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Gastric Syphilis


Presentation

  • Gastroscopy should be considered if syphilis of the tonsil is observed, particularly when gastrointestinal symptoms are present. Both the oral and the gastric lesion can be mistaken for malignant neoplasm.[ncbi.nlm.nih.gov]
  • The most common presenting symptoms were abdominal pain, nausea, and vomiting with signs of syphilis present in five patients (71%).[ncbi.nlm.nih.gov]
  • To the best of our knowledge this is the first report of gastric syphilis mimicking a lymphoma, and we believe that the recognition of this presentation is of particular importance to correctly set the disorder especially for therapeutic purposes and[ncbi.nlm.nih.gov]
  • Gastric syphilis is an uncommon extracutaneous manifestation of syphilis, occurring in less than 1% of patients, presenting nonspecific clinical manifestations. In general, it occurs on secondary stage.[ncbi.nlm.nih.gov]
  • Herein, we present a case of a 40-year-old HIV-infected man with gastric syphilis. Evaluation revealed a rapid plasma reagin (RPR) of 1:2056, and cerebrospinal fluid with evidence of neurosyphilis.[ncbi.nlm.nih.gov]
Pathologist
  • Gastroenterologists and pathologists must have an awareness that gastric syphilis can mimic lymphocytic gastritis and gastric lymphoma.[ncbi.nlm.nih.gov]
  • Kradin is also an Associate Pathologist at Massachusetts General Hospital in the Immunopathology Unit. His techniques include tissue culture and immunocytochemistry, flow cytometry, Northern blotting and immunocytochemistry. Dr.[books.google.com]
  • Pathologists in general are therefore inclined to look on most clinical reports as unreliable. Their attitude is tersely expressed in a statement by Sternberg 4[jamanetwork.com]
  • Clinicians must provide the following clinical details to the pathologist - History of immunosuppression, intake of drugs, past history of tuberculosis, sarcoidosis, Crohn's etc.[histopathology-india.net]
  • Several case reports and small series emphasize the importance of the gastroenterologist and pathologist remaining alert to the protean manifestations of syphilis and familiar with the histopathologic pattern of the disease.[clinicalgate.com]
Prostitute
  • Aka Prostitiues pupils – like prostitutes, they accommodate, but they don’t react![almostadoctor.co.uk]
  • Taking Fowler’s solution, a potassium arsenite solution developed by Thomas Fowler in 1786 as a treatment for various chronic disorders, was popular with Victorian prostitutes to give them rosy cheeks, an effect due to damage to the capillaries of the[jmvh.org]
  • Risk factors for syphilis: cocaine use and prostitution. Am J Public Health. 1990; 80 :853–857. [ PMC free article ] [ PubMed ] [ Google Scholar ] 282.[ncbi.nlm.nih.gov]
Chronic Fatigue Syndrome
  • Kradin has a number of clinical interests including Chronic Fatigue Syndrome, Interstitial Lung Disease, Multiple Chemical Sensitivity and Pulmonary Immunology. He also holds an Associate Professor position of Pathology at Harvard Medical School.[books.google.com]
Snoring
  • He complained of nausea and snoring; his left tonsil was enlarged. Spirochetes were detected in a smear preparation from the left tonsil.[ncbi.nlm.nih.gov]
Gastropathy
  • ., Hypertrophic gastropathy with gastric adenocarcinoma: Menetrier’s disease and lymphocytic gastritis? Gut. 1991;32:1565-7. INTERNET Feldman M and Jensen PJ. Large gastric folds: Hyperplastic and nonhyperplastic gastropathies. UpToDate.[rarediseases.org]
  • Ulceroinfiltrative syphilitic gastropathy: silver stain diagnosis from biopsy specimen. Am J Gastroenterol 1987;82:773–774. 9. Winters HA, Notar-Francesco V, Bromberg K, Rawstrom SA, Vetrano J, Prego V, Kuan J, Raufman JP.[synapse.koreamed.org]
  • Immuno-peroxidase technique (ABC method) used in formalin-fixed gastric biopsy specimens is extremely useful and essential for the diagnosis of syphilitic gastropathy. Copyright 1989, Igaku-Shoin Ltd. All rights reserved.[webview.isho.jp]
  • A hypertrophic and/or polypoid type of gastritis resembling Ménétrier’s disease with a similar type of protein-losing gastropathy has been described. 58, 59 Examination of biopsy specimens shows inflammatory debris, chronic active gastritis, and enlarged[clinicalgate.com]
Epigastric Tenderness
  • We report a 43-yr-old man suffering from epigastric tenderness with an initial diagnosis of gastric carcinoma; gastric syphilis was confirmed by demonstrating spirochetes in a gastric biopsy specimen by silver impregnation.[ncbi.nlm.nih.gov]
  • Epigastric pain/fullness was the most common presenting symptom (92%) and epigastric tenderness being the most common sign. Gastric bleeding of variable intensity was documented in 35% of the cases.[ncbi.nlm.nih.gov]
  • A 43-yr-old, apparently healthy man presented with a one month history of epigastric tenderness and anorexia.[synapse.koreamed.org]
  • CPC case: gastric syphilis History: A 25-year-old, apparently healthy man presented with one month history of epigastric tenderness and vomiting.[endotoday.com]
Abdominal Tenderness
  • Physical examination was normal except for mild abdominal tenderness in epigastrium. Endoscopy observed diminished gastric expandability and diffuse mucosal lesions, from cardia to pylorus.[endovitta.com.br]
  • Follow-Up Hospitalized patients receiving IV therapy should show substantial clinical improvement (e.g., defervescence, reduction in direct or rebound abdominal tenderness, and reduction in uterine, adnexal, and cervical motion tenderness) within 3-5[cdc.gov]
Facial Numbness
  • Here you can read posts from all over the web from people who wrote about Heartburn and Negative Pregnancy Test, about Negative Pregnancy Test and Heartburn on January 25, 2013 gerd Facial Numbness, Can Heartburn Cause Facial Numbness nursing Intervention[ict-accordance.eu]
Sexual Dysfunction
  • Dysfunction 1203 Chapter 104 Womens Sexual Dysfunction 1210 Chapter 105 Sexuality Education for Young People 1221 A CultureBound Sex Related Disorder in Indian Subcontinent 1225 Chapter 107 Clinical Services for Sexually Transmitted Infections and HIV[books.google.com]
Neurologic Manifestation
  • Manifestations of HIV 910 Chapter 77 Gastrointestinal Manifestations of HIV Infection and AIDS 927 Chapter 78 Renal Manifestations of HIV Infection and AIDS 951 Chapter 79 HIV and Endocrine Manifestations 960 Chapter 80 AIDS Associated Malignancies and[books.google.com]

Workup

  • Patients who do not demonstrate improvement within this time period usually require further diagnostic workup or surgical intervention, or both.[cdc.gov]
Gastric Lesion
  • Both the oral and the gastric lesion can be mistaken for malignant neoplasm.[ncbi.nlm.nih.gov]
  • To establish the diagnosis, evidence of Treponema pallidum in the gastric lesion is necessary. However, it is sometimes difficult to prove the presence of the organisms by conventional methods.[ncbi.nlm.nih.gov]
  • This case reminds us that gastric syphilis is one possibility in ulcerative gastric lesions.[ncbi.nlm.nih.gov]
  • Diagnostic antisyphilitic therapy improved the symptoms and gastric lesion promptly.[ncbi.nlm.nih.gov]
  • However, gastric syphilis should be considered in patients at risk for sexually transmitted disease who complain of nausea, vomiting, and abdominal pain and in whom unusual gastric lesions or presumed peptic ulcers resistant to standard therapy are found[ncbi.nlm.nih.gov]
Gastric Lesion
  • Both the oral and the gastric lesion can be mistaken for malignant neoplasm.[ncbi.nlm.nih.gov]
  • To establish the diagnosis, evidence of Treponema pallidum in the gastric lesion is necessary. However, it is sometimes difficult to prove the presence of the organisms by conventional methods.[ncbi.nlm.nih.gov]
  • This case reminds us that gastric syphilis is one possibility in ulcerative gastric lesions.[ncbi.nlm.nih.gov]
  • Diagnostic antisyphilitic therapy improved the symptoms and gastric lesion promptly.[ncbi.nlm.nih.gov]
  • However, gastric syphilis should be considered in patients at risk for sexually transmitted disease who complain of nausea, vomiting, and abdominal pain and in whom unusual gastric lesions or presumed peptic ulcers resistant to standard therapy are found[ncbi.nlm.nih.gov]
Lymphocytic Infiltrate
  • Chronic inflammation due to prominent plasma cells and lymphocytic infiltration suggests that syphilis be investigated as a potential cause. In present case, endovasculitis or hypertrophic arterial or venular walls were not prominent.[synapse.koreamed.org]

Treatment

  • Response to treatment is usually prompt and complete. The current syphilis epidemic will likely result in an increased incidence of gastric syphilis.[ncbi.nlm.nih.gov]
  • Positive results of serological tests for syphilis and regression of the lesions after antisyphilitic treatment were confirmatory of the diagnosis.[ncbi.nlm.nih.gov]
  • Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments.[books.google.com]
  • […] of HIV in Industrialized and Middle Income CountriesŠAdults Adolescents and Pediatric 1310 Chapter 115 Guidelines for the Treatment of HIV and AIDS in ResourceLimited Countries 1328 Chapter 116 Guidelines for Prevention of Perinatal HIV Infection 1345[books.google.com]
  • Features consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more that make reference quick and easy.[books.google.com]

Prognosis

  • Prognosis [ edit ] Left untreated, tabes dorsalis can lead to paralysis , dementia , and blindness . Existing nerve damage cannot be reversed. Epidemiology [ edit ] The disease is more frequent in males than in females.[en.wikipedia.org]
  • If the disease is recognized only by histologic examination, the prognosis is good. Prolonged (6- to 12-month) high-dose antibiotic treatment with penicillin or amoxicillin is indicated.[clinicalgate.com]

Etiology

  • The findings are etiologically non-specific and a high index of clinical suspicion is needed to prompt further evaluation and definitive diagnosis.[uscapknowledgehub.org]
  • Other rare etiologies for gastric ulcers may include unusual systemic diseases and unusual infectious pathogens. - Uncommon systemic diseases: Crohn's disease, mastocytosis, amyloidosis, sarcoidosis, vasculitis, eosinophilic gastroenteritis, and Zollinger-Ellison[karger.com]
  • Urologic examinations do not usually reveal a specific etiology.[cdc.gov]
  • Sanchez J, Volquez C, Totten PA, Campos PE, Ryan C, et al. (2002) The etiology and management of genital ulcers in the Dominican Republic and Peru. Sex Transm Dis 29: 559–567. View Article Google Scholar 57.[journals.plos.org]
  • The etiology of anorectal infections in homosexual men. Am J Med. 1981; 71 :395–406. [ PubMed ] [ Google Scholar ] 269.[ncbi.nlm.nih.gov]

Epidemiology

  • Studies in the epidemiology of syphilis: epidemiologic investigations in a series of 996 cases of acquired syphilis. Vener Dis Inform. 1940; 21 :349–369. [ Google Scholar ] 55. Clark E G, Danbolt N.[ncbi.nlm.nih.gov]
  • Epidemiology The number of cases in the UK is on the increase. In recent years there have been particular outbreaks in certain cities in the UK.[almostadoctor.co.uk]
  • An epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material. J Chronic Dis 2: 311–344. View Article Google Scholar 21.[journals.plos.org]
  • Epidemiology [ edit ] The disease is more frequent in males than in females. Onset is commonly during mid-life. The incidence of tabes dorsalis is rising, in part due to co-associated HIV infection [ citation needed ] .[en.wikipedia.org]
  • Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC: Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion 2011;84:102-113.[karger.com]
Sex distribution
Age distribution

Prevention

  • Features consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more that make reference quick and easy.[books.google.com]
  • Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic[books.google.com]
  • Gastric acidity would not prevent the organism from passing into the gut. 胃的酸度不能防止细菌进入肠道。 a gastric duodenal ] ulcer 胃十二指肠]溃疡 gastric stasis may result in nausea and vomiting 胃潴留可引起恶心和呕吐。 The wall of the stomach secretes gastric juice. 胃壁分泌胃液。[hujiang.com]
  • Heart failure then is a medical condition that needs to be treated to prevent a life-threatening heart attack.[ict-accordance.eu]
  • Prevention Messages Preventing the spread of STDs requires that persons at risk for transmitting or acquiring infections change their behaviors.[cdc.gov]

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