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Gastric Lymphoma


Presentation

  • Alarm symptoms, particularly persistent vomiting and weight loss, were more frequently present in patients with high-grade lymphoma than in those with low-grade lymphoma (54% vs. 28%; P 0.002).[ncbi.nlm.nih.gov]
Weight Loss
  • Symptoms mimicking gastritis-epigastric pain, hypochromic anemia, anorexia, and weight loss had been present for a few months before diagnosis. No Helicobacter pylori infection was shown at diagnosis.[ncbi.nlm.nih.gov]
  • Features of MyAccess include: Remote Access Favorites Save figures into PowerPoint Download tables as PDFs Go to My Dashboard Close • Epigastric pain and weight loss • Contrast radiographic or upper GI endoscopic evidence of gastric mass • Endoscopic[accesssurgery.mhmedical.com]
Fever
  • The patient was a 59-year-old immunocompetent man who presented with intermittent fever of unknown origin and epigastric pain for 18 days.[ncbi.nlm.nih.gov]
  • The main symptoms of lymphoma include: Night Sweats Fever Abdominal Pain Indigestion Nausea and Vomiting Gastrointestinal Bleeding Weight Loss Diarrhea Anaemia Tiredness Breathlessness Pruritis or itchy skin Headaches Edema or fluid accumulation in the[mystomachcancersymptoms.com]
  • He denied having fever, vomiting, diarrhea, bloody stools, melena or weight loss. Upon physical examination, left epigastric tenderness was noticed on abdominal palpation. The rest of the examination was unremarkable.[disastermilitarymedicine.biomedcentral.com]
  • B-symptoms (fever, night sweat and weight loss) are distinctly uncommon in contrast to nodal lymphomas, thus delaying the diagnosis [ 4 ].[pancreas.imedpub.com]
Fatigue
  • Symptoms include epigastric pain, early satiety, fatigue and weight loss.[en.wikipedia.org]
  • Three days later, the soldier was urgently referred back to the clinic due to a worsened abdominal pain, and marked fatigue. Physical examination revealed a heart rate of 120/min, blood pressure 120/75 mmHg and oral temperature of 37 c.[disastermilitarymedicine.biomedcentral.com]
  • Other general signs and symptoms, such as fatigue, weight loss, and appetite may also be seen Chemotherapy, surgery, radiation therapy, and other treatment measures may be used for treating Lymphoma of Stomach based on the assessment of the physician[dovemed.com]
  • It can have a variety of symptoms including fatigue, anorexia, weight loss and abdominal pain.[karger.com]
  • Stomach cancer care at Mayo Clinic Symptoms Signs and symptoms of gastroesophageal junction cancer and stomach cancer may include: Fatigue Feeling bloated after eating Feeling full after eating small amounts of food Severe, persistent heartburn Severe[mayoclinic.org]
Malaise
  • The boy also had a distended abdomen, general malaise, and tea-colored urine. Physical findings disclosed anemic conjunctiva and icteric sclera.[journals.lww.com]
  • RT toxicity In the series reported by Tsang et al toxicity reported included transient anorexia and malaise and occasional nausea or dyspepsia, and were treated conservatively. Late ulceration or hemorrhage was not observed.[slideshare.net]
Amyloidosis
  • Primary gastric lymphoma, an uncommon gastric tumor caused by infection with Helicobacter pylori, is rarely associated with gastric amyloidosis. Chronic bacterial infection is known to cause amyloidosis.[ncbi.nlm.nih.gov]
  • Crohn’s, sarcoid, TB • Syphilis • Amyloidosis[learningradiology.com]
Abdominal Pain
  • She presented at our hospital with epigastric abdominal pain and upper gastrointestinal bleeding. Chemotherapy alone sufficiently controlled the disease and no additional therapeutic modalities were needed.[ncbi.nlm.nih.gov]
  • Biopsy of both areas revealed lymphoma of the non-Hodgkin's type. 54 year-old man with severe abdominal pain. Endoscopy revealed a 3 cm duodenal ulcer to account for his pain, along with this 1 cm violaceous raised lesion in the gastric antrum.[endoatlas.com]
Vomiting
  • The diagnosis was suggested by feculent vomiting, and the fistula was located using barium enema and CT scan. Therapy consisted of local resection followed by combination chemotherapy.[ncbi.nlm.nih.gov]
  • Patients with gastritis may present with epigastric pain, nausea, vomiting, or loss of appetite.[ctisus.com]
  • Gastric Lymphoma 52 year-old woman with chronic gastritis following a subtotal gastrectomy 14 years previously, presented with early satiety and vomiting.[endoatlas.com]
  • […] pseudolymphoma -Consists of a mass of lymphoid tissue in the gastric wall often associated with an overlying mucosal ulcer -Represents response to chronic inflammation and is not malignant • The principal symptoms are epigastric pain and weight loss • Nausea and vomiting[accesssurgery.mhmedical.com]
Nausea
  • These include but are not limited to medications to counteract nausea and vomiting, intravenous fluids to treat dehydration, pain medications, antacids to lower the risk of ulcers, and bone marrow stimulating drugs to reverse the low white blood cell[rarediseases.org]
  • […] pseudolymphoma -Consists of a mass of lymphoid tissue in the gastric wall often associated with an overlying mucosal ulcer -Represents response to chronic inflammation and is not malignant • The principal symptoms are epigastric pain and weight loss • Nausea[accesssurgery.mhmedical.com]
  • The main symptoms of lymphoma include: Night Sweats Fever Abdominal Pain Indigestion Nausea and Vomiting Gastrointestinal Bleeding Weight Loss Diarrhea Anaemia Tiredness Breathlessness Pruritis or itchy skin Headaches Edema or fluid accumulation in the[mystomachcancersymptoms.com]
Epigastric Pain
  • Symptoms mimicking gastritis-epigastric pain, hypochromic anemia, anorexia, and weight loss had been present for a few months before diagnosis. No Helicobacter pylori infection was shown at diagnosis.[ncbi.nlm.nih.gov]
  • Features of MyAccess include: Remote Access Favorites Save figures into PowerPoint Download tables as PDFs Go to My Dashboard Close • Epigastric pain and weight loss • Contrast radiographic or upper GI endoscopic evidence of gastric mass • Endoscopic[accesssurgery.mhmedical.com]
Gastropathy
  • Although this infection has been linked to the development of duodenal ulcer, gastric ulcer, hypertrophic gastropathy, and gastric adenocarcinoma, the majority of infected persons remain asymptomatic throughout their lives.[doi.org]
  • ., 2010. [10] The endoscopic appearance of GAVE is similar to portal hypertensive gastropathy, but is not the same condition, and may be concurrent with cirrhosis of the liver. [2] [6] [15] [16] 30% of all patients have cirrhosis associated with GAVE.[en.wikipedia.org]
Acrocyanosis
  • In cold weather the patient experienced cold intolerance with acrocyanosis and small ulcerations on the ears. The test for heparin-precipitable protein ('cryofibrinogen') was strongly positive.[ncbi.nlm.nih.gov]
Liver Dysfunction
  • This case indicates that monotherapy using only rituximab may be a promising option for the treatment of patients with diffuse large B-cell lymphoma accompanied by severe liver dysfunction.[ncbi.nlm.nih.gov]
Long Arm
  • An interstitial deletion in the long arm of chromosome 8 as the sole structural anomaly was detected in a primary gastric diffuse large B-cell lymphoma, high-grade mucosa-associated lymphoid tissue (MALT) type, from a 74-year-old man.[ncbi.nlm.nih.gov]

Workup

  • In this patient , pancreatitis was the initial presentation of primary gastric lymphoma, which has not been commonly reported and therefore should be considered in the etiological workup.[ncbi.nlm.nih.gov]
  • The rest of his laboratory workup was unremarkable.[karger.com]
  • Conclusion In this patient , pancreatitis was the initial presentation of primary gastric lymphoma, which has notbeen commonly reported and therefore should be considered in the etiological workup.[pancreas.imedpub.com]
  • Report on a workup convened to discuss the pathologic and staging classifications of gastrointestinal tract lymphoma. Ann Oncol 1994; 5: 397–400. 2001 Lippincott Williams & Wilkins, Inc.[journals.lww.com]
Gastric Lesion
  • US findings paralleled endoscopy during follow-up under antiblastic treatment: both improvement and lack of change in the gastric lesions were reliably predicted by US.[ncbi.nlm.nih.gov]

Treatment

  • Surgical treatment had almost no impact on OS in the MALT type than conservative treatment (P   0.597).[ncbi.nlm.nih.gov]

Prognosis

  • The clinical course and prognosis of this disease are dependent on histopathological subtype and stage at the time of diagnosis.[ncbi.nlm.nih.gov]

Etiology

  • There is now good evidence that infection with Helicobacter pylori (Hp) is etiologically important.[ncbi.nlm.nih.gov]
  • Conclusion In this patient , pancreatitis was the initial presentation of primary gastric lymphoma, which has notbeen commonly reported and therefore should be considered in the etiological workup.[pancreas.imedpub.com]
  • Endoscopic studies are usually reserved for cases refractory to standard therapy with proton-pump inhibitors and/or antimicrobial agents or for those with unexplained etiology or 'red flags’.[disastermilitarymedicine.biomedcentral.com]
  • Disease Gastric adenocarcinoma Etiology Helicobacter pylori H. pylori is the single most important etiological agent in the pathogenesis of gastric cancer.[atlasgeneticsoncology.org]

Epidemiology

  • Abstract The aim of this study was to examine the clinicopathological features and epidemiology of primary gastric lymphoma in Jordan as a model for Middle East countries where such data is scarce.[ncbi.nlm.nih.gov]
  • Epidemiologic research: principles and quantitative methods. Belmont, Calif.: Lifetime Learning, 1982:159-80. 28. Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic research: principles and quantitative methods.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Sleisenger & Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management 8. Philadelphia: Saunders; 2006. p 567-85 Miljkovic' M,Senadhi V. Use of endoscopic ultrasound in diagnosing plasmacytoma of the pancreas.[pancreas.imedpub.com]
  • In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. . Accessed March 23, 2016. Gastric cancer.[mayoclinic.org]
  • "Hepatic encephalopathy: pathophysiology and emerging therapies". Med. Clin. North Am. 93 (4): 819–36, vii. doi : 10.1016/j.mcna.2009.03.009.[en.wikipedia.org]

Prevention

  • Consequently, a global therapeutic approach to the cure of PG-NHL has completely changed over the last 10 years: innovative, conservative options to reduce treatment toxicity, thus preventing systemic relapses, have made their appearance and are on the[ncbi.nlm.nih.gov]
  • The lymph node function is to prevent infections from entering the bloodstream. When the lymphatic system is fighting an active infection, you may notice that some of the lymph nodes in the area of the infection become swollen and tender.[webmd.com]

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