Presentation
On imaging, usually, they present as well-defined solid masses and can be quite large at presentation. Generally, they are hypoattenuating to muscle on CT and have a heterogeneous intermediate signal on both T1 and T2-weighted MRI sequences. [radiopaedia.org]
Rarely, it may also present in cervical region as slow growing painless neck mass. Here we present a 7 years old female child with 4 years duration of slow growing left lateral neck mass. [ncbi.nlm.nih.gov]
Finally, any patient with adrenal tumor presenting with watery diarrhea, VIP-producing ganglioneuroma must be kept as differential diagnosis. [jdrntruhs.org]
Entire Body System
- Pain
A 17-year-old man initially presented to his primary care physician with throat pain for 1 week and was started on amoxicillin. [ncbi.nlm.nih.gov]
Case Report: A 15 year old girl presented with abdominal pain and chronic constipation. A mass was seen between the uterus and sacrococcygeal bone in abdominal CT. It is resected totally and evaluated as ganglioneuroma. [medicinescience.org]
Abdominal pain Bloating If the tumor is near the spinal cord, it may cause: Compression of the spinal cord, which leads to pain and loss of strength or feeling in the legs, arms, or both Spine deformity These tumors may produce certain hormones, which [nlm.nih.gov]
Retroperitoneal ganglioneuroma, a rare cause of abdominal pain. [saudisurgj.org]
- Asymptomatic
CONCLUSION: AGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed. [ncbi.nlm.nih.gov]
GN do not secrete excess catecholamines or steroid hormones and are often clinically silent and asymptomatic even if they are large [ 2 ]. [hoajonline.com]
Ganglioneuromas are usually asymptomatic and often discovered incidentally as they are slow growing and usually endocrinologically inactive 11. [radiopaedia.org]
- Pathologist
In surgery, the tumor will be taken out and sent to a pathologist to confirm its nature and check for malignancy. [wisegeek.com]
Uses expanded tables to outline specific differential diagnostic points helpful for surgical pathologists. Discusses the key molecular aspects of tumor progression and risk assessment in all chapters that cover neoplastic disorders. [books.google.com]
The pathologist examines the biopsy under a microscope and arrives at a definitive diagnosis after a thorough evaluation of the clinical and microscopic findings, as well as by correlating the results of special studies on tissues (if required) The studies [dovemed.com]
Because this sort of thing is pretty rare, no fewer than four pathologists were involved in “ Dude, check this out .” Hey, I would have done the same. [jimcarson.com]
Liver, Gall & Pancreas
- Hepatomegaly
Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray. Ganglioneuroma features also observed in composite phaeochromocytomas or paragangliomas. [codes.iarc.fr]
Liver: can cause respiratory distress from hepatomegaly 3. Bone marrow: malignant cells should be limited to <10% nucleated cells. Can cause anemia. What are the different options for diagnosis of NB? 1. Histopathology of primary tumor OR 2. [pedsurgzone.blogspot.com]
Hepatomegaly, periostitis, widened cranial sutures, focal bone lucencies, focal bone sclerosis, and lucent submetaphyseal zones may indicate metastatic disease. [6] This frontal chest radiograph shows a right paraspinal well-defined density in the retrocardiac [emedicine.com]
Musculoskeletal
- Long Arm
Interestingly, also structural chromosome aberrations like MYCN amplifications, deletions at the chromosomal regions 1p36.3, or 11q, gains of long arms of chromosome 17, can be found in near-triploid tumours. [atlasgeneticsoncology.org]
Eyes
- Visual Impairment
Paraganglioma in children is extremely rare, and its production of catecholamine causes hypertension, headache, and/or acute visual impairment. [dl.ndl.go.jp]
Psychiatrical
- Suggestibility
However, some suggestive features on computed tomography and magnetic resonance imaging are helpful in achieving a correct diagnosis. [ncbi.nlm.nih.gov]
Neurologic
- Excitement
Enter a word (“newspaper”), a word combination (“exciting trip”) or a phrase (“with all good wishes”) into the search box. [en.pons.com]
Workup
We summarize the current principles regarding the diagnostic workup and treatment of these neoplasms, and we briefly review the literature. [ncbi.nlm.nih.gov]
An endocrine workup, including urine catecholamine and a 1mg overnight dexaméthasone suppression test, was normal. The lesion was completely extirpated through laparoscopic resection. [endocrine-abstracts.org]
Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. [books.google.com]
Treatment
Combining this case with similar cases at home and aboard and reviewing related literature, we formed conclusions based on the manifestations, diagnosis, treatment, and prognosis of this disease and provided treatments for similar cases. [ncbi.nlm.nih.gov]
Learn about arteriosclerotic (vascular) dementia diagnosis, symptoms, causes and treatments at Northwell Health Learn about Arteriovenous (AV) Fistula diagnosis, symptoms, causes and treatments at the Northwell Health Brain Aneurysm Center and Cerebrovascular [northwell.edu]
Prognosis
The prognosis is very good with surgical removal. [ncbi.nlm.nih.gov]
Prognosis is usually excellent, however, local recurrence has been reported. The differential depends on location; for thoracic lesions, consider the differential for a posterior mediastinal mass. [radiopaedia.org]
Etiology
[…] gland (~20-30% of cases), cervical and parapharyngeal area, urinary bladder, prostate, bone, pancreas, skin, orbit, paratesticular area, appendix, gastrointestinal tract ( Lack: Tumors of the Adrenal Glands and Extraadrenal Paraganglia, Vol.8, 2007 ) Etiology [pathologyoutlines.com]
PMID 10519894 Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. [atlasgeneticsoncology.org]
Epidemiology
Definition / general Mature, benign neoplasm that originates from neural crest cells of sympathetic ganglia or adrenal medulla On a spectrum, from least → most differentiated : neuroblastoma → ganglioneuroblastoma → ganglioneuroma Epidemiology At all [pathologyoutlines.com]
Other diagnoses must of course be suggested, but they will immediately be excluded for semiological or epidemiological reasons. [em-consulte.com]
Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. The book is an authoritative, concise reference, prepared by 150 authors from 20 countries. [books.google.com]
(USA); epidemiological characteristics were reported in Table 1. Figure 3 Flowchart illustrating the study identification and inclusion/exclusion process. [dmr.amegroups.com]
We report on the clinical presentation and discuss the origin, epidemiology, treatment, and management of this lesion. © 2017 The Author(s). Published by S. [karger.com]
Pathophysiology
[…] microscopic histopathological analysis, ganglioneuromas are characterized by spindle-shaped cells with cell borders in a fibrillar matrix containing ganglion cells with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. [1] Pathophysiology [wikidoc.org]
Prevention
In our case, a core needle biopsy preceding complete resection was helpful to prevent too extensive surgical approach. [ncbi.nlm.nih.gov]
Currently, there are no available methods to prevent Ganglioneuroma occurrence. What is the Prognosis of Ganglioneuroma? (Outcomes/Resolutions) Ganglioneuromas are generally slow-growing and benign (non-cancerous). [dovemed.com]
Traction on the tumor was kept to a minimum to prevent neurological complications. Preparation was made for neurosurgical resection of these pedicles. [academic.oup.com]