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Gentamycin


Presentation

  • Before treatment, VEMPs were present in the affected ear of eleven patients. After treatment VEMPs were absent in all the patients.[ncbi.nlm.nih.gov]
  • The authors present a case of chronic osteomyelitis of the proximal aspect of the left femur in a 37-year-old male patient secondary to hydatid disease of bone.[ncbi.nlm.nih.gov]
  • The significance of local antibiotic-releasing systems as an adjuvant therapy to avoid reinfections is the subject of the presented study.[ncbi.nlm.nih.gov]
  • The present study reports that the rate of synergism and synergistic effect in the combination vancomycin-gentamycin vary according to the MICs of gentamycin.[ncbi.nlm.nih.gov]
  • At presentation, best-corrected visual acuity was 20/20 in the right eye and counting fingers in the left eye.[ncbi.nlm.nih.gov]
Intravenous Administration
  • The intravenous administration of gentamicin may be particularly useful for treating patients with bacterial septicemia or those in shock.[druglib.com]
  • In a more recent report, a woman was given an overdose of gentamicin and developed myoclonus (involuntary muscle jerks or spasms), which abated when the intravenous administration of gentamicin was discontinued (7).[vestibular.org]
Asymptomatic
  • It remains asymptomatic over a long period. It is usually detected after a pathological fracture or secondary infection or following the onset of compressive myelopathy in cases of vertebral lesions.[ncbi.nlm.nih.gov]
Benign Paroxysmal Positional Vertigo
  • OBJECTIVES: To analyze the incidence and characteristics of benign paroxysmal positional vertigo (BPPV) in patients with Ménière's disease who did not respond to medical treatment and to whom intratympanic gentamycin treatment was proposed.[ncbi.nlm.nih.gov]
Alopecia
  • […] neutropenia, agranulocytosis, leukopenia, thrombocytopenia, pancytopenia Hepatic: hepatomegaly, hepatotoxicity, hepatic necrosis Musculoskeletal: joint pain, muscle twitching Respiratory: apnea Skin: exfoliative dermatitis, rash, pruritus, urticaria, purpura, alopecia[medical-dictionary.thefreedictionary.com]
Chronic Anxiety
  • Variations in nomenclature for the disease include pelvic floor myalgia syndrome, chronic anxiety syndrome, prostatodynia, interstitial cystitis and abacterial prostatitis, so comparison of treatment populations is difficult.[ncbi.nlm.nih.gov]
Dizziness
  • In spite of complete control of attacks a disabling ablation type of unsteadiness and dizziness affected 7 patients. Two patients required additional treatment after 5-8 months remission.[ncbi.nlm.nih.gov]
  • Stop using this medicine and check with your doctor right away if you or your child have sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears.[mayoclinic.org]
  • You should let your doctor know if you experience any hearing loss, sensation of ringing or other noise (tinnitus) in the ears, dizziness or unsteadiness at any point during treatment.[netdoctor.co.uk]
  • However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction : rash , itching /swelling (especially of the face/ tongue /throat), severe dizziness , trouble breathing .[webmd.com]
Vertigo
  • Eleven patients were group D (27%) and experienced persistent vertigo despite treatment.[ncbi.nlm.nih.gov]
  • Our treatment of choice for Meniére's disease is endolymphatic drainage surgery which resulted in 96% control of vertigo.[ncbi.nlm.nih.gov]
  • OBJECTIVES: To analyze the incidence and characteristics of benign paroxysmal positional vertigo (BPPV) in patients with Ménière's disease who did not respond to medical treatment and to whom intratympanic gentamycin treatment was proposed.[ncbi.nlm.nih.gov]
  • At follow-up, eleven patients (91.6%) were free of vertigo, while one patient had two vertigo spells 9 months after treatment. Before treatment, VEMPs were present in the affected ear of eleven patients.[ncbi.nlm.nih.gov]
  • Abstract From 1982 to 1987, 20 patients with disabling attacks of vertigo and severe hearing loss due to unilateral Ménière's disease were treated with local intratympanic gentamycin. In 18 patients control of vertiginous attacks was achieved.[ncbi.nlm.nih.gov]

Workup

Albuminuria
  • In parenteral group incidence was higher in females as compared to males and profile included nausea and vomiting, headache, cough, tinnitis, albuminuria, diminition of hearing and vertigo.[ncbi.nlm.nih.gov]
Prostatic Lesion
  • Fourteen tumor-negative prostate needle biopsies showed prostatitis lesions. One elevated PSA patient had 3 biopsies.[ncbi.nlm.nih.gov]

Treatment

  • OBJECTIVES: To analyze the incidence and characteristics of benign paroxysmal positional vertigo (BPPV) in patients with Ménière's disease who did not respond to medical treatment and to whom intratympanic gentamycin treatment was proposed.[ncbi.nlm.nih.gov]
  • RESULTS: No treatment failure and death were observed in our patients. Side effects after adjuvant treatment with collagenous gentamycin were not detected.[ncbi.nlm.nih.gov]
  • This treatment is also a most effective treatment, as it allows the effects of isosorbide to be obtained with smaller doses of gentamycin sulfate.[ncbi.nlm.nih.gov]
  • […] prophylaxis (5.6 /- 2.1 years) with episodes of intensive treatment of recurrences.[ncbi.nlm.nih.gov]
  • At follow-up, eleven patients (91.6%) were free of vertigo, while one patient had two vertigo spells 9 months after treatment. Before treatment, VEMPs were present in the affected ear of eleven patients.[ncbi.nlm.nih.gov]

Prognosis

Etiology

  • If anaerobic organisms are suspected as etiologic agents, consideration should be given to using other suitable antimicrobial therapy in conjunction with gentamicin.[druglib.com]
  • Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.[journals.plos.org]

Epidemiology

  • In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.[druglib.com]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Monitoring adequacy of drug clearance during gentamicin therapy Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to[mayomedicallaboratories.com]
  • . : Pathophysiology of tissue fluid. Proceedings of the Royal Society for Medicine 1972, 65: 715–719. Google Scholar 12. Mandell, G. L. : Interaction of intraleucocytic bacteria and antibiotics. Journal of Clinical Investigation 1973, 52: 1673–1679.[link.springer.com]

Prevention

  • Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.[ncbi.nlm.nih.gov]
  • Consequently, an efficacious gentamycin concentration can be achieved in the cardiac tissues but not in the pericardial fluid which makes gentamycin excellently suited for the prevention and treatment of the infectious complications of heart operations[ncbi.nlm.nih.gov]
  • This antibiotic functions by preventing protein synthesis. Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro .[sigmaaldrich.com]
  • It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. Gentamicin injection is usually used for serious bacterial infections for which other medicines may not work.[mayoclinic.org]

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