Symptoma

Generalized Pustular Psoriasis

GPP

In children, generalized pustular psoriasis is even more uncommon and may present as a severe and potentially life-threatening disorder. [ncbi.nlm.nih.gov]

  • Xerostomia

    In addition, secondary Sjögren's syndrome was diagnosed since she had keratoconjunctivitis sicca, xerostomia, raised erythrocyte sedimentation rate and positive antinuclear antibodies. [ncbi.nlm.nih.gov]

  • Abdominal Skin Rash

    A 21-year-old febrile lady presented to the emergency service with severe lid oedema, conjunctivitis, dry mouth and abdominal skin rash. [ncbi.nlm.nih.gov]

  • Acneiform Eruption

    Sebastian Bernardo and Mark Lebwohl, Pustular Psoriasis, Acneiform Eruptions in Dermatology, 10.1007/978-1-4614-8344-1_42, (295-307), (2013). Kara N. [doi.org]

  • Corneal Infiltrate

    Multiple focal sterile corneal infiltrates were seen. Haematological investigations and a skin biopsy were done as the consulting dermatologist suspected acute generalized pustular psoriasis. [ncbi.nlm.nih.gov]

After admission, the patient spiked a temperature of 102 degrees F with chills, the entire workup for which was negative, including blood cultures, chest x-ray, and urine analysis. She underwent skin biopsy to find the cause of her rash. [ncbi.nlm.nih.gov]

After admission, the patient spiked a temperature of 102 F with chills, the entire workup for which was negative, including blood cultures, chest x-ray, and urine analysis. She underwent skin biopsy to find the cause of her rash. [journals.lww.com]

  • Progesterone Increased

    Most cases of GPP in pregnancy occur late in the third trimester, generally when production of progesterone increases. [1] Infantile and juvenile [ edit ] GPP is a rare disease in general, but even more so in children. [en.wikipedia.org]

To demonstrate the efficacy and tolerability of adalimumab in the treatment of GPP. [ncbi.nlm.nih.gov]

Aim : To demonstrate the efficacy and tolerability of adalimumab in the treatment of GPP. [doi.org]

Prognosis Older patients with the von Zumbusch-type variant have a poorer prognosis. Children tend to have a good prognosis unless there is secondary infection. [patient.info]

The data included patient demographics, associated symptoms, aggravating factors, patterns of relapse and prognosis. Thirty-three patients with GPP were included in our study, with a mean age of 45.6 years and a male : female ratio of 1:1.2. [ncbi.nlm.nih.gov]

G.P.P. developing from acral pustulosis (acrodermatitis continua) has the worst prognosis and is likely to prove fatal. [doi.org]

"The prognosis of generalized pustular psoriasis". Br. J. Dermatol. 85 (5): 407–11. doi : 10.1111/j.1365-2133.1971.tb14044.x. PMID 5132156. Rosen RM (1991). "Annular pustular psoriasis induced by UV radiation from tanning salon use". [en.wikipedia.org]

Prognosis Psoriasis is a chronic (long-lasting) disease of the immune system. It cannot be cured. This means that most people have psoriasis for life. Pustular psoriasis flare-ups that may be painful and disabling. References [ ] [healthjade.com]

Epidemiology, etiology, diagnosis, and treatment options are discussed in this paper. [ncbi.nlm.nih.gov]

Various investigations provided no real clue to the etiology, but there was a relatively high incidence of seborrheic dermatitis. In contrast to adult patients, in only 12% was there a prior history of psoriasis vulgaris. [doi.org]

Epidemiology, etiology, diagnosis, and treatment options are discussed in this paper. [ncbi.nlm.nih.gov]

Murphy, The epidemiology of childhood psoriasis: a scoping review, British Journal of Dermatology, 174, 6, (1242-1257), (2016). [doi.org]

Epidemiology It is a rare condition: precise prevalence figures for the UK are not available. Prevalence is 7 per 1 million in Japan. [ 1 ] The average age of those affected is 50 but the range is wide. [patient.info]

References Iizuka H, Takahashi H, Ishida-Yamamoto A (2003) Pathophysiology of generalized pustular psoriasis. Arch Dermatol Res 295: S55-59. Tavarela Veloso F (2004) Review article: skin complications associated with inflammatory bowel disease. [omicsonline.org]

During the course of generalized pustular psoriasis, patients may present with various subtypes of psoriasis, 2,12 suggesting common pathophysiological mechanisms. [doi.org]

Pathophysiology ACH, like GPP, is also associated with precipitating factors. [dovepress.com]

Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 1998;83:1182-91. 7. Lamba G, Palaniswamy C, Singh T, Shah D, Lal S, Vinnakota R, et al. [jpharmacol.com]

Monitoring CD4 T lymphocyte count, preventing and correcting CD4 lymphocytopenia are important in the treatment course of juvenile GPP. [ncbi.nlm.nih.gov]

Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [doi.org]

The aim is to prevent further fluid loss, stabilise body temperature and restore electrolyte imbalance. Specialist care is essential. Affected areas are treated with bland topical compresses using emollients and low potency topical steroid creams. [dermnetnz.org]

Additional immunosuppressive agents, such as methotrexate, are sometimes given to prevent the development of antibodies to infliximab [2, 18]. [cureus.com]