Presentation
Diagnosis of sarcoidosis may be difficult, especially if no other typical features are present. [journals.lww.com]
Gastric sarcoidosis affects approximately 10% of patients with systemic disease and only rarely presents with symptoms. Here we present the case of a bleeding gastric ulcer in a 66-year-old female with pulmonary sarcoidosis. [elsevier.es]
Pediatric gastrointestinal sarcoidosis presenting with protein-losing enteropathy. [jhu.pure.elsevier.com]
Immune System
- Axillary Lymphadenopathy
Pulmonary nodules, pleural effusion, ascites, hepatomegaly, splenomegaly, and mesenteric as well as retroperitoneal and axillary lymphadenopathy were subsequently identified. [scielo.mec.pt]
Entire Body System
- Weight Loss
The first case was an 8-year-old Saudi girl who presented with fever, weight loss, and abdominal pain that was followed in a few months with hematemesis and development of hepatosplenomegaly. [ncbi.nlm.nih.gov]
We present an interesting case of gastric sarcoidosis in a 39-year-old Caucasian man with symptoms of epigastric pain and profound weight loss. [hindawi.com]
Despite compliance with treatment and proper dosing, the patient persisted to be febrile with further weight loss. [saudijgastro.com]
Here, we describe a case of gastrointestinal sarcoidosis in a 37-year-old male with symptoms of weight loss, fever, and abdominal pain. [ekjm.org]
- Poor Growth
CASE REPORT An 11-year-old white girl presented in September 2004 for evaluation of poor growth. [journals.lww.com]
Gastrointestinal
- Vomiting
The second case was a 9-year-old Sudanese boy who manifested with vomiting, epigastric pain, and weight loss. On upper endoscopy, both cases demonstrated severe erosive nodular gastric mucosa. [ncbi.nlm.nih.gov]
Other symptoms are early satiety, nausea, vomiting, hematemesis, melena, and weight loss [5]. Gastrointestinal sarcoidosis can present either as an ulcer or as diffuse involvement resembling linitis plastica. [hindawi.com]
Discussion: Colonic sarcoidosis is a rare entity which commonly presents with abdominal pain, nausea/vomiting, hematochezia, diarrhea and weight loss. [journals.lww.com]
Physical examination revealed an alert and oriented middle-aged woman in extremis who was vomiting dark-colored blood. [mdedge.com]
- Nausea
None of them had diarrhea. 3 Our patient presented without epigastric pain but his presenting symptoms were nausea and diarrhea. [academic.oup.com]
Michele initially had lots of gastric and epigastric burning pain; also lots of nausea (associated w/ dizziness, cold sweats). the pain was resolved after i had a course of biaxin, nausea is controlled by large doses of neurontin. probably all depends [inspire.com]
Other symptoms are early satiety, nausea, vomiting, hematemesis, melena, and weight loss [5]. Gastrointestinal sarcoidosis can present either as an ulcer or as diffuse involvement resembling linitis plastica. [hindawi.com]
Useful for chronic sarcoidosis; takes up to six months to become effective Azathioprine (Imuran) 50 to 150 mg daily; dosage adjusted for toxicity Nausea, neutropenia Not as widely studied as methotrexate; neutropenia and nausea more common problems [aafp.org]
- Periumbilical Pain
Clinical Case A 44-year-old woman with no relevant clinical background was hospitalized with a 2-weak history of epigastric and periumbilical pain, vomiting, abdominal distension, asthenia, and anorexia. [karger.com]
- Intestinal Disease
CD is a chronic inflammatory small intestinal disease with a prevalence of 1 % induced by gluten and related storage proteins of wheat, barley, and rye. [bmcgastroenterol.biomedcentral.com]
Workup
Given the multisystem involvement with significant chest findings, tissue findings of granulomatous disease, and negative workup for other causes of granulomatous inflammation, both cases were diagnosed with active disseminated sarcoidosis, and treated [ncbi.nlm.nih.gov]
Other laboratory workup to rule out the differential causes also came negative. With history of sarcoidosis, symptoms, and lab workup along with the histological findings the diagnosis was confirmed as gastric sarcoidosis. [hindawi.com]
Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. [books.google.es]
Persistent diarrhea in patients with even remote history of chronic pulmonary signs and symptoms should prompt workup for gastrointestinal involvement by this granulomatous disease. © The American College of Gastroenterology 2017. [journals.lww.com]
X-Ray
- Left Pleural Effusion
A body CT scan showed multiple peripheral and bilateral pulmonary nodules (Fig. 1 ), moderate left pleural effusion, bilateral axillary lymphadenopathy, slight homogeneous hepatosplenomegaly, multiple adenopathies in gastrohepatic ligament, and aortic [karger.com]
Proctoscopy
- Rectal Ulcer
On colonoscopy, a few scattered rectal ulcers were seen; otherwise, the terminal ileum, down to the sigmoid colon, seemed grossly healthy. Histologically, focal granulomas were present in tissue from the ascending colon to the rectum. [journals.lww.com]
Microbiology
- Tropheryma Whipplei
Angiotensin-converting enzyme (ACE) was elevated at 77 U/L, and rapid plasma reagin and Tropheryma whipplei testing were negative. Figure 2. EGD showing moderately erythematous mucosa at the pylorus. [acgcasereports.gi.org]
Angiotensin-converting enzyme (ACE) was elevated at 77 U/L, and rapid plasma reagin and Tropheryma whipplei testing were negative. [ncbi.nlm.nih.gov]
- Bartonella Quintana
Tests for serum antibodies against Bartonella quintana, B henselae, Histoplasma capsulatum and Coccidioides immitis showed negative results. [journals.lww.com]
- Coccidioides Immitis
Tests for serum antibodies against Bartonella quintana, B henselae, Histoplasma capsulatum and Coccidioides immitis showed negative results. [journals.lww.com]
Treatment
She received treatment with PPIs and H. pylori eradication therapy. Patient recovered well and her last endoscopy shows the lesion without ulceration ( Figure 2 ). ???? Figure 1. [elsevier.es]
The patient's course was favorable after treatment with prednisone and chlorambucil. Disseminated gastrointestinal sarcoidosis may be a previously unidentified cause of protein-losing enteropathy. [ncbi.nlm.nih.gov]
Prognosis
Prior reports on cancer related sarcoidosis are inconsistent in terms of prognosis; while some reports link sarcoidosis with a favorable prognosis, others associate it with recurrence and secondary malignancies. [ascopubs.org]
Prognosis and Patient Counseling. Generally, a good prognosis. Less than 5% of patients die of sarcoidosis, with neurosarcoidosis and cardiac sarcoidosis being the main causes of death. [clinicaladvisor.com]
TREATMENT AND PROGNOSIS The prognosis of sarcoidosis is good in most patients. The majority of patients with acute disease recover completely. Those patients who do have residual damage of affected organs usually have only minimal organ dysfunction. [meddean.luc.edu]
Seite 117 - Pulmonary sarcoidosis: role of CT in the evaluation of disease activity and functional impairment and in prognosis assessment. Radiology 191 (3): 675-680 141. [books.google.de]
Etiology
A case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med. 2001; 164(Suppl 11):2085-2091. Rybicki BA, Major M, Popovich J Jr., Maliarik MJ, Iannuzzi MC. [smartscitech.com]
The etiology of pneumatosis cystoides intestinalis in this case was likely multifactorial and involved both effects of the corticosteroids as well as the advanced nature of the gastrointestinal sarcoidosis. [ncbi.nlm.nih.gov]
These individuals are considered to have “granulomatous gastritis of uncertain etiology.” Some of these patients will eventually present with an identifiable etiology for the granulomatous gastritis. [peertechz.com]
ABSTRACT Sarcoidosis is a multisystemic granulomatous disease of unknown etiology that is based on the presence of non-caseating granulomas. Sarcoidosis commonly involves the lungs, skin, and eyes. [ekjm.org]
Even though it was first described by Sir Jonathan Hutchinson 140 years ago, to date the etiology is unclear [1]. It can involve any organ, with pulmonary involvement being the most common. [hindawi.com]
Epidemiology
and the Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit (B.A.R.). Address reprint requests to Dr. [nejm.org]
Introduction Definition a systemic inflammatory disease that is characterized by the presence of non-caseating granulomas Epidemiology incidence the lung is most commonly involved most common in African Americans Etiology unknown Pathogenesis macrophages [step2.medbullets.com]
Epidemiology of sarcoidosis: recent advances and future prospects. Semin Respir Crit Care Med 2007; 28:22-35. [PMID: 17330190] Rybicki B, Maliarik M, Major M, Popovich Jr J, Iannuzzi MC. Epidemiology, demographics, and genetics of sarcoidosis. [pancreas.imedpub.com]
In light of the strong epidemiological exposure, antituberculous medications were initiated (combination of isoniazid, pyrazinamide, ethambutol, and refampicin). [saudijgastro.com]
Pathophysiology
Unlike others on this topic, this text demonstrates how the endoscope incorporates pathophysiology, diagnostic, and treatment modalities into endoscopic practice. [books.google.es]
Analyses of gastrointestinal, oropharyngeal, lung and blood specimens will improve the understanding of H. pylori, VacA toxin, and other toxins as well as their potential role in pathophysiology of disease. [clinicaltrials.gov]
After I had thoroughly researched the mechanisms of action of LDN, I began prescribing it to patients who had inflammation as part of the pathophysiology of their conditions (Crohn's disease, ulcerative colitis, post-infectious IBS) and I saw good responses [ldnscience.org]
The differential diagnosis in particular with regard to refractory CD will be discussed based on a thorough clinical work-up, including genetic and immunological testing, that aimed to shed light on the pathophysiology of the disease association. [bmcgastroenterol.biomedcentral.com]
The exact mechanism of this relation is not known, but some evidence supports the hypothesis that this is a consequence of Th1 lymphokine prevalence. [55] [82] Tests of delayed cutaneous hypersensitivity have been used to measure progression. [83] Pathophysiology [en.wikipedia.org]
Prevention
Early recognition and prompt treatment are important to prevent irreversible renal complications. [jamanetwork.com]
Special chapters, such as the Designing Clinical Research in Gastrointestinal Endoscopy, The Prevention of Infection Following Gastrointestinal Endoscopy, Complications of Peptic Ulcer Disease, and Credentialing for Gastrointestinal Endoscopy, help make [books.google.es]
NYU Langone doctors manage the condition, helping to prevent any long-term complications. Treatment at NYU Langone Treatment for sarcoidosis depends on the severity and duration of the disease. [nyulangone.org]
A 1, 5 Calcitonin (Miacalcin) and bisphosphonates may be useful in preventing osteoporosis in patients with sarcoidosis taking long-term steroid therapy. [aafp.org]