Presentation
Gastroscopy should be considered if syphilis of the tonsil is observed, particularly when gastrointestinal symptoms are present. Both the oral and the gastric lesion can be mistaken for malignant neoplasm. [ncbi.nlm.nih.gov]
Presents more than 1,200 optimally sized multi-modality clinical images to help you recognize the characteristic appearance of both common and uncommon GI disorders. [books.google.com]
Entire Body System
- Lymphadenopathy
There may also be: Malaise / fever Sore throat Arthralgia Lymphadenopathy Alopecia Condylomata lata These are number moist papules found around the genital region Ulcers of the palate and buccal region Snail track ulcers – found in the mouth and genitalia [almostadoctor.co.uk]
Unilateral ulcerated tonsillar tumor with bilateral lymphadenopathy due to syphilis mimicking oropharyngeal cancer: A case report. Acta Oto-Laryngologica Case Reports, Vol. 1, Issue. 1, p. 126. [cambridge.org]
Importantly, two-thirds of patients have no concurrent clinical findings of syphilis such as genital ulcer, inguinal lymphadenopathy, or rash [2]. [ncbi.nlm.nih.gov]
Lymphadenopathy, mild fever, malaise, and weight loss are also common in secondary syphilis. The symptoms of secondary syphilis last several weeks, after which the patient enters the latent phase of the disease. [humpath.com]
Serial CT scans of the abdomen may show mesenteric lymphadenopathy. Endoscopy may show a chronic gastric ulcer, a coarsely granular duodenal mucosa, or fine white duodenal nodules. [clinicalgate.com]
Respiratoric
- Pharyngitis
Dense plasma cell-rich inflammation is a clue. https://twitter.com/RhondaYantiss/status/849812119860260865 https://twitter.com/Dermpathl/status/793593312154296320 syphilitic pharyngitis https://twitter.com/JAMADerm/status/675684032517185536 Stages primary [humpath.com]
Cefixime appears to be effective against pharyngeal gonococcal infection, but few patients with pharyngeal infection have been included in studies. No gonococcal strains resistant to cefixime have been reported. [cdc.gov]
For the last 7 days, he took doxycycline ordered by a general practitioner because of pharyngitis. [karger.com]
- Sore Throat
There may also be: Malaise / fever Sore throat Arthralgia Lymphadenopathy Alopecia Condylomata lata These are number moist papules found around the genital region Ulcers of the palate and buccal region Snail track ulcers – found in the mouth and genitalia [almostadoctor.co.uk]
Gastrointestinal
- Gastropathy
Mosnier JF, et al., Hypertrophic gastropathy with gastric adenocarcinoma: Menetrier’s disease and lymphocytic gastritis? Gut. 1991;32:1565-7. INTERNET Feldman M and Jensen PJ. Large gastric folds: Hyperplastic and nonhyperplastic gastropathies. [rarediseases.org]
Immuno-peroxidase technique (ABC method) used in formalin-fixed gastric biopsy specimens is extremely useful and essential for the diagnosis of syphilitic gastropathy. Copyright © 1989, Igaku-Shoin Ltd. All rights reserved. [webview.isho.jp]
Ulceroinfiltrative syphilitic gastropathy: silver stain diagnosis from biopsy specimen. Am J Gastroenterol 1987;82:773–774. 9. Winters HA, Notar-Francesco V, Bromberg K, Rawstrom SA, Vetrano J, Prego V, Kuan J, Raufman JP. [synapse.koreamed.org]
A hypertrophic and/or polypoid type of gastritis resembling Ménétrier’s disease with a similar type of protein-losing gastropathy has been described. 58, 59 Examination of biopsy specimens shows inflammatory debris, chronic active gastritis, and enlarged [clinicalgate.com]
Musculoskeletal
- Fracture
Skeletal involvement characteristically causes local pain, tenderness, swelling, and sometimes pathologic fractures. [humpath.com]
In addition, freeze-fracture microscopy studies have shown that the spirochete is largely devoid of integral outer-membrane proteins [73], [74]. [journals.plos.org]
Skin
- Skin Lesion
Gastric syphilis was then considered based on skin lesions and serological studies. Diagnostic antisyphilitic therapy improved the symptoms and gastric lesion promptly. [ncbi.nlm.nih.gov]
A darkfield examination of fluid expressed directly from a lesion is the time-honored diagnostic test for patients with the skin lesions of primary and secondary syphilis. [cancertherapyadvisor.com]
The skin lesions, which frequently occur on the palms or soles of the feet, may be maculopapular, scaly, or pustular. [humpath.com]
The figure shows histopathologic anomalies seen in punch biopsies obtained from four secondary syphilis patients skin lesions. Corresponding clinical appearance of the lesions are also shown. [journals.plos.org]
neurologic, ophthalmic, auditory, or gummatous lesions). [cdc.gov]
Eyes
- Visual Impairment
impairment, positive Romberg's test, and impaired response to light ( Argyll Robertson pupil ). [en.wikipedia.org]
Urogenital
- Urinary Incontinence
incontinence, dementia, deafness, visual impairment, positive Romberg's test, and impaired response to light ( Argyll Robertson pupil ). [en.wikipedia.org]
Neurologic
- Neurologic Manifestation
[…] of HIV 871 Chapter 75 Pulmonary Manifestations of HIV Disease 894 Chapter 76 Neurological Manifestations of HIV 910 Chapter 77 Gastrointestinal Manifestations of HIV Infection and AIDS 927 Chapter 78 Renal Manifestations of HIV Infection and AIDS 951 [books.google.com]
- Aphasia
Other presenting problems include aphasia and seizures. [cancertherapyadvisor.com]
Workup
Patients who do not demonstrate improvement within this time period usually require further diagnostic workup or surgical intervention, or both. [cdc.gov]
Gastroscopy
- Gastric Lesion
Both the oral and the gastric lesion can be mistaken for malignant neoplasm. [ncbi.nlm.nih.gov]
Treatment
Response to treatment is usually prompt and complete. The current syphilis epidemic will likely result in an increased incidence of gastric syphilis. [ncbi.nlm.nih.gov]
Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. [books.google.com]
However, due to the wide range of possible complications and unusual symptoms after intragastric balloon treatment, an interdisciplinary, instead of only a surgical or endoscopic, treatment and follow-up might be recommended in these patients. [karger.com]
(See the treatment recommendations section.) [cancertherapyadvisor.com]
Prognosis
Prognosis [ edit ] Left untreated, tabes dorsalis can lead to paralysis, dementia, and blindness. Existing nerve damage cannot be reversed. Epidemiology [ edit ] The disease is more frequent in males than in females. [en.wikipedia.org]
If the disease is recognized only by histologic examination, the prognosis is good. Prolonged (6- to 12-month) high-dose antibiotic treatment with penicillin or amoxicillin is indicated. [clinicalgate.com]
Etiology
These findings can mimic other etiologies, including infiltrating tumor, lymphoma, and Crohn’s disease. [ncbi.nlm.nih.gov]
The findings are etiologically non-specific and a high index of clinical suspicion is needed to prompt further evaluation and definitive diagnosis. [uscapknowledgehub.org]
Other rare etiologies for gastric ulcers may include unusual systemic diseases and unusual infectious pathogens. - Uncommon systemic diseases: Crohn's disease, mastocytosis, amyloidosis, sarcoidosis, vasculitis, eosinophilic gastroenteritis, and Zollinger-Ellison [karger.com]
Urologic examinations do not usually reveal a specific etiology. [cdc.gov]
Sanchez J, Volquez C, Totten PA, Campos PE, Ryan C, et al. (2002) The etiology and management of genital ulcers in the Dominican Republic and Peru. Sex Transm Dis 29: 559–567. View Article Google Scholar 57. [journals.plos.org]
Epidemiology
Structures every chapter consistently to include Findings, Imaging Modalities, Clinical Presentation, Pathology, Incidence/Prevalence and Epidemiology, What the Referring Physician Needs to Know, Suggested Readings, and Selected Images to make reference [books.google.com]
Studies in the epidemiology of syphilis: epidemiologic investigations in a series of 996 cases of acquired syphilis. Vener Dis Inform. 1940; 21 :349–369. [ Google Scholar ] 55. Clark E G, Danbolt N. [ncbi.nlm.nih.gov]
Epidemiology The number of cases in the UK is on the increase. In recent years there have been particular outbreaks in certain cities in the UK. [almostadoctor.co.uk]
An epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material. J Chronic Dis 2: 311–344. View Article Google Scholar 21. [journals.plos.org]
Prevention
Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic [books.google.com]
Prevention Messages Preventing the spread of STDs requires that persons at risk for transmitting or acquiring infections change their behaviors. [cdc.gov]
Gastric acidity would not prevent the organism from passing into the gut. 胃的酸度不能防止细菌进入肠道。 a gastric duodenal ] ulcer 胃十二指肠]溃疡 gastric stasis may result in nausea and vomiting 胃潴留可引起恶心和呕吐。 The wall of the stomach secretes gastric juice. 胃壁分泌胃液。 [hujiang.com]
Mucus – fd in moderate amts secreted by GOBLET cells of stomach to prevent autodigestion of stomach 4. Composition6.) Electrolytes – main electrolytes present is H+; also present are Na, Cl, P, Ca and Mg7.) [slideshare.net]
Division of STD Prevention. Sexually transmitted disease surveillance, 1996. Atlanta, Ga: Centers for Disease Control and Prevention; 1997. [ Google Scholar ] 73. Division of STD Prevention and Control. Syphilis: epidemiology and control. [ncbi.nlm.nih.gov]