Presentation
Four cases are presented here with radiological, endocrinological, and surgical findings. [ncbi.nlm.nih.gov]
[…] and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors [books.google.com]
Our patient presented with severe headache and features of panhypopituitarism. [japi.org]
Entire Body System
- Pathologist
Edited by four leading surgical pathologists - Noel Weidner, MD, Richard J. Cote, MD, Saul Suster, MD and Lawrence M. [books.google.com]
Subhashis Mitra Consultant Pathologist, Department of Pathology, Advanced Medicare and Research Institute (Vision Care Hospital, 223, 230 Barkohala Lane, Mukundapur, Kalikapur, Kolkata - 700 099, West Bengal India Source of Support: None, Conflict of [ijpmonline.org]
They come to the pathologist more frequently when they are at an advanced stage, producing a mass effect and/or hypothalamic. However, the most enigmatic form of granulomatous hypophysitis is idiopathic. [omicsonline.org]
- Weight Gain
In the last three years he had noticed an unexplained weight gain, decreased libido and sporadic visual defects. [omicsonline.org]
Gastrointestinal
- Constipation
Symptoms in this phase may include: Fatigue Dry skin Swollen eyes Intolerance to cold Constipation In the recovery phase, there is a depletion of the excess colloid and a resolution of symptoms. [news-medical.net]
Cardiovascular
- Tachycardia
Symptoms during this period may include: Neck pain Tender diffuse goiter Tachycardia Sweating Heat intolerance Nervousness Frequent bowel movements Fever The euthyroid phase is a transient phase without noticeable symptoms, which usually lasts from 1- [news-medical.net]
Skin
- Dry Skin
Symptoms in this phase may include: Fatigue Dry skin Swollen eyes Intolerance to cold Constipation In the recovery phase, there is a depletion of the excess colloid and a resolution of symptoms. [news-medical.net]
- Urticaria
[…] erythemarosus 強皮症:scleroderma リウマチ様結節:rheumatoid nodule ◎環状肉芽腫:granuloma annulare リポイド類壊死症:necrobiosis lipoidica 結節性多発動脈炎:polyarteritis nodosa 血栓性静脈炎:thrombophlebitis ◎leukocytoclastic vasculitis nodular amyloidosis ケロイド:keloid 肥厚性瘢痕:hypertrophic scar 色素性蕁麻疹:urticaria [medical-e.net]
Neurologic
- Tremor
SPINOCEREBELLARE DI HOLMES (RFG040) DISSINERGIA CEREBELLARE MIOCLONICA DI HUNT (RFG040) HALLERVORDEN-SPATZ, SINDROME DI (RFG040) MALATTIE SPINOCEREBELLARI (RFG040) MARINESCO-SJÖGREN, SINDROME DI (RFG040) PARAPLEGIA SPASTICA EREDITARIA (RFG040) SINDROME CON TREMORE [malattierare.toscana.it]
Workup
Autoimmune workup did not reveal any abnormality with CRP - 1.2 mg/l (normal < 7 mg/l); antinuclear antibodies (< 1:40), and antineutrophilic cytoplasmic antibodies (< 1:16), anti-TPO Ab - 4 IU/l (< 9), RA factor 4 IU/l (< 20), and anti-TTG Ab- 3.54 IU [ijem.in]
X-Ray
- Enlarged Sella
The MR imaging features included a thickened stalk, a diffusely and uniformly enlarged gland, a normal size or minimally enlarged sella, and enhancement of the optic chiasm. Hypophysitis is of two types: lymphocytic and granulomatous. [ajnr.org]
Magnetic resonance imaging (MRI) scan demonstrated an enlarged sella and a large well-marginated patchily enhancing soft tissue mass within sellar and suprasellar regions. There was no parasellar extension, and no necrosis or hemorrhage. [cancerjournal.net]
An unusual cause of hyperprolactinemia and enlarged sella turcica. JAMA. 1981. 246: 1811-2 36. Rivera JA. Lymphocytic hypophysitis: Disease spectrum and approach to diagnosis and therapy. Pituitary. 2006. 9: 35-45 37. [surgicalneurologyint.com]
Other Pathologies
- Granulomatous Tissue
The granulomatous reaction area that can accompany these rare tumors can lead to diagnostic errors unless adequate tissue and serial sections are available. [turkjpath.org]
Treatment
Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.com]
OBJECTIVE: To describe the clinical features of giant-cell granulomatous hypophysitis and to report on the results of corticosteroid treatment. [ncbi.nlm.nih.gov]
Corticosteroids are considered as primary treatment along with desmopressin if patients have DI to avoid traumatic effects of surgery. Surgical treatment is useful for relieving the elevated pressure effects on optic and occulomotor nerve. [jpgo.org]
Diagnosis and Treatment Accurate diagnosis of De Quervian’s thyroiditis is important because, unlike other conditions that cause symptoms of hyperthyroidism, it resolves spontaneously without the need for a specific treatment. [news-medical.net]
Prognosis
Provides all the information essential for completing a sign-out report: clinical findings, pathologic findings, diagnosis, treatment, and prognosis. [books.google.com]
Treatment and prognosis Based on case series-level evidence, good response is seen to corticosteroids such as prednisolone or hydrocortisone 1,2. [radiopaedia.org]
The effectiveness of radiotherapy is unknown in germinomas with granulomatous reaction but it has been reported to lead to a favorable prognosis 5. [turkjpath.org]
Radical surgery is the treatment of choice and carries an excellent prognosis with no recurrence. [edmcasereports.com]
Etiology
Stain for acid fast bacilli and fungal etiologies were negative. The evaluation of etiology and differential diagnosis of granulomatous hypophysitis was done. Tuberculosis was diagnosed. [endocrine-abstracts.org]
This classic histological finding differentiates it from the histological appearances of other etiologies of hypophysitis, those being: lymphocytic hypophysitis : lacks plasma cells and presents in a young female demographic 1,2 granulomatous hypophysitis [radiopaedia.org]
It was reasonably assumed, therefore, that this disease has an auto immune etiology. [pituitaryadenomas.com]
In the absence of any evidence of any local or systemic causes of granulomatous inflammation, an immune etiology has to be considered. [cancerjournal.net]
Perhaps this suggests an underlying and unifying autoimmune etiology for both GH and PCNSV with a common target found in both hypophyseal and vascular tissue. [surgicalneurologyint.com]
Epidemiology
The next and largest section of the book concerns autoimmune thyroid disease, and authors of these chapters take the reader through the basic epidemiology, genetic and environmental risk factors, immunopathogenesis, and the diagnostic and management aspect [books.google.com]
Epidemiology According to the one epidemiological study in Minnesota, there were 94 patients identified with De Quervain’s thyroiditis. This represents an incidence of 12.1 cases per 100,000 people per year. [news-medical.net]
Rose Departments of Pathology (P.C., P.C.B., N.R.R.), Epidemiology (C.N.), Neurosurgery (A.O.), Neuroradiology (M.G.P.), and Molecular Microbiology and Immunology (P.C., N.R.R.), The Johns Hopkins University, Baltimore, Maryland 21205 Diabetes and Endocrine [slideplayer.com]
[…] the two diseases represent an autoimmune spectrum from a purely lymphocytic form constituting the predominant early lesion to a granulomatous form appearing later. 1 Granulomatous hypophysitis, however differs from lymphocytic hypophysitis in certain epidemiological [japi.org]
Granulomatous hypophysitis, however, differs from lymphocytic hypophysitis in certain epidemiological features, which are mostly associated with pregnancy and autoimmune diseases [ 6 ]. [kjim.org]
Pathophysiology
The pathophysiologic process apparently begins as an acute inflammatory response with enlargement of the gland, as noted in 95% tissue-documented cases. [pituitaryadenomas.com]
Prevention
Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. [books.google.es]
[…] surgery is recommended for all cases to aid unequivocal diagnosis, disease specific therapy, rapid decompression and resolution of symptoms, and to obviate unnecessary steroid therapy. [1], [2] Frozen section examination can be done intra-operatively to prevent [ijpmonline.org]
There are valves in most veins to prevent backflow, veins are present throughout the body as tubes that carry blood back to the heart. [wikivisually.com]
The significance of this inflammatory reaction could be that to prevent the extent of the tumor, as reported in several types of malignant neoplasms as part of a spontaneous regression process [ 17 ]; the exclusivity in our case was that pituitary adenomas [omicsonline.org]
We describe a case of Wegener's granulomatosis with granulomatous hypophysitis and suggest possible indications revealed by MR imaging to allow medical management and prevent surgery. [ajnr.org]