A recent trend toward a younger reported age at presentation is recognized, with a mean age of presentation of 44 years. Prognosis If untreated, GCBL can be locally very destructive, extending into the pelvic organs and bony structures. [emedicine.medscape.com]

CASE REPORT: We present a case of 28-year-old female patient with condylomata gigantea (Buschke-Lowenstein tumor) in anal and perianal region with propagation on vulva and vagina. The local surgical excision and CO(2) laser treatment were performed. [ncbi.nlm.nih.gov]

[…] surgical and CO2 laser treatment}, author {Zivko Perisi{\'c} and Jelena Popovic Lazic and Branka Terzi{\'c} and Svetlana Perisic and Rajko Rasic}, journal {Archives of Gynecology and Obstetrics}, year {2003}, volume {267}, pages {263-265} } Case report.We present [semanticscholar.org]

We present a case of C. gigantea in a 23-year-old male-to-female transsexual, whose warts arose on the transplanted skin of a neovagina and in the perianal region. [journals.sagepub.com]

• Irritability

  Other implicated agents are chronic chemical exposure, chronic irritation, and poor hygiene. Etiology Chronic phimosis and poor penile hygiene have been postulated as inciting or contributing events. [emedicine.medscape.com]

• Colitis

  Chronic irritation, produced by a perianal fistula and ulcerative colitis, has been implicated as a causative factor. Immunosuppression secondary to HIV disease or due to immunosuppressive medication may be a predisposing factor. [emedicine.medscape.com]

Even with treatment, morbidity rates can be high because recurrences are very common with all treatment modalities. Inadequately treated GCBL has a relentless progression and is fatal by direct spread to pelvic organs. [emedicine.medscape.com]

The local surgical excision and CO2 laser treatment were performed. Histological examination showed presence of HPV type 11 without malignant potential.Result.Three months later, there was no recurrence. [semanticscholar.org]

[…] with immunosuppressive drugs - Syphilis (clinical features of first stage and second stage) - Previous treatment with Imiquimod within the last 30 days prior to visit 1 -Previous/concomitant treatment with any other immunomodulators within the last 90 [apps.who.int]

The local surgical excision and CO(2) laser treatment were performed. Histological examination showed presence of HPV type 11 without malignant potential. RESULT: Three months later, there was no recurrence. [ncbi.nlm.nih.gov]

By definition, adequately treated GCBL has a low recurrence rate and, therefore, an excellent prognosis. [emedicine.medscape.com]

Etiology Chronic phimosis and poor penile hygiene have been postulated as inciting or contributing events. This may account for the higher incidence in males who are uncircumcised. [emedicine.medscape.com]

Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum. 2001 Dec. 44(12):1878-86. [Medline]. [emedicine.medscape.com]

Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and reviews of the literature. Dis Colon Rectum 2001 ;44: 1878 – 86 Google Scholar Crossref Medline ISI 3. Fiumara, NJ, Di Mattia, A. [journals.sagepub.com]

Pathophysiology GCBL is slow growing, highly destructive to contiguous tissue, and seldom metastasizes. [emedicine.medscape.com]

November 2019 Main ID: EUCTR2012-004007-13-DE Date of registration: 06/06/2013 Prospective Registration: Yes Primary sponsor: Deutsches Krebsforschungszentrum (DKFZ Public title: This study will examine the hypothesis that Gardasil vaccination might prevent [apps.who.int]