Conclusions The present case is complex for multiple previously unreported manifestations. [nature.com]

Small osseous calcifications and abundant neurovascular bundles may also be present. [ojrd.biomedcentral.com]

• Splenomegaly

  Hereditary gingival fibromatosis: report of an affected family with associated splenomegaly and skeletal and soft-tissue abnormalities. Oral Surg. 1964;17:339–51. CAS PubMed Article Google Scholar 184. Chacon-Camacho OF, Vazquez J, Zenteno JC. [ojrd.biomedcentral.com]

• Arthritis

  Cherubism, gingival fibromatosis, epilepsy, and mental deficiency (Ramon syndrome) with juvenile rheumatoid arthritis. Am J Med Genet. 1986;25:433–41. CAS PubMed Article Google Scholar 178. [ojrd.biomedcentral.com]

Management of patients diagnosed with GF and AP includes non-surgical treatments, surgery with regenerative or resective therapy and anti-microbial treatment. [ojrd.biomedcentral.com]

Prognosis is precarious and the risk of recurrence exists. Background Gingival fibromatosis (GF) is a rare condition characterized by pathological, diffuse or local growth of gingiva. [ojrd.biomedcentral.com]

[…] by etiological heterogeneity [4, 23, 29, 41, 77]. [ojrd.biomedcentral.com]

Here, we review the literatures on gingival fibromatosis and briefly summarize some characters on clinical, etiological, genetic and histopathological aspects. [nature.com]

Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review. J Periodontol 2005; 76( 1): 3–10. Article Google Scholar 12 Jones G, Wilroy RS Jr, McHaney V. [nature.com]

Epidemiology GF associated with hereditary factors (non-syndromic) HGF (GINGF, ORPHA 2024, MIM 135300) is a rare disease with unknown prevalence [2–4] (Table 1). [ojrd.biomedcentral.com]

Pathogenesis and Pathophysiology The pathologic manifestation of GF is excessive accumulation of ECM proteins, including collagen type I [110–114]. [ojrd.biomedcentral.com]

It binds to the nascent type I procollagen peptides to prevent premature folding and aggregation of procollagen chains, and participates in the translocation and secretion of procollagen I into the extracellular space [115]. [ojrd.biomedcentral.com]