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Generalized Essential Telangiectasia

GET


Presentation

  • The diagnosis of generalized essential telangiectasia was made on the basis of clinical presentation and investigations.[ncbi.nlm.nih.gov]
  • A 56-year-old woman presented with multiple, erythematous cutaneous vessels that blanched with diascopy and were symmetrically distributed over both lower and upper extremities.[ncbi.nlm.nih.gov]
  • We present 2 patients, both women, with multiple telangiectasias and describe the histopathologic findings that led to the diagnoses of GET and CCV.[ncbi.nlm.nih.gov]
  • Following discharge from the dermatology department, the patient presented with chest pain and required emergency surgery for a type A thoracic aortic dissection.[ncbi.nlm.nih.gov]
  • We present a patient with a history of Graves' disease and low-titer anti-nuclear antibodies, who developed rapidly progressive generalized telangiectases.[ncbi.nlm.nih.gov]
Asymptomatic
  • The lesions had been present for approximately 6 years and were asymptomatic. Generalized essential telangiectasia (GET) is an idiopathic syndrome of widespread, asymptomatic telangiectases of unknown cause.[ncbi.nlm.nih.gov]
  • We present a 65-year-old man with a ten-month history of an asymptomatic eruption of the trunk and proximal aspects of the arms and hands that was comprised of macules and patches of telangiectases.[ncbi.nlm.nih.gov]
  • They are usually asymptomatic; however, some individual lesions can cause tingling, burning, or numbness.[dermatologyadvisor.com]
  • The term angiokeratoma is applied to a number of quite distinct conditions which share a common clinical presentation with asymptomatic hyperkeratotic vascular skin lesions and a histological combination of superficial dermal vascular ectasia. (12 Dec[kmle.co.kr]
Chills
  • A sapphire water-cooled chill tip was used to cool the skin during laser therapy. The treatment was performed every 4 weeks over a period of 6 months. After six treatment sessions an almost complete clearance of telangiectatic lesions was observed.[ncbi.nlm.nih.gov]
  • A sapphire water- cooled chill tip was used to cool the skin during laser therapy. The treatment was performed every 4 weeks over a period of 6 months. results.[documentslide.com]
Turkish
  • SCLERO.ORG Patient & Caregiver Stories Main Menu By Language: French German Greek Italian Polish Romanian Russian Spanish Turkish I have never met anyone with my complaint and as complaints go I realize I am lucky, but I must admit I wish it was not me[sclero.org]
Italian
  • SCLERO.ORG Patient & Caregiver Stories Main Menu By Language: French German Greek Italian Polish Romanian Russian Spanish Turkish I have never met anyone with my complaint and as complaints go I realize I am lucky, but I must admit I wish it was not me[sclero.org]
Vascular Disease
  • Although patients with GET lack the typical periungual telangiectases associated with autoimmune collagen vascular diseases, these patients may have an underlying autoimmune process.[ncbi.nlm.nih.gov]
  • At this point long-term prognosis is unknown, and future insights into this condition may show cutaneous collagenous vasculopathy to be a marker for connective tissue or vascular diseases.[aocd-grandrounds.org]
  • For example, conditions such diabetes and peripheral vascular disease may lead to serious complications, such as ulcers. Some medications, such as minocycline or isotretinoin, can lead to adverse reactions if not discontinued prior to the treatment.[clinicalgate.com]
  • A nevus flammeus can also be a component of a larger congenital vascular disease; the most common that involves the leg being KTS.[plasticsurgerykey.com]
Purpura
  • Side effects such as purpura, scarring, and pain did not occur. After a follow-up of 6 months, small telangiectatic lesions relapsed.[ncbi.nlm.nih.gov]
  • There is an absence of concurrent epidermal and dermal changes, e.g. purpura, atrophy, depigmentation, or follicular involvement, and an absence of systemic symptoms or concurrent diseases.[dermatologyadvisor.com]
  • Side effects such as purpura, scarring, and pain did not occur. After a follow-up of 6 months, small telangiectatic lesions relapsed. conclusion.[documentslide.com]
Angiokeratoma
  • Date Added: 2018-03-06 Angiokeratoma Angiokeratoma Corporis Diffusum Generalized Essential Telangiectasia Hereditary Hemorrhagic Telangiectasia Mastocytosis Telangiectasia[gulfdoctor.net]
  • Diagnosis confirmation Differential Diagnosis: Angiokeratoma corporis diffusum (Fabry syndrome) - presents early in life (inborn error of metabolism, X-linked), lesions are hyperkeratotic with lack of blanching Cutaneous collagenous vasculopathy - may[dermatologyadvisor.com]
  • Diagnosis confirmation Differential Diagnosis: Angiokeratoma corporis diffusum (Fabry syndrome) – presents early in life (inborn error of metabolism, X-linked), lesions are hyperkeratotic with lack of blanching Cutaneous collagenous vasculopathy – may[dermatologyadvisor.com]
  • The term angiokeratoma is applied to a number of quite distinct conditions which share a common clinical presentation with asymptomatic hyperkeratotic vascular skin lesions and a histological combination of superficial dermal vascular ectasia. (12 Dec[kmle.co.kr]
  • Apart from possible emotional distress Differential Diagnosis (Other conditions with similar appearance) Angiokeratoma Corporis Diffusum (Fabry Syndrome) Diagnosis Key Points *Diagnosis is determined through clinical inspection to resolve possible differential[ozarkderm.com]
Skin Lesion
  • On DermNet NZ Vascular skin lesions Telangiectasia Other websites Generalised Essential Telangiectasia – Medscape Reference Books about the skin See the DermNet NZ bookstore .[dermnetnz.org]
  • The term angiokeratoma is applied to a number of quite distinct conditions which share a common clinical presentation with asymptomatic hyperkeratotic vascular skin lesions and a histological combination of superficial dermal vascular ectasia. (12 Dec[kmle.co.kr]
Night Sweats
  • sweats, not sleeping etc) When my GP examined m … read more Dr.[justanswer.com]
Hyperkeratosis
  • […] disseminated eruption of telangiectases associated with erythematous and edematous macules. (05 Mar 2000) telangiectasia verrucosa A discrete, pink to red telangiectasia having a tendency to undergo secondary epithelial changes, including acanthosis and hyperkeratosis[kmle.co.kr]
Suggestibility
  • It was recently suggested that cutaneous collagenous vasculopathy (CCV) is clinically identical to GET but that the 2 conditions can be distinguished by their distinctive histopathologic findings.[ncbi.nlm.nih.gov]
  • Our results suggest that the Nd:YAG laser appears to be an effective and safe treatment option for generalized essential telangiectasia.[ncbi.nlm.nih.gov]
  • Access full-color images and more than 90 online-only topics at Expert Consult, as well as EBMs, Suggested Reading, Patient Teaching Guides, and additional algorithms.[books.google.de]
  • Sometimes there may be a family history, which suggests a genetic component. It is not associated with varicose veins or other venous disorders. Environmental factors such as sun exposure may possibly play a part in its development.[dermnetnz.org]
Meningism
  • Ferri’s popular "5 books in 1" format provides quick guidance on short QT syndrome, microscopic polyangiitis, fungal meningitis, and much more. This medical reference makes the answers you need even easier to find - anytime, anywhere.[books.google.de]
  • Inheritance: autosomal recessive. (16 Dec 1998) cephalo-oculocutaneous telangiectasia An angioma involving the skin of the face, orbit, meninges, and brain.[kmle.co.kr]
Coarse Tremor
  • tremor during rest and inhibited by a voluntary effort, or one which appears only upon movement.[kmle.co.kr]
Paresthesia
  • […] customers I was diagnosed with primary progressive multiple sclerosis I was diagnosed with primary progressive multiple sclerosis a little over 3 years ago and after receiving intense steroid treatment for inactive lesions I have been left with severe paresthesia[justanswer.com]
Burning Sensation
  • It is painful and has a burning sensation. No history of edema or ulceration. No family history. O/E: Both lower extremities show prominent superficial arborizing blood vessels. The red color suggests these are arterioles.[vgrd.blogspot.com]

Workup

  • This imaging is primarily used for the diagnostic workup of venous insufficiency. It is also used for directing that treatment, including varicose veins.[clinicalgate.com]
Colitis
  • […] was started at a dose of 25 mg daily, ultimately alternating daily between 50 and 75 mg daily to reach a 6-thioguanine nucleotide (6-TG) level of 254 pmol/8 x 108 RBC (the level associated with increased frequency of clinical response in ulcerative colitis[jddonline.com]

Treatment

  • The treatment was performed every 4 weeks over a period of 6 months. After six treatment sessions an almost complete clearance of telangiectatic lesions was observed. Side effects such as purpura, scarring, and pain did not occur.[ncbi.nlm.nih.gov]
  • Generalized essential telangiectasia (GET) is a notoriously difficult to treat disorder with no current satisfactory treatments. This case and discussion report the use of 6-mercaptopurine (6-MP) as a successful treatment for GET.[ncbi.nlm.nih.gov]
  • Generalized essential telangiectasia (GET) is a rare vascular condition with limited treatment options. We report the successful treatment of GET with the 585-nm flashlamp-pumped pulsed dye laser (FLPDL).[ncbi.nlm.nih.gov]
  • It has been used similarly to MERCAPTOPURINE in the treatment of leukemia.[bioportfolio.com]
  • A sapphire water- cooled chill tip was used to cool the cutaneous surface during treatment (cooling temperature 3â5 8 C). Signifi- cant success was seen after the first treatment with a fluence of 20 J/cm 2 .[documentslide.com]

Prognosis

  • Treatment can be difficult and expensive, but the therapeutic benefit of providing patients with a name and prognosis for their disease cannot be overemphasized.[ncbi.nlm.nih.gov]
  • At this point long-term prognosis is unknown, and future insights into this condition may show cutaneous collagenous vasculopathy to be a marker for connective tissue or vascular diseases.[aocd-grandrounds.org]
  • Different presentations of primary telangiectases have been arbitrarily classified as distinct syndromes, designated by terms that often are descriptive based on inheritance, age of onset, anatomic distribution, morphology, prognosis, or associated findings[dermaamin.com]

Etiology

  • Etiology The etiology is unknown. A role for sun exposure has been suggested. Pathophysiology The pathophysiology includes widespread dilation of dermal vessels.[dermatologyadvisor.com]
  • Generalized telangiectasia: a clinical study with special consideration of etiology and pathology. Arch Dermatol 1926;14:387-426. McGrae JD, Winklemann RK.[new.medigraphic.com]
  • Causes The causes of telangiectases are multifactorial, however, exact etiology/pathogenesis isn't known. What is known are behaviors/medical conditions that can lead to them.[hoojooskincare.blogspot.com]
  • We contribute 2 new cases of this entity to help establish its clinical and epidemiological characteristics and make its etiology better known. 2012 S.[karger.com]

Epidemiology

  • We contribute 2 new cases of this entity to help establish its clinical and epidemiological characteristics and make its etiology better known. 2012 S.[karger.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of generalized essential telangiectasia is not well understood.[ncbi.nlm.nih.gov]
  • Pathophysiology The pathophysiology includes widespread dilation of dermal vessels. Systemic Implications and Complications Telangiectasias are usually asymptomatic; there was one case report of associated gastrointestinal (GI) bleeding.[dermatologyadvisor.com]
  • The anatomy and pathophysiology of telangiectasia is presented in Chapters 1 and 3.[plasticsurgerykey.com]
  • Pathophysiology of Spider Angioma Spider angiomas occur as a result of the dilation of preexisting vessels. It is not a vascular proliferation. That means new vessels are not formed, only preexisting vessels dilate.[medcaretips.com]

Prevention

  • Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets[books.google.de]
  • Maintenance Chemotherapy Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.[bioportfolio.com]
  • As of right now, " there are no current guidelines to prevent telangiectases ." So the best you can do is avoid/protect against behaviors that can cause them.[hoojooskincare.blogspot.com]
  • Here it can widen (dilate) to allow heat within the body to pass out into the body thereby preventing the internal temperature from rising to dangerous levels.[healthhype.com]
  • These manifestations are not treated for cosmetic reasons but to prevent bleeding and infection ( Fig. 4.13 ) (see Chapter 13 ).[plasticsurgerykey.com]

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