On imaging, usually, they present as well-defined solid masses and can be quite large at presentation. Generally, they are hypoattenuating to muscle on CT and have a heterogeneous intermediate signal on both T1 and T2-weighted MRI sequences. [radiopaedia.org]

It occurs most frequently in the mediastinum (70%)2,3 and age at presentation is generally young.4 Most cases are asymptomatic. [archbronconeumol.org]

Their clinical presentation is mostly asymptomatic, and if any symptoms are present at all, they are usually nonspecific, with excellent prognosis. [karger.com]

Rarely, it may also present in cervical region as slow growing painless neck mass. Here we present a 7 years old female child with 4 years duration of slow growing left lateral neck mass. [ncbi.nlm.nih.gov]

• Abdominal Cramps

  Some develop sweating and hypertension (elevated catecholamines), abdominal cramping and diarrhea (vasoactive intestinal peptide) or virilizing symptoms in female patients (testosterone-producing Leydig cells). [webpathology.com]

• Clonus

  Her examination was notable only for deep tendon reflexes that were more brisk in the lower extremities than in the upper extremities without any clonus. [ajnr.org]

• Neglect

  The tumor was not excised because it was surrounded by vessels and hard to separate, leaving the risk of malignancy neglected by biopsy. [frontiersin.org]

We report the case of a 5-year-old girl who presented with hematuria and a urinary tract infection and on workup was found to have a large bladder mass. Transurethral resection and pathologic examination revealed the mass to be a ganglioneuroma. [ncbi.nlm.nih.gov]

An endocrine workup, including urine catecholamine and a 1mg overnight dexaméthasone suppression test, was normal. The lesion was completely extirpated through laparoscopic resection. [endocrine-abstracts.org]

Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. [books.google.com]

Table 2 Clinical, radiological, cyto/histological, and surgical features of patients affected by pancreatic ganglioneuroma Authors Symptoms Pre-operative workup Size (mm) site Type of procedure Complication Post-operative stay (days) Christein JD et al [dmr.amegroups.com]

Treatment ranged from observation to intense multimodal treatment depending on tumor stage and molecular markers. Histology was not used for treatment stratification [23–25]. [bmccancer.biomedcentral.com]

Treatment Treatment involves surgery to remove the tumor (if it is causing symptoms). Outlook (Prognosis) Most ganglioneuromas are noncancerous. The expected outcome is usually good. A ganglioneuroma may become cancerous and spread to other areas. [ufhealth.org]

Combining this case with similar cases at home and aboard and reviewing related literature, we formed conclusions based on the manifestations, diagnosis, treatment, and prognosis of this disease and provided treatments for similar cases. [ncbi.nlm.nih.gov]

Treatment consists of complete surgical resection when possible. Complete resection ensures thorough sampling of the tumor so that a confident diagnosis of ganglioneuroma can be made 12. [radiopaedia.org]

A biopsy of the tumor may be required to confirm the diagnosis.[4] Treatment[edit] Because ganglioneuromas are benign, treatment may not be necessary, as it would expose patients to more risk than leaving it alone. [en.wikipedia.org]

Prognosis is usually excellent, however, local recurrence has been reported. The differential depends on location; for thoracic lesions, consider the differential for a posterior mediastinal mass. [radiopaedia.org]

The prognosis is very good with surgical removal. [ncbi.nlm.nih.gov]

Furthermore, prognosis is usually excellent and without complications. [karger.com]

[…] gland (~20-30% of cases), cervical and parapharyngeal area, urinary bladder, prostate, bone, pancreas, skin, orbit, paratesticular area, appendix, gastrointestinal tract (Lack: Tumors of the Adrenal Glands and Extraadrenal Paraganglia, Vol.8, 2007) Etiology [pathologyoutlines.com]

PMID 10519894 Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. [atlasgeneticsoncology.org]

Definition / general Mature, benign neoplasm that originates from neural crest cells of sympathetic ganglia or adrenal medulla On a spectrum, from least → most differentiated: neuroblastoma → ganglioneuroblastoma → ganglioneuroma Epidemiology At all sites [pathologyoutlines.com]

We report on the clinical presentation and discuss the origin, epidemiology, treatment, and management of this lesion. © 2017 The Author(s). Published by S. [karger.com]

(USA); epidemiological characteristics were reported in Table 1. Figure 3 Flowchart illustrating the study identification and inclusion/exclusion process. [dmr.amegroups.com]

Other diagnoses must of course be suggested, but they will immediately be excluded for semiological or epidemiological reasons. [em-consulte.com]

[…] microscopic histopathological analysis, ganglioneuromas are characterized by spindle-shaped cells with cell borders in a fibrillar matrix containing ganglion cells with large round nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. [1] Pathophysiology [wikidoc.org]

In our case, a core needle biopsy preceding complete resection was helpful to prevent too extensive surgical approach. [ncbi.nlm.nih.gov]

Currently, there are no available methods to prevent Ganglioneuroma occurrence. What is the Prognosis of Ganglioneuroma? (Outcomes/Resolutions) Ganglioneuromas are generally slow-growing and benign (non-cancerous). [dovemed.com]

Traction on the tumor was kept to a minimum to prevent neurological complications. Preparation was made for neurosurgical resection of these pedicles. [academic.oup.com]