Conclusions The present case is complex for multiple previously unreported manifestations. [nature.com]

Small osseous calcifications and abundant neurovascular bundles may also be present. [ojrd.biomedcentral.com]

• Gingival Overgrowth

  (d) Gingival overgrowth of mandible, mainly in premolar region, is less severe than that of maxilla. Full size image There was massive gingival overgrowth in both maxillary and mandibular arches (Figure 1b–1d). [nature.com]

  overgrowth ECM: extracellular matrix EMT: epithelial/mesenchymal transition ER: endoplasmic reticulum ERS: enamel-renal syndrome FAM20A : family with sequence similarity 20, member A GF: gingival fibromatosis GO: gingival overgrowth HGF: hereditary gingival [ojrd.biomedcentral.com]

Treatment by surgical resection is generally followed by regrowth of the gingival tissues (summary by Pehlivan et al., 2009). [ncbi.nlm.nih.gov]

Management of patients diagnosed with GF and AP includes non-surgical treatments, surgery with regenerative or resective therapy and anti-microbial treatment. [ojrd.biomedcentral.com]

Treatment by surgical resection is generally followed by regrowth of the gingival tissues (summary by Pehlivan et al., 2009). (617626) (Updated 26-Feb-2023) MalaCards based summary: Fibromatosis, Gingival, 5, also known as fibromatosis, gingival, hereditary [malacards.org]

Prognosis is precarious and the risk of recurrence exists. Background Gingival fibromatosis (GF) is a rare condition characterized by pathological, diffuse or local growth of gingiva. [ojrd.biomedcentral.com]

[…] by etiological heterogeneity [4, 23, 29, 41, 77]. [ojrd.biomedcentral.com]

Here, we review the literatures on gingival fibromatosis and briefly summarize some characters on clinical, etiological, genetic and histopathological aspects. [nature.com]

Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review. J Periodontol 2005; 76( 1): 3–10. Article Google Scholar 12 Jones G, Wilroy RS Jr, McHaney V. [nature.com]

Epidemiology GF associated with hereditary factors (non-syndromic) HGF (GINGF, ORPHA 2024, MIM 135300) is a rare disease with unknown prevalence [2–4] (Table 1). [ojrd.biomedcentral.com]

Pathogenesis and Pathophysiology The pathologic manifestation of GF is excessive accumulation of ECM proteins, including collagen type I [110–114]. [ojrd.biomedcentral.com]

It binds to the nascent type I procollagen peptides to prevent premature folding and aggregation of procollagen chains, and participates in the translocation and secretion of procollagen I into the extracellular space [115]. [ojrd.biomedcentral.com]