Fever, malaise, headache, and sore throat are presenting features. The vesicles rupture to form ulcerative lesions with grayish exudates on the tonsils and the posterior pharynx. [www1.cgmh.org.tw]

Primary maternal infection may present as a flu-like syndrome with fever, headache, malaise, and myalgias. Many individuals with HSV-2 may never have sores or have only very mild symptoms. [perinatology.com]

Primary infection can present with generalized symptoms of fever and malaise as well. The painful lesions last for 10-14 days and are grouped. Primary infection can also be completely asymptomatic. [clinicaladvisor.com]

About 10 per cent of primary infections cause a more severe form of disease manifested by fever and malaise. [www2.health.vic.gov.au]

May have generalised symptoms of a viral illness (upper respiratory tract infection, mild fever, malaise). May experience photophobia. In immunocompromised individuals and neonates: may become generalised and life-threatening. [patient.info]

Intravenous administration of the drug initiated measurable levels in blood and tears, but not in CSF. However, intrathecal injection induced persistent high levels of Interferon in CSF. [healio.com]

Differential diagnosis for HSV-1 and oral lesions includes recurrent aphthous ulcers, aphthous stomatitis, syphilis, bacterial pharyngitis, Epstein-Barr virus, Stevens-Johnson syndrome, contact dermatitis, bullous impetigo, and enteroviruses. [clinicaladvisor.com]

"Recurrent herpes labialis, recurrent aphthous ulcers, and the menstrual cycle". J. Dent. Res. 53 (4): 797–803. doi : 10.1177/00220345740530040501. PMID 4526372. Chambers A, Perry M (2008). [en.wikipedia.org]

HO M, Nash C, Morgan CW, et al: Interferon administration in the cerebro spinal space and its effects on rabies in rabbits. Infect Immun 9:286, 1974. 39. [healio.com]

Some viruses including herpes simplex virus(HSV), varicella-zoster virus (VZV), and rabies may also travel to the CNS along nerves. Viruses are obligate intracellular organisms. [neuropathology-web.org]

One day prior to admission, right-sided convulsions began which slowly progressed to all of the trunk. [healio.com]

Involvement of the CNS is common, with prominent chorioretinitis and convulsions. In more recent studies, 43% of infected children have disease localized to the skin, eye, and mouth and 56% had either disseminated infection or infection of the CNS. [virology-online.com]

Four days before admission, she became pyrexic, extremely excited, and anorexic. One day prior to admission, right-sided convulsions began which slowly progressed to all of the trunk. [healio.com]

The infant was well up to 24 days of age when he was hospitalized at Hospital Guillermo Grant Benavente in Concepcion, Chile with 1-day history of fever, irritability, poor oral intake and generalized tonic-clonic seizures. [nature.com]

Pathological findings in the brain: (a) Massive destruction of normal tissue: (b) Focal gliosis: and (c) Calcified inclusion bodies. Paraffin sections, H and E stains, photomicrographs. [healio.com]

Pathologically, HIV encephalitis is characterized by diffuse myelin damage (spongy myelinopathy, gliosis), neuronal loss, vascular damage, microglial nodules, and lymphocytic infiltrates. [neuropathology-web.org]

MRI of the brain performed on day 22 of acyclovir (44 days of age) showed megacystic encephalomalacia with laminar necrosis, gliosis and cortical atrophy with parieto-occipital subdural effusions ( Figure 1a ). [nature.com]