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Gardnerella Vaginalis

Haemophilus Vaginalis


Presentation

  • A characteristic fishy odor was present in the urethral discharge of all three patients. G. vaginalis was isolated from the glans of all three, and clue cells were present in two.[ncbi.nlm.nih.gov]
  • Infected semen also presented significant differences in severely amorphous (p 0.02) and tapered sperm (p 0.01). Bacteriospermia and cells with attached bacteria (clue cells morphotype) were remarkable features observed.[ncbi.nlm.nih.gov]
  • Women had consistent vaginal microbiota over time if lactobacilli were the dominant spp. present.[ncbi.nlm.nih.gov]
  • No significant differences in number of epithelial cells and leukocytes, and total bacterial counts were present. CONCLUSIONS: There is a significant link between IBD and G. vaginalis biofilm.[ncbi.nlm.nih.gov]
  • Here we present a new murine vaginal infection model with a clinical isolate of G. vaginalis.[ncbi.nlm.nih.gov]
Periodontitis
  • P. (2010) A novel sialic acid utilization and uptake system in the periodontal pathogen Tannerella forsythia. J. Bacteriol. 192, 2285–2293 [ PMC free article ] [ PubMed ] [ Google Scholar ] 83. Byers H. L., Tarelli E., Homer K.[ncbi.nlm.nih.gov]
Hypotension
  • Institution of tocolytic therapy for preterm labor is associated with maternal complications of septic hypotension and pulmonary edema in one patient.[ncbi.nlm.nih.gov]
Meningism
  • A case of meningitis due to Gardnerella vaginalis occurred in a five-day-old newborn who had clinical signs of fever, polypnea and a grey complexion.[ncbi.nlm.nih.gov]
  • Neonatal meningitis due to Gardnerella vaginalis Eur J Clin Micro Infect Dis 1988 7 : 3 406–7 10. Furman LM . Neonatal Gardnerella vaginalis infection Pediatr Infect Dis J 1988 7 : 890 11. McGregor JA , French JI .[nature.com]
Salpingitis
  • The toxin could play a part in the development of salpingitis if G. vaginalis organisms gained access to the upper tract in large numbers. 2011 The Authors.[ncbi.nlm.nih.gov]
Vaginal Bleeding
  • Hysterectomy was performed in three patients because of persistent irregular vaginal bleeding.[ncbi.nlm.nih.gov]

Workup

Vibrio Vulnificus
  • F. (2011) Genomic and metabolic profiling of nonulosonic acids in Vibrionaceae reveal biochemical phenotypes of allelic divergence in Vibrio vulnificus. Appl. Environ. Microbiol. 77, 5782–5793 [ PMC free article ] [ PubMed ] [ Google Scholar ] 56.[ncbi.nlm.nih.gov]

Treatment

  • Forty-one of 47 (87%) patients given the single dose and 30 of 33 (91%) given the 7-day treatment were found to be cured seven days after treatment.[doi.org]
  • RESULTS: During treatment, patients developed clinically significant vaginitis, which the gynecologist considered to be exacerbated by the steroid treatment, leading to its withdrawal. All 3 vaginal specimens were positive for GV.[ncbi.nlm.nih.gov]
  • It is likely that the use of this probiotic strain for the treatment of bacterial vaginosis will provide a natural and nontoxic treatment modality. 2014 The Society for Applied Microbiology.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis The outlook is excellent. Bacterial vaginosis can return, but repeat treatment is usually successful. External resources CDC National Prevention Information Network (NPIN) National Center for HIV, STD and TB Prevention P.O.[drugs.com]

Etiology

  • Future studies with this model should facilitate investigation of important questions regarding BV etiology, pathogenesis and associated complications.[ncbi.nlm.nih.gov]
  • Our data indicate that balanoposthitis may have a polymicrobial and synergistic etiology involving G. vaginalis and anaerobic bacteria in the male lower genital tract; such an etiology is analogous to that of bacterial vaginosis.[ncbi.nlm.nih.gov]
  • Currently, the role of G. vaginalis in the etiology of BV remains a matter of controversy.[ncbi.nlm.nih.gov]
  • Abstract Despite the worldwide prevalence of bacterial vaginosis (BV), its etiology is still unknown. Although BV has been associated with the presence of biofilm, the ability of BV-associated bacteria to form biofilms is still largely unknown.[ncbi.nlm.nih.gov]
  • The etiology of the condition has been debated for nearly half a century and the lack of knowledge about its cause and progression has stymied efforts to improve therapy and prevention.[ncbi.nlm.nih.gov]

Epidemiology

  • The results indicate that SES may influence the epidemiology of BV and that the prevalence declines expressively in older women.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: This is the first comparative investigation on the epidemiology of G. vaginalis-associated BV in Bulgaria.[ncbi.nlm.nih.gov]
  • Author information 1 Unit of Epidemiology and Control of HIV/STD, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium; Laboratory Bacteriology Research, Faculty of Medicine & Health Sciences, University of Ghent, Ghent, Belgium[ncbi.nlm.nih.gov]
  • Abstract The Gardnerella vaginalis infection of the urogenital tract, an STD, is of clinical importance in females and of epidemiological importance in males.[ncbi.nlm.nih.gov]
  • Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest, 121 (2011), pp. 4610-4617 [2] J.M. Marrazzo. Interpreting the epidemiology and natural history of bacterial vaginosis: are we still confused.[bjid.org.br]
Sex distribution
Age distribution

Pathophysiology

  • Diagnostic modalities, specifically culturing techniques, are discussed, as well as suspected pathophysiologic mechanisms.[ncbi.nlm.nih.gov]

Prevention

  • Future research should focus on preventing its transmission and improved therapeutics for the biofilm infection that is caused by this pathogen and host anaerobes. The Author 2014.[ncbi.nlm.nih.gov]
  • The antibiotics metronidazole and tobramycin were highly effective in preventing biofilm formation, but had no effect on an established biofilm.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: These dual properties, toxin inhibition and biofilm retardation, justify further exploration of RC-101 as a candidate agent for bacterial vaginosis prevention.[ncbi.nlm.nih.gov]
  • The etiology of the condition has been debated for nearly half a century and the lack of knowledge about its cause and progression has stymied efforts to improve therapy and prevention.[ncbi.nlm.nih.gov]
  • Also, recombinant human lysozyme (rhLys) was able to both degrade biofilms and prevent their formation.[ncbi.nlm.nih.gov]

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