[…] scp=1942540522&partnerID=8YFLogxK U2 - 10.1007/s00268-003-7019-3 DO - 10.1007/s00268-003-7019-3 M3 - Review article VL - 28 SP - 387 EP - 392 JO - Presentations from the 9th Annual Electric Utilities Environmental Conference JF - Presentations from the [mayoclinic.pure.elsevier.com]

As the majority of the case reported in Table 1a, our patient did not present genetic anomaly. Duodenal somatostatinomas usually presented a low malignancy and the prognosis is good. [em-consulte.com]

It can present as a small submucosal nodule with arterial enhancement (image) and sometimes they lead to intussusception. GIST Typical GIST in the ileum presenting as an exophytic tumor. [radiologyassistant.nl]

Most tumours are clinically silent but they may cause pain, weight loss or present as a palpable mass. [patient.info]

Some patients present with nonspecific symptoms such as nausea, vomiting, dyspepsia, abdominal discomfort, or with complications such as gastrointestinal bleeding ( 5 ). The index case presented with massive GI bleeding. [tgc.amegroups.com]

• Weight Loss

  Signs and symptoms of GI carcinoid tumors in the jejunum and ileum may include: Abdominal pain Weight loss for no known reason Feeling very tired Feeling bloated Diarrhea Nausea Vomiting Colon Signs and symptoms of GI carcinoid tumors in the colon may [cancer.osu.edu]

  The patient had no flushing, abdominal pain, weight loss, or history of travel. She had received medical attention several times, and was treated symptomatically with antidiarrheal agents without significant relief. She had no allergies. [jamanetwork.com]

  Clinical features WDHA syndrome (Watery Diarrhea, Hypokalemia, Achlorhydria ) Weight loss Abdominal pain, nausea, vomiting Achlorhydria → ↓ iron and B 12 absorption → anemia Diagnosis ↑ Serum VIP concentration (> 75 pg/mL) Hypokalemia, hypercalcemia, [amboss.com]

  loss for no known reason Feeling very tired Feeling bloated Diarrhea Nausea Vomiting Signs and symptoms of GI carcinoid tumors in the colon may include the following: Abdominal pain Weight loss for no known reason Signs and symptoms of GI carcinoid tumors [cancer.uvahealth.com]

  […] some weight loss vomitting sweats shakes hot cold pain emotional skin tone looked unhealthy Read Sharon Tirone's Story Jim Bio: I was diagnosed in 2006 with a very rare NET Carcinoid Tumor Syndrome which the doctors told me for a year and a half that [blogforacure.com]

• Anemia

  Having certain conditions that affect the stomach's ability to make stomach acid, such as atrophic gastritis, pernicious anemia, or Zollinger-Ellison syndrome. Source: National Cancer Institute [aacrfoundation.org]

  Anemia may be a result of bleeding, liver problems or poor nutrition related to cancer. [cityofhope.org]

  Tumor Risk factors for gastrointestinal carcinoid tumor include: Family history of multiple endocrine neoplasia type 1 (MEN1) syndrome Certain conditions that affect the stomach's ability to produce stomach acid, such as atrophic gastritis, pernicious anemia [cancer.memorialhermann.org]

  Gastric carcinoid tumors are incidentally discovered when upper gastrointestinal endoscopies are performed for symptoms of ulcer, dyspepsia, abdominal pain, or anemia. [medicinenet.com]

  […] following: Having a family history of multiple endocrine neoplasia type 1 (MEN1) syndrome or neurofibromatosis type 1 (NF1) syndrome Having certain conditions that affect the stomach's ability to make stomach acid, such as atrophic gastritis, pernicious anemia [cancer.uvahealth.com]

• Fatigue

  One or more of the following symptoms may indicate carcinoid syndrome: facial flushing diarrhea abdominal pain (caused by blockage of the intestines) shortness of breath or wheezing fatigue rapid heartbeat weight gain or loss heart valve damage Patients [mskcc.org]

  In some areas, these tumors build up and cause no symptoms while in others, the symptoms can be significant, including: Cramps Belly pain, bloating Diarrhea Nausea Vomiting Fatigue Weight loss Jaundice Pain and bleeding Anemia Hormone-related problems [cityofhope.org]

  If you do have symptoms, they may include the following: Abdominal pain or bloating Blood in the stool Changes in stool color Constipation Diarrhea Fatigue Flushed skin in the face and neck Heartburn Jaundice (yellowed skin) Nausea Rectal bleeding and [mercy.com]

  […] which can be a sign of pellagra, a severe deficiency of vitamin B3 Mental disturbances, another sign of pellagra Constipation Nausea and vomiting Weight loss that cannot be explained Jaundice, which is when the skin and whites of the eyes turn yellow Fatigue [cancer.net]

  Side effects can include fatigue and redness in the treated area. If you get radiation to the neck or throat, you may have a sore throat, cough, or get short of breath. Chemotherapy. It uses drugs to stop cancer cells from growing. [webmd.com]

• Pathologist

  Our multispecialty staff includes: Oncologists Surgeons Radiologists Pathologists Registered Nurses Social Workers These and other specialists work collaboratively in a tumor board to provide the best possible care by creating a comprehensive, individualized [moffitt.org]

  Endoscopic biopsy involves removing tissue or cells to be viewed later under a microscope by a pathologist, and usually is done during an endoscopy. Blood chemistry studies may be ordered to check whether you are anemic. [cityofhope.org]

  Lymph nodes are removed and checked by a pathologist to see if they contain cancer. Radiofrequency ablation: The use of a special probe with tiny electrodes that release high-energy radio waves (similar to microwaves) that kill cancer cells. [dvohmg.com]

  History [ edit ] They were first characterized in 1907 by Siegfried Oberndorfer, a German pathologist at the University of Munich, who coined the term karzinoide, or "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite [en.wikipedia.org]

  The hematoxylin and eosin (H&E)-stained slides and immunohistochemical stains from each case were reviewed by two pathologists (SKM and SAK) to confirm the diagnosis. [nature.com]

• Weakness

  Over a long period of time, these hormone-like substances can damage heart valves, causing shortness of breath, weakness, and heart murmur. They may also cause weight gain, weakness, high blood sugar or diabetes, and increased body and facial hair. [nyp.org]

  These substances can damage heart valves, causing weakness, heart murmur, and shortness of breath. [encyclopedia.com]

  Facial flushing, which is redness and a warm feeling over the face Sweating Diarrhea Shortness of breath Wheezing or asthma-like symptoms Unexplained weight gain Weakness Fast heartbeat Heart murmur High blood pressure and significant fluctuations in [cancer.net]

  […] bleeding from the bottom (rectal bleeding) a tumour in the lung may cause a cough, which may make you cough up blood, and cause wheezing, shortness of breath, chest pain and tiredness a tumour in the stomach may cause pain, weight loss, tiredness and weakness [nhs.uk]

  You might also get problems like: Diarrhea Feel short of breath or wheeze Heartbeat starts to speed up Weight loss Feel weak Hair starts to grow on your body and face How Are Carcinoid Tumors Diagnosed? A lot of times they're found by chance. [webmd.com]

• Cough

  and you sometimes might cough up some bloody mucus. [webmd.com]

  which may make you cough up blood, and cause wheezing, shortness of breath, chest pain and tiredness a tumour in the stomach may cause pain, weight loss, tiredness and weakness Some tumours may not cause any symptoms and are discovered by chance. [nhs.uk]

  Symptoms of tumors not causing carcinoid syndrome may include: Abdominal pain or pressure Change in bowel habits Blood in a bowel movement Chest pain Cough Wheezing Blood-tinged sputum Weight loss Symptoms caused by carcinoid syndrome may be triggered [oregon.providence.org]

  […] greater than 25 mg provides strong evidence for the diagnosis of carcinoid syndrome: False positive results may occur with certain foods (eg, bananas, kiwi fruit, pineapple, plums, tomato products) and some drugs (eg, paracetamol, antipsychotics, some cough [patient.info]

  These are: bananas, pineapple and its juice, red plums, avocado, walnuts and other nuts, kiwi fruit, tomatoes, various cough medicines muscle relaxing medicines, acetaminophen (Tylenol), caffeine, fluorouracil, iodine solutions (Lugol’s solution), phenacetin [carcinoid.org]

• Sore Throat

  If you get radiation to the neck or throat, you may have a sore throat, cough, or get short of breath. Chemotherapy. It uses drugs to stop cancer cells from growing. You might take these in the form of pills or get them put into you through a vein. [webmd.com]

• Abdominal Pain

  However, some patients may experience symptoms such as facial flushing, diarrhea, abdominal pain, asthma, a rash, and dark-colored stools (which indicate intestinal bleeding). [mskcc.org]

  […] include the following: Abdominal pain Weight loss for no known reason Rectum Signs and symptoms of GI carcinoid tumors in the rectum may include: Blood in the stool Pain in the rectum Constipation Carcinoid Syndrome Carcinoid syndrome occurs when gastrointestinal [cancer.osu.edu]

  Colon Symptoms of GI carcinoid tumors in the colon may include the following: Abdominal pain. Weight loss for no known reason. Rectum Symptoms of GI carcinoid tumors in the rectum may include the following: Blood in the stool. Pain in the rectum. [rarecancers.org.au]

  Abdominal pain. Feeling bloated. Diarrhea. Wheezing or other trouble breathing. Fast heartbeat. These signs and symptoms may be caused by gastrointestinal carcinoid tumors or by other conditions. [navigatingcare.com]

  pain Weight loss for no known reason Feeling very tired Feeling bloated Diarrhea Nausea Vomiting Signs and symptoms of GI carcinoid tumors in the colon may include the following: Abdominal pain Weight loss for no known reason Signs and symptoms of GI [cancer.uvahealth.com]

• Nausea

  Signs and symptoms of GI carcinoid tumors in the duodenum may include: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing of the skin and whites of the eyes) Heartburn Jejunum The jejunum is the middle part [cancer.osu.edu]

  Both treatments were well tolerated, with the major side effects being abdominal pain and nausea in 14% of those in the lanreotide group and 29% of those in the octreotide group. [news.cancerconnect.com]

  Symptoms Signs and symptoms of GI carcinoid tumors in the duodenum (first part of the small intestine, that connects to the stomach) may include the following: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing [cancer.uvahealth.com]

  Mystic1der Cancer Type: Gastrointestinal Carcinoid Tumors Medical Term for the Type of Cancer: Carcinoid Tumor Gastrointestinal Carcinoid Tumors Symptoms : Server abdominal pain (on the right side near navel), Chills, Uncontrollable Shaking, Persistent Nausea [blogforacure.com]

  Nausea. Vomiting. Jaundice (yellowing of the skin and whites of the eyes). Heartburn. [rarecancers.org.au]

• Vomiting

  Signs and symptoms of GI carcinoid tumors in the duodenum may include: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing of the skin and whites of the eyes) Heartburn Jejunum The jejunum is the middle part [cancer.osu.edu]

  Symptoms Signs and symptoms of GI carcinoid tumors in the duodenum (first part of the small intestine, that connects to the stomach) may include the following: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing [cancer.uvahealth.com]

  […] pregnant when diagnosed. reconstruction Dec94 (flap) hysterectomy 2007 Oh Nov 94 skin cancer cells removed from face pain swelling emotional rollercoaster Chemotherapy Description, Dates & Side Effects: chemo side effects hair loss some weight loss vomitting [blogforacure.com]

  Vomiting. Jaundice (yellowing of the skin and whites of the eyes). Heartburn. [rarecancers.org.au]

• Constipation

  Signs and symptoms of GI carcinoid tumors in the duodenum may include: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing of the skin and whites of the eyes) Heartburn Jejunum The jejunum is the middle part [cancer.osu.edu]

  Symptoms Signs and symptoms of GI carcinoid tumors in the duodenum (first part of the small intestine, that connects to the stomach) may include the following: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing [cancer.uvahealth.com]

  Constipation Diarrhea. Change in stool color. Nausea. Vomiting. Jaundice (yellowing of the skin and whites of the eyes). Heartburn. [rarecancers.org.au]

  Constipation. Diarrhea. Change in stool color. Nausea. Vomiting. Jaundice (yellowing of the skin and whites of the eyes). Heartburn. [navigatingcare.com]

  If you do have symptoms, they may include the following: Abdominal pain or bloating Blood in the stool Changes in stool color Constipation Diarrhea Fatigue Flushed skin in the face and neck Heartburn Jaundice (yellowed skin) Nausea Rectal bleeding and [mercy.com]

• Loss of Appetite

  This can include: flushing severe diarrhoea loss of appetite weight loss increased heart rate wheezing sudden changes in your blood pressure. Remember, carcinoid is rare and these symptoms can all be caused by other medical conditions. [cancervic.org.au]

  Symptoms caused by the hormones (carcinoid syndrome) Typical symptoms of carcinoid syndrome include: diarrhoea, tummy pain and loss of appetite flushing of the skin, particularly the face fast heart rate breathlessness and wheezing These symptoms may [nhs.uk]

  Side effects of chemo include nausea, vomiting, hair loss, loss of appetite, and an increased risk for infections. Continued Chemoembolization. It's a treatment used to treat a carcinoid tumor that has spread to the liver. [webmd.com]

• Jaundice

  Signs and symptoms of GI carcinoid tumors in the duodenum may include: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing of the skin and whites of the eyes) Heartburn Jejunum The jejunum is the middle part [cancer.osu.edu]

  If you do have symptoms, they may include the following: Abdominal pain or bloating Blood in the stool Changes in stool color Constipation Diarrhea Fatigue Flushed skin in the face and neck Heartburn Jaundice (yellowed skin) Nausea Rectal bleeding and [mercy.com]

  Symptoms Signs and symptoms of GI carcinoid tumors in the duodenum (first part of the small intestine, that connects to the stomach) may include the following: Abdominal pain Constipation Diarrhea Change in stool color Nausea Vomiting Jaundice (yellowing [cancer.uvahealth.com]

  Scale-like skin sores, which can be a sign of pellagra, a severe deficiency of vitamin B3 Mental disturbances, another sign of pellagra Constipation Nausea and vomiting Weight loss that cannot be explained Jaundice, which is when the skin and whites of [cancer.net]

  Jaundice (yellowing of the skin and whites of the eyes). Heartburn. [rarecancers.org.au]

• Tachycardia

  [7] Clinical features Asymptomatic Abdominal pain Carcinoid syndrome Diarrhea and abdominal cramps (∼ 80% of cases ) Cutaneous flushing (85% of cases) Possible triggers: alcohol consumption, food intake, stress In severe cases, may be accompanied by tachycardia [amboss.com]

  The tumour may outgrow its blood supply and release large amounts of vasoactive mediators, causing cardiovascular collapse, tachycardia and altered mental state. [patient.info]

  Carcinoid syndrome is also characterized by: abdominal cramps breathlessness cyanosis diarrhea rapid heart beat (tachycardia) swelling around the eyes tearing wheezing Stress, strenuous exercise, eating spicy foods, or drinking alcohol can intensify these [encyclopedia.com]

  […] frothy, or bulky stools, gastrointestinal (GI) bleed or steatorrhea; may or may not be associated with abdominal pain, flushing, and cramps Cardiac manifestations (60%): Valvular heart lesions, fibrosis of the endocardium; may lead to heart failure with tachycardia [emedicine.medscape.com]

• Back Pain

  Too much gastrin may also cause: Stomach ulcers that keep coming back Pain in the abdomen, which may spread to the back (and may come and go or that goes away after taking an antacid) The flow of stomach contents back into the esophagus (gastroesophageal [cancer.osu.edu]

• Neck Pain

  This results in a series of symptoms: Diarrhea Shortness of Breath Wheezing Flushing of the Skin on the Face and Neck Pain or a Feeling of Fullness in the Abdomen If you observe any of these symptoms you should consult with a doctor immediately. [knowcancer.com]

• Ulcer

  This causes excess acid in the stomach and sometimes a peptic ulcer, which is an ulcer of the stomach or upper part of the small intestine. [cancer.osu.edu]

  This proved to be an ulcerating adenocarcinoma in a patient with M. Crohn. The diagnosis is seldom made pre-operatively due to lack of typical imaging features. [radiologyassistant.nl]

  Many small intestinal diseases (ulcers, cancers, lymphomas, bleeding blood vessels, as well as carcinoid tumors) have been discovered by capsule enteroscopy. [medicinenet.com]

  Her medical history reported a Barlow disease and a benign gastric ulcer with haemorrhage previously. First, an endogastroduodenal fibroscopy (EGDS) found a linear ulceration, without active bleeding. [em-consulte.com]

  […] developing a carcinoid tumour age and gender : carcinoid tumours are slightly more common in men than women certain stomach conditions change the production of acid in the stomach and can put you at slightly more at risk, for example, having a peptic ulcer [cancervic.org.au]

• Skin Rash

  Taking medicine for diarrhea Taking medicine for skin rashes Taking medicine to breathe easier Taking medicine before having anesthesia for a medical procedure Content was created using EBSCO’s Health Library. [cancer.uvahealth.com]

  Taking medicine for skin rashes. Taking medicine to breathe easier. Taking medicine before having anesthesia for a medical procedure. [missouricancer.com]

• Alopecia

  All prior chemotherapy or radiation-related toxicities must have resolved to < Grade 2 (following CTCAE V 4.03 grade levels), except alopecia and infertility. [clinicaltrials.gov]

• Erythema

  […] intestinal carcinoid; often associated with malignant carcinoid syndrome Cutaneous flushing: Early and frequent (94%) symptom; typically affects head and neck; often associated with an unpleasant warm feeling, itching, rash, sweating, palpitation, upper-body erythema [emedicine.medscape.com]

• Suggestibility

  Our results suggest that alterations in the Wnt/beta-catenin signaling pathway may be involved in the development of gastrointestinal carcinoid tumors. [ncbi.nlm.nih.gov]

  These data therefore suggest that the outcomes of patients with carcinoid tumors are highly dependent on the presence of symptoms and the site of origin. [mayoclinic.pure.elsevier.com]

  […] entity which has not in the past been referred to as MANEC Alternate/Historical Names High grade neuroendocrine carcinoma Diagnostic Criteria High grade, poorly differentiated neuroendocrine carcinoma makes up 30-70% of the tumor Morphologic features may suggest [surgpathcriteria.stanford.edu]

  […] carcinoids) bronchial carcinoid peripheral pulmonary carcinoid tumors primary hepatic carcinoid ovarian carcinoid : accounts for 0.5% of carcinoid tumors and 0.3% of ovarian tumors 7 thymic carcinoid Markers 5-HIAA (5-hydroxyindoleacetic acid): usually suggests [radiopaedia.org]

  Hormone replacement therapy (HRT) The same American study has suggested that current use of hormone replacement therapy is linked with doubling the risk of carcinoid tumours of the small bowel. [cancerresearchuk.org]

• Neglect

  And don't neglect your emotional needs while this is going on. Tap into your network of friends and relatives to get support as you take care of your health. [webmd.com]

Because of this, a multidisciplinary care team is critical for patient management starting from the earliest steps of the diagnostic workup. [jcmtjournal.com]

[…] imaging with somatostatin analogs attached to the radioactive tracer Technetium-99m bone scanning Procedures Endoscopic procedures, such as the following, may be used for biopsy and diagnosis: Bronchoscopy Esophagogastroscopy Gastroscopy Colonoscopy See Workup [emedicine.medscape.com]

When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. [dvohmg.com]

Treatment of BON cells with IGF-1 stimulated the release of CgA, while high intracellular CgA levels were maintained. The activation of raf-1/MEK1 reversed the effect of IGF-1 treatment by the depletion of intracellular CgA. [ncbi.nlm.nih.gov]

The prognosis for patients with GI carcinoid tumors is diverse. To determine the factors that significantly affect prognosis, we reviewed our experience. [mayoclinic.pure.elsevier.com]

Ilstrup Marilyn Churchward Article First Online: 19 July 2014 88 Downloads 50 Citations Abstract To evaluate long-term survival of patients with gastrointestinal carcinoid tumors and to assess factors that may influence prognosis, 154 patients (49% females [link.springer.com]

Moreover, there are no studies describing a definitive treatment strategy or prognosis associated with primary esophageal NETs. [bmccancer.biomedcentral.com]

Prognosis depends on site. [patient.info]

Recent reports have emphasised the value of the WHO classification and the tumour–node–metastasis staging system for determining prognosis for both gastrointestinal luminal and pancreatic NETs. 3, 4 In our article, we use “NETs” to include all the four [mja.com.au]

Disease Bronchial / Lung Carcinoid Etiology Lung and bronchial carcinoids are diagnosed most commonly in septuagenarians and are associated with smoking. [atlasgeneticsoncology.org]

In view of the magnitude of these changes, particularly for gastric tumors, further studies to examine the underlying etiology of these changes are urgently indicated. [nature.com]

(See grading and staging) Diagnosis The etiology of carcinoid tumors is not known, but genetic abnormalities are suspected. [emedicine.medscape.com]

Abstract OBJECTIVES: The epidemiology of gastrointestinal neuroendocrine tumors (GI-NETs) is poorly understood. [nature.com]

Demographic and disease data were used for epidemiological and survival analyses. [academic.oup.com]

Epidemiology References: [1] [2] Epidemiological data refers to the US, unless otherwise specified. Pathophysiology Carcinoid tumors are neuroendocrine tumors that arise from amine precursor uptake and decarboxylation (APUD) cells. [amboss.com]

One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008;26:3063-72. [ PubMed ] Delle Fave G, Capurso G, Milione M, et al. [tgc.amegroups.com]

Gastrointestinal carcinoid: epidemiological and survival evidence from a large population-based study (n = 25 531). Ann Oncol. 2013 Dec. 24 (12):3040-4. [Medline]. American Cancer Society. [emedicine.medscape.com]

Pathophysiology Carcinoid tumors are neuroendocrine tumors that arise from amine precursor uptake and decarboxylation (APUD) cells. [amboss.com]

Small bowel neuroendocrine tumors: From pathophysiology to clinical approach. World J Gastrointest Pathophysiol. 2016 Feb 15. 7 (1):117-24. [Medline]. Hande, KR. Chapter 232 - Neuroendocrine Tumors and the Carcinoid Syndrome. [emedicine.medscape.com]

Treatment Information about treatment, including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy Prevention, Genetics, Causes Information related to prevention, genetics, risk factors, and prevention Coping Information about [mercedcancersociety.org]

Causes, Risk Factors, and Prevention Learn about the risk factors for gastrointestinal carcinoid tumors and what you might be able to do to help lower your risk. [cancer.org]

Prevention There are no sure ways of preventing the onset of gastrointestinal carcinoid tumor. [knowcancer.com]

Learn More Patient Care Treatment & Support Cancer Types Treatment & Services For New Patients Billing & Insurance Wellness & Support Clinical Trials & Research Studies Screening & Prevention Cancer Screening & Prevention Family History Our Care Locations [healthcare.utah.edu]

Prevention There is no way to prevent the growth of a carcinoid tumor. One risk factor that you can control is smoking. You may be able to lower your risk for carcinoid tumor by not smoking. [oregon.providence.org]