This case study discusses the presentation, diagnosis, and complications of ECD. Case: A 65 year-old female presented with new onset, transient neurologic symptoms of ataxia, headaches, right sided weakness, and dysarthria. [journals.lww.com]

by the time these patients present to the hospital, up to 75% will already have metastatic disease. [cancertherapyadvisor.com]

General features The clinical presentation of metastatic lung carcinoma to the common sites is well known. [touchoncology.com]

It can present as a small submucosal nodule with arterial enhancement (image) and sometimes they lead to intussusception. GIST Typical GIST in the ileum presenting as an exophytic tumor. [radiologyassistant.nl]

Presenting signs include diarrhea, rectal bleeding, intussusception, anemia, prolapse, and failure to thrive. [emedicine.medscape.com]

• Weight Loss

  "If you're losing weight and not dieting, that's something to pay attention to," she explains. Be aware that the weight loss may be gradual. [prevention.com]

  Unintentional weight loss: While many cancers can cause weight loss due to the increased demands of the growing tumor, weight loss is particularly common in stomach cancer. [buoyhealth.com]

  GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass [orpha.net]

  The most common symptoms include: Pain or discomfort in the abdomen Nausea and vomiting Loss of appetite Fatigue or weakness Bleeding (vomiting blood or passing blood in stools) Weight loss Early satiety (cannot eat a complete meal because of a “full [patients.gi.org]

• Anemia

  Presenting signs include diarrhea, rectal bleeding, intussusception, anemia, prolapse, and failure to thrive. [emedicine.medscape.com]

  Pernicious anemia 12. h/o partial gastric resection 13. [slideshare.net]

  A slowly bleeding tumor may lead to anemia. Digested blood may cause the stool to become black or tarry. An obstruction—when the flow of food is completely blocked—may cause intense pain, nausea and vomiting and typically requires immediate surgery. [cancercenter.com]

  Click here to view Figure 5: (a–d) A male patient aged 59 Ys presented by abdominal pain and anemia. [tdj.eg.net]

• Fatigue

  Symptoms such as abdominal pain, nausea, and fatigue overlap with many other conditions and diseases. If you’re experiencing any of these or other abnormal symptoms, you should talk with your doctor. [healthline.com]

  GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass [orpha.net]

  Some common symptoms of cancer that develops in the small intestines include: Abdominal pain Unexplained weight loss Weakness or fatigue (sometimes a result of anemia) Bloody or tarry stools (from bleeding tumors) A noticeable lump in the abdomen Small [cancercenter.com]

  One or more of the following symptoms may indicate carcinoid syndrome: facial flushing diarrhea abdominal pain (caused by blockage of the intestines) shortness of breath or wheezing fatigue rapid heartbeat weight gain or loss heart valve damage Patients [mskcc.org]

• Abdominal Pain

  Peutz-Jeghers syndrome is diagnosed on the basis of family history, pigmented spots, and cramping abdominal pain. [emedicine.medscape.com]

  However, some patients may experience symptoms such as facial flushing, diarrhea, abdominal pain, asthma, a rash, and dark-colored stools (which indicate intestinal bleeding). [mskcc.org]

  This can also result in severe abdominal pain. Emergency surgery might be needed in these situations. [cancer.org]

  Patients experiencing upper GIB may present with hematemesis, dark stools, nausea, abdominal pain, syncope, and hematochezia if the bleeding is brisk enough. [cancertherapyadvisor.com]

  As with other intramural tumors, larger lesions can cause symptoms such as abdominal pain or manifest with gastrointestinal bleeding caused by ulceration of the overlying mucosa. [pubs.rsna.org]

• Loss of Appetite

  GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass [orpha.net]

  Nausea and vomiting Difficulty swallowing Heartburn Loss of appetite Weight loss Feeling tired Bloating Vomiting blood (in advanced stages) Cleveland Clinic News & More Cleveland Clinic News & More [my.clevelandclinic.org]

  Some are more obvious, such as: losing weight without trying to feeling or being sick having problems swallowing (dysphagia) a lump at the top of your tummy Others might be harder to spot, such as: heartburn or acid reflux loss of appetite symptoms of [nhs.uk]

  Stomach cancer unexplained weight loss or loss of appetite difficulty swallowing indigestion – e.g. pain or burning sensation in the abdomen (heartburn), frequent burping, reflux persistent nausea and/or vomiting with no apparent cause a sense of fullness [cancervic.org.au]

  Other possible symptoms of GISTs Other symptoms of GISTs can include: Abdominal (belly) pain A mass or swelling in the abdomen Nausea and vomiting Feeling full after eating only a small amount of food Loss of appetite Weight loss Problems swallowing [cancer.org]

• Melena

  She then presented with melena, was found to have a clean-based antral ulceration on EGD, and was treated conservatively. Several months later a PET scan revealed a new subepithelial duodenal mass with FDG avidity. Patient underwent an EUS with FNA. [journals.lww.com]

  […] mutation of c-kit 25% are clinically malignant Clinical features 2 - 3% of gastric malignancies Usually older adults, median age 60 - 65 years; 1% occur in children Male = female incidence Symptoms: abdominal pain, gastric outlet obstruction, mass effect, melena [pathologyoutlines.com]

  Massive hematemesis or melena is uncommon, but secondary anemia may follow occult blood loss. Occasionally, the first symptoms are caused by metastasis (eg, jaundice, ascites, fractures). [merckmanuals.com]

  Patients with gastric glomus tumors can be asymptomatic, or they can present with epigastric discomfort, hematemesis, or melena. Surgical resection is usually curative. [pubs.rsna.org]

• Abdominal Mass

  GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass [orpha.net]

  They may present as an abdominal mass, abdominal pain or, rarely, with jaundice, as in this case. Timely resection on diagnosis provides long-term survival. Conflict of interest: none declared. [academic.oup.com]

  Symptoms of abdominal mass and bowel obstruction. They may also present as an incidental finding during investigation for other diseases. [patient.info]

  Where the disease is advanced, the doctor’s examination may reveal: Abdominal mass/es; Enlarged lymph nodes (lymphadenopathy) Bowel obstruction; Fluid in the abdomen (ascites); Enlarged liver (hepatomegaly); and/or Lower extremity fluid accumulation [myvmc.com]

  […] computed tomography (CT) scan is of critical value in detection of an intra-abdominal mass. [touchoncology.com]

• Intestinal Disease

  Cecal Neoplasms + Colorectal Neoplasms + Duodenal Neoplasms Ileal Neoplasms Immunoproliferative Small Intestinal Disease Jejunal Neoplasms Stomach Neoplasms Zollinger-Ellison Syndrome All MeSH Categories Diseases Category Digestive System Diseases Gastrointestinal [ncbi.nlm.nih.gov]

• Headache

  Case: A 65 year-old female presented with new onset, transient neurologic symptoms of ataxia, headaches, right sided weakness, and dysarthria. [journals.lww.com]

  Large pituitary tumours may cause problems with vision or headaches. [yourhormones.info]

  Resulting symptoms may include headaches and visual problems, such as blurred vision. In addition to a prolactinoma, other tumors affecting the pituitary gland may occur. [rarediseases.org]

[…] and Staging Surgical Treatment Neoadjuvant Treatment Chemoradiation Chemotherapy for Palliation Summary and Further Reading Chapter 4 - Gastric Cancer Epidemiology and Clinical Presentation Diagnostic Workup, Staging and Surgery for Localised Disease [oncologypro.esmo.org]

The following tests are generally ordered in the workup of patients who present with nonspecific abdominal symptoms; abdominal pain; or complications such as hemorrhage, obstruction, or perforation: Complete blood cell count Coagulation profile Serum [emedicine.medscape.com]

Currently, there are no guidelines that recommend an initial endoscopic workup for evaluation of an underlying GI malignancy in dermatomyositis patients. [wjgnet.com]

Mucins (MUCs) appear to have limited utility in the workup of carcinomas of the digestive system. CK7 and CK20. The differential expression patterns of CK7 and CK20 are routinely used in the workup for adenocarcinomas of unknown primary. [archivesofpathology.org]

Therefore the first step in management is usually extensive imaging and other workup such as endoscopies and biopsies. [buoyhealth.com]

• Gastric Lesion

  However, those with a Japanese viewpoint diagnosed suspected or definite carcinoma in 77–94% of the gastric lesions, in 45–75% of the colorectal lesions, and in 81–100% of the oesophageal lesions. [gut.bmj.com]

  Six patients had both gastric and duodenal lesions. Eight patients had only gastric polyps, and four had duodenal polyps only. [link.springer.com]

  The three esophageal and two gastric lesions were successfully removed by endoscopic submucosal dissection, while the two colorectal lesions and the lesion in the external ear canal were surgically resected. [bmccancer.biomedcentral.com]

  Prognostic analysis of gastric gastrointestinal stromal tumor with synchronous gastric cancer. World J Surg Onocl. 2014;12:25. View Article Google Scholar Hedenbro JL, Ekelund M, Wetterberg P. Endoscopic diagnosis of submucosal gastric lesions. [wjso.biomedcentral.com]

  For mucosal gastric lesions, endoscopy may be indicated. Concurrent imaging with CT and 18-fluorodeoxyglucose positron emission tomography (FDG-PET) may aid in the interpretation of CT findings, particularly where there is peritoneal disease. [journals.lww.com]

Adjuvant Treatment Treatment of Unresectable Patients Palliative Treatment Second-Line Treatment Summary and Further Reading Chapter 8 - Hereditary Colorectal Cancer Syndromes Classification and Identification Non-Polyposis CRC Syndromes: Lynch Syndrome [oncologypro.esmo.org]

[…] by the treating physician - Failed prior treatment with imatinib mesylate, defined as either progression of disease or significant toxicity during treatment with imatinib mesylate that precluded further treatment - Male or Female, 18 years or older - [pfizer.com]

The OSUCCC – James is one of the few high-volume peritoneal cancer treatment centers in Central Ohio. [cancer.osu.edu]

[…] as access to the most advanced treatments possible. [muhealth.org]

Our team is here to guide you through the stomach cancer treatment process and offer you hope for the future. [bswhealth.com]

Prognosis is better with protruding tumors than with spreading tumors because protruding tumors become symptomatic earlier. [merckmanuals.com]

The book is divided into three main section - benign tumors, malignant tumors, and tumors with an indeterminate prognosis - reflecting the value of different imaging strategies as a function of a tumor's natural history. [books.google.ro]

Treatment and prognosis It is an aggressive tumor with a 5-year survival rate of less than 20%. Prognosis is correlated to the stage of the tumor at presentation. [radiopaedia.org]

[…] blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology [decs.bvs.br]

[…] histology blood blood supply cerebrospinal fluid chemical synthesis chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology [ncbi.nlm.nih.gov]

The most common primary sites of upper GIT metastases leading to upper GIB include melanoma, lung, pancreas, breast and colorectal. 4,5 Endoscopy is frequently used to evaluate the etiology of an upper GIB and can often assist in making the diagnosis [cancertherapyadvisor.com]

Only 500 cases have been described in the literature with longstanding uncertainty about etiology and classification. [journals.lww.com]

The Journal also offers basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. [springer.com]

The second section covers essential developments exploring epidemiological factors implicated in GI cancer, disease prevention, the new opportunities that promise to advance our understanding, molecular subtyping, and tailored treatment of these diseases [oncologypro.esmo.org]

AJR 180:185–189 Article PubMed Google Scholar Kindblom LG (2003) Gastrointestinal stromal tumors; diagnosis epidemiology, prognosis. ASCO Annual Meeting. [link.springer.com]

English: BS blood supply BL blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology [decs.bvs.br]

[…] analysis anatomy and histology blood blood supply cerebrospinal fluid chemical synthesis chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology [ncbi.nlm.nih.gov]

Looking for Zebras in Metastatic Colorectal Cancer January 4, 2019 Although colorectal cancer is one of the most commonly diagnosed cancers in the United States,1 and researchers’ understanding of the biology and pathophysiology of CRC has grown, its [ruesch.georgetown.edu]

Reticulocyte test and serum ferritin level test help to differentiate pathophysiological origin of anaemia. [ncbi.nlm.nih.gov]

In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed March 23, 2016. Gastric cancer. [mayoclinic.org]

Outline the pathophysiologic development of colorectal cancer. [slideshare.net]

Pathophysiology Benign small-bowel tumors may be found throughout the duodenum, jejunum, and ileum (in order of increasing frequency). Tumors may be single, multiple, or widespread (ie, as part of a polyposis syndrome). [emedicine.medscape.com]

Share on Pinterest Aspirin could prevent digestive cancers, especially in the elderly, suggests new research. [medicalnewstoday.com]

At the OSUCCC – James, cancer research experts focus on studying stomach cancer prevention, diagnosis, treatment and cure. [cancer.osu.edu]

Cancer prevention is an action taken to lower the chance of getting cancer. While there is no guarantee that you will not develop cancer, there are steps you can take to protect yourself. [compassoncology.com]

Colorectal Cancer Preventable. Treatable. Beatable. Each year nearly 137,000 people are diagnosed with colorectal cancer, often referred to as colon cancer, in the U.S. and over 50,000 people die from it annually. [asge.org]

[…] diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology GE genetics HI history IM immunology ME metabolism MI microbiology MO mortality NU nursing PS parasitology PA pathology PP physiopathology PC prevention [decs.bvs.br]