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Ganoderma Lucidum

Reishi


Presentation

Camping
  • Furthermore, ganodermanondiol also affected the mitogen-activated protein kinase (MAPK) cascade and cyclic adenosine monophosphate (cAMP)-dependent signaling pathway, which are involved in the melanogenesis of B16F10 melanoma cells.[ncbi.nlm.nih.gov]
Plethora
  • Whereas, chronic inflammation can be correlated well with the onset of a plethora of autoimmune disorders; rheumatoid arthritis, systemic lupus and polymyalgia, rheumatic and other diseases like asthma, inflammatory bowel diseases, cardiovascular disorders[ncbi.nlm.nih.gov]
Severe Pain
  • Administration of hot water soluble extracts of Ganoderma lucidum (GI) (36 to 72 g dry weight/day) decreased pain dramatically in two patients with postherpetic neuralgia recalcitrant to standard therapy and two other patients with severe pain due to[ncbi.nlm.nih.gov]
Chronic Watery Diarrhea
  • A 49-year-old male patient with non-Hodgkins lymphoma presented with chronic watery diarrhea. He had a history of consumption of powdered lingzhi extract as a dietary supplement and herbal medicine.[ncbi.nlm.nih.gov]
Epigastric Pain
  • A 47-year-old man presented with epigastric pain. Endoscopy revealed a large gastric ulcer, which on biopsy was diagnostic of large B-cell lymphoma.[ncbi.nlm.nih.gov]

Workup

Calcium Increased
  • Intracellular calcium increase and measurement of intracellular reactive oxygen species (ROS) were performed by using flow cytometry and inverted microscope.[ncbi.nlm.nih.gov]
Penicillium
  • The antimicrobial potential of 5 G. lucidum samples against 5 fungal pathogens (Fusarium oxysporum, Aspergillus niger, A. flavus, Penicillium sp., and Alternaria alternata) was observed.[ncbi.nlm.nih.gov]
Polyps
  • GLT inhibits PhIP/DSS-dependent expression of cyclin D1 and COX-2 in colon tissue Overexpression of cell cycle regulatory protein, cyclin D1, was detected in patients with adenomatous polyps and adenocarcinomas demonstrating its importance in colon carcinogenesis[dx.doi.org]
  • DSS 100 GLT 0 0.2 0.4 0.4 0.6 PhIP/DSS 300 GLT 0 0.0 0.2 0.3 0.6 GLT inhibits PhIP/DSS-dependent expression of cyclin D1 and COX-2 in colon tissue Overexpression of cell cycle regulatory protein, cyclin D1, was detected in patients with adenomatous polyps[pubmedcentral.nih.gov]

Treatment

  • Four of the compounds also caused apoptosis in Caco-2 cells with maximum 9.5% increase of sub-G1 accumulations (7-oxo-ganoderic acid Z treatment) and maximum 29.84% apoptotic cells in TUNEL assay (ganoderic acid DM treatment).[ncbi.nlm.nih.gov]
  • Treatment response Comparison 2.[doi.org]

Prognosis

  • Nevertheless there is a lack of curative therapies, especially for patients diagnosed with late stage, recurrent or aggressive disease, who have a poor prognosis.[ncbi.nlm.nih.gov]
  • This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional.[caloriebee.com]
  • Seite 170 - Effect of Krestin (PSK) as Adjuvant Treatment on the Prognosis After Radical Radiotherapy in Patients with Non-Small Cell Lung Cancer," Anticancer Research 13(5C) (September-October 1993): 1815-1820. ‎[books.google.com]
  • PubMed/NCBI 17 Qi M, Liu Z, Shen C, Wang L, Zeng J, Wang C, Li C, Fu W, Sun Y and Han B: Overexpression of ETV4 is associated with poor prognosis in prostate cancer: Involvement of uPA/uPAR and MMPs. Tumour Biol. 36:3565–3572. 2015.[spandidos-publications.com]

Etiology

  • One of the major etiologies of obstructive bladder dysfunction (OBD) is oxidative stress induced by I/R.[ncbi.nlm.nih.gov]
  • Candida albicans is the most important etiologic agent of candidiasis which includes about 60%-75% of this disease.[imedpub.com]

Epidemiology

  • In particular, epidemiological studies conducted in Asia suggest that mushroom intake, together with other phytotherapy substances, protects against cancer, specifically gastrointestinal (GI) and breast cancers.[oncotarget.com]
  • Tham DM, Gardner CD, Haskell WL (1998) Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 83:2223–2235 PubMed Google Scholar 18.[link.springer.com]
  • However, four recent epidemiological studies from Asia demonstrated inverse correlation between mushroom intake and gastric, gastrointestinal and breast cancer, respectively [7] – [10].[dx.doi.org]
  • Abstract Background Epidemiological studies suggest that mushroom intake is inversely correlated with gastric, gastrointestinal and breast cancers.[pubmedcentral.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Abstract Oxidative stress plays an important role in specific disease pathophysiology and the aging process. In the history of human kind, many herbs were utilized for disease prevention and anti-aging treatment.[ncbi.nlm.nih.gov]

Prevention

  • The GLE may be clinically applied in the prevention and/or treatment of cancer metastasis. Copyright 2016. Published by Elsevier GmbH.[ncbi.nlm.nih.gov]
  • Here, we show that GLT prevented formation of colonic tumors, inhibited focal hyperplasia and reduced the amount of ACF. Moreover, GLT also prevented colon inflammation and reduced the amount of colon infiltrating macrophages.[dx.doi.org]

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