Conclusions The present case is complex for multiple previously unreported manifestations. [nature.com]

Small osseous calcifications and abundant neurovascular bundles may also be present. [ojrd.biomedcentral.com]

• Swelling

  Lymphomas rarely manifest initially in the oral cavity, but misdiagnosis is highly probable because maxillary and mandibular swelling can mimic fibrotic lesion [47, 151]. [ojrd.biomedcentral.com]

• Pseudotumor

  Oral pseudotumor: benign polypoid masses following radiation therapy. Cancer. 2003;97:1353–57. PubMed Article Google Scholar 53. Liston SL, Dehner LP, Jarvis CW, Pitzele C, Huseby TL. Inflammatory pseudotumors in the buccal tissues of children. [ojrd.biomedcentral.com]

• Splenomegaly

  Hereditary gingival fibromatosis: report of an affected family with associated splenomegaly and skeletal and soft-tissue abnormalities. Oral Surg. 1964;17:339–51. CAS PubMed Article Google Scholar 184. Chacon-Camacho OF, Vazquez J, Zenteno JC. [ojrd.biomedcentral.com]

• Gingival Overgrowth

  (d) Gingival overgrowth of mandible, mainly in premolar region, is less severe than that of maxilla. Full size image There was massive gingival overgrowth in both maxillary and mandibular arches (Figure 1b–1d). [nature.com]

  Gingival overgrowth in cyclosporine A treated multiple sclerosis patients. J Periodontol. 1994;65:744–49. CAS PubMed Article Google Scholar 22. Kataoka M, Kido J, Shinohara Y, Nagata T. Drug-induced gingival overgrowth-a review. [ojrd.biomedcentral.com]

• Periodontitis

  Gingival enlargement and mesiodens associated with generalized aggressive periodontitis: a case report. Dent Update. 2012;39:364–66. PubMed Google Scholar 96. Novak KF, Novak MJ. Aggressive periodontitis. [ojrd.biomedcentral.com]

  Idiopathic gingival fibromatosis associated with generalized aggressive periodontitis: a case report. J Can Dent Assoc 2009; 75( 4): 291–295. PubMed Google Scholar 3 Hart TC, Zhang Y, Gorry MC et al. [nature.com]

• Gingival Hypertrophy

  Gingival hypertrophy: a solitary manifestation of scurvy. Am J Otolaryngol. 2008;29:426–28. CAS PubMed Article Google Scholar 43. McIntosh CL, Kolhatkar S, Winkler JR, Ojha J, Bhola M. [ojrd.biomedcentral.com]

Management of patients diagnosed with GF and AP includes non-surgical treatments, surgery with regenerative or resective therapy and anti-microbial treatment. [ojrd.biomedcentral.com]

Prognosis is precarious and the risk of recurrence exists. Background Gingival fibromatosis (GF) is a rare condition characterized by pathological, diffuse or local growth of gingiva. [ojrd.biomedcentral.com]

[…] by etiological heterogeneity [4, 23, 29, 41, 77]. [ojrd.biomedcentral.com]

Here, we review the literatures on gingival fibromatosis and briefly summarize some characters on clinical, etiological, genetic and histopathological aspects. [nature.com]

Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review. J Periodontol 2005; 76( 1): 3–10. Article Google Scholar 12 Jones G, Wilroy RS Jr, McHaney V. [nature.com]

Epidemiology GF associated with hereditary factors (non-syndromic) HGF (GINGF, ORPHA 2024, MIM 135300) is a rare disease with unknown prevalence [2–4] (Table 1). [ojrd.biomedcentral.com]

Pathogenesis and Pathophysiology The pathologic manifestation of GF is excessive accumulation of ECM proteins, including collagen type I [110–114]. [ojrd.biomedcentral.com]

It binds to the nascent type I procollagen peptides to prevent premature folding and aggregation of procollagen chains, and participates in the translocation and secretion of procollagen I into the extracellular space [115]. [ojrd.biomedcentral.com]