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Generalized Shwartzman Reaction


Presentation

  • Group A beta-hemolytic Streptococcus is a rare cause of peripartum infection, but it remains an extremely virulent pathogen with devastating consequences, thus requiring awareness of its presentation.[ncbi.nlm.nih.gov]
  • Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals.[dtic.mil]
  • Gaëtan Jasmin Butterworth-Heinemann, 21.01.2016 - 468 Seiten Endocrine Aspects of Disease Processes presents a critical review of hypothalamic hormones regulating the secretion of the anterior pituitary.[books.google.de]
  • An hypothesis which accounts for certain events in the generalized Shwartzman reaction, based on observations reported in this study, is presented. Footnotes Submitted: 6 May 1955 1955 Rockefeller University Press[jem.rupress.org]
  • An editorial team of leading authorities presents the latest on anesthesia techniques for labor and delivery and medical disorders that occur during pregnancy.[books.google.com]
Inflammation
  • Discussions focus on permeability of capillaries, cytoplasm, nucleus, gross pathology of inflammation, light microscope and the study of inflammation, and the physiologic approach to problems of inflammation.[books.google.de]
  • Prior to the endotoxin injection, biopsies of skin show normal vessels without microthrombi or significant inflammation.[ncbi.nlm.nih.gov]
Anemia
  • It is an acute, fluctuating illness whose major clinical manifestations are thrombocytopenia, hemolytic anemia with characteristically fragmented red blood cells, changing neurologic findings, fever, jaundice with both direct and indirect bilirubinemia[annals.org]
  • Prognostic importance of vascular lesions in acute renal failure with microangiopathic hemolytic anemia (hemolytic-uremic syndrome): clinico pathologic study in 20 adults. Kidney Int. 1979;15:548-58. Michael H, Hymphreys, Allen C Alfrey.[ijrcog.org]
Congestive Heart Failure
  • A chapter is devoted to the role of the adrenal cortex in the pathogenesis of a spontaneous hereditary congestive heart failure. The book can provide useful information to endocrinologist, doctors, students, and researchers.[books.google.de]
Physician
  • ‡Assistant professor of pathology, University of Southern California School of Medicine; head physician, Autopsy Service, Department of Pathology, Los Angeles County General Hospital.[nejm.org]
Pneumonia
  • Meningococcal pneumonia has been described and probably results from aspiration of N meningitidis.[img.medscape.com]
Hypertension
  • The text also looks into the pathogenesis of adrenal-regeneration and methyl-androstenediol hypertension; and the peripheral vasodilation and thymic tumors in magnesium-deficient rats.[books.google.de]
Heart Failure
  • A chapter is devoted to the role of the adrenal cortex in the pathogenesis of a spontaneous hereditary congestive heart failure. The book can provide useful information to endocrinologist, doctors, students, and researchers.[books.google.de]
Jaundice
  • It is an acute, fluctuating illness whose major clinical manifestations are thrombocytopenia, hemolytic anemia with characteristically fragmented red blood cells, changing neurologic findings, fever, jaundice with both direct and indirect bilirubinemia[annals.org]
Ulcer
  • Some of the topics covered in the book are the characteristics of brain plasticity under stress; the sleep-wakefulness patterns; the endocrine factors in the etiology of peptic ulcer; and blood sugar levels and allergies.[books.google.de]

Treatment

  • Treatment with heparin did not interfere with the lethal effect of single, large doses of meningococcus toxin.[ncbi.nlm.nih.gov]
  • The appearance of this heparin-precipitable fraction is prevented by treatment with heparin before endotoxin. It is not influenced by nitrogen mustard or cortisone.[jem.rupress.org]
  • Treatment of rabbits with nitrogen mustard to induce leukopenia blocked the induction of this reaction (2). Recent studies have provided support for the idea that blood monocytes may be crucial for the induction of the Shwartzman reaction.[link.springer.com]
  • Other drugs used in the treatment of fulminant meningococcemia are those used to support the circulation, such as dopamine, and those used to treat DIC. The treatment of DIC with heparin is controversial.[img.medscape.com]
  • However, an occasional unfortunate victim may die in profound and unresponsive shock hours after the onset of illness despite prompt and "adequate" treatment.[annals.org]

Prognosis

  • References Prognosis The prognosis of fulminant meningococcemia is guarded. Approximately one half of patients who present with this form of meningococcal disease do not survive, even with prompt administration of appropriate antimicrobial therapy.[img.medscape.com]

Etiology

  • Some of the topics covered in the book are the characteristics of brain plasticity under stress; the sleep-wakefulness patterns; the endocrine factors in the etiology of peptic ulcer; and blood sugar levels and allergies.[books.google.de]

Epidemiology

  • (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60[genecards.org]
  • The changing epidemiology of meningococcal disease in the United States, 1992-1996. J Infect Dis. Dec 1999;180(6):1894-901. [View Abstract] Ross SC, Densen P.[img.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Bacterial meningitis: recent advances in pathophysiology and treatment. Ann Intern Med. Apr 15 1990;112(8):610-23. [View Abstract] van de Beek D, de Gans J, McIntyre P, Prasad K.[img.medscape.com]

Prevention

  • Hemorrhagic necrosis of the skin which follows an intradermal injection of toxin in thorotrast-treated rabbits was also prevented by heparin.[ncbi.nlm.nih.gov]
  • The appearance of this heparin-precipitable fraction is prevented by treatment with heparin before endotoxin. It is not influenced by nitrogen mustard or cortisone.[jem.rupress.org]
  • Prevent and plan for potential complications associated with the advancing age of pregnant women.[books.google.com]
  • (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60[genecards.org]
  • Depletion of Plasma Factor XIII Prevents Disseminated Intravascular Coagulation-induced Organ Damage (1) The Catholic University of Korea, Department of Natural Sciences, College of Medicine, Seoul, Korea, (2) Soonchunhyang University, Department of Chemistry[th.schattauer.de]

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