Presentation
Cystic changes may be present. Other features: Smooth muscle fibres present in lamina propria. ; Stroma edematous and inflamed. ; Pseudo-invasion may be present. In Type II hyperplastic polyp, superficial glands show onion-skin like arrangement. [histopathology-india.net]
In this article, we present a case of heterotopic gastric mucosa forming a giant polyp in the mid jejunum. A review of the literature is presented, and the clinical and pathologic features of this unusual lesion are discussed. [ncbi.nlm.nih.gov]
Recurrent vomiting, colicky abdominal pain, constipation and abdominal distension can be the presenting complains. [3,4] Fever [3] Gastric inflammatory fibroid polyps can present with fever. [explainmedicine.com]
Entire Body System
- Familial Adenomatous Polyposis
The risk of upper gastrointestinal cancer in familial adenomatous polyposis. Gastroenterology 1992; 102:1980–1982. PubMed Google Scholar 57. Marcello PW, Asbun HJ, Veidenheimer MC, et al. Gastroduodenal polyps in familial adenomatous polyposis. [link.springer.com]
Gastric polyps may be found at endoscopy as a spontaneous benign condition, part of an adenomatous polyp syndrome (familial adenomatous polyposis [FAP]), part of a hamartomatous polyp syndrome (juvenile polyposis syndrome, Peutz-Jegher syndrome, and PTEN [journals.lww.com]
If you have familial adenomatous polyposis, your polyps will most likely need to be removed. Removal generally occurs during an endoscopy. After removal, your physician will likely do follow-up endoscopies. [vidanthealth.com]
Familial adenomatous polyposis. This rare, inherited syndrome increases the risk of colon cancer and other conditions, including stomach polyps. Certain medications. [mayoclinic.org]
Fundic Gland Polyps This is often linked to an inherited condition known as familial adenomatous polyposis (FAP). [healthhype.com]
- Fever
Recurrent vomiting, colicky abdominal pain, constipation and abdominal distension can be the presenting complains. [3,4] Fever [3] Gastric inflammatory fibroid polyps can present with fever. [explainmedicine.com]
However, some cases come on more slowly and start with dull generalized pain, loss of appetite, fatigue and fever, symptoms that get worse over time. [livestrong.com]
- Severe Pain
You have severe pain in your abdomen that does not go away after you take medicine. When should I contact my healthcare provider? You have indigestion that does not go away with treatment. You vomit after meals. [drugs.com]
Gastrointestinal
- Melena
A 70-year-old independent male, Chinese in ethnicity, with a background of diabetes mellitus, hypertension, and a simple renal cyst presented with a combination of melena, anemia, and intermittent vomiting of partially digested food after meals. [ncbi.nlm.nih.gov]
- Constipation
Recurrent vomiting, colicky abdominal pain, constipation and abdominal distension can be the presenting complains. [3,4] Fever [3] Gastric inflammatory fibroid polyps can present with fever. [explainmedicine.com]
Structural Anomalies Congenital Cysts, Duplications, and Diverticula of Intestine Intestinal Heterotopias Motility Disorders and Infiltrative Diseases Diverticulosis and Diverticulitis Hirschsprung Disease Small Bowel Diverticulosis Severe Idiopathic Constipation [euro-libris.ro]
Musculoskeletal
- Osteoporosis
The patient took alendronate for osteoporosis. The endoscopic examination revealed Helicobacter pylori positive antral atrophic gastropathy and a well delineated hemispherical polyp, 8 mm in diameter, in the antrum of the stomach. [ncbi.nlm.nih.gov]
Although there is no need to worry about malignancy related to PPI-induced FGPs, long-term use (>5 years) of PPIs has been associated with osteopenia and osteoporosis-related fractures. [journals.lww.com]
The administration of raloxifene ( Evista ) (a drug used to prevent and treat osteoporosis in postmenopausal women ) has been shown to decrease the size of fibroids in postmenopausal women, but results with this therapy in premenopausal women have been [medicinenet.com]
Treatment
Is development of gastric polyps during proton pump inhibitor therapy related to the length of treatment? Long-term treatment with proton pump inhibitors (PPI) is associated with increased serum gastrin levels. [healthonnet.org]
may also be a treatment option. [chicagoendoscopy.com]
It is not intended as medical advice for individual conditions or treatments. [drugs.com]
Prognosis
PMID 18267927 Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Miettinen M, Lasota J. Arch Pathol Lab Med. 2006 Oct;130(10):1466-78. [atlasgeneticsoncology.org]
Once a polyp is observed, it is removed or biopsied and its pathology identified Prognosis and management are specific to the underlying pathology. ©1st Postgraduate course, SSG Feb 13, SAID EM 22. [slideshare.net]
Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol. 2002; 33 (5):478–483. [ PubMed ] 72. Miettinen M, Sarlomo-Rikala M, Lasota J. [ncbi.nlm.nih.gov]
Google Scholar Jaffin BW, Kaye MD: The prognosis of gastric outlet obstruction. Ann Surg. 1985, 201: 176-179. [bmcgastroenterol.biomedcentral.com]
Accordingly, the present inventors have made extensive efforts to develop an effective gastric-cancer-specific methylation marker which makes it possible to diagnose cancer and the risk of carcinogenesis at an early stage and predict cancer prognosis. [patents.google.com]
Etiology
[…] an extremely rare presentation. [1,3] History of long term use of proton pump inhibitors (PPI) Long term use of PPIs leads to the development of fundic gland polyps. [1,2] History of Helicobacter pylori infection H. pylori infection is a recognized etiological [explainmedicine.com]
Recent studies suggest a neoplastic etiology due to a mutation, in some cases, in the alpha-type platelet-derived growth factor receptor gene (PDGFRa). [jbpml.org.br]
Disease Gastric adenocarcinoma Etiology Helicobacter pylori H. pylori is the single most important etiological agent in the pathogenesis of gastric cancer. [atlasgeneticsoncology.org]
Etiology and Pathophysiology Fundic gland polyp Sessile lesion usually Very low risk for malignancy (except in FAP syndrome) Associated with long-term PPI use Histology shows dilated oxyntic glands, lined by flattened parietal and mucous cells. [unboundmedicine.com]
Gross blood loss from ulcerated gastric hyperplastic polyps Figure 2: Large pedunculated gastric hyper plastic polyp 5 cm in longest diameter Figure 3: Endoclip placement for hemostasis We recommend that physicians become aware of large HPPs as rare etiology [sciforschenonline.org]
Epidemiology
↳ Vaccines Parenteral and Oral ↳ Immune Response ↳ Basic Science / Molecular Epidemiology / Evolution ↳ Toxins (esp. [helico.com]
Epidemiology • Frequency and type of gastric polyps vary depending on the population and location. [slideshare.net]
Epithelial (most common): fundic gland, hyperplastic, adenomas Endocrine: carcinoid tumors Infiltrative: xanthomas and lymphoid proliferations Mesenchymal: gastrointestinal stromal tumor (GIST), leiomyoma, fibroma, lipoma Inflammatory fibroid polyp Epidemiology [unboundmedicine.com]
Castano LR, Ruiz VMH, Jaramillo P, Sanín FE, Botero ML, et al. (2005) Gastric Polyps: epidemiological aspects and its relation with proton pump inhibitors. Rev Col Gastroenterol 20: 48-59. [omicsonline.org]
[…] appearance can occur Lamina propria shows edema, congestion, variable acute and chronic inflammation Smooth muscle strands can be seen extending from muscularis mucosa towards surface Thick walled vessels may be present towards the base of the polyp Epidemiology [pathologyoutlines.com]
Pathophysiology
Etiology and Pathophysiology Fundic gland polyp Sessile lesion usually Very low risk for malignancy (except in FAP syndrome) Associated with long-term PPI use Histology shows dilated oxyntic glands, lined by flattened parietal and mucous cells. [unboundmedicine.com]
[…] pump inhibitors (proposed by some authors, denied by others) [10] [11] [12] [13] Helicobacter pylori infection: there is a reverse relationship between infection and fundic gland polyps, and infection by H pylori causes polyps regression. [14] [15] Pathophysiology [en.wikipedia.org]
Prevention
The key is not the amount, although this helps somewhat, it is keeping a steady stream of polyols through FREQUENCY OF DOSE to prevent virus from attaching the cells. [earthclinic.com]
Although endoscopic coagulation of the pedicle proceeded slowly and with the utmost care causing apparently adequate coagulation of the stalk, the depth, of coagulation appeared insufficient to prevent major haemorrhage. [ncbi.nlm.nih.gov]
[…] steps you can take to prevent polyps, especially if you have a family history of polyps. [healthline.com]
This can be done with: Endoscopy Gastrostomy —removal through a cut in the stomach wall Partial gastrectomy —partial removal of the stomach to remove multiple polyps Not all polyps can be prevented. [health.cvs.com]