A clonal lymphoplasmocytic proliferation, e.g. plasmacytoma, is present in the majority of cases. Here we report on a 19-year-old male who presented with generalized seizures and an enhancing white matter lesion on MRI scans. [ncbi.nlm.nih.gov]

• Amyloidosis

  Abstract Light chain deposition disease (LCDD) is a form of monoclonal immunoglobulin deposition diseases (MIDD) which in contrast to light-chain derived (AL) amyloidosis is characterized by non-congophilic, non-fibrillary monoclonal protein deposits. [ncbi.nlm.nih.gov]

• Progressive Dementia

  This case, with primary progressive dementia and late-onset myoclonic epilepsy, differs from previously reported cases. [ncbi.nlm.nih.gov]

• Seizure

  For different seizure types, focal to bilateral tonic-clonic seizures (P   0.020) and myoclonic-atonic seizures (P   0.002) might correlate with unfavourable outcomes. [ncbi.nlm.nih.gov]

• Extrapyramidal Symptoms

  Neurological examination only showed mild cerebellar and extrapyramidal symptoms, whereas neuropsychological evaluation disclosed severe cognitive changes consistent with dementia. [ncbi.nlm.nih.gov]

• Asthenia

  Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. [ncbi.nlm.nih.gov]

With these data, the current American College of Emergency Physicians (ACEP) guidelines on the workup of new-onset seizures were applied to determine whether they could safely be used in patients with AIDS. [ncbi.nlm.nih.gov]

The awake EEG of patients with generalized tonic-clonic seizure may be normal; however, certain specific interictal EEG patterns can be distinctive of generalized epilepsy syndromes (see Workup). [emedicine.medscape.com]

• Generalized Epileptiform Discharges

  We describe a patient with generalized seizures who in the same EEG had spindles transforming into generalized epileptiform discharges and generalized epileptiform discharges transforming into spindles. [ncbi.nlm.nih.gov]

• Oxygen Saturation Decreased

  Arterial oxygen saturation decreased to 75 %. Chin lift was performed and 100 % oxygen was administrated via face mask, which increased saturation to 99 %. Midazolam 2 mg was administrated intravenously to control seizures. [ncbi.nlm.nih.gov]

• Arterial Oxygen Saturation Decreased

  Arterial oxygen saturation decreased to 75 %. Chin lift was performed and 100 % oxygen was administrated via face mask, which increased saturation to 99 %. Midazolam 2 mg was administrated intravenously to control seizures. [ncbi.nlm.nih.gov]

• White Matter Lesions

  Here we report on a 19-year-old male who presented with generalized seizures and an enhancing white matter lesion on MRI scans. [ncbi.nlm.nih.gov]

OBJECTIVE: To evaluate safety, tolerability, seizure frequency, and regional variations in treatment responses with the AMPA antagonist, perampanel, in a large extension study during up to 3 years of treatment. [ncbi.nlm.nih.gov]

All preoperative evaluation data correlated to generalized seizures and postoperative prognosis were collected and analysed. [ncbi.nlm.nih.gov]

Prognosis The morbidity for tonic-clonic seizure can be high because these patients experience no aura and thus the seizure strikes without warning; minor injuries are frequent. Patients can have posterior shoulder dislocations and broken bones. [emedicine.medscape.com]

What is the prognosis of epilepsy? 60% to 70% of people with epilepsy will respond satisfactorily to the first AED used. Prognosis is highly dependent on the cause of epilepsy and seizure type. [aesnet.org]

Many types of seizures are described, each attributed to a certain demon or departed spirit and given a prognosis. References Template:WH Template:WS [wikidoc.org]

The purpose of this investigation was to determine the relative importance of this medication as the etiology of new-onset seizures relative to other drugs and new-onset seizures in general. The study design was a retrospective case series. [ncbi.nlm.nih.gov]

Etiology Epilepsy Although these seizures are referred to as unprovoked, they may be triggered by certain provocative factors! [amboss.com]

The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185-191. [PubMed: 31852003] 5. McGee RE, Sajatovic M, Quarells RC, Johnson EK, Liu H, Spruill TM, Fraser RT, Janevic M, Escoffery C, Thompson NJ. [ncbi.nlm.nih.gov]

Shobi Sivathamboo, Piero Perucca, Dennis Velakoulis, Nigel C Jones, Jeremy Goldin, Patrick Kwan, Terence J O’Brien, Sleep-disordered breathing in epilepsy: epidemiology, mechanisms, and treatment, Sleep, 10.1093/sleep/zsy015, 41, 4, (2018). [onlinelibrary.wiley.com]

Epidemiology The age-adjusted incidence of epilepsy (ie, recurrent unprovoked seizures) ranges from 24-53 per 100,000 population per year. Approximately 20-25% of cases are classified as generalized seizures. [emedicine.medscape.com]

Definition References:[1][2][3][4][5] Epidemiology References:[6] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Seizure Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Seizure from other Diseases Epidemiology and Demographics Risk Factors Screening Natural History, Complications and Prognosis [wikidoc.org]

Recognition and characterization of individual diurnal seizure patterns offer new diagnostic and therapeutic options, including EEG or long-term video EEG monitoring scheduling, differential (day/night) medication dosing, and a better understanding of pathophysiologic [ncbi.nlm.nih.gov]

Pathophysiology Generalized epilepsy is thought to be initiated by 3 different mechanisms: Abnormal response of hyperexcitable cortex to initially normal thalamic input Primary subcortical trigger Abnormal cortical innervation from subcortical structures [emedicine.medscape.com]

The ILAE task force initially was interested in developing an entirely new seizure classification based anatomy, brain networks, or pathophysiology. “But we quickly realized that we just did not know enough about the underlying science,” Dr. [mdedge.com]

International classification of seizure types (1981) This classification is based on observation (clinical and EEG) rather than the underlying pathophysiology or anatomy. [wikidoc.org]

There’s no specific way to prevent developing epilepsy. If you have epilepsy, following a healthy lifestyle by getting plenty of sleep and eating well can decrease the chances of triggering a seizure. [healthline.com]

This uses a device to monitor brain activity and respond with electronic stimulation if it detects a seizure is about to take place.[16] Generalized seizure prevention Idiopathic epilepsy can not be prevented. [ada.com]

Management[edit] For a person experiencing a tonic–clonic seizure, first-aid treatment includes rolling the person over into the recovery position, which can prevent asphyxiation by preventing fluid from entering the lungs.[12] Other general actions to [en.wikipedia.org]

Sometimes, changing the diet of a child with epilepsy can help prevent seizures. [mountsinai.org]

Treatment Correct treatment can help reduce or prevent seizures. In some cases, treatment can help patients to remain free of seizures for the rest of their lives. [cedars-sinai.org]