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Giant Cell Glioblastoma


Presentation

  • A variant of GM, a multifocal giant cell glioblastoma, initially presenting in the cerebellum, has not previously been reported. A giant cell glioblastoma occurring in a 46-year-old man who presented initially with a cerebellar tumour is described.[ncbi.nlm.nih.gov]
  • Clinical presentation Giant cell glioblastomas are de novo lesions with symptoms at presentation similar to those of GBM.[prod.wiki.cns.org]
Photosensitivity
  • Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 20 Dihematoporphyrin Ether Phase 3,Phase 1 21 Ether Phase 3 22 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23 Dermatologic Agents Phase 3,Phase 1,Phase 2,Not Applicable 24 Photosensitizing[malacards.org]
  • It is a type of imaging agent and a type of photosensitizing agent. Gleostine listen (GLEE-oh-steen) A drug used to treat brain tumors that have already been treated with surgery or radiation therapy.[cancer.gov]
Shoulder Pain
  • Thirty-two months later he developed headache and shoulder pain with symptoms of normal pressure hydrocephalus. Head CT showed ventriculomegaly and SAH.[ncbi.nlm.nih.gov]
Withdrawn
  • Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Brain and Central Nervous System Tumors Male Breast Cancer Any 17 and under 18 - 34 35 - 50 51 - 69 70 Available Active, not recruiting Not yet recruiting Recruiting Completed Terminated Suspended Withdrawn[patientwing.com]
  • Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride 17 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn[malacards.org]
Ataxia
  • You are here Home / "Giant Cell Glioblastoma in the Cerebrum of a Pembroke Welsh Corgi" After developing ataxia, the loss of control of bodily movements, and panting, a female six year-old Pembroke Welsh corgi was diagnosed with giant cell glioblastoma[pages.wustl.edu]
  • […] rare. [1] Cerebellar glioblastoma multiforme (GBM) is a rare tumor that accounts for only 1% of all cases of GBM and its giant cell variant is even much rarely encountered in adults. [2] A 51-year-old woman complained of headache with vomiting and gait ataxia[ruralneuropractice.com]
Cervical Cord Compression
  • Due to the possibility of a rapid clinical deterioration in patients with high cervical cord compression, the diagnosis of drop metastasis to the spine should be considered in patients with a previous history of supratentorial GBM who present with acute[ncbi.nlm.nih.gov]
Generalized Seizure
  • We report a case of GC-GBM in a 42-year-old male with 3 months history of generalized seizures. He also complained of headache accompanied by vomiting since 1 month. The intensity of headache had increased over last 7 days.[indianjcancer.com]
Gait Ataxia
Papilledema
  • She had 6/36 visual acuity and mild papilledema bilaterally. Her gait was ataxic in nature and had positive cerebellar signs. Hermental status and other cranial nerve examinations were normal.[ruralneuropractice.com]

Workup

  • Neuroradiological workup revealed a large, high cervical compressive leptomeningeal mass consistent with a drop metastasis.[ncbi.nlm.nih.gov]
  • Workups for common metastatic lesions from breast, lung, colon, and secondary central nervous system lymphoma were found to be negative.[ruralneuropractice.com]
  • Radiography: X-rays are not often used in the workup of a patient with a malignant glioblastoma. Nevertheless, when the tumor is very aggressive, with invasion of the skull bones, skull erosive changes can be demonstrated on a skull x-ray.[brain-surgery.com]
  • Detection of many of the molecular changes that underlie the development of gliomas and other BT can now be done by immunohistochemistry and is getting into the mainstream of the diagnostic workup of BT.[neuropathology-web.org]
  • Another potentially useful immunostain in the diagnostic workup of gliomas is OLIG2.[nature.com]
Lymphocytic Infiltrate
  • By immunohistochemical staining, lymphocyte infiltration was found in 6 cases. GFAP and vimentin stained positive in all cases.[ncbi.nlm.nih.gov]
  • infiltrate, (4) eosinophilic granular bodies, (5) dense reticulin stain invested around each cell.[ijpmonline.org]

Treatment

  • Patients were retrospectively identified through chart review, and data pertaining to patient demographics, treatment plans, and follow-up were extracted from existing medical records.[ncbi.nlm.nih.gov]

Prognosis

  • The prognosis of GC is superior to that of GBM, and long-term survival is possible, suggesting aggressive therapy is warranted.[ncbi.nlm.nih.gov]

Etiology

  • […] with male to female ratio at 1.6 and 35% occur in patients [5] Some authors have proposed a possible association between genetic disorders such as neurofibromatosis type 1 [6] and tuberous sclerosis [7] and one study in primates hypothesized a possible etiological[pediatricneurosciences.com]
  • Medscape Education Pediatrics , November 2014 Neuroimaging of Epilepsy: A Review of MRI Findings in Uncommon Etiologies and Atypical Presentations of Seizures In patients with atypical or unusual epilepsy, appropriate, directed use of magnetic resonance[medscape.org]
  • PMID 18579016 What is the etiology of human brain tumors? A report on the first Lebow conference. Brem S, Rozental JM, Moskal JR. Cancer. 1995 Aug 15;76(4):709-13.[atlasgeneticsoncology.org]
  • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855–4878. pmid:8069852 View Article PubMed/NCBI Google Scholar 6.[journals.plos.org]

Epidemiology

  • Consequently, the epidemiology, natural history, and factors associated with outcome are not well defined. Patients diagnosed with GC from 1988 through 2004 were identified in the Surveillance, Epidemiology, and End Results (SEER) database.[ncbi.nlm.nih.gov]
  • Epidemiology Giant cell glioblastoma accounts for about 5% of all GBMs. The mean age of occurrence is 42 years. There is a male predominance (1.6:1).[prod.wiki.cns.org]
  • WHO Classification Standard name Giant-cell glioblastoma Structure Neuroepithelial tumors Astrocytic tumors Glioblastoma Giant-cell glioblastoma ICD-O Code & WHO Grade ICD-O Code 9441/3 WHO Grade IV Synonyms & Acronyms Synonyms Monstrocellular sarcoma Epidemiology[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • Another important issue is that in this study we did not analyzed the BRAF-KIAA1549 fusion as it displays a separate rearrangement with a distinct pathophysiological pathway, being predominantly found in pilocytic astrocytoma (PA).[journals.plos.org]

Prevention

  • These studies may uncover clues to help prevent, diagnose, and treat disease.[cancer.gov]
  • Página 310 - A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. ‎[books.google.es]
  • Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo 14 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo 15 Cyproheptadine in Preventing[malacards.org]
  • Evaluating the Latest Evidence and Grades of Recommendation CME / ABIM MOC Dr Alok Khorana and expert panel discuss the latest clinical evidence on the prevention and treatment of thrombosis in patients with cancer.[medscape.org]
  • The fields are believed to interfere with formation of the mitotic spindle as well as to affect polar molecules at telophase, thus preventing cell division.[wjso.biomedcentral.com]

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