Presentation
Additionally, contrary to previous literature that describes gemistocytic astrocytoma as a purely supratentorial lesion, we present two cases of gemistocytic astrocytoma involving the brainstem. [ncbi.nlm.nih.gov]
For a general discussion of clinical presentation, epidemiology, treatment please refer to the article on low grade astrocytomas. [radiopaedia.org]
Case Presentation The patient is a 26-year-old woman who initially presented with new-onset headache and blurry vision. Her neurologic examination was non-focal and without papilledema. Laboratory findings were unremarkable. [cureus.com]
Entire Body System
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Swelling
Changes (such as swelling) may be observed in the back of the eye, where the blind spot is. Usually there are no changes in temperature, blood pressure, pulse or respiratory rates except just before death. [cedars-sinai.edu]
Corticosteroids help lessen the swelling around the brain tumour and may relieve headaches and other symptoms. A commonly used corticosteroid is dexamethasone (Decadron, Dexasone). [cancer.ca]
Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain [emedicine.medscape.com]
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Inflammation
Other CNS tumors and conditions that have gemistocytes or gemistocyte-like cells include: [2] Oligodendroglioma with "minigemistocytes" Ependymoma Subependymal giant cell astrocytoma Astroblastoma Reactive gliosis in inflammation, infection, or demyelinating [wikidoc.org]
Skin
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Ulcer
But a few weeks later it was growing again, so off to 6 weeks radio, dex, and the stuff that stops the dex giving you an ulcer! I was climbing the walls with the dex! [cancercompass.com]
Psychiatrical
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Suggestibility
Some suggest that gemistocytic morphology should be considered as evidence of a higher grade astrocytoma. However, there is no consensus on the percentage of gemistocytes associated with a worse prognosis than otherwise expected. [ncbi.nlm.nih.gov]
These results suggest that the predominant tumor histology may be altered by selective pressures imposed by therapy. [cureus.com]
Some authors suggest that they should be considered WHO III tumors 2. The median with treatment is only 2.5 years, with a 5-year survival rate of 30% which is significantly worse than other low grade gliomas 4. [radiopaedia.org]
[…] each year in the United States if everyone maintained a healthy body weight: 1 Percentages from AICR/WCRF ’ s Policy and Action for Cancer Prevention, 2009 2 Calculated from total estimated incidence, Cancer Facts and Figures 2009, ACS These results suggest [news.cancerconnect.com]
Look on line for suggestions as well. Prayers to you and your husband! [cancercompass.com]
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Fear
To this day, we remain awed, humbled, blessed and ever so grateful for all the love and support we gained by sharing our fears and our feelings. [brainstormwebs.com]
Urogenital
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Cesarean Section
The patient was delivered by cesarean section and a total excision of the hemorrhagic tumor was carried out on the third day of his life. The histological study revealed gemistocytic astrocytoma (WHO grade II). [ncbi.nlm.nih.gov]
Workup
Detection of many of the molecular changes that underlie the development of gliomas and other BT can now be done by immunohistochemistry and is getting into the mainstream of the diagnostic workup of BT. [neuropathology-web.org]
Other Pathologies
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Lymphocytic Infiltrate
Survival time did not correlate with the presence of perivascular lymphocytic infiltration. [ncbi.nlm.nih.gov]
infiltrate Abscence of mitoses, microvascular proliferation, and necrosis Immunohistochemistry Gemistocytic astrocytoma is demonstrated by positivity to tumor marker such as GFAP. [5] Differentiating Gemistocytic Astrocytoma from other Diseases Gemistocytic [wikidoc.org]
Ridley, A, Cavanagh, JB 1971 Lymphocytic infiltration in gliomas: evidence of possible host resistance Brain 94 117 24 PubMed Google Scholar 23. [link.springer.com]
infiltration in the background of dense keloidlike fibrosis Clue 17 良性の乳管周囲を同心円状に取り巻く小型腫瘍細胞 Targetoid pattern(tumor cells concentrically arranged around ducts) Clue 18 ローゼンタール線維(棍棒状の好酸性無構造物) Rosenthal fibers(thick, elongated, eosinophilic structures) [kinpodo-pub.co.jp]
Treatment
Given the generally worse prognosis, most clinicians would favor a more aggressive approach to treatment. [radiopaedia.org]
It is not uncommon for treatment plans to wait to use radiation and or chemotherapy agents until tumor reach grade 3. [cancercompass.com]
Accessed on January 8, 2016 Treatment and prognosis of gemistocytic astrocytoma. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. . [wikidoc.org]
Moreover, we focus on the side effects (hypertension, deep vein thrombosis) induced by bevacizumab and their effective treatments. [journals.edizioniseed.it]
Can anyone please help me what exactly the treatment that he has to take? How long he can survive? He is now weak enough but everyother functionalities are normal. After operation his body weight looses 5kg. [csn.cancer.org]
Prognosis
Nevertheless, a precise diagnosis is crucial as the prognosis and therapy of these diseases are different. Quantitative MR imaging sequences, which provide metabolic and vascular information, could be useful in the prevention of misdiagnosis. [ncbi.nlm.nih.gov]
Given the generally worse prognosis, most clinicians would favor a more aggressive approach to treatment. [radiopaedia.org]
Prognosis Gemistocytic astrocytoma has a poorer prognosis than the other matched WHO grade II (low-grade) astrocytic tumors ( fibrillary astrocytoma, protoplasmic astrocytoma, and oligoastrocytoma ). [1] The 5-year survival rate of patients with gemistocytic [wikidoc.org]
Clinical Outcome and Prognostic Factors Background and Purpose: Although gemistocytic astrocytomas are considered slow-growing tumors, they often behave aggressively and carry the least favorable prognosis among low-grade astrocytomas. [link.springer.com]
Etiology
The etiology, cellular and molecular pathogenic mechanisms remain unclear to a great extent. [journal-imab-bg.org]
For the majority of astrocytoma, the etiology is unknown. Children with a familial cancer predisposition have an increased risk for developing both low grade and high grade gliomas. [childrensmn.org]
Epidemiology
For a general discussion of clinical presentation, epidemiology, treatment please refer to the article on low grade astrocytomas. [radiopaedia.org]
Accessed on January 5, 2016 8.0 8.1 Epidemiology of gemistocytic astrocytoma. Dr Ahmed Abd Rabou and A.Prof Frank Gaillard et al. Radiopaedia 2016. . [wikidoc.org]
SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study. Cancer Res. 2005 Apr 15;65(8):3049-52. Pass HI, et al., Evidence of an important role for SV40 in mesothelioma. [sv40foundation.org]
Epidemiologic data support a peak incidence in the fifth decade, a point between the peak incidence of diffuse astrocytomas (fourth decade) and glioblastomas (seventh decade). [2, 3] Pathologic confirmation comes from serial biopsies of individuals with [emedicine.medscape.com]
Pathophysiology
Gemistocytic astrocytoma is a histologic subtype of low grade astrocytoma, with a poorer prognosis than other matched WHO grade II astrocytic tumors. [1] Historical Perspective Gemistocytic astrocyte was first described by Franz Nissl in the 20th century. [2] Pathophysiology [wikidoc.org]
Astrocytomas in the base of the brain are more common in young people and account for roughly 75% of neuroepithelial tumors. [ citation needed ] Pathophysiology [ edit ] Astrocytoma causes regional effects by compression, invasion, and destruction of [en.wikipedia.org]
Pathophysiology There are two forms of nephrosclerosis: malignant (accelerated) and benign. Anat. [forexgrowthfunds.com]
[…] genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class. [5, 6, 7] These findings were also reported in a 2013 study. [8] Pathophysiology [emedicine.medscape.com]
Prevention
Quantitative MR imaging sequences, which provide metabolic and vascular information, could be useful in the prevention of misdiagnosis. [ncbi.nlm.nih.gov]
A report released by AICR estimated the number of cancers that could be prevented each year in the United States if everyone maintained a healthy body weight: 1 Percentages from AICR/WCRF ’ s Policy and Action for Cancer Prevention, 2009 2 Calculated [news.cancerconnect.com]
Quantitative MR imaging sequences, which provide metabolic and vascular information, could be useful in the prevention of misdiagnosis. The full text of this article is available in PDF format. [em-consulte.com]
Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials . [cancer.ca]
Prevention [ edit ] There are no precise guidelines because the exact cause of astrocytoma is not known. Treatment [ edit ] For low-grade astrocytomas, removal of the tumor generally allows functional survival for many years. [en.wikipedia.org]