The clinical records of all molar patients were reviewed regarding presentation, treatment, and follow-up. [ncbi.nlm.nih.gov]

• Cervical Lymphadenopathy

  She presented two years later (June 1992) with bilateral cervical lymphadenopathy. Cervical tuberculous lymphadenitis was confirmed by biopsy and Ziehl-Neelsen method. There were no clinical symptoms of tuberculosis. [ncbi.nlm.nih.gov]

• Lymphadenopathy

  She presented two years later (June 1992) with bilateral cervical lymphadenopathy. Cervical tuberculous lymphadenitis was confirmed by biopsy and Ziehl-Neelsen method. There were no clinical symptoms of tuberculosis. [ncbi.nlm.nih.gov]

• Flushing

  Case 4 was a 51-year-old woman who presented to her GP with a 6-month history of lethargy, flushes, abdominal distension and irregular vaginal bleeding. On examination, she was noted to have a palpable goitre and a central abdominal mass. [doi.org]

• Suggestibility

  The latter suggests a hitherto unreported novel link between ASPP1 and the extrinsic pathway of apoptosis. [ncbi.nlm.nih.gov]

  Findings (eg, very high beta-hCG levels, classic ultrasonographic findings) may suggest the diagnosis, but biopsy is required. [merckmanuals.com]

• Fear

  Anxious patients scored higher for fear of recurrence (r 0.49, p 0.0001), of infertility (r 0.40, p 0.001) and of conceiving again (r 0.30, p 0.01). They experienced the measurements as a burden (r 0.35, p 0.003). [ncbi.nlm.nih.gov]

  She may be consumed with confusion and fear, asking herself "How will I tell my children? Will I be able to continue caring for them? Will I live through this?" [thebabycorner.com]

  This would help to allay fears, enhance compliance, quality of life and control over the disease and treatment. [journals.plos.org]

  Summary Gestational trophoblastic disease, although highly curable, is an emotionally traumatic event in a women’s life, not only because of the pregnancy loss, but also because of the fear of cancer. [mymolarpregnancy.com]

• Agitation

  Thyroid function tests showed her to be hyperthyroid, with TSH –1, FT4 73 pmol l –1 and FT3 21.6 pmol l –1, in keeping with her symptoms of breathlessness, agitation and resting tachycardia. She was commenced on carbimazole and propranolol. [doi.org]

• Focal Neurological Deficit

  • CNS(10%): may develop focal neurological deficits. 19. [slideshare.net]

• Uterine Hemorrhage

  Intrauterine balloon catheterization appears to be a promising alternative to control uterine hemorrhage and preserve fertility for young women undergoing treatment for gestational trophoblastic disease. [ncbi.nlm.nih.gov]

  Hydatidiform Mole Many patients with complete mole present with or develop anemia from uterine hemorrhage and may require transfusion support. [clinicaladvisor.com]

• Sexual Dysfunction

  Psychological morbidity rates exceeded community norms, but sexual dysfunction rates, although high, are likely consistent with local norms. [ncbi.nlm.nih.gov]

Recently, PCR-based short tandem repeat DNA genotyping has emerged as a powerful diagnostic measure in the workup of gestational trophoblastic disorders, particularly hydatidiform moles. [ncbi.nlm.nih.gov]

If malignancy is suspected, workup must include an x-ray of the chest to screen for lung metastases. Hydatidiform moles are normally treated via dilation and curettage, whereas choriocarcinoma typically requires chemotherapy. [amboss.com]

Metastatic workup:• Includes:• Xray chest and CT scan• USG and CT scan abdomen and pelvis• CT or MRI scan of head• hCG levels can be measured in CSF to exclude cerebral involvement if CT brain is normal.• Ratio of plasma to CSF hCG has to be lower than [slideshare.net]

See Workup for more detail. Management Patients with GTN are subdivided into 2 groups: those with a WHO score of less than 7 (low-risk) and those with a score of 7 or higher and who are at high risk of therapy failure. [emedicine.com]

• Pleural Mass

  A CT scan of the chest revealed a pleural mass and serum Beta-subunit of HCG was high. After treatment the hormonal level became normal and the patient remains asymptomatic. [ncbi.nlm.nih.gov]

When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Clinical trials are taking place in many parts of the country. [cancer.gov]

However, it is associated with significant neutropenia often requiring dose reductions and treatment delays. We describe the use of granulocyte colony-stimulating factor (G-CSF) in three patients in order to maintain the treatment schedule. [ncbi.nlm.nih.gov]

A patient with metastatic, poor prognosis disease and a large metastatic lesion on her left fifth digit is presented. The clinical course and complete response to EMACO chemotherapy are outlined. [ncbi.nlm.nih.gov]

Only a few women with GTD have a poor prognosis, e.g. some forms of stage IV GTN. The FIGO staging system is used. [en.wikipedia.org]

Prior evidence shows that FIGO score 7 is associated with poorer prognosis. [2minutemedicine.com]

This case has interesting etiologic implications, but it is difficult to make any extrapolation from this very peculiar case in terms of definition/quantification of maternal and paternal components in the development of gestational trophoblastic disease [ncbi.nlm.nih.gov]

[…] an invasive mole Etiology Risk factors Prior molar pregnancy History of miscarriage Patients 15 and 35 years Complete mole Does not contain any fetal or embryonic parts Caused by fertilization of an empty egg that does not carry any chromosomes The [amboss.com]

Etiology The etiology of gestational trophoblastic tumors is not known. [rarediseases.info.nih.gov]

The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. [ncbi.nlm.nih.gov]

Numero Pagine: 205 Rilegatura: Rilegato Formato: 25x31 Prezzo Copertina: 150.55 Sconto 15% Descrizione Comprehensive presentation of histological diagnosis and differential diagnoses of GTD In-depth reviews of the molecular genetic background of GTD, epidemiology [libreriascientifica.com]

Pathophysiology Hydropic degeneration of chorionic villi with concomitant proliferation of cytotrophoblasts and syncytiotrophoblasts death of the embryo Clinical features Complete mole Vaginal bleeding during the first trimester Uterus size greater than [amboss.com]

Pathophysiology Fertilization occurs as the sperm enters the ovum. In instances of a partial mole, two sperms might fertilize a single ovum. Reduction division or meiosis was not able to occur in a partial mole. [nurseslabs.com]

[…] hydatidiform molar pregnancy Asian or American Indian ancestry, or (for GTN only) African ancestry Older maternal age – women 40 years Familial disease – rare, more common in recurrent CHM NLRP7 and (rarely) KHDC3L gene mutations implicated (Wang, 2009) Pathophysiology [arupconsult.com]

Some comments about diabetes mellitus are made regarding: history, pathophysiology, value of glucose tolerance tests, dietary management and preferred methods of delivery. [link.springer.com]

Triploid partial moles which arise mainly from dispermic fertilization may also be prevented by ICSI. [ncbi.nlm.nih.gov]

Causes & Prevention NCI does not have PDQ evidence-based information about prevention of gestational trophoblastic disease. Screening NCI does not have PDQ evidence-based information about screening for gestational trophoblastic disease. [cancer.gov]