The content of this Science & Innovation Webinar and opinions expressed by the presenters are those of the sponsor or presenters and not of AMCP. Sponsored by: ©2022 Apellis Pharmaceuticals, Inc. All rights reserved. 07.22 US-GA-2200252 v1.0 [amcp.org]

The RPD could then be defined as either “not determinable” (grader was <90% certain that RPD was present) or “yes” (grader was >90% certain that RPD was present). [karger.com]

Of these, 38 of 50 with VA data (76%) presented with a VA less than 20/40, and 8 of 50 (16%) presented with legal blindness (VA less than 20/400). [jamanetwork.com]

A patient presenting with bilateral geographic atrophy and visual acuities poor enough to categorize him as legally blind at the relatively young age of 60. [aaopt.org]

• Falling

  Complete retina services in Iowa are available at Wolfe Eye Clinic in Ames, Cedar Falls, Des Moines, Fort Dodge, Hiawatha (Cedar Rapids), Iowa City, Marshalltown, Ottumwa, Pleasant Hill, Spencer and Waterloo. [wolfeeyeclinic.com]

  Writing in a note to clients earlier this week, Umer Raffat, an analyst at Evercore ISI, said the readout is "considered one of the biggest catalysts in entire biopharma this fall." [biopharmadive.com]

  Consider writing with bolder pens and markers, setting your devices to display large print, and using motion-sensor lights around your home so that you don’t fall while searching for the light switch. [webmd.com]

  Reading Speed Assessment Patients with extrafoveal GA lesions may be able to see single letters on a traditional eye chart because a single letter may fall within the foveal region. [ophthalmologybreakingnews.com]

  Vision loss due to AMD can affect a person’s quality of life and lead to various complications, such as: a higher risk of falls an inability to carry out daily activities, including driving anxiety and depression However, rehabilitation and support are [medicalnewstoday.com]

• Asymptomatic

  2 testing to include asymptomatic persons in prioritized settings. [nejm.org]

  Fluorescein dye retinal angiography of patient with wet AMD, area of leakage corresponds to hemorrhage in figure 3A Presentation The main symptom of AMD is loss of central vision, but initially AMD may be asymptomatic. [morancore.utah.edu]

  Small serous PEDs are frequently detected on OCT in eyes with asymptomatic or quiescent disease and also in contra-lateral eyes. [reviewofophthalmology.com]

  is a leading cause of sight loss in people over the age of 65 in the United States and other Western countries.2 In the United States, more than 2 million people have the advanced forms of AMD.3 The early and intermediate stages of AMD usually are asymptomatic [geographicatrophyinfo.com]

  The ingrown nail becomes asymptomatic within half an hour of splinting, and the granuloma heals within 3 to 6 weeks. [magiran.com]

• Surgical Procedure

  And most of the patients who had any issues that were reported on safety, were with respect to, for example, the surgical procedure itself with some redness of the eye. [modernretina.com]

  Two totally different minimally invasive surgical procedure puncture factors with thrombolysis in a affected person with bilateral basal ganglia hemorrhages. Int J Gen Med. 2020;13:1435–1439. [aiexpress.io]

  Gyroscopetx.com While this approach avoids the need for vitrectomy or retinotomy, it is still a surgical procedure that requires patients to go to the operating room. [seekingalpha.com]

  The anti-VEGF route has traditionally been the focus of therapies, which have produced superior outcomes than earlier laser, sham, and surgical procedures. [cureus.com]

  Therapies and Surgical Procedures for Wet Age-Related Macular Degeneration Medical professionals have three strong treatment options for wet AMD. They are: Photodynamic Laser Therapy. [myvision.org]

• Swelling

  Swelling of the retina leads to vision decline and death of the retinal cells, which can irreversibly cause blindness if not adequately treated. [graybug.vision]

  Eye with Wet AMD: As the macula thins, blood vessels under the macula may start to swell and grow more than normal. These vessels can break and leak blood into the eye causing vision loss. [fightingblindness.ca]

  Optical Coherence Tomography (OCT) This non-invasive test takes detailed cross-sectional images of your retina to help the doctor spot areas of swelling, thinning, and thickening. It is also used to track progress during treatment. [myvision.org]

  Eyes with RAP exhibited retinal–retinal or retinochoroidal anastomosis in FA or ICGA and retinal swelling with or without RPE detachment in SD-OCT images. [journals.plos.org]

  Optical Coherence Tomography Optical coherence tomography (OCT) is a noninvasive test that produces detailed cross-sectional images of your retina, allowing your doctor to spot areas of thinning, thickening, or swelling. [everydayhealth.com]

• Fever

  Symptoms were classified into typical (fever, cough, and shortness of breath), atypical, and none. [nejm.org]

  Systemic symptoms including vomiting, abdominal pain and fever were not uncommon (16%) and they were likely due to underlying disease rather than brain bleeding per se. [aiexpress.io]

• Scotoma

  People with GA develop what are known as scotomas, blind spots in or near their central field of vision. The scotomas grow in area over time causing more central vision loss. [fightingblindness.org]

  This means that while central vision may be preserved, areas of vision located just outside the point of fixation could be lost to scotomas (blind spots). [spherixglobalinsights.com]

  Although it begins slowly, geographic atrophy is a progressive and irreversible disease that leads to central scotomas. A person with geographic atrophy will see a central scotoma, a blind spot directly in their center of vision. [associatedretinaconsultants.com]

  He has central scotomas OU on Goldmann visual field testing. [aaopt.org]

  Millie’s vision has worsened in part because she has developed a scotoma in her macula. Scotomas are often described as blind spots, but they are not actually dark areas that block our view but rather the absence of vision itself. [visionaware.org]

• Visual Impairment

  Enlargement rates varied widely but was on average 1.09 mm2 per year, and moderate to severe visual impairment was present in 66% of eyes with GA before death. [jamanetwork.com]

  GA is progressive and irreversible, leading to central visual impairment and permanent loss of vision. [dukeeyecenter.duke.edu]

  In the US, the total geographic atrophy cases by visual impairment were 397,400+, 662,400+, and 264,900+ for mild, moderate to severe, and patients going for surgery or having legal blindness, respectively, in 2020. [digitaljournal.com]

  As a vision rehabilitation specialist, I help people who have visual impairments better understand their eye conditions. Frequently, my clients are confused by what they can or cannot see. [visionaware.org]

  Extent of Exacerbation of Chronic Health Conditions by Visual Impairment in Terms of Health-Related Quality of Life. JAMA Ophthalmol. 2015; 133:1267-1275. [roche.com]

• Visual Impairment

  Enlargement rates varied widely but was on average 1.09 mm2 per year, and moderate to severe visual impairment was present in 66% of eyes with GA before death. [jamanetwork.com]

  GA is progressive and irreversible, leading to central visual impairment and permanent loss of vision. [dukeeyecenter.duke.edu]

  In the US, the total geographic atrophy cases by visual impairment were 397,400+, 662,400+, and 264,900+ for mild, moderate to severe, and patients going for surgery or having legal blindness, respectively, in 2020. [digitaljournal.com]

  As a vision rehabilitation specialist, I help people who have visual impairments better understand their eye conditions. Frequently, my clients are confused by what they can or cannot see. [visionaware.org]

  Extent of Exacerbation of Chronic Health Conditions by Visual Impairment in Terms of Health-Related Quality of Life. JAMA Ophthalmol. 2015; 133:1267-1275. [roche.com]

• Central Scotoma

  Although it begins slowly, geographic atrophy is a progressive and irreversible disease that leads to central scotomas. A person with geographic atrophy will see a central scotoma, a blind spot directly in their center of vision. [associatedretinaconsultants.com]

  He has central scotomas OU on Goldmann visual field testing. [aaopt.org]

  GA leads to central scotomas, which are blind or blurry spots in the central field of vision. These areas typically expand over time, gradually causing permanent loss of visual acuity. [texasretina.com]

  scotoma (20 central degrees) sparing the fovea (arrows). [jscimedcentral.com]

  This loss of our straight ahead vision is called a central scotoma - it is a gray or black spot that appears in the center of one's vision. Other vision changes involve: 1. Reading slower The speed of reading drops as GA progresses 2. [webrn-maculardegeneration.com]

• Blurred Vision

  Most patients have no serious visual disturbances and some may have some mild signs of visual discomfort or blurred vision. The majority of patients will remain at this early stage and never progress to the more serious forms. [alkeuspharma.com]

  Symptoms may include: Distorted or blurred vision Straight lines may appear wavy Small blind spots which may interfere with reading and seeing objects clearly It is important if you or a loved one are experiencing any of the symptoms above to call your [wolfeeyeclinic.com]

  Later, if the disease progresses, people experience wavy or blurred vision, and, if the condition continues to worsen, central vision may be completely lost. People with very advanced macular degeneration are considered legally blind. [macular.org]

  Dilation of your eyes is safe, but your vision will be blurred for several hours afterward until the medication wears off. [verywellhealth.com]

  Age-related macular degeneration (AMD) affects a person’s central vision. It becomes more common after the age of 60 years. The first sign of AMD is often blurred vision. Reading, writing, recognizing faces, and driving can become more difficult. [medicalnewstoday.com]

Nonetheless, sufferers beneath 50 years with no historical past of hypertension are more likely to have metabolic or intoxication induced SSBBGH which ought to immediate acceptable etiology-based workup and intervention. [aiexpress.io]

[…] coherence tomography (optional; may be used to follow disease progression): To examine retinal thickness Multifocal electroretinography (optional; may be used to follow disease progression): To evaluate functional response of retinal rods and cones See Workup [emedicine.medscape.com]

• Central Scotoma

  Although it begins slowly, geographic atrophy is a progressive and irreversible disease that leads to central scotomas. A person with geographic atrophy will see a central scotoma, a blind spot directly in their center of vision. [associatedretinaconsultants.com]

  He has central scotomas OU on Goldmann visual field testing. [aaopt.org]

  GA leads to central scotomas, which are blind or blurry spots in the central field of vision. These areas typically expand over time, gradually causing permanent loss of visual acuity. [texasretina.com]

  scotoma (20 central degrees) sparing the fovea (arrows). [jscimedcentral.com]

  This loss of our straight ahead vision is called a central scotoma - it is a gray or black spot that appears in the center of one's vision. Other vision changes involve: 1. Reading slower The speed of reading drops as GA progresses 2. [webrn-maculardegeneration.com]

However, no approved treatment exists for the dry form of the disease. [medscape.com]

Food and Drug Administration (FDA) for the treatment of geographic atrophy. [pipelinereview.com]

Treatment appeared to cause a lower-than-expected rate of a side effect involving leakage from retinal blood vessels. [biopharmadive.com]

The prognosis is poor due to unavailability of treatment. Currently there are no effective preventive measures or any approved medical or surgical treatments that can stop progression or reverse the visual loss. [webeyeclinic.com]

Moreover, the results at 18 months were a continuation of the treatment effect seen at 12 months, a 27.38% difference between active treatment and sham, favouring the former (p = 0.0072). [europe.ophthalmologytimes.com]

This may be useful for determining prognosis and clinical trial eligibility as well as phenotype–genotype correlation. [bjo.bmj.com]

Several factors that could inform an individual's disease prognosis have been replicated in multiple cohorts: baseline lesion size, lesion location, multifocality, FAF patterns, and fellow eye status. [pubmed.ncbi.nlm.nih.gov]

Prognosis Most people with AMD will retain good central vision and the ability to read in their lifetime. This is because 90% of people have dry AMD. This is associated with a more favorable prognosis. [potomacretina.com]

The prognosis is poor due to unavailability of treatment. Currently there are no effective preventive measures or any approved medical or surgical treatments that can stop progression or reverse the visual loss. [webeyeclinic.com]

Overview Symptoms and Causes Diagnosis and Tests Management and Treatment Prevention Outlook / Prognosis Living With Age-Related Macular Degeneration Overview Symptoms and Causes Diagnosis and Tests Management and Treatment Prevention Outlook / Prognosis [my.clevelandclinic.org]

Co-existence of multiple etiologies is possible. Table 3 summarizes all SSBBGH etiologies in descending order. [aiexpress.io]

While the etiology of GA is not completely understood, inflammatory processes involving the activation of resident immune cells of the retina called microglia are likely to contribute. [clinicaltrials.gov]

That could provide new insights into the etiology of the disease. "AI can help us see beyond what the human eye can see," Ferrara told Medscape Medical News. [medscape.com]

This difference probably relies on the different etiologic mechanisms. [biomedres.us]

According to the description from ClinicalTrials.gov, "While the etiology of GA is not completely understood, inflammatory processes involving the activation of resident immune cells of the retina called microglia is likely to contribute. [webrn-maculardegeneration.com]

“Delveinsight Business Research LLP” DelveInsight’s “Geographic Atrophy Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology as well as the Geographic [digitaljournal.com]

[…] email that contains a secure link for resetting your password If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password Home AI/Deep Learning Cataracts Cornea and External Disease COVID-19 Epidemiology [ajo.com]

EpiCast Report: Age-Related Macular Degeneration – Epidemiology Forecast to 2026, November 2017, GDHCERX Related Companies GlobalData GlobalData exists to help businesses decode the future to profit from faster, more informed decisions. [clinicaltrialsarena.com]

There is an unmet need to better understand the events leading to atrophy and to identify high-risk features for functional loss as well as potential associations with epidemiological, environmental and genetic factors,” he said. [euretina.org]

Epidemiology SSBBGH is more commonly reported in Asia (68.3%) compared to other continents (31.6%). The majority of SSBBGH cases from Asia were from Japan (21/41; 51.2%) and India (6/41; 14.6%). [aiexpress.io]

[…] and Jillian Martin and Daniela Ferrara and Giovanni Staurenghi}, journal={Ophthalmology}, year={2019} } Topics from this paper 23 Citations Citation Type Citation Type All Types Background Citations Results Citations Age-Related Macular Degeneration: Pathophysiology [semanticscholar.org]

The pathophysiology is not fully known. Many different parameters are described to play a role in the development of the disease, e.g. genetic and environmental factors. [vtc.meduniwien.ac.at]

Further investigation with visualization techniques might help understand the pathophysiology behind the predictions. The predictions may be improved by combining with imaging modalities like near-infrared and/or optical coherence tomography. [spiedigitallibrary.org]

The pathophysiology of the condition remains unclear and although advances in research have identified several therapeutic targets, there are currently no approved treatments to prevent either the onset or progression of GA. [graybug.vision]

Pathophysiology Clinical pathophysiology The clinical definition of early age-related macular degeneration (AMD or ARMD) varies with the source consulted. [emedicine.medscape.com]

Geographic Atrophy is a devastating blinding disease without any approved or effective treatment currently available to prevent its onset or slow down its progression. [graybug.vision]

Laser treatment in patients with bilateral large drusen: the complications of age-related macular degeneration prevention trial. Complications of Age-Related Macular Degeneration Prevention Trial Research Group. [pubmed.ncbi.nlm.nih.gov]

General recommendations for the prevention of geographic atrophy include getting adequate vitamin intake, which experts suggest may prevent further oxidative damage. [verywellhealth.com]

Nutritional supplements are recommended to prevent development of n-AMD but no delay of atrophy is proven. Management focuses on surveillance and early treatment of occurring n-AMD. [vtc.meduniwien.ac.at]

[…] netbook desktop mobile tablet-landscape tablet phone-landscape phone Research to Prevent Blindness   News  RPB News In October, Research to Prevent Blindness held a virtual event, "RPB Lunch & Learn: Eye on Dry AMD," designed to educate RPB's community [rpbusa.org]