ncbi.nlm.nih.gov]
Radiculopathy
  • We report a 34-year-old male patient who presented with typical lumbar radiculopathy. He had low back pain radiating to the right lower leg with numbness. His MRI revealed a herniated disc at L5-S1 compressing the right nerve root.[ncbi.nlm.nih.gov]

Workup

  • We summarize the current principles regarding the diagnostic workup and treatment of these neoplasms, and we briefly review the literature.[ncbi.nlm.nih.gov]
  • An endocrine workup, including urine catecholamine and a 1mg overnight dexaméthasone suppression test, was normal. The lesion was completely extirpated through laparoscopic resection.[endocrine-abstracts.org]
  • Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate.[books.google.com]
Posterior Mediastinal Mass
  • The differential depends on location; for thoracic lesions, consider the differential for a posterior mediastinal mass.[radiopaedia.org]
  • On evaluation with computed tomography scan of the chest, he was found to have a large 16 x 14 cm posterior mediastinal mass compressing the inferior vena cava and liver, and shifting the heart to the opposite side.[ncbi.nlm.nih.gov]
  • We present a case of a posterior mediastinal mass with a large fatty component seen on MR imaging studies. This is a rare finding that distinguishes ganglioneuroma from other posterior mediastinal tumors ( 10 ).[ajnr.org]

Treatment

  • Combining this case with similar cases at home and aboard and reviewing related literature, we formed conclusions based on the manifestations, diagnosis, treatment, and prognosis of this disease and provided treatments for similar cases.[ncbi.nlm.nih.gov]
  • Because ganglioneuromas are benign, treatment may not be necessary, as it would expose patients to more risk than leaving it alone. If there are symptoms or major physical deformity, treatment usually consists of surgery to remove the tumor.[en.wikipedia.org]
  • Treatment consists of complete surgical resection when possible. Complete resection ensures thorough sampling of the tumor so that a confident diagnosis of ganglioneuroma can be made 12.[radiopaedia.org]

Prognosis

  • Complete resection of ganglioneuroma following with a low recurrence rate and a good prognosis, patient does not need further chemotherapy, radiation therapy, or other treatments.[ncbi.nlm.nih.gov]
  • Prognosis is usually excellent, however, local recurrence has been reported. The differential depends on location; for thoracic lesions, consider the differential for a posterior mediastinal mass.[radiopaedia.org]

Etiology

  • […] gland ( 20-30% of cases), cervical and parapharyngeal area, urinary bladder, prostate, bone, pancreas, skin, orbit, paratesticular area, appendix, gastrointestinal tract ( Lack: Tumors of the Adrenal Glands and Extraadrenal Paraganglia, Vol.8, 2007 ) Etiology[pathologyoutlines.com]
  • PMID 10519894 Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.[atlasgeneticsoncology.org]

Epidemiology

  • Definition / general Mature, benign neoplasm that originates from neural crest cells of sympathetic ganglia or adrenal medulla On a spectrum, from least most differentiated : neuroblastoma ganglioneuroblastoma ganglioneuroma Epidemiology At all sites,[pathologyoutlines.com]
  • Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. The book is an authoritative, concise reference, prepared by 150 authors from 20 countries.[books.google.com]
  • Other diagnoses must of course be suggested, but they will immediately be excluded for semiological or epidemiological reasons.[em-consulte.com]
  • We report on the clinical presentation and discuss the origin, epidemiology, treatment, and management of this lesion. 2017 The Author(s). Published by S.[karger.com]
  • PMID 10379019 Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study. Breslow NE, Beckwith JB Journal of the National Cancer Institute. 1982 ; 68 (3) : 429-436.[atlasgeneticsoncology.org]
Sex distribution
Age distribution

Pathophysiology

  • […] microscopic histopathological analysis, ganglioneuromas are characterized by spindle-shaped cells with cell borders in a fibrillar matrix containing ganglion cells with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. [1] Pathophysiology[wikidoc.org]

Prevention

  • In our case, a core needle biopsy preceding complete resection was helpful to prevent too extensive surgical approach.[ncbi.nlm.nih.gov]
  • Currently, there are no available methods to prevent Ganglioneuroma occurrence. What is the Prognosis of Ganglioneuroma? (Outcomes/Resolutions) Ganglioneuromas are generally slow-growing and benign (non-cancerous).[dovemed.com]
  • Traction on the tumor was kept to a minimum to prevent neurological complications. Preparation was made for neurosurgical resection of these pedicles.[academic.oup.com]

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