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Gemcitabine

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Presentation

  • "Hospira heard calls from physicians and pharmacists for a larger presentation of gemcitabine in line with dosing practices, and we've met their needs," said Thomas Moore, president, U.S., Hospira.[web.archive.org]
  • The author reports a 68-year-old woman who presented with a 4-month history of bilateral vision loss.[ncbi.nlm.nih.gov]
  • A 56-year-old woman presented with anasarca, hypoalbuminaemia and hypotension following cycle 3 day 1 of adjuvant gemcitabine for stage II pancreatic cancer.[ncbi.nlm.nih.gov]
  • We present a case of gemcitabine-induced radiation recall that manifested as myositis with associated dermatitis in the posterior thigh of a patient with remote history of localized radiotherapy for biopsy-proven breast cancer metastasis.[ncbi.nlm.nih.gov]
Malnutrition
  • Available RecruitingTreatment Malignant Neoplasm of Pancreas 1 Not Available Terminated Not Available Cancer, Breast 1 Not Available TerminatedTreatment Malignant Neoplasm of Pancreas 1 Not Available TerminatedTreatment Malignant Neoplasm of Pancreas / Malnutrition[drugbank.ca]
Photosensitivity
  • In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. photosensitizing agent A chemical compound that can be excited by light of a specific[ebi.ac.uk]
Progressive Visual Loss
  • A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine.[ncbi.nlm.nih.gov]
Myopathy
  • The present observation suggests that gemcitabine monotherapy without adjuvant radiotherapy can cause myopathy through vascular lesions, a mechanism which also underlies the more common side effects of this treatment.[ncbi.nlm.nih.gov]
Excitement
  • In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. photosensitizing agent A chemical compound that can be excited by light of a specific[ebi.ac.uk]

Workup

  • Unnecessary antibiotic exposure is increasing the risk for clostridium difficile and or antibiotic resistance, therefore awareness of this reaction is critical, as to avoid unnecessary antibiotics, and costly diagnostic workups.[ncbi.nlm.nih.gov]
Staphylococcus Aureus
  • Qiu Lau, Yoke Tan, Vanessa Goh, David Lee, Fui Ng, Esther Ong, Jeffrey Hill and Cheng Chia, An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA), Antibiotics, 4, 4, (424), (2015).[doi.org]

Treatment

  • Effects on the liver This treatment can affect how your liver works. This usually goes back to normal after treatment. You will have blood tests to check how well your liver is working during your treatment.[macmillan.org.uk]
  • Marked shrinkage of the mass was observed after two treatment cycles, and partial remission was achieved. The abdominal pain was relieved. The adverse effects were tolerable and treatment cost was acceptable.[ncbi.nlm.nih.gov]
  • Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer and current treatments exert small effects on life expectancy. The most common adjuvant treatment for PDAC is gemcitabine.[ncbi.nlm.nih.gov]
  • Here, we present a rare case of TTP associated specifically with gemcitabine treatment, and further, we briefly discuss the manifestations, treatment options and outcomes related to the complication.[ncbi.nlm.nih.gov]
  • The dual effects of inhibition of PAKs make PAK-targeted therapy more potent for the treatment of PDA. The combination of PAK inhibitors with gemcitabine may be a more effective therapeutic approach in PDA treatment.[ncbi.nlm.nih.gov]

Prognosis

  • NMC is a very rare disease with poor prognosis. This study is the first to report response of NMC to gemcitabine and vinorelbine.[ncbi.nlm.nih.gov]
  • LMS are aggressive, metastatic tumors with poor prognosis where effective therapeutic interventions are wanting. Our studies demonstrate the potential utility of mocetinostat combined with gemcitabine for the treatment of LMS.[ncbi.nlm.nih.gov]
  • Advanced pancreatic adenocarcinoma still remains associated with a desperate prognosis. Nevertheless, treatment options for patients with metastasized disease have improved considerably over the last few years.[ncbi.nlm.nih.gov]
  • Lower PDAC expression predicted a poor prognosis in PDAC patients. CONCLUSIONS: Thus, these results indicated that lncRNA AB209630 may be a potential target of PDAC.[ncbi.nlm.nih.gov]
  • BACKGROUND: Pancreatic cancer is a highly lethal malignancy with a poor prognosis. This study was set up to investigate the combined effect of gemcitabine and fisetin, a natural flavonoid from plants, on human pancreatic cancer cells.[ncbi.nlm.nih.gov]

Etiology

  • A cytotoxic etiology has also been hypothesized, because the majority of causative agents are cytotoxic drugs [ 23 ].[academic.oup.com]
  • "Capillary leak syndrome: etiologies, pathophysiology, and management". Kidney International. 92 (1): 37–46. doi : 10.1016/j.kint.2016.11.029. PMID 28318633. Kasi PM (January 2011). "Thrombotic thrombocytopenic purpura and gemcitabine".[en.wikipedia.org]
  • Cancer Control. 2017; 24(1):54-56 [ PubMed ] Related Publications Thrombotic microangiopathy syndromes consist of a collection of disorders with a varied etiology that share common clinical and pathological features.[cancerindex.org]

Epidemiology

  • Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015;24(9):1319–26. doi: 10.1158/1055-9965.epi-15-0199.[doi.org]
  • Alvaro D, Crocetti E, Ferretti S, Bragazzi MC, Capocaccia R: Descriptive epidemiology of cholangiocarcinoma in Italy.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of both of these reactions are still unknown, though it is theorized that areas of lymphedema may both increase concentration of gemcitabine and reduce its rate of metabolism leading to increased drug exposure time.[ncbi.nlm.nih.gov]
  • Increasing evidences have proved that long noncoding RNAs (lncRNAs) modulate the tumorigenesis of bladder cancer involved in multiple pathophysiological processes.[ncbi.nlm.nih.gov]
  • "Capillary leak syndrome: etiologies, pathophysiology, and management". Kidney International. 92 (1): 37–46. doi : 10.1016/j.kint.2016.11.029. PMID 28318633. Kasi PM (January 2011). "Thrombotic thrombocytopenic purpura and gemcitabine".[en.wikipedia.org]
  • The pathophysiology of gemcitabine-induced radiation recall and erysipeloid reactions remains unclear.[academic.oup.com]

Prevention

  • Early detection and close ophthalmic monitoring may allow concurrent cancer treatment and prevention of possible chemotherapy-induced ocular side effects.[ncbi.nlm.nih.gov]
  • Additionally, an emerging trend of hypomagnesemia associated with PRES has been documented inside and outside the context of malignancy and suggests a possible target for treatment and prevention warranting further investigation.[ncbi.nlm.nih.gov]
  • The aim of intravesical therapy in NMIBC is to prevent tumour recurrence and progression and to avoid the morbidity associated with cystectomy.[cochrane.org]
  • Your doctor will give you anti-sickness drugs to help prevent or control sickness. Take the drugs exactly as your nurse or pharmacist tells you. It is easier to prevent sickness than to treat it after it has started.[macmillan.org.uk]
  • Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug.[cancer.gov]

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