Presentation
Gastroscopy should be considered if syphilis of the tonsil is observed, particularly when gastrointestinal symptoms are present. Both the oral and the gastric lesion can be mistaken for malignant neoplasm. [ncbi.nlm.nih.gov]
Presents more than 1,200 optimally sized multi-modality clinical images to help you recognize the characteristic appearance of both common and uncommon GI disorders. [books.google.com]
Immune System
- Inguinal Lymphadenopathy
Importantly, two-thirds of patients have no concurrent clinical findings of syphilis such as genital ulcer, inguinal lymphadenopathy, or rash [2]. [ncbi.nlm.nih.gov]
The most common clinical manifestation of LGV among heterosexuals is tender inguinal lymphadenopathy that is most commonly unilateral. [cdc.gov]
Entire Body System
- Pain
The most common presenting symptoms were abdominal pain, nausea, and vomiting with signs of syphilis present in five patients (71%). [ncbi.nlm.nih.gov]
You may experience pains that feel like heartburn or period pains in early pregnancy Really threw You must be a member to answer questions. [ict-accordance.eu]
A 57-year-old man presented with weight loss and severe epigastric pain that had lasted for three weeks and was not relieved by anti-acids. [em-consulte.com]
Now more commonly called "tabetic ocular crises", an attack is characterized by sudden, intense eye pain, tearing of the eyes and sensitivity to light. [1] [2] "Tabes dorsalgia" is a related lancinating back pain. [en.wikipedia.org]
- Weight Loss
A 57-year-old man presented with weight loss and severe epigastric pain that had lasted for three weeks and was not relieved by anti-acids. [em-consulte.com]
The most common clinical manifestations of gastric syphilis are abdominal pain, vomiting, and weight loss. Endoscopic findings in the stomach range from minimal nodularity and erythema to deep ulceration. [ncbi.nlm.nih.gov]
A 23-year-old man presented with epigastric pain associated with nausea, anorexia, generalized malaise and 11 kg weight loss that started 1 month prior to his clinical consultation. [endovitta.com.br]
Epigastric pain, anorexia, nausea, vomiting and weight loss are common symptoms in gastric syphilis ( 2 ), but there are no clear diagnostic criteria. [synapse.koreamed.org]
- Lymphadenopathy
There may also be: Malaise / fever Sore throat Arthralgia Lymphadenopathy Alopecia Condylomata lata These are number moist papules found around the genital region Ulcers of the palate and buccal region Snail track ulcers – found in the mouth and genitalia [almostadoctor.co.uk]
Unilateral ulcerated tonsillar tumor with bilateral lymphadenopathy due to syphilis mimicking oropharyngeal cancer: A case report. Acta Oto-Laryngologica Case Reports, Vol. 1, Issue. 1, p. 126. [cambridge.org]
Importantly, two-thirds of patients have no concurrent clinical findings of syphilis such as genital ulcer, inguinal lymphadenopathy, or rash [2]. [ncbi.nlm.nih.gov]
Lymphadenopathy, mild fever, malaise, and weight loss are also common in secondary syphilis. The symptoms of secondary syphilis last several weeks, after which the patient enters the latent phase of the disease. [humpath.com]
Serial CT scans of the abdomen may show mesenteric lymphadenopathy. Endoscopy may show a chronic gastric ulcer, a coarsely granular duodenal mucosa, or fine white duodenal nodules. [clinicalgate.com]
- Weakness
Those with tabes dorsalis may also require physical therapy to deal with muscle wasting and weakness. Preventive treatment for those who come into sexual contact with an individual with syphilis is important. [en.wikipedia.org]
Muscle weakness, pain, decreased muscle coordination, and loss of movement of the limbs are possible. heart and blood vessel damage: Syphilis has a particular tendency to damage the walls of the aorta, the body's biggest artery, which can lead to an aneurysm [medbroadcast.com]
Anamnesis revealed, among other symptoms, weakness, easy fatigue, and melena in the previous few days. For the last 7 days, he took doxycycline ordered by a general practitioner because of pharyngitis. [karger.com]
[…] were written and tables of evidence constructed summarizing the type of study (e.g., randomized controlled trial, case series), the study population and setting, the treatments or other interventions, outcome measures assessed, reported findings, and weaknesses [cdc.gov]
- Mucosal Edema
The endoscopic findings include mucosal edema, erosions, superficial ulcers, nodularity, and hypertrophy of gastric folds [3]. These findings can mimic other etiologies, including infiltrating tumor, lymphoma, and Crohn’s disease. [ncbi.nlm.nih.gov]
Gastrointestinal
- Nausea
The most common presenting symptoms were abdominal pain, nausea, and vomiting with signs of syphilis present in five patients (71%). [ncbi.nlm.nih.gov]
Case 3 : A 20-year-old unmarried female complained of severa epigastralgia with nausea and loss of appetite. Upper GI series revaled scattered and small spots of the antrum of the stomach. [petit.lib.yamaguchi-u.ac.jp]
- Vomiting
The most common presenting symptoms were abdominal pain, nausea, and vomiting with signs of syphilis present in five patients (71%). [ncbi.nlm.nih.gov]
A 36 year-old man presented with complaints of nausea of two months duration, 3-4 weeks of burning upper abdominal pain, and several days of protracted vomiting with intermittent hematemesis (vomiting of blood). [endoatlas.com]
Case 2 : A 35-year-old married female complained of severa epigastric dull pain, naused, and vomitting. Upper GI series revealed multiple irregular depressed lesions, but no narrowing of the antrum of the stomach. [petit.lib.yamaguchi-u.ac.jp]
- Epigastric Pain
A 61-year-old man suffering from epigastric pain, nausea, and vomiting had an initial diagnosis of gastric carcinoma; the pathologic diagnosis was equivocal. Eventually, gastric syphilis was diagnosed. [ncbi.nlm.nih.gov]
A 23-year-old man presented with epigastric pain associated with nausea, anorexia, generalized malaise and 11 kg weight loss that started 1 month prior to his clinical consultation. [endovitta.com.br]
- Gastropathy
Mosnier JF, et al., Hypertrophic gastropathy with gastric adenocarcinoma: Menetrier’s disease and lymphocytic gastritis? Gut. 1991;32:1565-7. INTERNET Feldman M and Jensen PJ. Large gastric folds: Hyperplastic and nonhyperplastic gastropathies. [rarediseases.org]
Immuno-peroxidase technique (ABC method) used in formalin-fixed gastric biopsy specimens is extremely useful and essential for the diagnosis of syphilitic gastropathy. Copyright © 1989, Igaku-Shoin Ltd. All rights reserved. [webview.isho.jp]
Ulceroinfiltrative syphilitic gastropathy: silver stain diagnosis from biopsy specimen. Am J Gastroenterol 1987;82:773–774. 9. Winters HA, Notar-Francesco V, Bromberg K, Rawstrom SA, Vetrano J, Prego V, Kuan J, Raufman JP. [synapse.koreamed.org]
A hypertrophic and/or polypoid type of gastritis resembling Ménétrier’s disease with a similar type of protein-losing gastropathy has been described. 58, 59 Examination of biopsy specimens shows inflammatory debris, chronic active gastritis, and enlarged [clinicalgate.com]
Liver, Gall & Pancreas
- Hepatomegaly
A tender hepatomegaly with irregular borders was palpable two centimeters below the right costal margin. [scielo.mec.pt]
Hepatomegaly and skeletal abnormalities are also common. Nearly half of untreated children with neonatal syphilis will develop late manifestations. [humpath.com]
Skin
- Ulcer
Unless syphilis is considered as a cause of gastric mucosal inflammation and ulceration, misdiagnosis may delay appropriate treatment, and serious complications can occur. [ncbi.nlm.nih.gov]
Gastric ulcer, also stomach ulcer, is pathology of the stomach that is evident grossly. It can be benign or malignant. General May be benign or malignant. Causes: Gastric carcinoma. Peptic ulcer disease. Helicobacter gastritis. [librepathology.org]
• Polypoid —barium in interstices, frequently with ulceration; sometimes resembles metastatic disease such as melanoma • Ulcerative —shallow, saucer-like ulcer indistinguishable from ca • Infiltrative —thickened, irregular folds, simulating the appearance [learningradiology.com]
Furthermore, gastric ulcer may be the result of stress (hypoxic ischemic mucosa), may occur in the course of sepsis [ 26 ], severe burn (Curling's ulcer) [ 27 ], or after brain injuries (Cushing's ulcer) [ 28 ]. [karger.com]
- Erythema
Endoscopic findings in the stomach range from minimal nodularity and erythema to deep ulceration. Complications of gastric syphilis include hemorrhage, gastric outlet obstruction, and perforation. [ncbi.nlm.nih.gov]
The endoscopic appearance may vary from diffuse edema, erythema, friable or multiple erosions, to ulceration. Moreover, endoscopic gastric mucosal biopsies are often nonspecific histologically. [synapse.koreamed.org]
Endoscopy shows numerous shallow, irregular ulcers with overlying white exudate and surrounding erythema (see Fig. 51-5 B ). The surrounding mucosa also demonstrates a nodular appearance. [clinicalgate.com]
Diagnostic Considerations A diagnosis of Candida vaginitis is suggested clinically by pruritus in the vulvar area together with erythema of the vagina or vulva; a white discharge may occur. [cdc.gov]
- Eruptions
The rash of congenital syphilis is more severe than that of adult secondary syphilis, with bullous eruption of the palms and soles of the feet and epidermal sloughing. [humpath.com]
In agreement with Chapel's [32] and Mindel's classic descriptions of SS [32], [33], most subjects also had faint macular and papular eruptions, which were diffusely disseminated over the trunk and upper and lower extremities ( Figure 3A–B ). [journals.plos.org]
Urogenital
- Genital Lesions
There were no genital lesions. [ncbi.nlm.nih.gov]
However, the majority of persons with genital HSV infection do not have a history of typical genital lesions. [cdc.gov]
Workup
Patients who do not demonstrate improvement within this time period usually require further diagnostic workup or surgical intervention, or both. [cdc.gov]
Microbiology
- Treponema Pallidum
Syphilis serologies were positive for VDRL and Treponema pallidum reagents. Immunohistochemical tests were positive for Treponema pallidum and CD138. [endovitta.com.br]
Abstract Syphilis, a venereal infection caused by the spirochetal bacterium Treponema pallidum, has long been considered a primary public health concern in the United States. [ncbi.nlm.nih.gov]
PICTURES IN CLINICAL MEDICINES Gastric Syphilis Naoya Itoh, Harutaka Katano, Shu-ichi Nakayama, Hanako Kurai Author information Keywords: gastric syphilis, Treponema pallidum JOURNALS OPEN ACCESS 2017 Volume 56 Issue 13 Pages 1753 DOI https://doi.org/ [jstage.jst.go.jp]
- Chlamydia
Treatment for chlamydia only, if the prevalence of N. gonorrhoeae is low but the likelihood of chlamydia is substantial. [cdc.gov]
Trends in sexually transmitted diseases in the United States: 2015 national data for gonorrhea, chlamydia and syphilis. Available at: http://www.cdc.gov/std/stats15/syphilis.htm. Accessed 29 November 2016.) [cancertherapyadvisor.com]
Gastroscopy
- Gastric Lesion
Both the oral and the gastric lesion can be mistaken for malignant neoplasm. [ncbi.nlm.nih.gov]
Treatment
Response to treatment is usually prompt and complete. The current syphilis epidemic will likely result in an increased incidence of gastric syphilis. [ncbi.nlm.nih.gov]
Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. [books.google.com]
However, due to the wide range of possible complications and unusual symptoms after intragastric balloon treatment, an interdisciplinary, instead of only a surgical or endoscopic, treatment and follow-up might be recommended in these patients. [karger.com]
(See the treatment recommendations section.) [cancertherapyadvisor.com]
Prognosis
Prognosis [ edit ] Left untreated, tabes dorsalis can lead to paralysis, dementia, and blindness. Existing nerve damage cannot be reversed. Epidemiology [ edit ] The disease is more frequent in males than in females. [en.wikipedia.org]
If the disease is recognized only by histologic examination, the prognosis is good. Prolonged (6- to 12-month) high-dose antibiotic treatment with penicillin or amoxicillin is indicated. [clinicalgate.com]
Etiology
These findings can mimic other etiologies, including infiltrating tumor, lymphoma, and Crohn’s disease. [ncbi.nlm.nih.gov]
The findings are etiologically non-specific and a high index of clinical suspicion is needed to prompt further evaluation and definitive diagnosis. [uscapknowledgehub.org]
Other rare etiologies for gastric ulcers may include unusual systemic diseases and unusual infectious pathogens. - Uncommon systemic diseases: Crohn's disease, mastocytosis, amyloidosis, sarcoidosis, vasculitis, eosinophilic gastroenteritis, and Zollinger-Ellison [karger.com]
Urologic examinations do not usually reveal a specific etiology. [cdc.gov]
Sanchez J, Volquez C, Totten PA, Campos PE, Ryan C, et al. (2002) The etiology and management of genital ulcers in the Dominican Republic and Peru. Sex Transm Dis 29: 559–567. View Article Google Scholar 57. [journals.plos.org]
Epidemiology
Structures every chapter consistently to include Findings, Imaging Modalities, Clinical Presentation, Pathology, Incidence/Prevalence and Epidemiology, What the Referring Physician Needs to Know, Suggested Readings, and Selected Images to make reference [books.google.com]
Studies in the epidemiology of syphilis: epidemiologic investigations in a series of 996 cases of acquired syphilis. Vener Dis Inform. 1940; 21 :349–369. [ Google Scholar ] 55. Clark E G, Danbolt N. [ncbi.nlm.nih.gov]
Epidemiology The number of cases in the UK is on the increase. In recent years there have been particular outbreaks in certain cities in the UK. [almostadoctor.co.uk]
An epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material. J Chronic Dis 2: 311–344. View Article Google Scholar 21. [journals.plos.org]
Prevention
Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic [books.google.com]
Prevention Messages Preventing the spread of STDs requires that persons at risk for transmitting or acquiring infections change their behaviors. [cdc.gov]
Gastric acidity would not prevent the organism from passing into the gut. 胃的酸度不能防止细菌进入肠道。 a gastric duodenal ] ulcer 胃十二指肠]溃疡 gastric stasis may result in nausea and vomiting 胃潴留可引起恶心和呕吐。 The wall of the stomach secretes gastric juice. 胃壁分泌胃液。 [hujiang.com]
Mucus – fd in moderate amts secreted by GOBLET cells of stomach to prevent autodigestion of stomach 4. Composition6.) Electrolytes – main electrolytes present is H+; also present are Na, Cl, P, Ca and Mg7.) [slideshare.net]
Division of STD Prevention. Sexually transmitted disease surveillance, 1996. Atlanta, Ga: Centers for Disease Control and Prevention; 1997. [ Google Scholar ] 73. Division of STD Prevention and Control. Syphilis: epidemiology and control. [ncbi.nlm.nih.gov]